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What You Need to Know Before Taking Diclofenac for Pain Relief

Dr. Priya Sammani (MBBS)
Medically Reviewed by Dr. Priya Sammani (MBBS) ✓ Medically Reviewed
📅 Updated: Oct 20, 2026 • ⏱ 9 min read • Editorial Policy
What You Need to Know Before Taking Diclofenac for Pain Relief
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You might sometimes wake up with a pounding headache, a throbbing toothache, stiff joints, or sharp cramps. When pain strikes, many of us reach for a quick pain relief pill to get through the day.

One of the most common and widely prescribed medicines doctors recommend for these pains is Diclofenac. However, taking this medicine requires careful attention to your health history and daily habits.

Let us walk through everything you need to know about Diclofenac in clear, simple terms so you can use it safely and effectively.

Key Takeaways at a Glance

  • Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) used to treat pain, swelling, and arthritis.
  • Always inform your doctor about heart conditions, high blood pressure, or stomach ulcers before starting.
  • Take your medicine with a glass of water and food or milk to protect your stomach lining.
  • Never combine Diclofenac with other NSAIDs like ibuprofen or with alcohol to prevent dangerous bleeding.
  • Seek emergency medical help right away if you experience chest pain, severe stomach pain, or black stools.
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What is Diclofenac?

Simply put, Diclofenac is a medicine given to reduce pain, swelling, and discomfort from conditions like arthritis. It belongs to a family of medicines called NSAIDs, which stands for Non-Steroidal Anti-Inflammatory Drugs.

You might already know other medicines in this family, such as ibuprofen or naproxen. Diclofenac works primarily by stopping your body from making the natural chemicals that cause pain and swelling.

It helps you move more comfortably when joint pain or inflammation slows you down. However, because it is a strong medicine, it is not suitable for everyone.

Things to Tell Your Doctor Before Starting This Medicine

This is a very important step. If you have any of the health conditions listed below, you must tell your doctor before you start taking Diclofenac.

Health Condition or Habit Why You Must Tell Your Doctor
Heart disease, heart attack, or heart failure This medicine can raise your risk of heart attacks and strokes.
Recent bypass surgery (CABG) Taking this medicine right after heart bypass surgery is extremely dangerous.
High blood pressure Diclofenac can cause your blood pressure levels to go even higher.
Stomach ulcers or bleeding The medicine greatly increases your risk of stomach bleeding and sores.
Kidney or liver disease Your kidneys and liver process this medicine; impaired organs can suffer severe damage.
Asthma Some people with asthma experience severe breathing reactions from NSAIDs.
Bleeding disorders or blood thinners Combining them raises your chance of dangerous, uncontrolled bleeding.
Regular alcohol use or smoking These habits greatly increase the chance of stomach irritation and bleeding.
Pregnancy or breastfeeding Taking this in late pregnancy can cause serious harm to your unborn baby.
Allergies to Diclofenac or other drugs Previous allergic reactions can trigger severe, life-threatening sensitivities.

How to Use This Medicine Properly

Always take your medicine exactly as your doctor tells you. Following simple usage rules protects your stomach and ensures the medicine works right.

  • Take each tablet with a full glass of water.
  • Take your doses at the exact times your doctor recommended every single day.
  • Never crush, break, chew, or split the tablet. Swallow it whole so it releases properly.
  • You can take this medicine with or without food. However, if your stomach feels upset, take it with a meal or a glass of milk.
  • Keep taking the medicine until your doctor tells you to stop.

What to Do If You Miss a Dose

If you forget to take your medicine, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose completely.

Just return to your normal dosing schedule with the next pill. Never take two doses at the same time to make up for a missed pill.

What to Do If You Take Too Much

If you suspect you have taken too many pills by accident, act quickly. Call your local emergency services right away or go straight to the nearest hospital emergency department.

Taking an overdose of Diclofenac can cause dangerous internal bleeding, severe stomach pain, extreme drowsiness, and breathing trouble.

Other Medicines That May Interact With Diclofenac

Diclofenac can react poorly when mixed with certain other medicines. Tell your doctor about every single product you use, including vitamins, herbal remedies, and supplements.

Critical Safety Warning

Never take Diclofenac alongside Ketorolac, Cidofovir, or Methotrexate. Combining these medicines can lead to severe organ damage and toxic reactions.

Other Medicines and Substances That Interact With Diclofenac
Alcohol and alcoholic beverages
Aspirin and similar pain relievers
Blood thinners such as Warfarin
Other NSAIDs like Ibuprofen or Naproxen
Medicines for high blood pressure
Diuretics or water pills
Lithium and Cyclosporine
Steroid medicines like Prednisone and Pemetrexed

Things to Watch Out For While Taking Diclofenac

While using this medicine, keep a close eye on how your body feels. Certain warning signs require immediate medical attention.

Stomach Bleeding Warnings

This medicine can cause serious stomach ulcers and bleeding without any warning signs. Watch for sharp stomach pain, vomiting blood that looks like coffee grounds, or passing black, tarry stools. If you notice any of these signs, stop taking the medicine and see a doctor right away.

Heart and Stroke Risks

Diclofenac does not protect against heart attacks. Long-term use, especially if you have existing heart disease, can increase your risk of heart attacks and strokes.

  • Avoid other pain relievers: Do not take aspirin, ibuprofen, or naproxen at the same time, as this raises your risk of stomach ulcers.
  • Stay away from alcohol: Drinking alcohol while taking this medicine increases your risk of stomach bleeding and irritation.
  • Watch for skin reactions: Serious skin rashes, blisters, or fever can happen weeks into treatment. Report skin changes right away.
  • Pregnancy restrictions: Never take this medicine after 30 weeks of pregnancy because it harms the unborn baby.
  • Dizziness and drowsiness: If this medicine makes you dizzy or tired, avoid driving cars or operating heavy machinery.

Possible Side Effects of Diclofenac

Like all medicines, Diclofenac can cause side effects. Some are mild and go away. This others require urgent medical care.

Serious Side Effects (Seek Medical Help Right away) Main Warning Signs
Allergic reactions Skin rashes, itching, swollen face, lips, tongue, or trouble breathing.
Stomach bleeding Black stools, vomiting coffee-ground material, red urine, purple skin spots.
Heart attack Chest pain, pain spreading to your arm or shoulder, sweating, shortness of breath.
Stroke Sudden numbness in your face or arm, trouble speaking, dizziness, loss of balance.
Liver injury Upper right stomach pain, yellow eyes or skin, dark urine, loss of appetite.
Kidney injury Passing much less urine, swollen ankles, feet, or hands.
Common, Mild Side Effects (Report to Your Doctor If Persistent)
Headaches and mild dizziness
Mild stomach discomfort or heartburn
Loss of appetite
Nausea or feeling sick to your stomach

💡 Take-Home Message

Diclofenac is a powerful and effective medicine, but it must always be used under a doctor's guidance. Tell your doctor about your complete medical history and all other medicines you take.

Take your tablets with food or milk to protect your stomach lining, and avoid alcohol completely while on this treatment. Watch closely for warning signs such as chest pain, breathing trouble, or black stools, and seek emergency help right away if they happen.

If you are pregnant or planning to become pregnant, talk to your doctor before taking this medicine to ensure the safety of both you and your baby.

Sources & References:
1. Cleveland Clinic. Diclofenac Tablets: Uses, Side Effects & Warnings. Available at: https://my.clevelandclinic.org/
2. Mayo Clinic. Diclofenac (Oral Route) Proper Use. Available at: https://www.mayoclinic.org/
3. National Health Service (NHS UK). Diclofenac: Painkiller. Available at: https://www.nhs.uk/
4. U.S. Food and Drug Administration (FDA). NSAID Medicine Guide and Safety Warnings. Available at: https://www.fda.gov/
5. National Institutes of Health (NIH) / PubMed. Clinical Pharmacology of Non-Steroidal Anti-Inflammatory Drugs.

❓ FAQ

Frequently Asked Medical Questions (FAQ)

Evidence-based clinical answers to common patient questions

Can I take Diclofenac on an empty stomach?

You can take it with or without food. However, taking it with a meal or a glass of milk helps prevent stomach upset and heartburn.

What should I do if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next scheduled pill, skip the missed dose and resume your normal schedule.

Is it safe to drink alcohol while taking Diclofenac?

No, you should avoid alcohol entirely. Combining alcohol with Diclofenac greatly increases your risk of developing stomach ulcers and bleeding.

Can pregnant women take Diclofenac?

You should avoid taking Diclofenac during pregnancy, especially during the last three months, as it can cause serious harm to your unborn baby.

When should I seek emergency medical help?

Seek emergency medical care right away if you experience chest pain, shortness of breath, severe stomach pain, or black, tarry stools.

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⚠️ Important: Medical articles and information on Nirogi Lanka are strictly for educational and awareness purposes and do not substitute professional medical advice, diagnosis, or treatment. Always consult a qualified physician for any medical concerns.