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What You Need to Know Before Getting a Diclofenac Injection for Pain

Dr. Priya Sammani (MBBS)
Medically Reviewed by Dr. Priya Sammani (MBBS) ✓ Medically Reviewed
📅 Updated: Oct 22, 2026 • ⏱ 8 min read • Editorial Policy
What You Need to Know Before Getting a Diclofenac Injection for Pain
Table of Contents ▾

Severe body pain can strike at any time. You might feel a sharp ache in your joints, a stiff lower back, or heavy soreness after surgery. When pain becomes too strong to manage at home, a doctor may give you a powerful pain relief injection.

One of the most common and widely used options in medical clinics is the Diclofenac injection. While this medicine is very effective at stopping severe pain, it also carries important risks. Let us walk through everything you need to know about how it works and how to stay safe.

Key Takeaways About Diclofenac Injections

  • Diclofenac is a strong prescription NSAID used for short-term, severe pain relief in clinical settings.
  • You must tell your doctor about any history of heart disease, stomach ulcers, or kidney issues before getting it.
  • Never combine this injection with other pain relievers like ibuprofen or aspirin unless your doctor tells you to.
  • Watch out for serious warning signs like dark stools, chest pain, or sudden skin rashes, and seek urgent help if they occur.
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What Is Diclofenac?

Simply put, Diclofenac is a strong medicine used to treat pain and swelling. It belongs to a group of medicines known as NSAIDs, which stands for Non-Steroidal Anti-Inflammatory Drugs. This means it does not contain steroids, but it fights inflammation and soreness inside your body.

When you feel pain from an injury or a condition like arthritis, your body releases certain chemicals that cause swelling and discomfort. Diclofenac blocks those chemicals to reduce swelling and bring you fast relief. Doctors usually give this injection in a hospital or clinic for short-term, intense pain.

What to Tell Your Doctor Before Getting This Medicine

This step is extremely important for your health and safety. Before you receive a Diclofenac injection, you must share your complete medical history with your doctor. Using this medicine when you have certain health conditions can lead to severe complications.

Imagine you already suffer from gastritis or stomach ulcers. A powerful medicine like Diclofenac can easily harm your stomach lining and cause bleeding. If your doctor knows about this beforehand, they can choose a safer medicine or give you an extra drug to protect your stomach. Always be completely honest about your health.

Make sure to tell your doctor right away if any of the following health conditions or personal habits apply to you:

Health Condition or Habit Why Your Doctor Needs to Know
Heart disease, heart failure, or past bypass surgery Diclofenac can raise your risk of heart attacks and strokes.
High blood pressure This medicine can push your blood pressure even higher.
Stomach ulcers, gastritis, or bleeding in your gut It increases the danger of serious stomach bleeding and painful sores.
Kidney or liver disease Your organs may struggle to process the drug, leading to further damage.
Asthma or breathing problems Some people with asthma experience dangerous airway tightening from NSAIDs.
Taking blood thinners (like Warfarin or Apixaban) Combining these medicines multiplies your risk of internal bleeding.
Pregnancy or breastfeeding It can harm an unborn baby, especially in the final months of pregnancy.
Smoking or regular alcohol use These habits aggravate your stomach and worsen bleeding risks.
Past drug allergies (to aspirin or other NSAIDs) Sharing this prevents sudden, life-threatening allergic reactions.

How Is This Injection Used?

You cannot take this medicine at home by yourself. A trained nurse or doctor must give you a Diclofenac injection inside a medical clinic or hospital.

  • For children: Giving this medicine to young patients requires extreme care. Doctors follow strict guidelines based on body weight and age.
  • For older adults: Adults over age 65 are often more sensitive to this medicine. Doctors usually give them a lower dose to keep them safe.

What Happens If You Receive Too Much?

Because medical professionals give this injection in a clinic, an accidental overdose is rare. However, if you ever suspect you received too much medicine, get help right away. Call your local emergency services or go to the nearest emergency department right away.

Important Safety Rules While Taking Diclofenac

While you are receiving this treatment, you must follow a few simple rules to protect your health and avoid dangerous complications.

  • Avoid other pain relievers: Do not take aspirin, ibuprofen, or naproxen unless your doctor tells you to. Mixing these drugs spikes your risk of stomach ulcers and internal bleeding.
  • Watch for stomach bleeding: Stomach bleeding can happen without any early warning signs. If you notice severe stomach pain, vomit that looks like coffee grounds, or dark black stools, tell a doctor right away.
  • Understand heart risks: This medicine does not protect you from heart attacks. In fact, using it for a long time can raise your heart attack risk. Talk to your doctor if you take daily aspirin for your heart.
  • Stay away from alcohol: Drinking alcohol while taking this medicine irritates your stomach lining and raises your chance of internal bleeding.
  • Check for skin reactions: Serious skin rashes can sometimes appear days after starting treatment. If you get a fever, body aches, red skin, or blistering that causes peeling, seek emergency medical help.
  • Be careful during pregnancy: If you are pregnant, talk to your doctor very carefully. Taking this medicine between weeks 20 and 30 of pregnancy can harm your baby. Never use it after 30 weeks.
  • Watch for dizziness: This medicine can make you feel sleepy or dizzy. Avoid driving or operating heavy machinery until you know how the injection affects your body.

Possible Side Effects You Might Experience

Like all medicines, Diclofenac can cause side effects. Some reactions are mild. This others require urgent medical attention.

Side Effect Type Description and Signs
Severe Allergic Reactions Skin rashes, itching, swelling of your face, lips, tongue, or throat.
Signs of Bleeding Black tarry stools, vomiting dark blood, dark urine, or unusual bruising.
Heart Attack Warnings Chest pain spreading to your arm or jaw, sudden shortness of breath, nausea.
Stroke Symptoms Sudden numbness in your face or arm, trouble speaking, or confusion.
Liver or Kidney Harm Swollen ankles, passing less urine, yellow skin, or pain on your upper right side.
Mild Headaches A mild, temporary headache that usually fades as the medicine wears off.
Nausea and Stomach Discomfort Mild heartburn or a queasy stomach after getting the injection.

When to Call Emergency Services

Call 911 (US/Canada), 999 (UK), or go to your nearest Emergency Department right away if you experience chest pain, trouble breathing, sudden weakness on one side of your body, severe swelling of your face or throat, or vomit that looks like coffee grounds.

💡 Take-Home Message

  • Diclofenac is a potent prescription pain relief injection given by professionals for severe body pain.
  • Always share your complete medical history—especially heart, kidney, and stomach issues—with your doctor before receiving it.
  • Never mix this medicine with other non-steroidal anti-inflammatory drugs unless your doctor instructs you to do so.
  • Seek immediate medical help if you notice warning signs like dark stools, chest discomfort, or severe allergic rashes.
  • Pregnant women must be extremely cautious and discuss every risk with their doctor before using this medicine.
❓ FAQ

Frequently Asked Medical Questions (FAQ)

Evidence-based clinical answers to common patient questions

Why would a doctor choose a Diclofenac injection over pills?

An injection delivers the medicine directly into your system, allowing it to work much faster than oral tablets. Doctors often use it when you experience sudden, intense pain that requires immediate medical intervention.

Can I drive home after receiving this injection?

It is best to wait and see how your body reacts. Because Diclofenac can cause dizziness or drowsiness in some people, you should avoid driving until you feel completely alert and steady.

Is it safe to take Diclofenac if I have high blood pressure?

NSAIDs like Diclofenac can raise your blood pressure and interfere with certain blood pressure medicines. Always let your doctor know if you have hypertension so they can monitor your readings closely.

What should I do if my pain does not go away after the injection?

Never take another dose or add extra pain pills on your own. Speak with the nurse or doctor who treated you so they can evaluate your condition and recommend safe next steps.

How long does a Diclofenac injection take to start working?

When given by injection, Diclofenac usually begins to relieve pain within fifteen to thirty minutes. Its peak effectiveness generally occurs within the first hour of administration.

📚

Verified Scientific & Medical References (PubMed / WHO)

✓ Peer-Reviewed Sources
  1. NHS UK. Diclofenac: Uses, dosage, and side effects. Available at: nhs.uk/medicines/diclofenac/.
  2. Mayo Clinic. Diclofenac (Intramuscular Route, Intravenous Route). Available at: mayoclinic.org.
  3. Cleveland Clinic. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs). Available at: clevelandclinic.org.
  4. U.S. Food and Drug Administration (FDA). NSAID Patient Information Guide. Available at: fda.gov.
  5. World Health Organization (WHO). Guidelines for the Management of Acute Pain. Available at: who.int.
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