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Dealing with an enlarged prostate? Here is everything you need to know about Dutasteride.

Dr. Priya Sammani (MBBS)

Medically reviewed by Dr. Priya Sammani (MBBS) — Updated on Oct 22, 2026 · 9 min read

Dealing with an enlarged prostate? Here is everything you need to know about Dutasteride.
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As you get older, you might notice changes in how you use the bathroom. Maybe you wake up several times during the night, or you feel like your bladder never quite empties completely. For many men, these frustrating changes happen because the prostate gland gets larger with time.

Doctors call this common condition Benign Prostatic Hyperplasia, or BPH for short. While it is not cancer, it can certainly disrupt your daily routine and sleep. Doctors often prescribe a special medicine called Dutasteride to help shrink the prostate and ease these symptoms.

Let us walk through everything you need to know about Dutasteride. We will cover how it works, what to expect while taking it, and important safety rules you must follow to protect your health and your family.

Key Takeaways About Dutasteride

  • Dutasteride shrinks an enlarged prostate gland to make urination easier and more comfortable.
  • It belongs to a class of medicines called 5-alpha reductase inhibitors.
  • It can take six to twelve months to experience the full benefits of this medicine.
  • Pregnant women must never touch or handle crushed or leaking Dutasteride capsules.
  • You must wait six months after stopping the medicine before you can donate blood.
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What Exactly Is Dutasteride?

Simply put, Dutasteride is a prescription medicine used to treat the symptoms of an enlarged prostate, known medically as Benign Prostatic Hyperplasia or BPH. Over time, this medicine works to gradually reduce the physical size of your prostate gland.

When the prostate shrinks, it takes the pressure off your urinary tube. This relief helps your urine flow much easier and stops those frustrating bathroom rushes. You will likely feel much more comfortable throughout your day and night.

This medicine belongs to a group of drugs called 5-alpha reductase inhibitors. A very common brand name for this drug is Avodart, though your doctor might prescribe a generic version. If you have any questions about your specific prescription, always talk to your doctor or pharmacist.

Things to Tell Your Doctor Before Starting This Medicine

Before you take your very first dose of Dutasteride, you must share your complete medical history with your doctor. Giving your doctor a full picture of your health ensures this medicine is safe and right for you.

Be sure to mention if any of the following situations apply to your current health status:

Your Health Condition Why Your Doctor Needs to Know
Liver disease Your liver processes Dutasteride. If your liver is weak, your doctor may need to adjust your dose.
Prostate cancer history This medicine affects PSA blood test results used to screen for cancer. Your doctor must track this carefully.
Allergies to medicines Tell your doctor if you ever had an allergic reaction to Dutasteride, Finasteride, or similar drugs.
Pregnant partner or family planning This is vital. The active ingredients can harm a developing male baby if absorbed.
Breastfeeding partner Your doctor needs to evaluate any potential exposure risks through bodily fluids.

The Correct Way to Take This Medicine

Taking Dutasteride correctly is straightforward, but you must follow your doctor's instructions closely every single day.

  • Swallow the capsule whole with a full glass of water.
  • Never crush, chew, break, or open the capsule. The liquid inside can irritate your skin.
  • You can take this medicine with food or on an empty stomach, whichever you prefer.
  • Try to take your capsule at the exact same time every day to keep a steady level in your body.
  • Never stop taking your medicine without talking to your doctor first.

What If You Miss a Dose?

If you forget to take your daily capsule, take it as soon as you remember later that day. However, if it is almost time for your next scheduled dose, skip the missed dose entirely.

Just return to your normal daily schedule with the next dose. Never take a double dose to make up for a missed capsule, as this can increase your risk of unwanted side effects.

What Should You Do If You Take Too Much?

If you accidentally take more capsules than your doctor prescribed, stay calm, but act quickly. Contact your local emergency services right away, or go directly to the nearest hospital emergency department.

Take your medicine bottle with you so the medical staff can see exactly what and how much you consumed. Quick professional guidance will help keep you safe.

Other Medicines That May Interact with Dutasteride

Your doctor must know about every single product you take. This includes prescription drugs, over-the-counter medicines, vitamins, and herbal supplements. Some products can change how Dutasteride works in your body.

Pay special attention if you take any of the following types of medicines:

  • Antiviral medicines used to treat HIV or AIDS.
  • Boceprevir treatment therapies.
  • Antifungal medicines like ketoconazole or itraconazole.
  • Certain common antibiotics like erythromycin or telithromycin.
  • Cimetidine, diltiazem, or verapamil heart and stomach drugs.
  • Herbal supplements like saw palmetto.

Important Note: This list is not exhaustive. Always share a complete list of everything you eat with your doctor. Be sure to mention if you smoke or drink alcohol regularly, as lifestyle habits also matter.

Important Precautions While Taking This Medicine

1. Blood Donation Restrictions

While you are taking Dutasteride, and for six full months after you stop taking it, you must not donate blood. This rule exists because donated blood could be given to a pregnant woman. If the medicine enters her bloodstream, it could cause severe harm to a developing baby boy. Always confirm with your doctor when it is safe to donate blood again.

2. Results Take Time to Appear

Dutasteride works gradually inside your body. It can take anywhere from six to twelve months to see the maximum improvement in your urinary flow and symptoms. Do not panic if you do not see huge changes during your first few weeks. Stay patient and keep taking your medicine as prescribed.

3. Extreme Danger to Pregnant Women

Critical Safety Warning: Pregnant women, or women who might become pregnant, must never touch leaking or crushed Dutasteride capsules. The active medicine absorbs easily through the skin and can severely damage the normal development of a male baby's genitals. If skin contact ever happens accidentally, wash the area right away with plenty of soap and water, and contact a doctor right away.

4. Effects on PSA Blood Tests

Your doctor uses a blood test called a PSA (Prostate-Specific Antigen) test to screen for prostate cancer. Dutasteride lowers your PSA levels naturally. If you need a PSA test, you must tell the lab and your doctor that you take Dutasteride so they can interpret your results accurately.

Potential Side Effects of Dutasteride

Like all medicines, Dutasteride can cause side effects, though many men experience very few or none at all. Most common side effects are mild and manageable.

Side Effect Category What to Look For & Action to Take
Serious Allergic Reactions
Call emergency services right away
Skin rashes, hives, itching, or swelling of your face, lips, tongue, and throat that makes breathing difficult.
Breast Changes
Report to your doctor promptly
New lumps, tenderness, pain, swelling, or unusual fluid discharge from your nipples.
Common Adjustments
Monitor and discuss if persistent
Lower sex drive, ejaculation changes, or mild erectile difficulties. These often improve as your body adjusts.

How to Store Your Medicine Properly

Proper storage keeps your medicine safe, effective, and away from children who might accidentally swallow it.

  • Store your capsules well out of the reach and sight of children and pets.
  • Keep them at normal room temperature, ideally between 15°C and 30°C (59°F to 86°F).
  • Protect the capsules from excessive heat, bright light, and moisture. Do not store them in a humid bathroom.
  • Always keep the container lid tightly closed when not in use.
  • Safely discard any expired or unwanted medicine through a local pharmacy take-back program.
❓ FAQ

Frequently Asked Medical Questions (FAQ)

Evidence-based clinical answers to common patient questions

Can Dutasteride cure my enlarged prostate permanently?

Dutasteride manages and shrinks an enlarged prostate, but it is not a permanent cure. If you stop taking the medicine, your prostate will likely grow back to its previous size over time, and your urinary symptoms will return.

Is it safe to crush or open Dutasteride capsules?

No, you should never crush, chew, or open these capsules. The liquid inside can absorb through your skin and poses a severe health risk, especially to women who are pregnant or may become pregnant.

How long do I need to wait before donating blood?

You must wait at least six full months after taking your final dose of Dutasteride before you donate blood. This waiting period ensures that any trace of the medicine has completely left your system.

Will this medicine affect my sexual health?

Some men notice temporary side effects like a lower sex drive or mild erectile changes. These symptoms often improve over time as your body adjusts to the medicine, but you should discuss any concerns with your doctor.

What should I do if I miss a daily dose?

Take your missed capsule as soon as you remember that day. If it is almost time for your next scheduled dose, skip the missed one entirely and continue with your normal routine without doubling up.

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Verified Scientific & Medical References (PubMed / WHO)

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