Let's learn about the Glasdegib (Daurismo) pill used to treat cancer

Has your doctor prescribed Glasdegib (Daurismo) for you or someone in your family for a cancer called Acute Myelogenous Leukemia? It's a very powerful drug with a complicated name. So, this is a very simple and friendly way to talk about this drug, how it's used, and what we need to be especially careful about.

What kind of medicine is Glasdegib?

Simply put, Glasdegib is a drug that targets cancer cells and stops them from growing. Cancer cells in our body need special proteins to grow. What this drug does is stop the function of those proteins. In this way, when cancer cells cannot grow, we get a big help in controlling cancer.

This medicine is mainly used to treat a type of blood cancer called acute myelogenous leukemia. Sometimes, your doctor may also prescribe this medicine for other conditions. Your doctor will explain this to you in detail.

The most important things to tell your doctor before taking this medicine

Since Glasdegib is a very strong medicine, it is very important to inform your doctor about any other medical conditions you have. If you have any of the conditions below, tell your doctor about it before starting the medicine.

• If you have heart disease.
• If you have previously had irregular heartbeats.
• If you have a history of any muscle-related diseases.
• If you have kidney disease.
• If you have liver disease.
• If the level of electrolytes in the blood (e.g. potassium, magnesium) is too low or too high.
• If you have had an allergic reaction to Glasdegib, other medicines, foods, dyes, or preservatives.
• If you are pregnant, or are planning to become pregnant soon.
• If you are a breastfeeding mother.

How to use the medicine correctly?

It is very important to take the medicine exactly as prescribed by the doctor, in the correct dosage, at the correct time.

• Swallow this tablet whole with a glass of water. Do not break, crush, or chew the tablet.
• You can take this with or without food. But the most important thing is to take it the same way every day . For example, if you start taking it after a meal, take it every day after a meal. If you start taking it before a meal, take it every day before a meal.
• Never stop taking medication suddenly without your doctor's advice.
• If you are giving this medicine to children, talk to a pediatrician about it and only use it according to his or her instructions.
• If you accidentally take too much medicine: If you think you have taken too much medicine, immediately call the National Poisons Information Centre at the Colombo National Hospital , or go to the nearest Emergency Treatment Unit (ETU).

What do you do if you miss a dose?

If you forget to take a dose, take it as soon as you remember. However, if it is less than 12 hours until your next dose, skip the missed dose and take the next dose at the scheduled time. Never take two doses at once.

What are the contraindications for using this medicine?

Glasdegib can interact with other medications, so it is important to tell your doctor about all medications you are taking.

Do not take these medications with Glasdegib:

• Cisapride
• dronedarone
• fluconazole
• pimozide
• posaconazole
• saquinavir
• thioridazine

These medications may also interact with Glasdegib:

• Antiviral drugs for HIV or AIDS
• Some medications for fungal infections (e.g. itraconazole, ketoconazole)
• Some antibiotics (e.g. clarithromycin)
• Some medications for seizures (e.g. carbamazepine, phenytoin)
• Other medications that cause irregular heartbeats (prolong the QT interval)
• Traditional medicines such as St. John's Wort
• Grapefruit juice

This list is not complete. So give your doctor a complete list of all the medications, vitamins, herbal remedies, and supplements you take. Don't forget to tell them if you smoke or drink alcohol.

Things to be especially careful about when taking Glasdegib

• Blood tests: It is mandatory to have blood tests (blood work) as prescribed by your doctor while taking this medication.
• Pregnancy: Women should avoid becoming pregnant while taking this medication and for at least 30 days after stopping the medication. Men should also avoid fathering a child while taking this medication and for at least 30 days after stopping the medication. This medication can cause serious harm to an unborn baby.
• Breastfeeding: Avoid breastfeeding your baby while taking the medicine and for at least 30 days after stopping.
• Sperm and blood donation: Avoid donating sperm or blood while taking the medication and for at least 30 days after stopping.
• Fertility: This medicine may affect your ability to have children. If you have any concerns about this, talk to your doctor.

Side effects that may occur due to medication

Like any medicine, Glasdegib can have side effects. Some require urgent attention, while others are common.

If you experience any other unusual symptoms not mentioned in this list, please inform your doctor about them as well.

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