You may have heard that when a doctor gives you an injection, they give you another medicine along with it. Or you may have heard of a medicine that helps to send a type of fluid under the skin when it is difficult to give saline into a vein in cases like dehydration. One medicine that is used in such cases and has a slightly special function is Hyaluronidase, which we are talking about today.
Simply put, what is Hyaluronidase?
Hyaluronidase is a protein that occurs naturally in our bodies. It is used as a medicine to enhance the effectiveness of other injectable medications, that is, to help those medications work.
Think of the tissue under your skin as a sponge. Sometimes it can be difficult for this sponge to absorb medications or liquids. This Hyaluronidase medication temporarily loosens the sponge, making it easier for other medications or liquids to spread and be absorbed into the body. This allows the other medication to work more quickly and effectively.
This medicine may also be used for other purposes. If you have any questions about it, you can ask your doctor. Vitrase is a well-known brand name for this medicine.
Things you should tell your doctor before taking this medicine
Before you are given this medicine, it is important that your medical team knows some things. Be sure to tell them if you have any of the conditions below.
- If you have allergies to bee or other insect stings.
- If there is any infection, wound, or swelling at the site where the vaccine is expected to be given.
- If you have ever had an unusual or allergic reaction to hyaluronidase, lamb protein, beef protein, thimerosal, or other medicines, foods, dyes, or preservatives.
- If you are pregnant , or trying to get pregnant.
- If you are a breastfeeding mother .
It is very important to tell your doctor about anything like this, because only then can they determine whether this medication is appropriate and safe for you.
How to use the medicine and things to be careful about
This medicine is given as an injection under the skin (subcutaneous) or into a muscle (intramuscular). This is not a medicine that you can take home. This medicine is given in a hospital or clinic by a doctor or a trained medical staff member . So you don't need to worry about it.
What if you give it to small children?
If you are giving this medicine to young children, you should talk to your pediatrician about it. Although this medicine can be used even on newborn babies in some special cases, there are some things to be careful about.
What if the medication dose increases?
Since this is given in a hospital, you don't have to worry about an overdose. The medical staff will take good care of it. If you feel anything unusual, immediately inform the hospital staff. If you need information about any poisoning in our country, you can also call the National Poison Information Center at the Colombo National Hospital .
Other things that may interact with this medicine
Some medications you are taking may interact with Hyaluronidase. Therefore, it is very important to tell your doctor about all the medications you are taking, including prescription medications, over-the-counter medications, herbal remedies, and dietary supplements .
The table below lists some of the things that may interact with this medicine.
| Drug category | Examples |
|---|---|
| ACTH | ACTH hormone |
| Antihistamines | Medicines for allergies and colds |
| Aspirin and similar medications | Aspirin |
| Benzodiazepines | Medication for anxiety or sleep |
| Female hormones | Hormones such as estrogens |
| Furosemide | A medicine given to remove fluid from the body |
| Phenytoin | A medicine for fits |
| Steroid medication | Prednisone, Cortisone |
This list does not include all possible reactions. Also, tell your doctor if you smoke, drink alcohol, or use other drugs.
Let's learn about side effects.
Like any medicine, this can cause side effects in some people. However, not everyone gets them. If you do experience any side effects, it is important to be aware of them.
| Side effects of Hyaluronidase injection | |
|---|---|
| Side effects that should be reported to your doctor or medical staff immediately | |
| Allergic Reactions | Skin rash, itching, swelling of the face, lips, or tongue |
| Breathing difficulties | Difficulty breathing |
| Chest pain | Chest pain |
| Other serious symptoms | Feeling cold and feverish, fast or irregular heartbeat, fainting, nausea or vomiting, excessive swelling at the injection site |
| Side effects that should be reported to the doctor if they persist or are bothersome | |
| Minor changes at the injection site | Redness, slight pain, or swelling at the injection site |
If you notice anything unusual that isn't on this list, don't be afraid to ask your doctor about it.
Take-Home Message
- Hyaluronidase is a special injection that helps another medication work. It's more like an "adjuvant" than a medication given alone.
- This vaccine is given by a medical professional in a hospital or clinic. It is not a medicine you can take home.
- It is essential to inform your doctor about any allergies you have and all other medications you are taking.
- If you experience severe allergic symptoms such as difficulty breathing or facial swelling, seek medical advice immediately.
- Follow your doctor's instructions exactly. If you have any questions, don't hesitate to ask them.
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