Has your doctor prescribed you or someone in your family a vaccine called Lanadelumab? This is a relatively new and unique drug, so you probably have a lot of questions in your mind. You may be wondering things like, "What is this drug?", "What does it actually do?", "What should I be careful about when using it?" So today, let's talk about this drug called Lanadelumab (often called TAKHZYRO) in a simple and clear way.
What exactly is Lanadelumab?
Simply put, Lanadelumab is a protein specially made in a lab to act like part of our body's immune system. In medical terms, we call this a Monoclonal Antibody .
This medicine is mainly used to prevent attacks of swelling that occur in a rare, hereditary condition called 'Hereditary Angioedema' (HAE) . A person with HAE suddenly starts to swell in various parts of the body for no apparent reason. This swelling is especially common in areas such as the face, hands, feet, throat, and intestines. This swelling is sometimes very painful. If it occurs in the throat, it can cause difficulty breathing and can be dangerous. So, the Lanadelumab injection works by controlling the occurrence of such swelling, reducing the frequency of them, and helping you live a normal life.
Things you need to tell your doctor before starting medication
Before you start using this medicine, you must inform your doctor of the following information.
- Allergies: Tell your doctor if you have had an allergic reaction to Lanadelumab, any other medicine, food, preservatives, or dyes.
- Pregnancy and breastfeeding: It is very important to tell your doctor if you are trying to get pregnant, are already pregnant, or are breastfeeding, as special consideration should be given to the use of this medicine in these situations.
How is this vaccine used?
This is the most important part to know about this medicine.
How to get vaccinated
This medicine is given under the skin. We call it a subcutaneous injection . Your doctor or healthcare professional will usually show you how to give yourself this injection at home. They will show you how to prepare the medicine, where to inject it (for example, the skin on your stomach or thigh), and the correct way to inject it.
The most important thing is to follow the instructions they give you exactly. It is very important to take the right dose, at the right time, on the right day. Continue to use this medicine until your doctor tells you to stop.
Disposing of used needles and syringes
This is very important. Never throw used needles and syringes in the trash. Doing so can be a danger to others. They should be disposed of in a special, thick plastic container (sharps container). If you don't have one, ask your doctor about how to get one.
Use for children
This medicine can usually be prescribed by a doctor to young children over 12 years of age, depending on their medical condition. However, it is done under special medical supervision and with a few precautions.
Overdose
Imagine that you have accidentally taken more medicine than the prescribed dose. If this happens, do not panic and immediately call the National Poisons Information Centre at the National Hospital in Colombo. Or, go to the Emergency Department (ETU) of the nearest hospital. Do not take this lightly.
Be aware of side effects
Like any medicine, Lanadelumab can cause side effects in some people. Some of these may require immediate medical attention, while others may be common. Let's look at these separately.
| Type of side effect | Characteristics |
|---|---|
| Side effects that you should report to your doctor immediately | |
| Allergic Reactions | Skin rash, severe itching, hives all over the body, swelling of the face, lips, tongue or throat. |
| Signs of Infection | Fever, chills, persistent cough, sore throat. |
| Side effects that are usually not dangerous, but should be reported to the doctor if they persist | |
| Injection site reactions | Pain, redness, itching, or swelling at the injection site (this usually subsides within a few days). |
| Other common side effects | Headache, muscle pain, dizziness, diarrhea (bloating). |
Remember, this list only includes some of the most commonly reported side effects. If you experience any unusual symptoms, don't be afraid to talk to your doctor about them.
Other things to consider
What if I miss a dose of medication?
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time. Never take a double dose. If you are unsure, ask your doctor.
Dizziness
Some people may feel a little dizzy after taking this medicine. Therefore, do not stand up suddenly from a sitting or standing position. This is especially important if you are elderly (over 65 years of age). Changing positions frequently can reduce the risk of dizziness and falls.
Interactions with other drugs
This medicine has not been extensively studied to see how it interacts with other medicines you are taking. Therefore, be sure to tell your doctor about any other medicines you are taking (including over-the-counter medicines, vitamins, herbal remedies, and supplements), if you smoke , or if you drink alcohol.
Medicine storage
Keep this medicine out of the reach of children . Your doctor or healthcare professional will advise you on the correct way to store this medicine at home (e.g., in the refrigerator or at room temperature). Follow these instructions carefully. Never use or throw away expired medicine.
Take-Home Message
- Lanadelumab is a specific vaccine given to prevent swelling in hereditary angioedema (HAE).
- This is an injection that is injected under the skin, and you will be clearly instructed on how to do it correctly. Follow the instructions exactly.
- Be sure to tell your doctor about any allergies you have, other medical conditions, and if you are pregnant or breastfeeding before starting the medication.
- Dispose of used needles and syringes only in a special sharps container.
- If you experience any allergic symptoms, signs of infection (fever, cough), or anything else unusual, notify your doctor immediately.
- Never stop taking the medicine, change the dosage, or give this medicine to others without your doctor's advice.
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