We know that living with Multiple Sclerosis (MS) can be challenging at times. You may feel overwhelmed by the constant symptoms and sudden flare-ups. However, there are new treatments that can help manage this condition. Ofatumumab is one such treatment. So today, let's talk about this drug, how it works, and what to be careful about when using it.
What kind of medicine is Ofatumumab?
Simply put, Ofatumumab is a drug used to treat Multiple Sclerosis (MS). The most commonly used brand name for it is Kesimpta.
Imagine, in MS, our body's own defense system, the immune system , mistakenly attacks our own nervous system. This is what causes the symptoms of MS. Ofatumumab works by slowing down the overactive immune system and calming it down. This can reduce the number of flare-ups.
The important thing is that this is not a cure for MS. However, it can help you control the disease, reduce symptoms, and live a normal life.
Things you need to tell your doctor before starting medication
Before deciding whether this treatment is right for you, it's important to discuss some things with your doctor. If any of the following apply to you, be sure to mention them.
- Current infections: Tell us if you currently have a minor infection like a cold or flu, or if you have or have had a viral infection like Hepatitis B , chickenpox, or herpes.
- Immune system problems: If you have any other immune system weakness or condition, other than MS.
- Vaccines: If you have recently received a vaccine, or are planning to receive one in the future, especially live virus vaccines, you should tell your doctor.
- Allergies: If you have an allergy to Ofatumumab or any other medicine, food, or dye.
- Pregnancy: If you are pregnant, trying to get pregnant, or suspect you are pregnant, this is very important.
- Breastfeeding: If you are a mother who is breastfeeding a child.
How should I use the medicine?
This medicine is given as a subcutaneous injection . It may feel a little strange at first, but don't worry. Your doctor or a trained nurse will show you how to give yourself this injection.
Always read the INSTRUCTIONS FOR USE that comes with this medicine carefully. If you have any questions, don't hesitate to ask your doctor.
Another important thing is to never throw used needles and syringes in the trash. There is a special container for them (sharps container) . If you don't have one, ask your doctor about how to get one. This is very important for your safety and the safety of others.
Things to be especially careful about when taking medication
While taking this medicine, it's a good idea to pay a little more attention to your health.
Regular medical checkups
Your doctor will tell you to come in for check-ups at regular intervals. He or she may also order some blood tests . It is important to do these things regularly and without skipping them.
Risk of infection
Because this medicine reduces the activity of the immune system, you may be slightly more likely to develop infections. Therefore,
- If you experience symptoms such as fever, chills, sore throat, and cough , do not self-medicate and call your doctor immediately.
- Try to stay away from people who are sick.
- If you get an injury and it doesn't heal quickly, tell your doctor about it.
A very rare but serious brain infection
Don't be alarmed by this, but it's important to know. Very rarely, in some patients, this medicine can cause a serious brain infection called Progressive Multifocal Leukoencephalopathy (PML) . This can be life-threatening. Therefore, if you experience any of the following symptoms, seek medical advice immediately .
- Vision problems (blurred vision, double vision)
- Thinking or memory problems
- Difficulty speaking
- Difficulty walking or standing, loss of balance
If you experience any of these symptoms and are unable to speak to your doctor, go to the nearest hospital's Emergency Treatment Unit (ETU) as soon as possible.
Pregnancy and breastfeeding
This is a very important point.
- It is essential to avoid pregnancy while taking this medication, as well as for 6 months after stopping the medication .
- If you become pregnant during this time, the baby in the womb could suffer serious harm .
- If you are planning to have a child, talk to your doctor about the safest method before starting treatment.
Possible side effects
Like any medicine, this one can have side effects. Some of them are serious, some are common. You can learn more about them in the table below.
| Side effect | Description and what to do |
|---|---|
| Side effects that should be reported to your doctor immediately | |
| Allergic reactions | Skin rash, itching, swelling of the face, lips, tongue or throat. These can be serious, so seek medical advice immediately. |
| Infections | Fever, chills, cough, sore throat, non-healing wounds, urinary tract infection or pain, and body aches. If you have any of these, tell your doctor immediately. |
| Usually nothing to worry about (but tell your doctor if it persists) | |
| Back pain | This is a common occurrence, but if it is severe or persistent, tell your doctor . |
| Headache | It can occur early in the medication. |
| Pain at the injection site | It is normal to experience redness, itching, or slight pain at the injection site. |
How do you store and dispose of the medicine?
- Storage: This medicine is best stored in the refrigerator . Do not freeze. Keep it in its original carton. Remove it from the refrigerator 15-30 minutes before you plan to inject it. Do not shake the medicine at any time. If you cannot store it in the refrigerator, it can be stored at room temperature for up to 7 days. However, keep it in the original carton, protected from light, and do not use any leftovers after 7 days.
- Disposal: Expired or unwanted medications should be disposed of safely. Consult your doctor about the best method for this.
Finally, don't panic if you miss a dose. Call your doctor right away and ask what to do next. Also, tell your doctor about any other medications (such as steroids like Prednisolone ) and vitamins you're taking, as some things may interact with this medication.
Take-Home Message
- Ofatumumab is a drug that helps control MS and reduces disease progression, but it is not a cure.
- Before starting treatment, tell your doctor about all your medical conditions, especially infections, allergies, and pregnancy plans.
- While taking the medicine, watch out for signs of infection such as fever and cough. Also, seek medical advice immediately if you develop serious symptoms such as problems with vision, speech, or walking.
- Avoid getting pregnant completely while taking this medicine and for 6 months after stopping.
- Never share your medicine with others. Store it properly and dispose of used needles safely.
- Talk openly with your doctor about any problems or doubts you have.


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