Has your doctor prescribed you a medicine called Posaconazole? This medicine is usually given to prevent dangerous fungal or yeast infections that can take advantage of a weakened immune system. So taking this medicine can be a bit scary, but don't worry. Today, we'll talk in simple terms about how to use this medicine exactly and what you need to be careful about.
What exactly is Posaconazole?
Simply put, posaconazole is an antifungal medication. When our immune system is weakened, certain types of fungi in the environment can enter our bodies and cause serious infections. For example, after certain treatments given to cancer patients, or after organ transplants, the immune system is weakened. In such cases, doctors prescribe this medication to prevent these fungal infections from occurring.
Things you need to tell your doctor before starting medication
Before your doctor prescribes this medication, it is very important that you give him a complete description of your health condition. This will help him decide if this medication is right for you. Be sure to mention the following in particular:
- If you have any heart disease .
- If you have ever had an irregular heartbeat before.
- If a doctor has told you that your blood levels of calcium, magnesium, or potassium are low .
- If you have kidney disease or liver disease .
- If you have had an allergic reaction to posaconazole or any other antifungal medicine, any other medicine, food, or dye.
- If you are pregnant, or are expecting a baby .
- If you are a breastfeeding mother .
Giving this information to the doctor is very important for your safety.
How should I use this medicine?
The method of using the medicine is very simple, but it is important to follow the instructions exactly.
- This tablet should be swallowed whole with water . Never cut, crush, or chew the tablet. This tablet is designed to dissolve in the intestines (gastro-resistant), so breaking it may prevent the medicine from working.
- Try to take your medicine at the same time every day. Then it will become a habit.
- This can be taken with or without food. However, if you experience stomach upset or nausea, it is best to take it with a meal .
- Continue using this medicine until your doctor tells you to stop.
What if you give it to children?
This medicine is also given to children over 2 years of age in some special cases. However, only your doctor can decide on this. Therefore, if you are giving it to a child, follow the doctor's instructions exactly.
What to do if you take too much medicine?
Imagine you have taken more than the prescribed dose. If this happens, do not panic and immediately call the National Poisons Information Centre at the Colombo National Hospital . Or go to the Emergency Treatment Unit (ETU) of the nearest hospital.
This medicine has been prescribed for you only. Never share this medicine with anyone else, even if they have the same symptoms as you.
What if I miss a dose of medication?
If you miss a dose, take it as soon as you remember. But if it is less than 12 hours until your next dose, skip the missed dose. Skip it and take your next dose at the usual time. Never take a double dose.
Other medications that may interact with this medicine
This is the part that you need to pay the most attention to . Posaconazole is a drug that can interact with many other medications. Therefore, you should tell your doctor about all the medications you are taking, including those prescribed by your doctor, those purchased at the pharmacy, traditional medicines, vitamins, and supplements.
The two tables below clearly show this.
| Never take posaconazole with this medicine! | |
|---|---|
| Drug category | Examples |
| Some cholesterol-lowering medications | atorvastatin, lovastatin, simvastatin |
| Medication for irregular heartbeat | dronedarone, quinidine |
| Ergot Alkaloids (given for migraine) | ergotamine, dihydroergotamine |
| Other | cisapride, ibrutinib, lapatinib, pimozide, sirolimus |
| Please inform your doctor as this medication may cause problems. | |
|---|---|
| Antivirals for HIV or Hepatitis | Ex: Atazanavir, Ritonavir |
| Medication for anxiety or sleep | alprazolam, midazolam, triazolam |
| Medication for high blood pressure | diltiazem, nifedipine, verapamil |
| Some anti-cancer drugs | venetoclax, vincristine, vinblastine |
| Diabetes medication | glipizide |
| Medicine for migraine | phenytoin |
| Immune-suppressing drugs | cyclosporine, tacrolimus |
| Other | digoxin, rifabutin, metoclopramide |
This list is not complete, so it's best to tell your doctor about all the medications you take.
Things to be careful about when taking medicine
While taking the medication, see your doctor at regular intervals to check your condition. He or she may also order blood tests to check things like your liver function.
If you have severe diarrhea or persistent vomiting , tell your doctor immediately, as this may mean that the medication you have taken is not being absorbed properly.
What are the possible side effects?
Like any medicine, posaconazole can cause side effects in some people. Some of these are serious, while others are mild.
| Side effect | Description |
|---|---|
| Side effects that should be reported to your doctor immediately | |
| Allergic reactions | Skin rash, itching, swelling of the face, lips or tongue. |
| Changes in heart rate | Difficulty breathing, chest pain, dizziness, feeling like your heart is beating fast, fainting. |
| Symptoms of liver damage | Dark yellow/brown urine, yellowing of the eyes or skin, loss of appetite, pain in the upper right side of the stomach, and feeling lethargic. |
| Other | Fever, diarrhea or vomiting that can't be stopped. |
| Things that are usually not serious, but should be reported to the doctor if they persist | |
| Cough | If it persists or is bothersome, tell your doctor . |
| Headache | If it persists or is bothersome, tell your doctor . |
| Nausea | If it persists or is bothersome, tell your doctor . |
| Stomach ache | If it persists or is bothersome, tell your doctor . |
Take-Home Message
- Posaconazole is a medication that is given to prevent fungal infections in people with weakened immune systems.
- Swallow this tablet whole , without cutting, crushing, or chewing .
- Tell your doctor about all other medications you are taking (including traditional medicines).
- If you experience severe vomiting or stomach upset , tell your doctor immediately, as the absorption of the medicine may be reduced.
- If you experience any serious side effects, such as yellowing of the skin, difficulty breathing, or bruising, seek medical advice immediately.
- Never stop taking your medication on your own. Always follow your doctor's instructions .


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