He aha ka Somatostatin? E aʻo kākou e pili ana i kēia hormone kupaianaha i loko o ko kākou kino!

I kēia lā, e kamaʻilio kākou e pili ana i kahi ʻelele kemika kupanaha a koʻikoʻi loa i loko o ko kākou kino. ʻO somatostatin kona inoa. ʻAʻole paha ʻoe i lohe i kēia inoa ma mua. Akā, ua ʻike anei ʻoe, kōkua ia i ka hoʻomalu ʻana i nā mea he nui i loko o ko kākou kino, e like me kahi haku huna. E nānā kākou i ke ʻano o ka somatostatin, pehea e hana ai, a me kona koʻikoʻi i ko kākou olakino.

He aha maoli ka Somatostatin?

I ka ʻōlelo maʻalahi, ʻo ka somatostatin kahi hormone i hana ʻia i loko o ko mākou kino. I kēia manawa ke noʻonoʻo nei paha ʻoe i ke ʻano o nā 'hormones'. He mea maʻalahi loa ia. ʻO nā hormones he mau kemika e lawe ana i nā leka ma waena o nā ʻāpana like ʻole o ko mākou kino. Ua like lākou me nā 'postmen' i loko o ko mākou kino. Ke haʻi aku nei kēia mau leka i ko mākou mau ʻōpū, ʻili, a me nā ʻiʻo e hana i kekahi mea a i ʻole e hoʻōki i ka hana ʻana i kekahi mea.

No laila, ʻo kēia hormone kūikawā i kapa ʻia ʻo somatostatin ke kāohi nui nei i ka hana ʻana o nā hormones ʻē aʻe, kaohi i kekahi mau hana i loko o kā mākou ʻōnaehana hoʻoheheʻe (gastrointestinal (GI) tract), a kaohi pū i ka mahele wikiwiki o nā cell (ʻoi aku hoʻi nā cell cancer). Ua like ia me kahi mākaʻi kaʻa, ke nui loa kekahi mea, hāʻawi ʻo ia i ka hōʻailona, ​​"ʻAe, ʻae, e hoʻōki i kēia manawa."

Ma hea i hana ʻia ai kēia somatostatin?

I kēia manawa, e nānā kākou i kahi e hana ʻia ai kēia hormone somatostatin kupaianaha i loko o ko kākou kino. Hana ʻia ia ma kekahi mau wahi:

• ʻŌnaehana Gastrointestinal (GI): ʻO kēia ka ʻōnaehana ʻōnaehana lōʻihi e like me ka paipu e holo ana mai ka waha a i ka anus e kōkua iā mākou e hoʻoheheʻe i ka meaʻai a mākou e ʻai ai. ʻO kēia kahi e pili ai kou mau ʻōpū.
• ʻAkeka: He ʻāpana kēia i loko o ko kākou ʻōpū. He ʻāpana ka ʻāpana e hana ana i kekahi mau kemika. Hana ka ʻakeka i nā enzyme e kōkua i ka hoʻoheheʻe ʻana i ka meaʻai, a me nā hormones koʻikoʻi e like me ka insulin a me ka glucagon .
• Hypothalamus: Aia kēia i loko o ko kākou lolo. Ua like ia me ke 'kikowaena hoʻomalu' o ko kākou kino. Kōkua ia i ka mālama ʻana i ka homeostasis (ʻo ia hoʻi, ka mālama ʻana i kahi kūlana paʻa o loko). Hāʻawi pū ia i nā kauoha i ka pituitary gland, aia ma lalo o ka hypothalamus, e hoʻokuʻu i kekahi mau hormones.
• ʻŌnaehana Aʻalolo Waena (CNS): Hoʻokomo pū kēia i ko kākou lolo a me ke kaula kuamoʻo. Ma o kēia ʻōnaehana aʻalolo e hoʻouna ʻia ai nā leka mai ka lolo a i ke koena o ke kino.

Nā inoa ʻē aʻe no somatostatin

Ua ʻike ʻia ʻo Somatostatin e kekahi mau inoa ʻē aʻe. Inā haʻi kāu kauka i kekahi o kēia mau inoa, ke kuhikuhi nei paha lākou i ka mea like:

• SS, SST a i ʻole SOM
• ʻO ka hormone hoʻopaʻa hormone ulu (GHIH)
• ʻO ka mea hoʻokuʻu Somatotropin -inhibiting factor (SRIF)
• ʻO ka hormone hoʻokuʻu-hoʻokuʻu Somatotropin (SRIH)

Hoʻohana ʻia anei ka somatostatin ma ke ʻano he lāʻau lapaʻau?

ʻAe, i kekahi manawa, hoʻohana nā kauka i ka somatostatin synthetic ma ke ʻano he lāʻau lapaʻau e mālama ai i kekahi mau maʻi. Eia kekahi laʻana:

• ʻO kekahi mau maʻi gastrointestinal
• He ʻano laha ʻole ka Acromegaly kahi e hana nui ai ke kino i ka hormone ulu.
• ʻO kekahi ʻano maʻi kanesa i kapa ʻia ʻo nā neuroendocrine tumors (NETs) .
• ʻO kekahi mau maʻi endocrine ʻē aʻe (ʻo ia hoʻi, ka ʻōnaehana glandular e hana ana i nā hormones).

He aha nā hana nui o ka hormone somatostatin?

ʻAe, e nānā kākou i ka hana nui o kēia hormone somatostatin.

I ka ʻōlelo maʻalahi, ʻo kāna hana nui ka hoʻōki ʻana i ka hana ʻana o nā hormones ʻē aʻe i hana ʻia e kā mākou ʻōnaehana endocrine a me ka kaohi ʻana i ka hoʻokuʻu ʻia ʻana o kekahi mau mea huna mai ka ʻōnaehana exocrine.

ʻO ka 'ʻōnaehana endocrine' e pili ana i ka ʻōnaehana e hoʻopuka pololei i nā hormones mai nā glands i loko o ko mākou kino i loko o ke koko. ʻO nā hiʻohiʻona e komo pū me ka thyroid gland, ka pituitary gland, a me nā adrenal glands . ʻO ka 'exocrine system' e pili ana i ka ʻōnaehana e hoʻokuʻu i nā huahana i hana ʻia e nā glands ma o kahi duct. ʻO nā hiʻohiʻona e komo pū me nā salivary glands a me nā hou glands .

No laila, e like me ke pani ʻana i ka piula wai, hoʻōki ka somatostatin i ke kahe ʻana o kekahi mau hormones a me nā mea huna i pono ʻole ai ko mākou kino. E noʻonoʻo wale, inā ʻoe e waiho wale i kahi piula wai e wehe ana, e hoʻonele wale ʻia ka wai, ʻeā? Pēlā nō, inā hana ke kino i nā hormones ma mua o ka mea e pono ai, hiki ke kū mai nā pilikia. Hoʻomalu ʻo Somatostatin i kēlā.

ʻO kekahi mea ʻē aʻe, kōkua pū ka somatostatin i ka hoʻōki ʻana i nā pūnaewele mai ka māhele wikiwiki ʻana, e like me nā pūnaewele maʻi kanesa.

Hana pū ia ma ke ʻano he neurotransmitter i loko o ko kākou ʻōnaehana nerve waena (CNS). He ʻelele kemika ka neurotransmitter a kekahi neuron e hoʻokuʻu ai e hoʻohuli i kekahi cell nerve.

Pehea ka hopena o ka somatostatin i nā ʻāpana like ʻole o ko mākou kino

I kēia manawa, e nānā kākou pehea e pili ai ka somatostatin i kēlā me kēia ʻāpana o ko kākou kino:

• I loko o ka hypothalamus: Hoʻōki ʻo Somatostatin i ka hoʻokuʻu ʻia ʻana o nā hormones i hana ʻia e ko kākou pituitary gland, e like me ka hormone ulu , ka hormone hoʻoulu thyroid (TSH) , a me ka prolactin .
• I loko o ka pancreas: Maanei, ʻo ka insulin ,Hoʻopaʻa ia i ka hoʻokuʻu ʻia ʻana o nā hormones pancreatic e like me ka glucagon a me ka gastrin , a kāohi pū i ka hoʻokuʻu ʻia ʻana o nā enzymes pancreatic e kōkua i ka hoʻoheheʻe ʻana i ka meaʻai.
• I loko o ka ʻōnaehana hoʻoheheʻe (GI tract): Hoʻemi ia i nā mea huna gastric, kahi i hoʻoulu ʻia i ka wā e ʻai ai mākou. Hoʻopale pū ia i ka hoʻokuʻu ʻia ʻana o nā hormones digestive e like me secretin a me gastrin .
• I loko o ka ʻōnaehana nerve waena (CNS): Maanei, kōkua ia i ka hoʻololi ʻana i ke ala e hoʻouna ʻia ai nā leka ma o nā aʻalolo (neurotransmission) a me ke ala e hoʻokumu ʻia ai nā hoʻomanaʻo.

He aha ke kumu o ka hoʻokuʻu ʻia ʻana o somatostatin?

ʻAe, i kēia manawa ke noʻonoʻo nei paha ʻoe, 'Pehea e hoʻokuʻu ʻia ai kēia somatostatin? He aha ke kumu?' ʻO kaʻoiaʻiʻo, ʻaʻole maopopo loa i nā kānaka ʻepekema pehea e kāohi ai ko mākou kino i ka hoʻokuʻu ʻia ʻana o kēia somatostatin, a me nā ʻiʻo e hoʻoulu ai i kona hoʻokuʻu ʻia ʻana. A hiki i kēia manawa, ua ʻike ʻia he nui nā ʻano cell like ʻole a me nā protein e pili ana.

Ua hōʻike ʻia kekahi noiʻi ʻo ka glucose , ke kumu nui o ka ikehu o ko mākou kino, ʻaʻole wale ia e kāohi i ka hoʻokuʻu ʻia ʻana o ka somatostatin, akā e kōkua pū ana hoʻi i kāna hana ʻana. Ma kēlā noiʻi, ua ʻike nā kānaka ʻepekema i ka wā e haʻahaʻa ai nā pae glucose koko, hoʻoulu ka insulin i ka hoʻokuʻu ʻana o ka somatostatin (ʻo ia hoʻi, e hoʻōki i ka hana ʻana o ka insulin), a i ka wā e kiʻekiʻe ai nā pae glucose koko , hoʻoulu ka glucagon i ka hoʻokuʻu ʻana o ka somatostatin (ʻo ia hoʻi, e hoʻōki i ka hana ʻana o ka glucagon).

ʻO ia hoʻi, ʻoiai ʻo ka insulin e hoʻohaʻahaʻa i nā pae kō koko, ke haʻahaʻa kou kō koko, hoʻokuʻu ʻia ka somatostatin e pale aku iā ia mai ka hāʻule ʻana i lalo, e hoʻōki i ka hoʻokuʻu ʻana o ka insulin. He mea kupaianaha ke ʻano o ka hoʻomalu ʻia ʻana o nā mea i loko o ko kākou kino, ʻeā?

Nā pilikia a me nā kūlana e pili ana iā Somatostatin

ʻO ka maʻamau, he mea kākaʻikahi nā pilikia nui me ka somatostatin. Akā ʻo ke kūlana nui e kū mai ana he ʻano maʻi kanesa kākaʻikahi loa i kapa ʻia ʻo somatostatinoma . He puʻupuʻu kēia e ulu ana i loko o ka ʻōnaehana endocrine. Ulu kēia puʻupuʻu i loko o ka pancreas a i ʻole ka ʻōnaehana digestive (GI tract). ʻO kēia ke kumu o ka hana nui ʻana o ka somatostatin.

Hiki ke kū koke kēia ʻano, i kapa ʻia ʻo somatostatinoma, a i ʻole hiki ke pili pū me kekahi mau maʻi genetic . ʻO kekahi o kēia mau ʻano:

• Nā Neoplasia Endocrine lehulehu (MEN ʻano 1):He ʻano laha ʻole loa kēia, kahi e ulu ai nā ʻōkolo he nui ma nā ʻāpana like ʻole o ka ʻōnaehana endocrine.
• ʻO Neurofibromatosis ʻano 1 (NF1): He maʻi hoʻoilina nō hoʻi kēia. Hoʻoulu ia i nā kiko café-au-lait a me nā puʻupuʻu maikaʻi ʻole ma ka ʻili.
• ʻO ka maʻi Von Hippel-Lindau: He maʻi hoʻoilina laha ʻole kēia. Hiki iā ia ke hana i nā puʻupuʻu maikaʻi a ʻino paha i loko o ka lolo, ke kaulahao kuamoʻo, nā maka, nā puʻupaʻa, ka pancreas, a me nā kelepa adrenal.

Ke hana nui ʻia ka somatostatin, ua emi nui ka hana ʻana o nā hormones endocrine ʻē aʻe. Hiki ke like nā hōʻailona o kēia me nā hōʻailona o nā maʻi ʻē aʻe he nui. No laila, hiki ke paʻakikī i kekahi manawa ke ʻike pololei i kahi maʻi i kapa ʻia ʻo somatostatinoma.

ʻO ka mea nui, he mea kakaikahi loa kēia mau pilikia e pili ana i ka somatostatin, ʻo ia hoʻi, ʻaʻohe mea e hopohopo ai ka hapa nui o ka poʻe.

Eia kekahi, he kakaikahi loa nā hōʻike e pili ana i nā pae haʻahaʻa ma mua o ka maʻamau o ka somatostatin i loko o ke kino o ke kanaka.

He aha nā hoʻokolohua e nānā ai i nā pae somatostatin?

Ma muli o ka laha ʻole o nā pilikia e pili ana i ka somatostatin, ʻaʻole hoʻāʻo pinepine nā kauka i nā pae somatostatin o kēlā me kēia kanaka. Eia nō naʻe, inā he kānalua no kahi puʻupuʻu laha ʻole e hana nui ana i ka somatostatin i kapa ʻia he somatostatinoma, e like me ka mea i ʻōlelo ʻia ma mua, hoʻohana ʻia kahi hoʻāʻo koko i kapa ʻia ʻo somatostatin-like-immunoreactivity (SLI) e ʻike ai.

Āhea wau e ʻike ai i ke kauka e pili ana i koʻu mau pae somatostatin?

ʻAʻole pono ʻoe e hopohopo e pili ana i kāu mau pae somatostatin, no ka mea, he kakaikahi wale nā ​​​​pilikia e pili ana i kēia.

Eia nō naʻe, inā ua ʻike ʻia kahi lālā o ka ʻohana pili (makua a kaikaina paha) me kahi maʻi e like me ka multiple endocrine neoplasia type 1 (MEN type 1), neurofibromatosis type 1 (NF1), a i ʻole ka maʻi Von Hippel-Lindau, he mea nui e haʻi i kāu kauka. No ka mea he mau maʻi hoʻoilina kēia, hiki paha iā ʻoe ke pilikia i ka loaʻa ʻana o ka somatostatinoma. A laila hiki i kāu kauka ke hana i nā hoʻokolohua e ʻike ai inā loaʻa iā ʻoe ke maʻi.

Nā mea nui e hoʻomanaʻo (Leka Lawe-Home)

ʻAe, eia nā mea nui e pono ai ʻoe e hoʻomanaʻo mai kā mākou i kamaʻilio ai i kēia lā:

• He hormone 'haku' ʻo Somatostatin nona ke kuleana koʻikoʻi i loko o ko mākou kino, e kaohi ana i nā hormones ʻē aʻe.
• Hoʻomalu nui ia i nā mea e like me ka hana ʻana o nā hormones ʻē aʻe, ka hana o ka ʻōnaehana hoʻoheheʻe, a me ka māhele wikiwiki ʻana o nā cell.
• ʻO nā pilikia me ka somatostatin he mea laha ʻole loa ia.ʻO ka pilikia nui he puʻupuʻu laha ʻole i kapa ʻia ʻo somatostatinoma.
• Inā loaʻa i kekahi o kou ʻohana nā maʻi hoʻoilina e like me MEN type 1, NF1, a i ʻole ka maʻi Von Hippel-Lindau , e kamaʻilio me kāu kauka e pili ana i ia mea.
• Mai makaʻu wale i kēia. He mea nui e makaʻala i kēia mau ʻōnaehana kupaianaha i loko o ko kākou kino.

No laila, he mea leo ʻole ka somatostatin, akā he mea nui loa ia, i loko o ko kākou kino. Inā e hana pono ana ia i kāna hana, ʻaʻohe mea a kākou e makaʻu ai!

ʻO Somatostatin, Somatostatin, Hormone, Pancreas, Hypothalamus, ʻŌnaehana Hoʻoheheʻe, Somatostatinoma, Somatostatinoma, GHIH, ʻŌnaehana Endocrine, Kanesa