Ke hana nei kou kino i ka insulin? E ʻike kākou me ka hoʻāʻo C-peptide!

Ua ʻike anei ʻoe aia kekahi hoʻāʻo e hiki ke haʻi mai iā mākou i ka ʻike nui e pili ana i ka hiki o ko mākou kino ke hana i kahi hormone i kapa ʻia ʻo insulin? Ua kapa ʻia ʻo ia ka hoʻāʻo C-peptide. ʻAʻole paha ʻoe i lohe i kēia hoʻāʻo ma mua. Akā hiki ke lilo i mea nui loa no kekahi mea i loaʻa i ka maʻi diabetes a i ʻole ke kānalua nei he maʻi diabetes ko lākou. E kamaʻilio kākou e pili ana i ka hoʻāʻo C-peptide i kēia lā, ʻeā?

He aha ka C-peptide? No ke aha he mea nui ia iā mākou?

I ka ʻōlelo maʻalahi, he mea liʻiliʻi ʻo C-peptide i hana ʻia e ko kākou pancreas, ke kino a kākou e kapa nei he "Pancreas" ma ka ʻōlelo Pelekania, ke hana ia i ka hormone insulin. Ua like ia me kahi huahana liʻiliʻi e puka mai ana mai kahi hale hana ke hana ʻia kahi huahana nui. No laila, ua hana like ʻia ʻo C-peptide a me ka insulin e ko kākou pancreas.

I kēia manawa, e nīnau paha ʻoe, "No laila he aha ka insulin?" He hormone koʻikoʻi loa ka insulin e kaohi ana i ke kiʻekiʻe o ke kō, a i ʻole ka glucose, i loko o ko kākou koko. ʻO ka insulin ka mea e kōkua ai i nā ʻāpana o ko kākou kino e hoʻohana i ka glucose a kākou e loaʻa ai ke ʻai kākou ma ke ʻano he ikehu.

E nānā i kēia manawa, ʻaʻole hiki i ka poʻe me ka maʻi diabetes Type 1 ke hana i ka insulin. No laila, pono lākou e hoʻokomo i ka insulin ma waho. Akā, hana ka poʻe me ka maʻi diabetes Type 2 i ka insulin, akā ʻaʻole lawa ka nui, a i ʻole ʻaʻole pane pono nā ʻāpana o ke kino i kēlā insulin (kapa mākou i kēia he "kū'ē ʻana o ka insulin"). I kekahi manawa, emi iho ka hana ʻana o ka insulin i ka poʻe me ka maʻi diabetes Type 2 i ka hala ʻana o ka manawa a pono lākou e lawe i ka insulin ma waho.

ʻO kēia ka manawa e lilo ai ka hoʻāʻo C-peptide i mea nui. No ka mea, inā lawe kekahi i ka insulin mai waho, ʻaʻole hele pū ka C-peptide me kēlā insulin. Hoʻopuka wale ʻia ka C-peptide ke hana ʻia ka insulin i loko o ke kino. No laila, me kēia hoʻāʻo, hiki i kā mākou mau kauka ke ʻike pono i ka nui o ka insulin i hana ʻia i loko o kou kino ponoʻī, i loko o kou pancreas ponoʻī. ʻO ia hoʻi, hiki iā ia ke haʻi i ka ʻokoʻa ma waena o ka insulin i hana ʻia e ke kino (Endogenous insulin) a me ka insulin i lawe ʻia ma ke ʻano he lāʻau lapaʻau (Exogenous insulin).

Ua kapa ʻia hoʻi kēia hoʻāʻo:

• Hoʻohui i ka insulin peptide
• ʻInisulina C-peptide
• ʻO ka Proinsulin C-peptide

Pehea e pili ai nā pae C-peptide i ka maʻi diabetes?

ʻO kahi mea e hoʻomanaʻo ai, ʻaʻole hiki i kahi hoʻāʻo C-peptide wale nō ke ʻike maopopo inā he maʻi diabetes kekahi a ʻaʻole paha. Hōʻike wale ia iā ʻoe inā hiki i kou pancreas ke hana i kāna insulin ponoʻī, a i ʻole ka nui.

I mea e ʻike pono ai inā he maʻi diabetes kou, e noi ke kauka iā ʻoe e hana i kahi hoʻāʻo glucose koko, a i ʻole kahi hoʻāʻo A1c, nāna e ana i kou awelika o ke kō koko i nā mahina ʻekolu i hala.

No laila, no ke aha e ʻōlelo ai nā kauka i kēia hoʻāʻo C-peptide?

Aia kekahi mau kumu e paipai ai kāu kauka i kahi hoʻāʻo C-peptide. E nānā kākou i ko lākou ʻano:

• E hoʻokaʻawale i ke ʻano o ka maʻi diabetes āu: ʻo ia hoʻi, e hoʻoholo inā he ʻano 1 a i ʻole ʻano 2 (hana ʻia kēia me nā hoʻokolohua ʻē aʻe).
• E hōʻoia i ka hana pono ʻana o kāu lāʻau lapaʻau no ka maʻi diabetes.
• E hoʻoholo inā lawa ka insulin i hana ʻia e kou kino, a inā paha he pono ʻoe i nā inikini insulin a i ʻole kahi pamu insulin.
• E ʻimi i nā kumu o ke kō koko haʻahaʻa: Kāhea mākou i kēia hypoglycemia.
• E hoʻomaopopo i ka ʻokoʻa ma waena o ka insulin i hana ʻia ma loko a me ka insulin i hoʻokomo ʻia ma waho.
• ʻAʻole pinepine loa, hiki i kēia ke kōkua i ka hāʻawi ʻana i kekahi ʻike e pili ana i ka maʻi kanesa pancreatic.

ʻO wai ka mea e hana i kēia hoʻāʻo C-peptide? Pehea e hana ʻia ai?

ʻO ka maʻamau, e ʻōlelo aku kāu mea mālama mua a i ʻole kahi endocrinologist i kahi hoʻāʻo C-peptide. Hana pinepine ʻia kēia hoʻāʻo e kahi kahu maʻi a mea loea lab paha.

Hoʻohana pinepine ʻia ka C-peptide ma ka lawe ʻana i kahi hāpana koko . Ma ke keʻena o ke kauka, ke keʻena lapaʻau, a i ʻole ka lab, e hoʻokomo kahi kahu maʻi i kahi nila lahilahi i loko o kahi aa koko ma kou lima a hōʻiliʻili i kahi koko liʻiliʻi i loko o kahi ʻōmole. Hiki paha iā ʻoe ke ʻeha iki i ka wā e hoʻokomo ʻia ai ka nila, akā ʻaʻole ia he mea ʻino loa.

I kekahi manawa hiki ke hana ʻia kēia hoʻāʻo me kahi hāpana mimi . Akā ke hana ʻoe i kēlā, pono ʻoe e hōʻiliʻili i kāu mimi āpau i loko o 24 mau hola. Inā pēlā, e hāʻawi kāu kauka iā ʻoe i kahi pahu no ia mea a e hāʻawi iā ʻoe i nā kuhikuhi no ke ʻano o ka hōʻiliʻili ʻana a me ka hoʻihoʻi ʻana. Pono paha ʻoe e mālama i ka pahu ma kahi anu, e like me ka pahu hau. Akā, ʻaʻole hana mau nā kauka i kēia hoʻāʻo mimi.

Pono anei au e hoʻokē ʻai ma mua o kēia hoʻāʻo C-peptide?

ʻAe, inā ʻoe e loaʻa ana i kēia hoʻāʻo koko, e noi ʻia paha ʻoe e hoʻokē ʻai no 8 a 12 mau hola (ua maikaʻi ka wai wale nō) . Kāhea mākou i kēia ʻo "Hoʻokē ʻai". Eia nō naʻe, i kekahi manawa, makemake paha kāu kauka e nānā i kāu mau pae C-peptide ma hope o kou ʻai ʻana i kahi mea a hoʻoulu ʻia kou pancreas. I ka manawa pinepine, nānā pū ʻia ka pae glucose koko me nā pae C-peptide.

Eia kekahi, e noi paha kāu kauka iā ʻoe e hoʻōki i ka lawe ʻana i kekahi mau lāʻau lapaʻau no kekahi manawa. No laila, ʻoi aku ka maikaʻi o ka nīnau ʻana i kāu kauka i ka mea e pono ai ʻoe e hana ma mua o ka hoʻāʻo ʻana.

Aia kekahi mau pilikia me kēia hoʻāʻo?

ʻO ka ʻoiaʻiʻo, he liʻiliʻi loa ka pilikia o nā hoʻokolohua koko. ʻAʻohe pilikia i ʻike ʻia i nā hoʻokolohua mimi. No laila , ʻaʻohe kumu e makaʻu ai.

ʻEhia ka manawa e hiki ai ke loaʻa nā hopena o ka hoʻāʻo C-peptide?

Hiki ke hala nā hopena o kēia hoʻāʻo, ʻo ia hoʻi ka hōʻike, mai hoʻokahi a ʻelima mau lā e hōʻea ai. Hiki ke ʻokoʻa kēia ma muli o ke kauka a me ka lab.

He aha ka waiwai maʻamau o kahi hoʻokolohua C-peptide?

ʻO ka pae olakino no kahi hoʻāʻo C-peptide i manaʻo ʻia he 0.5 ng/mL a i 2.0 ng/mL (a i ʻole 0.17 a i 0.83 nmol/L) . Eia nō naʻe, e hoʻomanaʻo e hiki ke ʻokoʻa iki kēia mau waiwai mai ka hale hana a i ka hale hana, no laila he mea nui e hoʻohālikelike i kāu mau hopena i ka pae maʻamau ma kāu hōʻike.

He aha ka manaʻo o nā hopena o ka hoʻāʻo C-peptide?

ʻAe, e nānā kākou i nā mea a nā waiwai i loko o kēia hōʻike hoʻāʻo e ʻōlelo nei.

Inā haʻahaʻa ka pae C-peptide (C-peptide haʻahaʻa)

Inā haʻahaʻa ka pae C-peptide i loko o kou kino, aia kekahi mau kumu:

• Ke haʻahaʻa kou pae kō koko a ʻaʻole ʻoe i ʻai koke aku nei, he mea maʻamau paha ka haʻahaʻa o C-peptide.
• Eia nō naʻe, hiki ke manaʻo ʻia hoʻi ʻaʻole lawa ka insulin i hana ʻia e kou kino .
• A i ʻole, inā ʻoe e hoʻokomo i ka insulin ma waho, e emi paha ka C-peptide (no ka mea, ʻaʻole hele mai ka C-peptide me ka insulin i lawelawe ʻia ma waho).
• Hiki ke pili kēia kūlana, ʻoiai inā kiʻekiʻe kou pae kō koko, me nā kūlana olakino e hiki mai ana:
• ʻO ka maʻi diabetes ʻano 1 : ʻO kēia no ka mea ʻaʻole hana ka pancreas o kēia poʻe i ka insulin.
• ʻO ka maʻi diabetes ʻano 2 : Hana ʻia kēia ke hiki ʻole i ka pancreas ke hana i ka insulin.

ʻO kekahi mea e hiki ke ʻōlelo ʻia e pili ana i nā pae C-peptide haʻahaʻa, ʻo ia ka lawa ʻole o ka mālama ʻana no ka maʻi diabetes .

Aia kekahi mau kūlana ʻē aʻe kahi e emi ai nā pae C-peptide i ka emi ʻana o nā pae kō koko:

• ʻO ka maʻi ʻo Addison : He kūlana kēia kahi i hana ʻole ai kāu mau kelepa adrenal i ka lawa o nā hormones cortisol a me aldosterone. ʻO ka hopena pinepine kēia i ke kō koko haʻahaʻa.
• Maʻi akepaʻa .
• Ke hāʻawi ʻana i ka insulin mai waho (injection/inhalation) `(Insulin Exogenous)` .

Nā pae C-peptide kiʻekiʻe

I kēia manawa, e nānā kākou i ka mea e hana ʻia inā hōʻike ka hōʻike ua ʻoi aku ke kiʻekiʻe o kāu pae C-peptide ma mua o ka maʻamau. ʻO ke ʻano paha kēia e hana nui ana kou kino i ka insulin . Eia kekahi o nā kūlana e hiki ai ke hana i kēia:

• ʻO ka maʻi CushingʻO kēia ka manawa e hana nui ai kou kino i ka hormone cortisol.
• Ke kū'ē ʻana o ka insulin : Ma kēia, ʻoiai aia ka insulin i loko o ke kino, ʻaʻole pane pono nā cell iā ia. No laila, hana hou ke kino i ka insulin.
• Ka haʻahaʻa o ka potassium i loko o ke koko (Hypokalemia) .
• ʻO ka maʻi diabetes ʻano 2 : Hiki ke hana kēia, ʻoiai i nā pae mua, i ka wā e hoʻāʻo ai ke kino e hana i ka insulin hou aʻe.
• He puʻupuʻu pancreatic : No ka laʻana, he insulinoma.
• Ka hāʻule ʻana o nā puʻupaʻa : Ma muli o ka wehe ʻia ʻana o ka C-peptide mai ke kino ma o nā puʻupaʻa, ke hana pono ʻole nā ​​​​puʻupaʻa, hiki ke piʻi aʻe nā pae C-peptide i loko o ke koko.

He mea nui: Inā ʻaʻole hōʻike iki ka hoʻāʻo C-peptide i ka C-peptide, ʻo ia hoʻi, pono ʻoe e lawe i ka insulin ma waho. Hiki ke hana ʻia kēia ma o nā inikini insulin a i ʻole ka pamu insulin.

Leka Lawe-Home

ʻAe, no laila ke lana nei koʻu manaʻo ua ʻike maikaʻi ʻoe i ka hoʻāʻo C-peptide a mākou i kamaʻilio ai.

• ʻO C-peptide kahi mea e ana i ka nui o ka insulin i hana ʻia e ko mākou kino.
• Kōkua kēia i ka hoʻokaʻawale ʻana ma waena o ka maʻi diabetes type 1 a me type 2 .
• Hoʻohana ʻia nō hoʻi ia e ʻike i ka maikaʻi o nā lāʻau lapaʻau no ka maʻi diabetes .
• Kōkua nō hoʻi kēia i ka ʻike ʻana i kekahi mau pilikia olakino ʻē aʻe .

Inā ua noi ʻia ʻoe e kāu kauka e hana i kēia hoʻāʻo C-peptide, e hōʻoia e nīnau pono iā ia i ka mea e hana ai a me ka mea ʻaʻole e hana ma mua o ka hoʻāʻo. Mai makaʻu i kekahi mea, he hoʻāʻo maʻalahi wale nō kēia e hāʻawi ana i ka ʻike waiwai e pili ana i kou olakino. ʻO ka mea nui loa, ʻo ke kamaʻilio ʻana me kāu kauka e pili ana i nā mea āpau a nīnau i kāu mau nīnau.

ʻO C-peptide, maʻi diabetes, insulin, pancreas, nā hoʻāʻo koko, nā hormones, olakino