Ua manaʻo paha ʻoe e like me ka nui o kou kāmaʻa, a i ʻole ua paʻa ke apo āu i ʻaʻahu ai i kou manamana lima? Malia paha he ʻokoʻa iki ke ʻano o kou helehelena ke nānā ʻoe i nā kiʻi kahiko? Hana ʻia ka nui o kēia mau mea i ka hala ʻana o ka manawa, i kekahi manawa no nā makahiki, no laila ʻaʻole mākou e nānā nui iā lākou. Akā he hōʻailona paha kēia o kahi maʻi laha ʻole i kapa ʻia ʻo Acromegaly . Mai hopohopo, e kamaʻilio mākou e pili ana i nā mea āpau ma nā ʻōlelo maʻalahi.
I ka ʻōlelo maʻalahi, he aha ka Acromegaly?
ʻO ka Acromegaly kahi maʻi i hoʻokumu ʻia e ko mākou kino e hana nui ana i ka hormone ulu, a i ʻole Growth Hormone (GH) . Kōkua kēia hormone iā mākou e ulu i ko mākou wā ʻōpiopio. Eia nō naʻe, inā e hoʻomau ʻia kēia hormone e hūnā ʻia ma hope o ko mākou pau ʻana i ka ulu ʻana, ʻo ia hoʻi, ma hope o ko mākou lilo ʻana i poʻe mākua, hoʻomaka kekahi mau ʻāpana o ko mākou kino, ʻoiai nā iwi o nā lima, nā wāwae, a me ke alo, e ulu nui loa.
ʻIke pinepine ʻia kēia ʻano maʻi i ka poʻe waena. Akā, ʻaʻole kēia manaʻo ʻaʻole ia e hana ʻia i ka poʻe ʻōpio. Inā piʻi ka hormone ulu ma kēia ʻano i ka wā ʻōpiopio, ua kapa ʻia ke ʻano he gigantism. A laila ulu lākou i ke kiʻekiʻe loa.
ʻAʻole ʻo Acromegaly kahi kūlana o ka piʻi ʻana o ke kiʻekiʻe, akā he loli i ke ʻano o nā iwi i ulu mua. Ma muli o ka lohi o kēia mau loli, ʻaʻole paha e ʻike ʻia he maʻi lapaʻau no nā makahiki.
No ke aha e ulu ai ka acromegaly? He aha nā kumu?
ʻO ke kumu nui o kēia, he ʻōpū liʻiliʻi e like me ka nui o ka pī ma ke kumu o ko kākou lolo. Kāhea mākou iā ia ʻo ka Pituitary Gland . ʻO ke kumu maʻamau o ka Acromegaly he puʻupuʻu ʻaʻole cancerous (benign) i loko o kēia gland. Ua kapa ʻia kēia puʻupuʻu he Pituitary Adenoma . Hoʻoulu kēia puʻupuʻu i ka pituitary gland a hana i ka nui o ka hormone ulu (GH).
Hōʻiliʻili kēia hormone GH keu i loko o ko kākou koko a hōʻailona i ke akepaʻa e hana i kahi hormone ʻē aʻe i kapa ʻia ʻo IGF-1 (Insulin-like Growth Factor-1) . ʻO kēlā hormone IGF-1 ke kumu o ka ulu ʻana o ko kākou mau iwi a me nā ʻōpū ʻē aʻe i ke ʻano ʻē. Hoʻopilikia pū ia i ke ʻano o ko kākou kino e kaohi ai i ke kō a me ka momona, e hoʻonui ana i ka pilikia o ka loaʻa ʻana o nā maʻi ʻē aʻe.
I ka liʻiliʻi loa, hiki ke hana ʻia kēia ʻano ma muli o nā puʻupuʻu e ulu ana ma nā wahi ʻē aʻe o ka pancreas, ke akepaʻa, a i ʻole ka lolo. Ua ʻike ʻia e ka noiʻi he kuleana ko kekahi mau kumu hoʻoilina.
He aha nā hōʻailona o ka acromegaly?
Hoʻomaka pinepine kēia mau hōʻailona e ʻike mālie ʻia, no laila e lōʻihi paha ka manawa e ʻike ai ʻoe i ka ʻokoʻa.
| ʻAno hiʻohiʻona | Nā loli i ʻike ʻia |
|---|---|
| Nā loli o waho i ke kino |
|
| Nā hiʻohiʻona maʻamau ʻē aʻe |
Pehea e ʻike ai i kēia maʻi?
He mea nui e ʻike koke i kēia maʻi. Ke ʻike ʻoe i ke kauka ma muli o kēia mau hōʻailona, e nīnau ʻo ia iā ʻoe i nā nīnau e like me:
- He aha nā loli āu e ʻike ai?
- I ka manawa hea ʻoe i ʻike mua ai i kēia mau loli?
- Pehea kou manaʻo i kēia manawa?
A laila, hana ʻia kekahi mau hoʻokolohua e hōʻoia i ka hōʻailona.
Nā hoʻokolohua nui
- Nā hoʻāʻo koko: Hana ʻia kahi hoʻāʻo koko e ʻike ai inā kiʻekiʻe kāu mau pae hormone IGF-1 no kou mau makahiki.
- Hoʻāʻo Hoʻomanawanui Glucose: Maanei, hāʻawi ʻia ʻoe i kahi mea inu kō a ana ʻia kou kō koko a me nā pae hormone GH no ʻelua hola. ʻO ka maʻamau, pono e hāʻule nā pae GH ma hope o ka inu ʻana i ke kō. Inā ʻaʻole lākou, a noho kiʻekiʻe, he hōʻailona ia o ka acromegaly.
Nā hoʻokolohua ʻē aʻe
- MRI a i ʻole CT scan: Kōkua kēia mau scan i ka ʻike ʻana i kahi puʻupuʻu pituitary.
- Nā hoʻāʻo X-ray: E nānā no ka mānoanoa o ka iwi.
- Echocardiogram: He hoʻāʻo ultrasound o ka puʻuwai e ʻike ai inā ua hoʻopilikia ʻia ka puʻuwai.
- Colonoscopy: E nānā i ke olakino o ka kolona.
- Haʻawina Hiamoe: E ʻike inā loaʻa iā ʻoe ka Sleep Apnea.
He aha nā lāʻau lapaʻau?
Na kāu kauka e hoʻoholo i ka hoʻolālā lapaʻau kūpono loa nāu ma muli o kou makahiki, ke kūlana olakino, a me ke koʻikoʻi o kou kūlana. ʻEkolu mau koho lapaʻau nui.
1. ʻoki kino:
ʻO ka pinepine, ʻo ka lāʻau lapaʻau mua ka ʻoki ʻana e wehe i ka puʻupuʻu pituitary. He mea nui loa kēia inā e kaomi ana ka puʻupuʻu i nā aʻalolo e hoʻopilikia ana i ka ʻike. Wehe ke kauka ʻoki i ka puʻupuʻu ma o kahi ʻoki liʻiliʻi ma ka ihu a i loko paha o ka lehelehe luna. Hiki ke hoʻomaka nā hōʻailona e hoʻomaikaʻi i loko o kekahi mau lā ma hope o ke ʻoki ʻana.
2. Lāʻau lapaʻau:
Inā he mau ʻāpana i koe o ka puʻupuʻu ma hope o ke ʻoki ʻana a inā makemake ʻoe i ke kōkua hou aku i ka kaohi ʻana i kāu mau pae hormone, e kuhikuhi kāu kauka i ka lāʻau lapaʻau. Hoʻohaʻahaʻa kēia mau lāʻau i kāu mau pae GH a pale paha i kona hopena ma ke kino.
- Nā analog Somatostatin (e.g. lanreotide, octreotide)
- Nā mea hoʻopilikia i ka mea loaʻa o ka hormone ulu (e.g. pegvisomant)
- Nā agonists Dopamine (e.g. cabergoline)
3. Hoʻōla Pāhawewe:
Inā aia nō nā ʻāpana o ka puʻupuʻu i koe ma hope o ke ʻoki ʻana a me ka lāʻau lapaʻau, a inā pono e hoʻemi hou ʻia nā pae GH, hoʻohana ʻia ka radiation therapy. Hoʻōki kēia i ka ulu ʻana o ka puʻupuʻu a hōʻemi i ka hana ʻana o GH. Hiki i nā ʻano hana hou e like me ka stereotactic radiosurgery ke hāʻawi i nā dosis kiʻekiʻe o ka radiation i ka puʻupuʻu me ka ʻole o ka hōʻino ʻana i nā ʻiʻo olakino.
Nā pilikia e hiki mai ana inā ʻaʻole mālama ʻia
Hiki i ka Acromegaly ke hoʻoulu i nā pilikia olakino koʻikoʻi inā ʻaʻole mālama pono ʻia, no laila mai hoʻowahāwahā i kēia maʻi.
- Maʻi cardiovascular
- Maʻi diabetes
- Ke koko kiʻekiʻe
- ʻO ka ʻāʻī (Osteoarthritis)
- ʻO ka maʻi Carpal Tunnel
- Apnea hiamoe
- Ka nalowale o ka ʻike
- Hoʻonui ʻia ka pilikia o ka maʻi ʻaʻai colon
- Ke kaomi ʻana o ke aʻalolo spinal
Hiki i kēia maʻi ke hoʻoweliweli i ke ola inā ʻaʻole mālama ʻia, no laila he mea nui e ʻimi koke i ke kōkua lapaʻau inā loaʻa nā hōʻailona.
Leka Lawe-Home
- He maʻi laha ʻole ka Acromegaly i hoʻokumu ʻia e ka hana nui ʻana o ke kino i ka hormone ulu (GH).
- ʻO ke kumu nui o kēia he ʻōpū ʻaʻole maʻi kanesa (benign) e ulu ana i loko o ka pituitary gland.
- Hiki ke ʻike lohi loa ʻia nā ʻōuli (ka hoʻonui ʻia ʻana o nā lima, nā wāwae, a me ke alo), no laila e lōʻihi paha ka manawa e ʻike ai iā lākou.
- Hiki ke hoʻomalu pono ʻia kēia kūlana me ke ʻoki kino, ka lāʻau lapaʻau, a me ka radiation therapy.
- Hiki i ka ʻike mua ʻana a me ka mālama ʻana ke kōkua i ka pale ʻana i nā pilikia koʻikoʻi a hiki iā ʻoe ke ola i kahi ola maʻamau. Inā he mau hopohopo kāu, e ʻike pono i kāu kauka.
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