Manaʻolana Hou no ka Maʻi Alzheimer? E Kamaʻilio Kēia E Pili Ana I Kēia Mau Lāʻau Anti-Amyloid

He mea paʻakikī ke haʻi aku i ke kaumaha āu e ʻike ai i ka ʻike ʻana i kahi lālā o ka ʻohana a i ʻole kahi hoaaloha pili e hoʻopoina mālie i nā mea āpau a lilo i mea hiki ʻole ke hana i nā hana o kēlā me kēia lā ma o lākou iho. He maʻi ʻehaʻeha loa ka maʻi Alzheimer. A hiki i kēia manawa, ʻo nā lāʻau lapaʻau wale nō e kāohi ana i nā hōʻailona, ​​​​akā i kēia manawa ke kamaʻilio nei ke ao nei e pili ana i kahi lāʻau hou e kuhikuhi pololei ana i ke kumu o kēia maʻi. I kēia lā ke kamaʻilio nei mākou e pili ana i kēia manaʻolana hou, ʻo ia ka lāʻau Anti-Amyloid.

I ka ʻōlelo maʻalahi, he aha kēia lāʻau Anti-Amyloid?

I loko o ka lolo o kekahi kanaka me ka maʻi Alzheimer, hōʻiliʻili kekahi ʻano protein i kapa ʻia ʻo `beta-amyloid` me ke kumu ʻole. E noʻonoʻo iā ia e like me ke au e hele ana ma o kahi uea uila, ʻo ia ke ʻano o ka hele ʻana o ka ʻike ma waena o nā neurons i loko o ko kākou lolo. Hōʻiliʻili kēlā protein `beta-amyloid` a hana i nā `plaques` e like me ka popo ma waena o kēia mau cell nerve. A laila hoʻopilikia kēia i ke kahe o ka ʻike. ʻO kēia ke kumu nui o ka nalowale o ka hoʻomanaʻo a me ka hiki ʻole ke noʻonoʻo pono.

Hana kēia papa lāʻau hou, i kapa ʻia ʻo anti-amyloid, ma ka wehe ʻana i nā plaques 'beta-amyloid' i hōʻiliʻili ʻia mai ka lolo. ʻO ia hoʻi, hoʻouka ia i ke kumu kumu o ka maʻi ma mua o ka hoʻopau wale ʻana i nā hōʻailona. ʻO ka manaʻolana ma ka wehe ʻana i kēia mau plaques, e hiki i nā hunaola o ka lolo ke hana olakino no ka manawa lōʻihi.

No loko kēia o kahi ʻano o nā lāʻau i kapa ʻia ʻo 'immunotherapy'. I ka pololei, hāʻawi ʻia kēia mau lāʻau lapaʻau ma ke ʻano he ʻano antibody (monoclonal antibody) i hana kūikawā ʻia ma kahi keʻena hoʻokolohua. Ke komo kēia mau antibodies i ko mākou kino, ʻike lākou i kēlā mau protein 'beta-amyloid' ʻino, hoʻopili iā lākou, a luku iā lākou.

ʻO nā lāʻau lapaʻau nui ʻelua e pili ana i ka amyloid i ʻāpono ʻia i kēia manawa ʻo ia ka `donanemab (Kisunla)` a me ka `lecanemab-irmb (Leqembi)`. Aia kekahi lāʻau lapaʻau i kapa ʻia ʻo `aducanumab (Aduhelm),` akā ua hoʻihoʻi ʻia mai ka mākeke e ka hui nāna i hana.

Pehea e loaʻa ai iaʻu kēia lāʻau lapaʻau? Aia kekahi mau hopena ʻaoʻao?

Hāʻawi ʻia kēia lāʻau lapaʻau ma o kahi hopena saline (IV infusion) i loko o kahi aa. He hola paha kēia. Hāʻawi pinepine ʻia ʻo `Leqembi` i kēlā me kēia ʻelua pule, a hāʻawi pinepine ʻia ʻo `Kisunla` i kēlā me kēia ʻehā pule. Hoʻomaka ʻoe me kahi mahele liʻiliʻi a hoʻonui mālie iā ia i ka mahele i kuhikuhi ʻia e kāu kauka.

I ka ʻōlelo maʻalahi, hiki i kēia ke hana i kahi pehu i loko o ka lolo a i ʻole nā ​​​​kiko liʻiliʻi o ke kahe koko i loko o ka lolo. ʻOiai e hoʻopau pinepine kēia ma kāna iho, he mea nui e makaʻala i kēia. ʻO ia ke kumu e pono ai ʻoe e loaʻa i nā scan MRI maʻamau o ka lolo i ka wā o kēia lāʻau lapaʻau.

Pehea ka maikaʻi o kēia lāʻau lapaʻau?

Eia ka ʻāpana paʻakikī. Ua hōʻike ʻia nā noiʻi e hiki i kēia mau lāʻau ke wehe i nā plaques 'beta-amyloid' i loko o ka lolo. He mea maikaʻi kēlā.

Eia nō naʻe, aia nō nā manaʻo like ʻole e pili ana i ka nui o ka hoʻomanaʻo o ka mea maʻi a me ka hiki ke hana i nā hana o kēlā me kēia lā e hoʻomaikaʻi maoli ma hope o ka wehe ʻana i kēlā mau plaques. Ua hōʻike kekahi mau noiʻi hiki i kēia mau mea ke hoʻolohi iki i ka holomua o ka maʻi. ʻAʻole ia manaʻo ua ho'ōla loa ʻia ka maʻi, akā ua hoʻolohi ia i ka maʻi mai ka lilo ʻana i mea ʻino.

Manaʻo nā kānaka ʻepekema hiki ke manaʻo ʻia nā hopena maikaʻi loa inā hoʻomaka ʻia kēia lāʻau i nā pae mua o ka maʻi , ma mua o ka hiki ʻana mai o ka pōʻino nui i ka lolo.

ʻO wai ka mea hiki ke loaʻa i kēia lāʻau lapaʻau?

ʻAʻole hiki ke hāʻawi ʻia kēia i kēlā me kēia maʻi Alzheimer. I kēia manawa, ua ʻōlelo ʻia kēia no kahi helu palena loa o ka poʻe.

• No nā poʻe i nā pae mua o ka maʻi: ʻO ia hoʻi, ka poʻe me ka maʻi Alzheimer i hoʻomaka mua ʻia a i ʻole ka poʻe me ke ʻano i kapa ʻia ʻo 'mild cognitive impairment'. ʻAʻole maopopo inā he mea pono kēia no ka poʻe me ka maʻi ʻoi aku ka holomua.
• No ka poʻe i hōʻoia ʻia he mau plaques amyloid:Ma mua o ke kau ʻana o kāu kauka i kēia lāʻau lapaʻau, pono lākou e hōʻoia inā aia maoli kēia mau palaki i loko o kou lolo. Hiki paha i kēia ke pili i kahi scan PET a i ʻole kahi kīpē spinal.

ʻO wai ka poʻe hiki ʻole ke loaʻa i kēia lāʻau lapaʻau?

ʻAʻole i aʻo ʻia kēia lāʻau lapaʻau ma nā hoʻokolohua lapaʻau he nui, no laila he mea weliweli paha ke hāʻawi ʻana i kēia lāʻau i nā poʻe me nā pilikia olakino penei:

• ʻO ka poʻe e lawe ana i nā lāʻau lapaʻau e pale ai i ke kāpili ʻana o ke koko (koe naʻe ka aspirin).
• ʻO ka poʻe i ʻeha mua i nā hōʻeha puʻuwai a i ʻole nā ​​hahau.
• ʻO nā kānaka me nā maʻi kahe koko.
• Nā kānaka me nā maʻi puʻupaʻa a i ʻole ke akepaʻa.

ʻO kekahi mea ʻē aʻe, he pipiʻi loa kēia mau lāʻau lapaʻau. Ma kahi ʻāina e like me Sri Lanka, hiki ke paʻakikī i nā poʻe he nui ke loaʻa i kēia mau mea. ʻAʻole maʻamau kēia mau mea i kēia manawa.