Ke makewai mau nei ʻoe a mimi pinepine? Hiki paha kēia ma muli o nā maʻi Arginine Vasopressin (Diabetes Insipidus)

E noʻonoʻo ʻoe ʻaʻohe mea nui ka nui o ka wai āu e inu ai, manaʻo ʻoe ua makewai ʻoe. I ka manawa like, pono ʻoe e hele pinepine i ka lua. ʻAʻole hiki iā ʻoe ke hiamoe maikaʻi i ka pō, a pono ʻoe e ala i nā manawa he nui. ʻAʻole anei kēia he kūlana hopohopo iki? ʻOiai he nui ka poʻe e manaʻo nei he mea maʻamau kēia, i kekahi manawa hiki ke lilo i hōʻailona o kekahi pilikia ʻē aʻe i loko o ko mākou kino. I kēia lā e kamaʻilio mākou e pili ana i kahi ʻano maʻi kakaikahi, akā hiki ke mālama ʻia. ʻO ia ka Arginine Vasopressin Disorders, a i ʻole Diabetes Insipidus e like me ka ʻike ʻana o ka poʻe he nui ma kona inoa kahiko.

I ka ʻōlelo maʻalahi, he aha nā maʻi Arginine Vasopressin?

ʻOiai he ʻano paʻakikī iki ka inoa, he mea maʻalahi loa ke hoʻomaopopo i ka mea e hana nei. I ka ʻōlelo maʻalahi, he kūlana kēia kahi hiki ʻole i ko mākou kino ke mālama i ka nui o ka wai e pono ai. No laila, hoʻokuʻu ʻia ka nui o ka wai e pono ai i loko o ka mimi.

ʻO ke kumu nui o kēia, he hormone i loko o ko kākou kino. Ua kapa ʻia ʻo Arginine Vasopressin (AVP) . Ua kapa pū kekahi mau kauka iā ia he Antidiuretic Hormone (ADH) . Ua like kēia hormone AVP me kahi luna e hāʻawi ana i nā kuhikuhi i ko kākou mau puʻupaʻa. ʻO ia ka mea e haʻi aku i nā puʻupaʻa, "ʻAe, pono ke kino i ka wai i kēia manawa, no laila e mālama i kekahi wai a hoʻēmi i ka nui o ka wai i hoʻokuʻu ʻia ma ke ʻano he mimi."

I kēia maʻi, hiki ke hoʻopilikia ʻia kēia kaʻina hana ma nā ʻano nui ʻelua:

1. AVP Deficiency (AVP-D): ʻO kēia ka manawa ʻaʻole hana ko kākou lolo i ka hormone AVP i ka nui e pono ai. ʻO ia hoʻi, ʻaʻohe mea nāna e kuhikuhi i nā puʻupaʻa.

2. Ke Kūʻē ʻana i ka AVP (AVP-R): Ma kēia, ʻoiai ua hana ka lolo i ka nui o ka hormone AVP, ʻaʻole ʻae nā puʻupaʻa i ka ʻōlelo aʻoaʻo. E like me ka hāʻawi ʻana o ka luna i ka ʻōlelo aʻoaʻo akā hoʻowahāwahā nā limahana.

ʻO kēlā me kēia ʻano, ua like ka hopena hope loa: kānana nā puʻupaʻa i ka wai e like me kā lākou e pono ai a hoʻokuʻu iā ia ma ke ʻano he mimi. ʻO ka hopena, nalowale ke kino i ka wai e pono ai.

He aha nā hōʻailona o kēia maʻi?

ʻO nā hōʻailona nui a ʻike nui ʻia o kēia maʻi:

• Makewai nui (polydipsia): Manaʻo ʻoe ʻaʻole ʻoe e makewai me ka nānā ʻole i ka nui o ka wai āu e inu ai.
• Ka mimi pinepine ʻana: ʻO ka pono e ala i luna i nā manawa he nui e mimi, ʻaʻole wale i ke ao, akā i ka pō hoʻi (nocturia).
• Nui ka mimi ʻana: He nui loa ka nui o ka mimi i hana ʻia. ʻAʻohe kala o ka mimi a he wai.

He hōʻailona ikaika kēia mau hōʻailona e hana pono ʻole ana kekahi mea i loko o kou kino. No laila, inā loaʻa iā ʻoe kēia mau hōʻailona, ​​​​he mea nui loa e ʻike koke i ke kauka.

Pehea e ʻike ʻia ai kēia mau hōʻailona i nā keiki ʻōpio?

ʻAʻole hiki i nā keiki ʻōpio ke ʻōlelo pololei "Ua makewai au." No laila, inā loaʻa iā lākou kēia maʻi, ʻokoʻa iki paha ke ʻano o nā hōʻailona.

• Ka make wai nui
• Ka paʻa ʻana o ka ʻōpū
• Ka luaʻi ʻana
• Kuni pinepine
• Hoʻomaha mau a uē
• ʻAʻole e ulu pono (ʻaʻole e loaʻa ke kaumaha)

No ke aha lā e kū mai ai kēia kūlana?

Aia kekahi mau kumu kūpono no kēia, ma muli o ke ʻano o ke kūlana.

Nā kumu o ka hemahema o Arginine Vasopressin (AVP-D)

ʻO kēia ke ʻano maʻamau. Hoʻokumu ʻia ia e ka hōʻino ʻana i nā ʻāpana o ka lolo e hana ana i ka hormone AVP (ka hypothalamus a i ʻole ka pituitary gland).

• Nā ʻeha poʻo a i ʻole nā ​​​​ʻoki kino: Hiki ke hōʻino ʻia kēia mau ʻāpana e ke ʻoki kino a i ʻole kahi ulia i ka lolo.
• Nā puʻupuʻu: Ma muli o kekahi mau puʻupuʻu e hana ʻia ana i loko o ka lolo.
• Ka mumū: Nā kūlana mumū i hoʻokumu ʻia e nā maʻi e like me ka sarcoidosis a i ʻole ka maʻi puʻupuʻu.
• Nā kumu hoʻoilina: Nā loli hoʻoilina i hoʻoilina ʻia.
• Idiopathic: I kekahi mau hihia, ma kahi o ka hapalua o nā hihia āpau, ʻaʻohe kumu kikoʻī e loaʻa.

Nā kumu o ke kū'ē ʻana o Arginine Vasopressin (AVP-R)

ʻAʻohe pilikia me ka lolo e hana ana i ka hormone, aia ka pilikia ma nā puʻupaʻa.

• Nā kumu hoʻoilina: Nā pilikia hoʻoilina i hoʻoili ʻia mai nā hanauna aku.
• Kekahi mau lāʻau lapaʻau: ʻOi aku kekahi mau lāʻau lapaʻau no ka maʻi noʻonoʻo, e like me ka lithium.
• Ka ālai ʻana o ke ala mimi.
• Hoʻonui ʻia ka nui o ka calcium i loko o ke koko (Hypercalcemia).
• Ka haʻahaʻa o ka potassium i loko o ke koko (Hypokalemia).

Nā kūlana kūikawā e kū mai ana i ka wā hāpai

He mea kākaʻikahi loa, hiki i nā wāhine ke loaʻa i kēia maʻi no kekahi manawa i ka wā hāpai. ʻO kēia no ka mea, ua wāwahi kahi enzyme i hana ʻia e ka placenta i ka hormone AVP o ka makuahine i ka wā hāpai. ʻOi aku ka kiʻekiʻe o kēia pilikia no nā makuahine e hāpai ana i nā māhoe a no nā makuahine i loaʻa nā maʻi e like me ka preeclampsia, e hoʻopilikia ana i ka hana o ke ake. Akā, ʻo ka nūhou maikaʻi, e nalowale loa kēia maʻi i loko o ʻelua a ʻekolu mau pule ma hope o ka hānau ʻana.

He aha nā pilikia e hiki ai i kēia ke hana?

ʻO ka pilikia nui a weliweli loa o kēia maʻi, ʻo ia ka dehydration , ʻo ia hoʻi ka nalowale ʻana o ka wai a me nā electrolytes no ke kino e hana pono ai.

ʻO ka maʻamau, hiki iā ʻoe ke uku no ka nalowale ma ka inu ʻana i ka wai lawa e kūlike me ka nui o ka mimi āu e hana ai. Akā inā no kekahi kumu ʻaʻole hiki iā ʻoe ke inu i ka wai lawa, hiki iā ʻoe ke maloʻo loa i ka wā koke.

Pehea e ʻike ai ke kauka i kēia?

Aia kekahi mau maʻi maʻamau ʻē aʻe e hiki ai ke hoʻoulu i ka makewai pinepine a me ka mimi ʻana. Eia kekahi laʻana, ka maʻi diabetes mellitus. No laila, ʻo ka mea mua a ke kauka e hana ai, ʻo ia ke nānā i nā maʻi like ʻē aʻe.

Hana ʻia kekahi mau hoʻokolohua e ʻike pololei i kēia maʻi.

• Hoʻāʻo Hoʻonele Wai: ʻO kēia ke ala hilinaʻi loa e ʻike ai i kēia maʻi. Ma kēia hoʻāʻo, pono ʻoe e hele me ka ʻole o ka inu ʻana i kekahi wai no kekahi mau hola. Hana ʻia kēia ma kahi haukapila ma lalo o ka nānā pololei ʻana a ke kauka a kahu maʻi paha. ʻO kēia no ka mea hiki i kēia ke alakaʻi i ka maloʻo. Inā loaʻa iā ʻoe kēia maʻi, e hoʻomau kou kino i ka hana ʻana i ka nui o ka mimi ʻoiai ʻaʻole ʻoe i inu i ka wai. I ke kanaka olakino, e emi ana kāu mimi i hoʻopuka ʻia, a e hana wale ʻoe i kahi liʻiliʻi o ka mimi melemele ʻeleʻele, i hoʻopaʻa ʻia.
• Nā hoʻokolohua ʻē aʻe:
• Ke nānā ʻana i nā pae kō koko (e hōʻoia ʻaʻole ʻoe he maʻi diabetes).
• Urinalysis - E nānā i ka nui (osmolality) o ka mimi.
• Nā hoʻāʻo koko - e ana i kahi mea i kapa ʻia ʻo Copeptin, e pili ana i ka hormone AVP.
• MRI scan - e ʻike inā he hōʻino i ka pituitary gland a i ʻole hypothalamus i loko o ka lolo.

He aha nā lāʻau lapaʻau no kēia?

Aia nā koho lapaʻau ma muli o ka loaʻa ʻana o AVP-D a i ʻole AVP-R iā ʻoe, akā me ka nānā ʻole i ka lāʻau lapaʻau, he mea pono ka inu ʻana i ka wai lawa.

Ka mālama ʻana i ke kūlana AVP-D

ʻO Desmopressin ka lāʻau lapaʻau nui i hoʻohana ʻia no kēia. He hormone synthetic kēia e hana ana e pani i ka hormone AVP i nalowale. Hiki ke lawe ʻia ma ke ʻano he pila, ʻaila ihu, a i ʻole injection. Hāʻawi ʻia kekahi manawa no nā kūlana manawa pōkole e kū mai ana i ka wā hāpai.

Ka mālama ʻana i ke kūlana AVP-R

He mea paʻakikī iki ka mālama ʻana i kēia. No ka mea, ʻaʻole ka pilikia ma ʻaneʻi ka nele o nā hormones, akā, ʻo ka pane ʻole ʻana o nā puʻupaʻa iā lākou. No laila, pono e hoʻohana pū ʻia nā ʻano lāʻau like ʻole.

• ʻO nā diuretics Thiazide: ʻOiai he ʻano lāʻau lapaʻau kēia e hoʻonui ai i ka hoʻopuka mimi, hana like ʻole lākou ma kēia ʻano a hōʻemi i ka hoʻopuka mimi.
• Nā lāʻau anti-inflammatory nonsteroidal (NSAIDs): Kekahi mau lāʻau lapaʻau i loko o ka māhele ʻeha.
• Inā loaʻa kēia maʻi i kahi lāʻau ʻē aʻe āu e lawe nei, e hoʻololi kāu kauka i kēlā lāʻau a kuhikuhi i kahi lāʻau ʻē aʻe.

No ke aha i hoʻololi ʻia ai ka inoa mai 'Diabetes Insipidus' a i 'Diabetes Insipidus'?

He pilikia kēia i loaʻa i nā poʻe he nui. No ka manawa lōʻihi, ua kapa ʻia kēia maʻi ʻo Diabetes Insipidus. Akā i ka makahiki 2022, ua hui pū kekahi mau hui lapaʻau nui a hoʻoholo e hoʻololi i kēia inoa.

ʻO ke kumu nui, ʻo ia ka huikau i hoʻokumu ʻia e ka huaʻōlelo "Diabetes". Hoʻohana pinepine mākou i ka "Diabetes" e pili ana i ka Diabetes Mellitus . He maʻi maʻamau loa ia ma ko mākou ʻāina. Hōʻike ʻia ia e ka piʻi ʻana o ke kō koko. ʻOiai he mau hōʻailona like nā maʻi ʻelua o ka makewai pinepine a me ka mimi ʻana, he mau maʻi ʻokoʻa loa kēia ʻelua . He ʻokoʻa loa hoʻi nā lāʻau lapaʻau.

Ua alakaʻi ka inoa "Diabetes Insipidus" i kekahi mau maʻi i kuhi hewa ʻia he maʻi diabetes mellitus, a me nā hewa lapaʻau. No ka hoʻopau ʻana i kēia huikau, ua hoʻohana ʻia ka inoa "Arginine Vasopressin Disorder" e pili ana i ke kūlana.

Hiki anei ke ola me ka holomua me kēia maʻi?

ʻAe, hiki nō ia. Inā loaʻa iā ʻoe ka lāʻau kūpono no kēia ʻano a inu i ka wai e like me ka ʻōlelo a kāu kauka, ʻaʻole ʻoe e loaʻa i nā pilikia koʻikoʻi.

Eia nō naʻe, aia kekahi mau hui i kahi pilikia kiʻekiʻe iki aʻe:

• Nā pēpē liʻiliʻi
• Nā kānaka ma luna o 65 mau makahiki
• ʻO nā kānaka me kekahi mau pilikia olakino noʻonoʻo a i ʻole nā ​​​​kīnā ulu

Hiki i kēia poʻe ke paʻakikī i ka hoʻomaopopo ʻana i ka wā e make wai ai lākou a i ʻole ke noi ʻana i ka wai i kēlā manawa, kahi e hoʻonui ai iā lākou i ka pilikia o ka make wai.

Inā manaʻo ʻoe e noho mau ana ʻoe i loko o ka lumi ʻauʻau, a ʻaʻohe mea nui ka nui o kāu inu ʻana, ʻaʻole hiki iā ʻoe ke hoʻopau i kou make wai, e hoʻomanaʻo he kūlana hiki ke hoʻokele ʻia kēia. E hoʻomohala kāu kauka i kahi hoʻolālā lapaʻau kūpono iā ʻoe. E haʻi pū ʻo ia iā ʻoe i ka nui o ka wai āu e inu ai i kēlā me kēia lā e pale aku ai i ka maloʻo ʻana. No laila, mai makaʻu e ʻimi i ka ʻōlelo aʻoaʻo lapaʻau.