E aʻo kākou e pili ana i ka mea huna o ka lolo e hōʻoluʻolu ai i kou manaʻo - GABA (gamma-aminobutyric acid)?

Ke manaʻo nei ʻoe i kekahi manawa ua kaumaha, hopohopo, a makaʻu wale paha? A i ʻole ke loaʻa nei iā ʻoe ka hiamoe ʻole i ka pō? Ma hope o kēia mau mea, aia paha kahi ʻelele kemika liʻiliʻi i loko o ko kākou lolo. ʻO ia ka mea a kākou e kamaʻilio ai i kēia lā. ʻO GABA ia. Hana ia e like me ke pihi 'hoʻoluʻolu' i loko o ko kākou lolo.

He aha ka GABA (gamma-aminobutyric acid)?

I ka ʻōlelo maʻalahi, he kemika ʻo GABA e hoʻouna i nā leka ma waena o nā ʻaʻalolo (neurons) i loko o ko kākou lolo. Ua like ia me kahi mea leka akamai i loko o ko kākou kino. Akā, ʻo ka mea kūikawā e pili ana i ia mea, ʻo ia ka "hōʻoluʻolu" i ka hana pono ʻole o ka lolo. ʻO ia hoʻi, ke kāohi nei ia i nā ʻaʻalolo o ka lolo mai ka hoʻoulu nui ʻia a me ka hoʻonāukiuki ʻia. Ua kapa ʻia kēia ʻano kemika e nā kānaka ʻepekema he neurotransmitters. E noʻonoʻo iā GABA he "brake" e kaohi ana i ka wikiwiki o ko kākou ʻōnaehana nerve waena, ʻo ia hoʻi ko kākou lolo a me ke kaula spinal. ʻO ia ka mea e kōkua iā kākou e ʻole e pīhoihoi nui a makaʻu paha.

Pehea e hana ai ʻo GABA? He aha ka mea e hana nei i loko o ko kākou lolo?

I kēia manawa, e nānā i ke ʻano o ka hana ʻana o kēia GABA i loko o ko kākou lolo. He ʻano hana kupaianaha loa ia. He miliona a he piliona ko kākou mau hunaola nerve i loko o ko kākou lolo. Pono kākou e hoʻouna i kahi leka mai kekahi hunaola nerve i kekahi. Aia kekahi hakahaka liʻiliʻi ma waena o kēia mau hunaola nerve ʻelua. Ua kapa ʻia kēlā he `(Synapse)` a i ʻole he nerve junction.

ʻO kahi `(Neurotransmitter)` e like me GABA e hana i kēia ma ka lawe ʻana i ka leka ma waena o kēia hui ʻana a hoʻopili i nā `(Receptors)` kikoʻī ma ke kelepona aʻe. Ua like ia me ke kī e hoʻokomo ana i loko o kahi laka. E like me ka hiki ʻole i kēlā me kēia kī ke wehe i kēlā me kēia laka, ʻaʻole hiki i kēlā me kēia `(Neurotransmitter)` ke hoʻopili i kēlā me kēia `(Receptor)`. Loaʻa iā GABA ʻelua mau `(Receptors)` kikoʻī e ʻike iā ia - `(GABA-A)` a me `(GABA-B)`.

No laila, ke hele ʻo GABA a hoʻopaʻa i kēia mau mea loaʻa, hoʻemi ia i ka hiki o ke kelepona nerve aʻe ke pane. ʻO ia hoʻi, hoʻemi ia i ka manawa kūpono o kēlā kelepona e hana i kahi leka pono ʻole a hoʻouna paha iā ia i kekahi. ʻO ia ke kumu i kapa ʻia ai ʻo GABA he "inhibitory" a i ʻole neurotransmitter hōʻoluʻolu.

He aha nā pono olakino e hāʻawi ai ʻo GABA?

No laila, he aha nā pono olakino a mākou e loaʻa ai mai GABA, ka mea e hōʻoluʻolu ai i ka lolo ma kēia ʻano? He nui maoli. E noʻonoʻo, ua "kaumaha" loa ʻoe, ʻo ia hoʻi, i ka wā e kaumaha nui ana ʻoe, ʻaʻole kou manaʻo ma kahi hoʻokahi, hopohopo nui ʻoe, a me he mea lā e kuʻi ana kou umauma. I kēlā manawa, inā kūpono ka pae GABA i loko o kou kino, e hōʻoluʻolu ia i kou manaʻo a kōkua iā ʻoe e hōʻemi i kēia kaumaha .

Loaʻa iā GABA kahi hiki kupaianaha ke kāohi i ka hopohopo . Kōkua ia i ka hoʻēmi ʻana i ka makaʻu pono ʻole a me ka hopohopo e pili ana i nā mea āpau.

ʻO kekahi mea ʻē aʻe, ʻaʻole hiki i kekahi poʻe ke hiamoe i ka pō. Huli wale lākou i ka wā e moe ai, akā ʻaʻole lākou e hiamoe iki. Hōʻike ka noiʻi o kēia manawa e kōkua pū ana ʻo GABA i ka hiamoe maikaʻi a hoʻomaha .

GABA a me Glutamate: Ke kuapo 'On-Off' o ka lolo

Me GABA, aia kekahi '(Neurotransmitter)' koʻikoʻi loa i loko o ko kākou lolo. ʻO ia hoʻi ʻo '(Glutamate)'. Hana kēia mau mea ʻelua e like me nā ʻaoʻao ʻelua o kahi ʻāpana kālā, a i ʻole e like me nā kuapo 'on' a me 'off' ʻelua. ʻO ia hoʻi, ma nā ʻaoʻao ʻē aʻe kekahi i kekahi.

• GABA: 'Hoʻopau' i ka hana o ka lolo a hoʻomālielie iā ia (inhibitory).
• Glutamate: 'Hoʻāla' a hoʻoulu i ka hana lolo (stimulant).

No laila, i mea e hana pono ai ko kākou lolo, pono ke kaulike ma waena o ka mana hōʻoluʻolu o GABA a me ka mana hoʻoulu o `(Glutamate) . E like me ka mea hoʻolalelale a me ka paleki o ke kaʻa. Ke hana pono nā mea ʻelua a i ka manawa kūpono hiki iā kākou ke holo mālie a palekana. Inā nalowale kēia kaulike, kū mai nā pilikia like ʻole. ʻO ka mea kupanaha, ua hana ʻia kēia mea hōʻoluʻolu i kapa ʻia ʻo GABA mai ka mea hoʻoulu `(Glutamate). Aia kahi `(enzyme)` kūikawā i loko, ʻo ia hoʻi, kahi enzyme (`glutamic acid decarboxylase`).

Hana pū kekahi ʻo GABA me kekahi neurotransmitter ʻē aʻe, ʻo serotonin. ʻO ka ʻoiaʻiʻo, hana pū nā neurotransmitter he nui, i kekahi manawa kūʻē kekahi i kekahi, e mālama pono i ko mākou kino a me ka lolo.

Nā maʻi e hiki ke hana ʻia e nā pae GABA haʻahaʻa

E noʻonoʻo i ka mea e hiki mai ana inā ʻaʻole hana pono kēia hoʻololi leka GABA, ʻo ia hoʻi, ua haʻahaʻa nā pae GABA i loko o ka lolo? Hiki i kēia ke alakaʻi i nā ʻano pilikia olakino neurological a me ka noʻonoʻo. Ua ʻike ʻia e ka noiʻi ʻana hiki i ka emi ʻana o ka hana GABA ke kōkua i nā kūlana e like me:

• Hopohopo a me nā maʻi naʻau: Manaʻo mau i ka makaʻu, ka hopohopo, ka nalowale ʻana o ka hauʻoli, a me ka hiki ʻole ke noʻonoʻo pono.
ʻO Schizophrenia : He maʻi noʻonoʻo paʻakikī i hōʻailona ʻia e ka nalowale o ka pilina me ka ʻoiaʻiʻo a me ka ʻike ʻana, ka lohe ʻana, a me ka noʻonoʻo ʻana i nā mea ʻoiaʻiʻo ʻole.
• Ka maʻi autism spectrum: He maʻi ulu i hōʻailona ʻia e nā hemahema i ka launa pū ʻana a me ke kamaʻilio ʻana.
• Kaumaha: He manaʻo kaumaha no ka wā lōʻihi, ka nalowale o ka hoihoi i kekahi mea, a me ka manaʻo o ka luhi i ke ola.
• ʻEpilepsy a me nā hopu ʻana: ʻO nā kūlana e like me nā hoʻopūʻiwa a me nā hopu ʻana e kū mai ana i loko o ke kino ma muli o ka hyperactivity koke ʻole o nā hunaola nerve i loko o ka lolo.

Ma waho aʻe o kēia mau kūlana nui, aia kekahi mau maʻi ʻē aʻe i manaʻo ʻia e pili ana me ka hemahema o GABA:

• Ka nele o ka Pyridoxine:He maʻi laha ʻole kēia. Hoʻokumu ʻia ia e ka nele o ka wikamina B6 (pyridoxine), he mea nui ia no ka hana ʻana o GABA. ʻO ka maʻamau, ʻo ia ke kumu o nā hopu pinepine ʻana i nā keiki ʻōpio. He paʻakikī ke kāohi i kēia mau hopu me nā lāʻau anti-epileptic maʻamau, akā hiki ke ho'ōla ʻia me nā mea hoʻohui wikamina.
• ʻO ka encephalopathy hepatic: Maʻi akepaʻa koʻikoʻi e hoʻopilikia ana i ka hana o ka lolo.
• ʻO ka maʻi o Huntington: He maʻi hoʻoilina e hoʻopau mālie i nā hunaola lolo.
• ʻO Dystonia a me ka spasticity: Nā kūlana i hōʻike ʻia e ka ʻoʻoleʻa ʻana o nā ʻiʻo a me ka twitching.
• Hypersomnia: Manaʻo nui ka hiamoe a hiamoe nui paha i ke ao.

Aia kekahi mau pono olakino no ka hoʻonui ʻana i nā pae GABA?

Ke aʻo nei nā kānaka noiʻi i nā hopena o ka hoʻonui ʻana i nā pae GABA. ʻOiai ʻaʻole i maopopo loa nā hōʻike, ke noiʻi ʻia nei inā hiki i ka GABA ke kōkua i ka mālama ʻana a i ʻole ka pale ʻana i kekahi mau maʻi olakino. Eia kekahi laʻana:

• Ke koko kiʻekiʻe
• ʻAʻole hiki ke hiamoe
• Maʻi diabetes

Pono ka noiʻi hou aku ma luna o kēia mau mea.

Nā ʻano lāʻau lapaʻau e pili ana i ka GABA

Ma muli o kēia koʻikoʻi o GABA, ua hoʻomohala nā mea hana lāʻau lapaʻau i nā lāʻau lapaʻau he nui e kuhikuhi ana i nā "mea loaʻa" GABA. Hana kēia mau mea ma ke kōkua ʻana a i ʻole ka hoʻonui ʻana i nā hopena hōʻoluʻolu kūlohelohe o GABA. Ua lohe paha ʻoe i kēia mau mea:

• Benzodiazepines: ʻO kēia papa o nā lāʻau lapaʻau e komo pū ana me diazepam (ʻike ʻia hoʻi ʻo Valium) a me alprazolam (ʻike ʻia hoʻi ʻo Xanax) a hoʻohana ʻia e mālama i ka hopohopo, ka insomnia, nā hopu ʻana, a me ka haʻalele ʻana i ka waiʻona. Hoʻohana ʻia hoʻi lākou ma ke ʻano he anesthesia i ka wā o ke ʻoki kino.
• Barbiturates: He ʻano lāʻau hoʻomaha kēia e hoʻoulu ai i ka hiamoe. Eia nō naʻe, ʻaʻole i maʻamau ka hoʻohana ʻana i kēia manawa.
• ʻO Vigabatrin (Sabril®): He lāʻau lapaʻau i hoʻohana ʻia no ka mālama ʻana i nā hopu ʻana a me nā ʻūmiʻi ʻiʻo i nā keiki ʻōpio.
• Flumazenil (Romazicon®): Hoʻohana ʻia e mālama i ka overdose benzodiazepine. Hoʻohana ʻia nō hoʻi e hoʻomaikaʻi i ke kūlana noʻonoʻo i ka encephalopathy hepatic, kahi kūlana i hoʻokumu ʻia e ka maʻi akepaʻa.
• ʻAkika Valproic: He lāʻau hoʻomalu kēia e hoʻomalu ai i nā hopu epileptic.
• ʻO Zolpidem (ʻike ʻia hoʻi ʻo Ambien® a i ʻole Edluar®): He lāʻau lapaʻau nui kēia no ka insomnia.
• ʻO Propofol (i ʻike ʻia hoʻi ʻo Diprivan®): He lāʻau lapaʻau i hoʻohana ʻia e hoʻomālielie a hoʻomoe i ka mea maʻi i ka wā o ka anesthesia laulā.
• Baclofen (`Baclofen (Lioresal®, Gablofen®)`): He mea hoʻomaha i ka ʻiʻo.

E hoʻomanaʻo: Pono e hoʻohana ʻia kēia mau lāʻau lapaʻau a me nā lāʻau like ʻē aʻe ma lalo o ka nānā ʻana a ke kauka. ʻO ka hoʻohana ʻana iā lākou ma kāu iho, a i ʻole no ka mea ua haʻi aku kekahi iā ʻoe e hana pēlā, hiki ke hōʻeha nui. No laila e makaʻala.

He mea pono anei nā mea hoʻohui GABA?

I kēia manawa, e nīnau paha kekahi, 'No ke aha lā e hiki ʻole ai iā kākou ke kūʻai i ka GABA ma ke ʻano he mea hoʻohui?' ʻAe, loaʻa ka GABA ma ke ʻano he mea hoʻohui meaʻai. Akā, aia kahi pilikia liʻiliʻi ma ʻaneʻi. ʻAʻole maopopo loa ka nui o ka GABA a kākou e lawe ai ma ka waha e komo maoli ana i loko o ko kākou lolo.

No ka mea, ua hoʻopuni ʻia ko kākou lolo e kahi membrane pale kūikawā i kapa ʻia ʻo "blood-brain barrier". Ua like kēia me kahi puka, ʻaʻole e ʻae i nā kemika āpau e komo maʻalahi i ka lolo, e ʻae wale ana i nā mea i koho ʻia. No laila, ʻaʻole lawa nā hōʻike ʻepekema ikaika e ʻōlelo ai inā he hopena maoli kēia mau mea hoʻohui GABA i ka lolo a i ʻole. No laila, pono e hana hou ʻia ka noiʻi ma kēia me ka hoʻohana ʻana i kahi hui nui o ka poʻe. Ma muli o ke kūlana o kēia manawa, ʻaʻole naʻauao ka hoʻohana ʻana i nā mea hoʻohui GABA me ka ʻole o ke kamaʻilio ʻana me ke kauka.

Aia kekahi mau meaʻai i loaʻa ka GABA?

Aia maoli nō hoʻi ka GABA i loko o kekahi mau meaʻai. Eia kekahi laʻana:

• Nā meaʻai i hoʻoulu ʻia: nā mea e like me kimchi (kahi pickle Korea), miso (kahi kāpili soy Kepani), a me tempeh (kahi huahana soy Indonesian).
• Nā ʻano kī: Loaʻa pū kekahi GABA i ke kī ʻōmaʻomaʻo, ke kī ʻeleʻele, a me ke kī oolong.
• Nā meaʻai ʻē aʻe: ʻO nā meaʻai e like me ka laiki ʻeleʻele, ka soybeans, ka pī, ka chestnuts (kahi ʻano pīnati), nā halo, nā tōmato, ka spinach, ka broccoli, ka kāpeti, ka cauliflower, nā ʻōpuʻu Brussels (kahi ʻano kāpeti liʻiliʻi), nā hua i ʻōpuʻu ʻia (e.g., nā pīni ʻōmaʻomaʻo ke ʻōpuʻu ʻia), a me ka ʻuala momona, aia pū kekahi GABA a kōkua paha i ke kino e hana i ka GABA.

Akā e like me ka mea i ʻōlelo ʻia e pili ana i nā mea hoʻohui, ʻaʻohe wehewehe maopopo no ka nui o ka GABA mai kēia mau meaʻai e hiki ai i ka lolo. He mea maikaʻi ke hoʻokomo iā lākou ma ke ʻano he ʻāpana o ka papaʻai olakino, akā ʻaʻole kūpono ke hilinaʻi wale i kēia mau meaʻai ma ke ʻano he lāʻau lapaʻau kūikawā no kahi kūlana kikoʻī. Eia kekahi, e ʻimi i ka ʻōlelo aʻoaʻo lapaʻau e pili ana i kēia.

ʻO ka mea hope loa, nā mea e hoʻomanaʻo ai (Leka Lawe-Home)

No laila, ua maopopo paha iā ʻoe i kēia manawa ʻo ka GABA (gamma-aminobutyric acid) a mākou i kamaʻilio ai i kēia lā he neurotransmitter ia e hōʻoluʻolu i ko mākou lolo a he mea nui loa ia no ko mākou olakino noʻonoʻo, hiamoe, a me ka hana o ko mākou kino ma ke ʻano holoʻokoʻa.

Kōkua ia i ka hoʻomalu ʻana i ka hopohopo, ke kaumaha, a me ka hiamoe ʻole. Hiki i nā pae GABA haʻahaʻa ke alakaʻi i nā maʻi neurological a me nā maʻi psychiatric like ʻole. Hana kekahi mau lāʻau lapaʻau ma ka hoʻopaʻa ʻana i ka ʻōnaehana GABA.

Pono nā noiʻi ʻepekema hou aʻe e pili ana i nā pono o nā mea hoʻohui GABA a me nā meaʻai i loaʻa iā GABA. No laila, inā he mau hopohopo, kānalua, a nīnau paha kāu e pili ana i ka GABA, ʻo ka mea maikaʻi loa a palekana hoʻi e hana ai, ʻo ia ke ʻike i kāu kauka ʻohana, e kūkākūkā i kou kūlana, a loaʻa i ka ʻōlelo aʻoaʻo kūpono.Mai hele i ka hana ma muli o nā kuhi wale a i ʻole nā ​​lohe wale. He waiwai kou olakino iā ʻoe.

ʻGABA , gamma-aminobutyric acid, neurotransmitter, lolo, olakino noʻonoʻo, hopohopo, hiamoe