Ua kuhikuhi anei kāu kauka iā Glasdegib (Daurismo) nou a i ʻole kekahi o kou ʻohana no kahi maʻi kanesa i kapa ʻia ʻo Acute Myelogenous Leukemia? He lāʻau ikaika loa ia me kahi inoa paʻakikī. No laila, he ala maʻalahi a aloha kēia e kamaʻilio ai e pili ana i kēia lāʻau, pehea e hoʻohana ʻia ai, a me nā mea e pono ai mākou e makaʻala nui.
He aha ke ʻano lāʻau lapaʻau ʻo Glasdegib?
I ka ʻōlelo maʻalahi, he lāʻau lapaʻau ʻo Glasdegib e kuhikuhi ana i nā hunaola kanesa a kāohi iā lākou mai ka ulu ʻana. Pono nā hunaola kanesa i loko o ko mākou kino i nā protein kūikawā e ulu ai. ʻO ka hana a kēia lāʻau lapaʻau, ʻo ia ke kāohi i ka hana o kēlā mau protein. Ma kēia ʻano, ke hiki ʻole i nā hunaola kanesa ke ulu, loaʻa iā mākou ke kōkua nui i ka kaohi ʻana i ka kanesa.
Hoʻohana nui ʻia kēia lāʻau lapaʻau e mālama i kahi ʻano maʻi koko i kapa ʻia ʻo ka leukemia myelogenous acute. I kekahi manawa, hiki i kāu kauka ke kuhikuhi i kēia lāʻau lapaʻau no nā kūlana ʻē aʻe. E wehewehe kāu kauka i kēia iā ʻoe me nā kikoʻī.
ʻO nā mea nui e haʻi aku i kāu kauka ma mua o ka lawe ʻana i kēia lāʻau lapaʻau
ʻOiai he lāʻau ikaika loa ʻo Glasdegib, he mea nui loa ia e hoʻomaopopo i kāu kauka e pili ana i nā kūlana olakino ʻē aʻe āu e loaʻa nei. Inā loaʻa iā ʻoe kekahi o nā kūlana ma lalo nei, e haʻi i kāu kauka e pili ana i ia mea ma mua o ka hoʻomaka ʻana i ka lāʻau.
- Inā he maʻi puʻuwai kou.
- Inā ua loaʻa iā ʻoe nā puʻuwai puʻuwai kūpono ʻole ma mua.
- Inā he moʻolelo kou no kekahi mau maʻi e pili ana i nā ʻiʻo.
- Inā he maʻi puʻupaʻa kou.
- Inā he maʻi kou akepaʻa.
- Inā haʻahaʻa loa a kiʻekiʻe loa paha ka pae o nā electrolytes i loko o ke koko (e.g. potassium, magnesium).
- Inā ua loaʻa iā ʻoe kahi hopena maʻi i Glasdegib, nā lāʻau lapaʻau ʻē aʻe, nā meaʻai, nā kala, a i ʻole nā mea mālama.
- Inā hāpai ʻoe, a i ʻole e hoʻolālā ana e hāpai koke.
- Inā he makuahine hānai waiū ʻoe.
ʻO ka hūnā ʻana i kēia ʻike mai kāu kauka mai hiki ke hoʻoweliweli i kou olakino, no laila mai makaʻu e kamaʻilio ākea e pili ana i nā mea āpau.
Pehea e hoʻohana pono ai i ka lāʻau lapaʻau?
He mea nui loa e lawe i ka lāʻau lapaʻau e like me ke kauoha a ke kauka, ma ke ʻano kūpono, i ka manawa kūpono.
- E ale i kēia papa me ke aniani wai. Mai uhaʻi, kuʻi, a nau paha i ka papa.
- Hiki iā ʻoe ke lawe i kēia me ka meaʻai a me ka ʻole. Akā ʻo ka mea nui loa, ʻo ia ke lawe ʻana iā ia ma ke ʻano like i kēlā me kēia lā.Eia kekahi laʻana, inā hoʻomaka ʻoe e lawe ma hope o ka ʻai ʻana, e lawe i kēlā me kēia lā ma hope o ka ʻai ʻana. Inā hoʻomaka ʻoe e lawe ma mua o ka ʻai ʻana, e lawe i kēlā me kēia lā ma mua o ka ʻai ʻana.
- Mai ho'ōki koke i ka lawe ʻana i ka lāʻau me ka ʻole o ke aʻo ʻana a kāu kauka.
- Inā ʻoe e hāʻawi ana i kēia lāʻau lapaʻau i nā keiki, e kamaʻilio me ke kauka lapaʻau e pili ana i ia mea a e hoʻohana wale ia e like me kāna mau kuhikuhi.
- Inā lawe hewa ʻoe i ka nui o ka lāʻau lapaʻau: Inā manaʻo ʻoe ua lawe nui ʻoe i ka lāʻau lapaʻau, e kāhea koke aku i ke Kikowaena ʻIke Poisons National ma ka Halemai Lahui ʻo Colombo , a i ʻole e hele i ka Emergency Treatment Unit (ETU) kokoke loa.
He aha kāu e hana ai inā e poina ʻoe i kahi lāʻau?
Inā poina iā ʻoe ke lawe i kahi lāʻau, e lawe koke iā ia i kou hoʻomanaʻo ʻana. Eia nō naʻe, inā ʻaʻole i hala ma mua o 12 mau hola a hiki i kāu lāʻau aʻe, e kāpae i ka lāʻau i hala ʻole a lawe i ka lāʻau aʻe i ka manawa i hoʻonohonoho ʻia. Mai lawe i ʻelua mau lāʻau i ka manawa hoʻokahi.
He aha nā contraindications no ka hoʻohana ʻana i kēia lāʻau?
Hiki iā Glasdegib ke launa pū me nā lāʻau lapaʻau ʻē aʻe, no laila he mea nui e haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau āpau āu e lawe nei.
Mai lawe i kēia mau lāʻau lapaʻau me Glasdegib:
- ʻO Cisapride
- dronedarone
- fluconazole
- pimozide
- posaconazole
- saquinavir
- thioridazine
Hiki i kēia mau lāʻau lapaʻau ke launa pū me Glasdegib:
- Nā lāʻau lapaʻau antiviral no ka maʻi HIV a i ʻole AIDS
- ʻO kekahi mau lāʻau lapaʻau no nā maʻi fungal (e like me itraconazole, ketoconazole)
- Kekahi mau lāʻau antibiotic (e.g. clarithromycin)
- ʻO kekahi mau lāʻau lapaʻau no ka hopu ʻana (e like me ka carbamazepine, phenytoin)
- ʻO nā lāʻau lapaʻau ʻē aʻe e hoʻoulu ai i ka puʻuwai puʻuwai kūpono ʻole (e hoʻolōʻihi i ka manawa QT)
- Nā lāʻau lapaʻau kuʻuna e like me ka St. John's Wort
- Wai ʻāpala
ʻAʻole i piha kēia papa inoa. No laila e hāʻawi i kāu kauka i kahi papa inoa piha o nā lāʻau lapaʻau āpau, nā huaora, nā lāʻau lapaʻau lāʻau, a me nā mea hoʻohui āu e lawe ai. Mai poina e haʻi iā lākou inā ʻoe e puhipaka a inu waiʻona paha.
Nā mea e makaʻala nui ai i ka wā e lawe ana iā Glasdegib
- Nā hoʻāʻo koko: He mea koi ʻia e loaʻa nā hoʻāʻo koko (hana koko) e like me ke kauoha a kāu kauka i ka wā e lawe ana i kēia lāʻau.
- Hāpai: Pono nā wāhine e pale i ka hāpai ʻana i ka wā e lawe ana i kēia lāʻau lapaʻau a no ka liʻiliʻi he 30 mau lā ma hope o ka hoʻōki ʻana i ka lāʻau lapaʻau. Pono hoʻi nā kāne e pale i ka hānau ʻana i kahi keiki i ka wā e lawe ana i kēia lāʻau lapaʻau a no ka liʻiliʻi he 30 mau lā ma hope o ka hoʻōki ʻana i ka lāʻau lapaʻau. Hiki i kēia lāʻau lapaʻau ke hōʻeha nui i kahi pēpē i hānau ʻole ʻia.
- Ka hānai waiū: ʻOiai e lawe ana i ka lāʻau lapaʻau a no ka liʻiliʻi he 30 mau lā ma hope o ka hoʻōki ʻana.Mai hānai i ka pēpē me ka waiū umauma.
- Hāʻawi ʻana i ka sperm a me ke koko: E pale i ka hāʻawi ʻana i ka sperm a i ʻole ke koko i ka wā e lawe ana i ka lāʻau lapaʻau a no ka liʻiliʻi he 30 mau lā ma hope o ka hoʻōki ʻana.
- Ka hānau keiki: Hiki i kēia lāʻau lapaʻau ke hoʻopilikia i kou hiki ke loaʻa nā keiki. Inā he mau hopohopo kāu e pili ana i kēia, e kamaʻilio me kāu kauka.
Nā hopena ʻaoʻao e hiki mai ana ma muli o ka lāʻau lapaʻau
E like me nā lāʻau lapaʻau āpau, hiki iā Glasdegib ke loaʻa nā hopena ʻaoʻao. Pono kekahi i ka nānā koke ʻana, aʻo nā mea ʻē aʻe he mea maʻamau.
| Ka hopena ʻaoʻao | Wehewehena |
|---|---|
| Nā mea e hōʻike koke aku ai i kāu kauka a i ʻole ka ʻOihana Hoʻopilikia (ETU) | |
| Nā hopena alerika | ʻŌhūhū ʻili, maneʻo, pehu o ka maka, nā lehelehe a i ʻole ke alelo. |
| Nā pilikia hanu | Paʻakikī ka hanu ʻana. |
| Nā hōʻailona o ka maʻi | Kuni, anu, ʻeha ka ʻāʻī, nā ʻeha waha. |
| ʻEha ʻiʻo | ʻEha nui a koʻikoʻi hoʻi o nā ʻiʻo i wehewehe ʻole ʻia. |
| Ke kahe koko ʻano ʻē | ʻEleʻele a koko paha ka lepo; ka luaʻi ʻana i kahi mea e like me ke kofe; nā kiko ʻulaʻula ma ka ʻili; ke kahe ʻana o ke koko mai ka ihu, nā ʻāʻī, a i ʻole nā maka; ka palapū ʻē o ka ʻili. |
| Nā loli i ka helu o ka puʻuwai | ʻEha ka umauma, ka poniuniu, ka puʻuwai wikiwiki a ʻano ʻole paha, ka manaʻo palupalu, ka poniuniu. |
| Luhi maʻamau ʻole | Ke manaʻo nei i ka nāwaliwali loa, ka luhi a i ʻole ka maʻi ʻē. |
| E haʻi i kāu kauka inā hoʻomau a hoʻopilikia paha. | |
| Hoʻololi i ka ʻono | Hoʻololi ka ʻono o ka meaʻai. |
| Ka paʻa ʻana o ka ʻōpū | Ka paʻakikī o ka hele ʻana i ka noho. |
| Ka luaʻi | Manaʻo e luaʻi ana. |
| Pehu ʻana | Ka pehu ʻana o nā kuʻekuʻe wāwae, nā wāwae, a i ʻole nā lima. |
| Luhi nui | Manaʻo iki i ka luhi. |
Inā loaʻa iā ʻoe kekahi mau hōʻailona ʻē aʻe i ʻōlelo ʻole ʻia ma kēia papa inoa, e ʻoluʻolu e hoʻomaopopo i kāu kauka e pili ana iā lākou.
Leka Lawe-Home
- E lawe mau iā Glasdegib e like me ke kauoha a kāu kauka, i ka manawa kūpono, a ma ka nui kūpono.
- Ma mua o ka hoʻomaka ʻana i ka lāʻau lapaʻau, e haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau āpau, nā huaora, nā lāʻau lapaʻau kuʻuna āu e lawe nei, a me nā kūlana olakino āu e loaʻa nei.
- E pale i ka hāpai ʻana, ka hānai ʻana i ka waiū, ka hāʻawi koko, a me ka hāʻawi sperm i ka wā e lawe ana i kēia lāʻau lapaʻau a no 30 mau lā ma hope o ka hoʻōki ʻana. Pili kēia i nā wahine a me nā kāne.
- Inā loaʻa nā hopena ʻaoʻao koʻikoʻi (e like me ka paʻakikī o ka hanu ʻana, ke kahe ʻana o ke koko, ka ʻeha o ka umauma), e ʻike koke i ke kauka a i ʻole e hele i ka Emergency Department (ETU).
- Ua kuhikuhi ʻia kēia lāʻau lapaʻau nou wale nō. Mai kaʻana like me nā poʻe ʻē aʻe no kekahi kumu.
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