He mea maʻamau i kekahi ke manaʻo i ka makaʻu nui a me ka haʻalulu ke lohe lākou i nā huaʻōlelo "colorectal cancer". Eia nō naʻe, mahalo i nā holomua o ka lāʻau lapaʻau i kēia lā, he nui nā lāʻau lapaʻau hou a holomua e hiki ke kōkua iā mākou e hoʻoponopono i ia mau maʻi. I kēia lā, e kamaʻilio mākou e pili ana i kahi ʻano "targeted therapy" i ʻokoʻa mai ka chemotherapy kuʻuna a kuhikuhi pono i nā cell cancer.
I ka ʻōlelo maʻalahi, he aha kēia mau Monoclonal Antibodies?
Ma mua o ko kākou hoʻomaopopo ʻana i kēia, e nānā kākou i ka ʻōnaehana pale kupaianaha o ko kākou kino. Ke komo mai kahi germ, e like me ka bacteria a i ʻole ka virus, i loko o ko kākou kino, hana kā kākou ʻōnaehana pale i nā protein kūikawā e hiki ke ʻike i kēia mau mea komo hewa, hoʻopili iā lākou, a luku iā lākou. Kāhea mākou i kēia mau "bodyguards," a i ʻole nā antibodies e ʻoi aku ka pololei.
I kēia manawa, ʻo kēia mau "(Monoclonal Antibodies)" he ʻano antibodies artificial i hana ʻia i loko o kahi lab me ka hoʻohana ʻana i ka ʻenehana kūikawā. Hana ʻia kēia mau mea e hoʻouka i hoʻokahi wale nō pahuhopu kikoʻī. I mea e pololei ai, ua hoʻolālā ʻia lākou e ʻike i kahi mea kikoʻī, e like me kahi protein ma luna o ka ʻili o kahi cell kanesa, e hoʻopili wale iā ia, a luku i kēlā cell kanesa .
Ua like kēia me kahi commando i hoʻomaʻamaʻa kūikawā ʻia e hiki ke loaʻa i kahi ʻenemi ma kahi piha kanaka a hoʻouka wale i kēlā ʻenemi me ka ʻole o ka hōʻeha ʻana i kekahi. No laila, ma kahi o ka hōʻino ʻana i nā hunaola maikaʻi i loko o ke kino e like me ka chemotherapy maʻamau, hiki ke manaʻo ʻia he emi nā hopena ʻaoʻao o kēia ʻano lapaʻau no ka mea ʻoi aku ka kikoʻī.
Nā lāʻau lapaʻau e hoʻōki ai i ka ulu ʻana o nā kīʻaha koko i ka maʻi kanesa (Angiogenesis Inhibitors)
ʻAʻole ka maʻi kanesa he mea e ulu wale ana. Ua like ia me kahi mea kanu. Pono ia i ka meaʻai e ola ai, e ulu ai, a e ulu. No ka loaʻa ʻana o kēia meaʻai, hoʻoulu nā hunaola kanesa i nā kīʻaha koko hou a puni lākou iho. Kāhea mākou i kēia kaʻina hana he "angiogenesis." No laila, inā mākou e hoʻōki i nā kīʻaha koko e hoʻolako ana i kēia "meaʻai a me ka mea inu" i ke kanesa, hiki iā mākou ke hoʻōki i ka ulu ʻana o ke kanesa, ʻeā? ʻO ia ka mea a mākou e kapa nei he papa o nā lāʻau lapaʻau e hana ana i kēlā.
Penei ka hana a Bevacizumab (Avastin):
ʻO Bevacizumab (inoa hōʻailona: Avastin) kahi lāʻau lapaʻau koʻikoʻi i kēia papa. Hoʻouna nā hunaola kanesa i kahi hōʻailona e haʻi iā lākou e "kūkulu i nā kīʻaha koko." Ua kapa ʻia kēia hōʻailona ʻo vascular endothelial growth factor, a i ʻole VEGF. ʻO ka mea a Avastin e hana ai, ʻo ia ke ālai i kēlā hōʻailona mai ka hiki ʻana i kahi i manaʻo ʻia. I nā huaʻōlelo maʻalahi, ke kāohi nei ia i ka "leka e kūkulu i nā kīʻaha koko" i hoʻouna ʻia e ke kanesa a luku iā ia.
Hoʻōki kēia i ke kanesa mai ka hana ʻana i nā kīʻaha koko hou, kahi e hoʻolohi ai i ka ulu ʻana o ke kanesa. Ua ʻae ʻia kēia lāʻau lapaʻau no ke kanesa colon i laha (metastasized) i nā ʻāpana ʻē aʻe o ke kino. ʻOiai ʻaʻole hiki iā ia ke ho'ōla piha i ke kanesa, ua ʻike ʻia nā noiʻi hiki iā Avastin, ke hāʻawi ʻia me ka chemotherapy, ke hoʻolōʻihi i ka manawa ola o nā maʻi ma kahi o 5 mau mahina .
ʻO `Fruquintinib (Fruzaqla)`, `ramucirumab (Cyramza)`, a me `ziv-aflibercept (Zaltrap)` kekahi o nā lāʻau lapaʻau hou e kuhikuhi pū ana iā VEGF.
Pehea e hāʻawi ʻia ai ʻo Avastin? He aha nā hopena ʻaoʻao?
He inikini intravenous (IV) ʻo Avastin. Hāʻawi pinepine ʻia i kēlā me kēia ʻelua a ʻekolu pule me ka chemotherapy.
He mea nui loa ka ʻike ʻana i nā hopena ʻaoʻao hiki ke loaʻa mai kēia lāʻau lapaʻau.
| ʻAno o ka hopena ʻaoʻao | Wehewehena |
|---|---|
| Nā hopena ʻaoʻao maʻamau |
|
| Nā hopena ʻaoʻao koʻikoʻi |
|
Nā lāʻau lapaʻau e hoʻopilikia pololei i ka ulu ʻana o nā hunaola kanesa
ʻO Cetuximab (Erbitux) a me panitumumab (Vectibix) ʻelua ʻano ʻē aʻe o nā antibodies monoclonal. Hana like ʻole kēia mau mea. Hoʻopili lākou i kahi protein i kapa ʻia ʻo epidermal growth factor receptor (EGFR) ma luna o ka ʻili o nā cell cancer.
E noʻonoʻo i kēia `EGFR` ma ke ʻano he kuapo `Hā` e haʻi ana i kahi cell kanesa e `māhele koke a ulu hou aku.` ʻO ka mea a nā lāʻau lapaʻau `Erbitux` a me `Vectibix` e hana ai, ʻo ia ke kau ʻana ma luna o kēia kuapo a `ālai` iā ia. A laila, ʻaʻole hiki i ka hōʻailona kūlohelohe e haʻi ana i ke cell e ulu ke hoʻohuli i ke kuapo. Ma kēia ʻano, ua kāohi ʻia ka ulu ʻana o nā cell kanesa.
Iā wai kēia lāʻau lapaʻau i hāʻawi ʻia ai?
Ua ʻāpono ʻia ʻo Erbitux lāua ʻo Vectibix e mālama i ka maʻi ʻaʻai colon i pālahalaha i nā ʻāpana ʻē aʻe o ke kino.
Hāʻawi ʻia ka lāʻau pale ʻo Erbitux i hoʻokahi manawa i ka pule, ma ke ʻano hoʻokahi a i ʻole me ka lāʻau chemotherapy ʻo irinotecan (Camptosar). Hāʻawi ʻia ka lāʻau pale ʻo Vectibix i kēlā me kēia ʻelua pule me ka hui pū ʻana me nā lāʻau chemotherapy ʻē aʻe.
He mea nui loa ma mua o ka hāʻawi ʻana i kēia lāʻau lapaʻau, e hana ʻia kahi hoʻāʻo hoʻololi genetic kūikawā ma kāu mau cell kanesa e ʻike ai inā e hana kēia lāʻau lapaʻau no kēlā kanesa. ʻAʻole kūpono kēia mau mea no nā kanesa āpau. No laila, ua hana maoli ʻia kēia hoʻāʻo.
He aha nā hopena ʻaoʻao o Erbitux lāua ʻo Vectibix?
Loaʻa i kēia mau lāʻau lapaʻau nā hopena ʻaoʻao kikoʻī.
| Nā hopena ʻaoʻao maʻamau o Erbitux a me Vectibix | |
|---|---|
| Nā pilikia ʻili | Nā pehu e like me ka ʻākena, nā ʻōhū ʻili, a me ka ʻili maloʻo. Akā ʻo ka mea kupanaha, i kekahi manawa ʻo kēia mau hopena ʻili ke ʻano o ka hana maikaʻi ʻana o ka lāʻau lapaʻau e kūʻē i ka maʻi kanesa. |
| Nā hopena ʻaoʻao ʻē aʻe |
|
Leka Lawe-Home
- He lāʻau lapaʻau holomua nā Monoclonal Antibodies e kuhikuhi pono ana a hoʻouka i nā hunaola kanesa. He ʻokoʻa lākou mai nā lāʻau lapaʻau chemotherapy maʻamau.
- Hoʻopau kekahi mau lāʻau lapaʻau i ke kahe koko i ke kanesa, aʻo kekahi e ālai i ka ʻōnaehana hōʻailona e hoʻoulu ai i ka ulu ʻana o nā cell cancer.
- Loaʻa i kēia mau lāʻau lapaʻau a pau ko lākou mau hopena ʻaoʻao ponoʻī. E kūkākūkā ākea i kēia mau mea me kāu kauka ma mua o ka hoʻomaka ʻana i ka lāʻau.
- ʻAʻole kūpono kēia mau lāʻau lapaʻau no nā kānaka a pau. Na kāu kauka e hoʻoholo i ka lāʻau lapaʻau maikaʻi loa iā ʻoe ma muli o ke ʻano o ka maʻi kanesa āu, pehea ka mamao o kona laha ʻana, a me nā hopena o nā hoʻokolohua genetic kūikawā.
- Inā loaʻa iā ʻoe a i ʻole kekahi o kou ʻohana ka maʻi kanesa, mai hopohopo. E kamaʻilio me kāu kauka ʻōpū e pili ana i nā koho lapaʻau āpau i loaʻa, ko lākou mau pono a me nā pōʻino, a e hoʻoikaika e kū i ka lāʻau.
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