He lāʻau lapaʻau i kuhikuhi ʻia e pepehi i nā hunaola kanesa: E aʻo kākou e pili ana i nā mea hoʻopale PARP

Inā ʻoe e hakakā nei me ka maʻi kanesa, a inā he mea aloha kāu i loaʻa iā ia, ua kamaʻāina paha ʻoe i nā huaʻōlelo e like me "chemotherapy" a me "radiation therapy." Ua lohe paha ʻoe e pili ana i nā hopena ʻaoʻao e hele mai me kēia mau lāʻau lapaʻau. Akā i kēia lā e kamaʻilio mākou e pili ana i kahi papa lāʻau hou e kuhikuhi wale ana i nā cell cancer a hōʻemi nui i ka hōʻino ʻana i nā cell olakino. Ua kapa ʻia kēia mau mea he PARP Inhibitors .

I ka ʻōlelo maʻalahi, he aha kēia PARP Inhibitor?

I mea e hoʻomaopopo ai i kēia, pono mua kākou e hoʻomaopopo i kahi kaʻina hana liʻiliʻi akā koʻikoʻi loa e hana ʻia ana i loko o nā pūnaewele o ko kākou kino. Aia i loko o kēlā me kēia pūnaewele o ko kākou kino kahi mea i kapa ʻia ʻo DNA. E noʻonoʻo iā ia e like me kahi palapala hoʻolālā nui i kākau i lalo pehea e hana ai nā mea āpau i loko o ko kākou kino. I kekahi manawa, ua hōʻino iki ʻia nā ʻaoʻao o kēia palapala hoʻolālā DNA.

ʻO kēia kahi e komo mai ai kahi protein i kapa ʻia ʻo PARP . ʻO "PARP" kahi pōkole no Poly (ADP-ribose) polymerase . Ua like ʻo PARP me kahi "mechanic hoʻoponopono" i loko o kā mākou mau cell. Ke hōʻino ʻia ka DNA, komo ka protein PARP a hoʻoponopono iā ia. He mea nui kēia no ke ola ʻana o nā cell olakino.

Akā ʻo ka pilikia, hoʻohana pū nā hunaola kanesa i kēia ʻano hana PARP no ko lākou pono. Ke hōʻino ʻia ka DNA o nā hunaola kanesa, hoʻohana pū lākou i kēia PARP e hoʻoponopono iā ia. ʻO ka hopena, ʻaʻole make nā hunaola kanesa, akā e hoʻomau i ka ulu a laha ma ke kino holoʻokoʻa.

Ma ke ʻano he hopena no kēia, hoʻohana nā kauka i kahi lāʻau i kapa ʻia ʻo PARP Inhibitor. ʻO "Inhibitor" ke ʻano he "mea pale." ʻO ka hana a kēia lāʻau lapaʻau, ʻo ia ke "ākea" i ka ʻōnaehana PARP e kōkua ana i nā hunaola kanesa. Me ke kōkua ʻole o PARP, nāwaliwali mālie ke hunaola kanesa, ʻaʻole hiki ke hoʻoponopono i ka DNA i hōʻino ʻia, a make hope.

ʻO nā ʻano nui o nā mea hoʻopaʻa PARP i hoʻohana ʻia ma ka honua

Aia kekahi mau mea hoʻopaʻa PARP i ʻae ʻia i kēia manawa no ka mālama ʻana i ka maʻi kanesa. Inā kuhikuhi kāu kauka i kekahi o kēia mau mea nāu, aia paha ia ma kēia papa inoa.

He aha nā ʻano maʻi kanesa e hoʻohana ʻia ai kēia lāʻau lapaʻau?

Hoʻohana pinepine ʻia nā mea hoʻopaʻa PARP no nā maʻi kanesa i ʻoi aku ka holomua a i ʻole ua pālahalaha i nā ʻāpana ʻē aʻe o ke kino (metastatic). Aia kekahi mau ʻano maʻi kanesa e pono nui ai lākou.

• Ka maʻi ʻaʻai umauma
• Ka maʻi ʻōpū
• Ka maʻi ʻaʻai o ka ʻōpū Fallopian
• Ka maʻi ʻaʻai prostate
• Ka maʻi ʻaʻai peritoneal mua
• Ka maʻi ʻaʻai pancreatic

ʻO ka pilina kūikawā me nā hoʻololi ʻana o ka gene BRCA

Eia kekahi mea āu e pono ai e ʻike e pili ana i ka gene BRCA . ʻO BRCA kekahi gene koʻikoʻi e kōkua i ka hoʻoponopono ʻana i ka DNA i loko o kā mākou mau cell a pale i ka maʻi kanesa. Akā, loaʻa paha i kekahi poʻe kahi mutation i loko o kēia gene BRCA. ʻO ia hoʻi, ʻaʻole hana pono kekahi o kā lākou mau ʻōnaehana hoʻoponopono DNA nui. Ma muli o kēia, ʻoi aku ka nui o ko lākou pilikia o ka loaʻa ʻana o ka maʻi kanesa.

E noʻonoʻo i kahi kaʻa me ʻelua mau ʻōnaehana paleki. ʻO BRCA kekahi, a ʻo PARP kekahi. I loko o kahi cell kanesa me kahi hoʻololi gene BRCA, ua haki mua kekahi ʻōnaehana paleki (BRCA). No laila, hilinaʻi nui kēlā cell kanesa i ka ʻōnaehana paleki ʻē aʻe (PARP) e ola ai.

I kēia manawa ke hāʻawi mākou i nā lāʻau PARP Inhibitor, hoʻopau mākou i kēlā ʻōnaehana paleki lua. A laila ʻaʻohe ala o ke kelepona kanesa e hoʻoponopono ai i kāna DNA, a make wale ia. ʻO ia ke kumu he mea kūpono loa nā PARP Inhibitors no nā maʻi kanesa me nā hoʻololi gene BRCA.

Pehea e loaʻa ai iaʻu ka lāʻau lapaʻau a pehea ka lōʻihi?

ʻO kekahi o nā pono o kēia lāʻau lapaʻau, ʻo ia ka hiki ʻana mai o nā mea āpau ma ke ʻano pila (nā capsule a i ʻole nā ​​papa). No laila, hoʻokahi a ʻelua paha manawa e lawe ai ʻoe i kēia lāʻau lapaʻau i ka lā. I kekahi manawa, ua lawa paha kēia lāʻau lapaʻau wale nō. I kekahi manawa, pono paha ʻoe e lawe pū me nā lāʻau lapaʻau ʻē aʻe no ka maʻi kanesa.

Eia kekahi laʻana, ma hope o nā lāʻau lapaʻau e hōʻino ana i ka DNA o nā hunaola kanesa, e like me ka chemotherapy a i ʻole ka radiation therapy, hiki iā ʻoe ke hāʻawi i kahi mea hoʻopaʻa PARP. A laila, ʻoiai ʻaʻole kōkua ʻo PARP i kēlā mau hunaola kanesa i hōʻino ʻia e hoʻoponopono iā lākou iho, ua hōʻoia ʻia e make kēlā mau hunaola.

Ka manawa lapaʻau

ʻOkoʻa kēia mai kēlā kanaka a kēia kanaka.

• Ua kuhikuhi ʻia kēia lāʻau lapaʻau no kekahi poʻe no kahi manawa kikoʻī, e like me ʻelua a ʻekolu paha mau makahiki, ma hope o ka pau ʻana o ka mālama ʻana i ka chemotherapy.
• Hoʻomau kekahi poʻe i ka lawe ʻana i kēia lāʻau lapaʻau inā pono ia no ko lākou kino.
• I kekahi manawa, inā ʻoi aku ka nui o nā hopena ʻaoʻao ma mua o nā pono o ka lāʻau lapaʻau, hiki iā ʻoe ke kamaʻilio me kāu kauka a hoʻōki i ka lāʻau.

He aha nā pōmaikaʻi a me nā pōʻino o kēia lāʻau lapaʻau?

ʻAʻole hiki i nā mea hoʻopaʻa PARP ke ho'ōla loa i ke kanesa. Eia nō naʻe, hiki iā lākou ke kōkua i nā poʻe maʻi me kekahi ʻano kanesa e ola lōʻihi . Hoʻomalu kēia mau lāʻau i ka ulu ʻana o ke kanesa. Kāhea nā kauka i kēia he hoʻonui i ka "progression-free survival rate." I ka ʻōlelo maʻalahi, hoʻonui lākou i ka manawa e noho maikaʻi ai ke kanesa me ka ʻole o ka ʻino. I kekahi mau hihia, hiki iā lākou ke ʻoi aku ka maikaʻi ma mua o ka chemotherapy.

Eia nō naʻe, i ka hala ʻana o ka manawa, hoʻomaka kekahi mau hunaola kanesa e hoʻomohala i ke "kūʻē" i kēia mau lāʻau. ʻO ia hoʻi, ʻaʻole hana hou nā lāʻau. Hiki ke hana kēia ma waena o 40% a me 70% o nā maʻi. Ke hoʻāʻo nei nā kānaka ʻepekema e hoʻomaopopo i ke kumu o kēia hana a ke noiʻi nei i nā ala hou e hoʻomaikaʻi ai i kēia mau lāʻau.

E makaʻala hoʻi kākou i nā hopena ʻaoʻao.

E like me nā lāʻau lapaʻau maʻi kanesa, hiki i nā mea hoʻopaʻa PARP ke hana i kekahi mau hopena ʻaoʻao. Akā, ʻaʻole loaʻa i nā kānaka a pau. A hiki ke kāohi ʻia ka nui o kēia mau mea.

I ka liʻiliʻi loa, hiki i kekahi mau mea hoʻopaʻa PARP ke hoʻonui i ka pilikia o ka hoʻomohala ʻana i kahi ʻano maʻi koko i kapa ʻia ʻo acute myeloid leukemia . Eia nō naʻe, he ʻano laha ʻole kēia.

I ka manawa hea e hoʻomaopopo koke ai i kāu kauka

Inā ʻoe e lawe ana i kahi mea hoʻopaʻa PARP, he mea nui e haʻi i kāu kauka inā loaʻa iā ʻoe kekahi mau hopena ʻaoʻao hou a i ʻole e ʻoi aku ka ʻino . Hiki iā ia ke hoʻololi i ka nui o ka lāʻau a kuhikuhi paha i nā lāʻau lapaʻau ʻē aʻe e kōkua i nā mea e like me ka nausea.

ʻOi loa aku inā ʻike ʻoe i nā hōʻailona penei:E haʻi koke aku i kāu kauka a i ʻole ka haukapila e mālama nei:

• Nā hōʻailona o ka maʻi: kuni, anuanu, a me ka haʻalulu.
• Nā hōʻailona o ka maʻi pneumonia: Paʻakikī ka hanu ʻana, ka hanu ʻana, ka paʻa ʻana o ka umauma, a pēlā aku (He ʻano mumū kēia o nā māmā).
• Nā hōʻailona o ke koko ʻūlū: pehu wāwae, ʻeha, ʻulaʻula a ʻeha paha o ka umauma, paʻakikī ke hanu.