Ua hewa pū kekahi kāu mau cell plasma? He mea weliweli anei kēia leukemia cell plasma?

Ua lohe paha ʻoe i kahi maʻi i kapa ʻia ʻo 'Plasma Cell Leukemia'? He mea weliweli paha ke kani ʻana o ka inoa. Akā, he maʻi ʻaʻai koʻikoʻi a laha ʻole ia e hoʻopilikia ana i kahi ʻano cell i loko o ko mākou kino i kapa ʻia ʻo nā cell plasma. Mai hopohopo, e wehewehe mākou i nā mea āpau ma ke ʻano maʻalahi e hiki ai iā ʻoe ke hoʻomaopopo.

He aha ka maʻi leukemia cell plasma?

ʻAe, e nānā mua kākou i ke ʻano o ka Plasma Cell Leukemia. I ka ʻōlelo maʻalahi, he ʻano ʻoi aku ka ikaika a me ka wikiwiki o ka laha ʻana o kekahi ʻano maʻi ʻē aʻe i kapa ʻia ʻo Multiple Myeloma.

Loaʻa iā kākou āpau kahi ʻano kelepona kūikawā i kapa ʻia he mau kelepona plasma i loko o ko kākou kino. ʻO kēia nā kelepona e hana i nā antibodies, ʻo ia nā mea nui e kōkua i ko kākou kino e pale aku i nā maʻi, e like me ka maʻi. Ua like kēia mau kelepona plasma me nā kiaʻi palekana o ke kino ponoʻī o ko kākou kino.

Akā, i kekahi manawa, hoʻomaka kēia mau cell plasma e hana ma ke ʻano ʻē, e like me nā cell kanesa . ʻO ia ka manawa e hoʻomaka ai nā pilikia. ʻO ka maʻamau, i ka hihia o 'Multiple Myeloma', ua waiho nui ʻia kēia mau cell plasma maikaʻi ʻole i loko o ko kākou iwi iwi . ʻO ka iwi iwi ka ʻāpana palupalu a huʻahuʻa i loko o ko kākou mau iwi.

Eia nō naʻe, i loko o ka Plasma Cell Leukemia, he mea ʻokoʻa iki ka mea e hana ʻia. Maanei, puka mai kēlā mau cell plasma maʻamau ʻole, kanesa mai loko mai o ka iwi iwi, komo i loko o ko kākou koko, ʻo ia hoʻi, ke kahe koko, a hoʻomaka e hele a puni ke kino. E noʻonoʻo, ʻo ka mea e hana ʻia ma ʻaneʻi ua like ia me kekahi mau lawehala weliweli e pakele ana mai ka hale paʻahao a hoʻopilikia i ke kūlanakauhale.

ʻO kēia ka ʻokoʻa nui ma waena o 'Multiple Myeloma' a me 'Plasma Cell Leukemia'. ʻO ia ke kumu i manaʻo ʻia ai ka Plasma Cell Leukemia (PCL) he maʻi ʻoi aku ka ikaika a me ka wikiwiki o ka laha ʻana.

ʻO wai ka mea i loaʻa pinepine i kēia maʻi?

I kēia manawa, ke noʻonoʻo nei paha ʻoe i ka mea e loaʻa ai kēia maʻi i kapa ʻia ʻo Plasma Cell Leukemia. E like me ka mea i ʻike nui ʻia, ʻoi aku ka maʻamau o kēia maʻi i waena o nā kāne ma waena o 55 a me 65 mau makahiki. Eia kekahi, ua ʻike kekahi mau noiʻi he kiʻekiʻe aʻe ka nui o kēia maʻi i waena o ka poʻe ʻeleʻele .

Akā ʻo ka mea nui loa, ma ke ʻano holoʻokoʻa, he maʻi laha ʻole kēia. ʻO ka ʻoiaʻiʻo, ʻo ka leukemia cell plasma (PCL) ke ʻano laha ʻole o ka hui kanesa i kapa ʻia ʻo multiple myeloma. Ua hōʻike ʻia he hapa liʻiliʻi loa ia, ma kahi o 2% a 3% o nā kanesa cell plasma āpau. No laila, ʻaʻole ia he maʻi i loaʻa i nā poʻe he nui.

Aia nā lāʻau lapaʻau no kēia. Hiki i kēia mau lāʻau lapaʻau ke kōkua i ka kaohi ʻana i ka ulu ʻana o ke kanesa, hoʻēmi i nā hōʻailona a hoʻomaʻalahi i ke ola, a hoʻolōʻihi i ka manawa hiki iā ʻoe ke ola i kekahi ʻano. Eia nō naʻe, i ka hapa nui o nā hihia, he paʻakikī ke ho'ōla loa i kēia maʻi. Akā, ʻaʻole maikaʻi ke haʻalele i ka manaʻolana. Ma muli o nā lāʻau lapaʻau hou, ua hiki i nā kauka ke hoʻolōʻihi i ke ola o nā maʻi me ka Plasma Cell Leukemia. Eia nō naʻe, nui aku nā mea e ʻike ʻia ma kēia kahua ma o ka noiʻi hou aku.

Aia kekahi mau ʻano o ka maʻi leukemia cell plasma (PCL)?

ʻAe, aia ʻelua ʻano nui o ka leukemia cell plasma (PCL). E aʻo kākou e pili ana iā lāua ʻelua.

• PCL Mua: ʻO kēia ka wā e loaʻa ai i ke kanaka ka leukemia cell plasma (PCL) me ka ʻole o ka loaʻa ʻana o ka myeloma multiple ma mua. ʻO ke ʻano kēia, ke kaʻapuni nei nā cell plasma maʻamau ʻole i loko o ke koko i ka manawa o ka hōʻoia ʻana. ʻO kēia ka mea i ʻike ʻia i ka hapa nui o nā maʻi PCL ( ma kahi o 60%) . Ma kahi o hoʻokahi i loko o hoʻokahi miliona o ka heluna kanaka i hoʻopilikia ʻia e kēia kūlana PCL mua.

• PCL Lua: Hana ʻia kēia ke loaʻa i ke kanaka ka myeloma lehulehu, akā i ka hala ʻana o ka manawa, lilo ka maʻi i ʻoi aku ka koʻikoʻi a lilo i leukemia cell plasma (PCL). ʻO ke ʻano kēia e ulu ana ka PCL ma ke ʻano he ʻano myeloma koʻikoʻi. Hōʻike ka noiʻi ma waena o 0.5% a me 4% o nā maʻi myeloma lehulehu e ulu i ka PCL lua. Ma kahi o 40% o nā maʻi PCL e hāʻule i loko o kēia māhele.

He aha nā hōʻailona o ka maʻi leukemia cell plasma (PCL)?

Hiki ke ʻokoʻa nā hōʻailona o ka leukemia cell plasma (PCL) mai kēlā kanaka a kēia kanaka. Eia nō naʻe, aia kekahi mau hōʻailona maʻamau a mākou e nānā ai:

• Luhi: Manaʻo mau i ka luhi, me he mea lā ʻaʻole hiki iā ʻoe ke hana i kekahi mea.
• Anemia: I ka ʻōlelo maʻalahi, he nele kēia i ke koko. Lilo ke kino i ke keʻokeʻo, luhi ʻoe, a luhi ʻoe ʻoiai ke piʻi ʻana i nā alapiʻi. ʻO kēia no ka mea ua kāohi ʻia ka hoʻokumu ʻia ʻana o nā hunaola koko ʻulaʻula olakino e kēlā mau hunaola plasma maikaʻi ʻole.
• Hoʻonui ʻia ke kahe ʻana o ke koko: ʻOiai he ʻeha liʻiliʻi e lōʻihi ka manawa e hoʻōki ai i ke kahe ʻana o ke koko, hiki ke hoʻoulu i nā ʻāʻī koko a i ʻole ka palapū ma ka ʻili.
• ʻEha iwi: Hiki ke loaʻa ka ʻeha iwi, ʻoiai ma nā wahi e like me ka iwi kuamoʻo, nā iwi ʻaoʻao, a me nā pūhaka.
• Haʻihaʻi iwi: I kekahi manawa, lilo nā iwi i nāwaliwali loa a hiki i ka iwi ke haki me ka hāʻule wale ʻana, ʻoiai me ka ʻole o kahi ʻeha nui.
• Hoʻonui ʻia ka nui o ka calcium i loko o ke koko (Hypercalcemia):He ʻano koʻikoʻi kēia. Ke piʻi aʻe ka nui o ka calcium i loko o ke koko, hiki ke ʻike ʻia nā hōʻailona e like me ka nausea, ka luaʻi ʻana, ka waha maloʻo, ka huikau, a me ka makewai nui.
• Nā maʻi pinepine: I ka emi ʻana o ka pale ʻana o ke kino, loaʻa pinepine nā maʻi e like me ke anu a me ka maʻi palū, a i ka wā e loaʻa ai, lōʻihi ka manawa e hoʻōla ai.
• Ka pōʻino o nā puʻupaʻa: Hiki i nā protein i hana ʻia e kēlā mau cell plasma maʻamau ʻole ke hōʻino i nā puʻupaʻa.

Inā loaʻa iā ʻoe kekahi a ʻoi aku paha o kēia mau hōʻailona, ​​mai hopohopo, no ka mea, hiki iā lākou ke lilo i mau hōʻailona o nā maʻi ʻē aʻe. Eia nō naʻe, inā hoʻomau kēia mau hōʻailona, ​​​​he manaʻo maikaʻi mau ke ʻike i ke kauka no ka ʻōlelo aʻo.

He aha ke kumu o ka maʻi leukemia cell plasma (PCL)?

ʻO ka ʻoiaʻiʻo, ʻaʻole i ʻike ʻia e nā kānaka noiʻi ke kumu pololei o ka leukemia cell plasma (PCL). Akā ʻo ka mea i ʻike ʻia, ua hoʻokumu ʻia ia e nā loli genetic i loaʻa i loko o nā genes o nā cell plasma i ko lākou ulu ʻana. I ka ʻōlelo maʻalahi, aia nā hewa i loko o ka DNA o nā cell plasma.

Eia nō naʻe, he mea pohihihi nō ke kumu o kēia mau loli hoʻoilina . He mea paʻakikī ke ʻōlelo pololei i nā mea pili i ke kaiapuni, nā mana o ke ʻano o ka nohona, a i ʻole nā ​​kumu ʻē aʻe e kōkua ai i ia mea. ʻOiai he maʻi laha ʻole kēia, he mea paʻakikī iki nō hoʻi ka noiʻi ʻana iā ia.

Pehea e ʻike ʻia ai ka maʻi leukemia cell plasma (PCL)?

I mea e ʻike pono ai inā loaʻa i kekahi ka maʻi leukemia cell plasma (PCL), pono ke kauka e hana i kekahi mau hoʻokolohua.

1. Hoʻāʻo koko: ʻO kēia ke kaʻina hana maʻalahi loa. Lawe ʻia kahi hāpana o kou koko a ana ʻia ka helu o nā cell plasma ʻē i loko. I ka PCL, ʻoi aku ma mua o 5% o kāu mau cell koko keʻokeʻo āpau i hana ʻia me kēia mau cell plasma ʻē.

2. Biopsy iwi: Pili kēia i ka lawe ʻana i kahi hāpana liʻiliʻi o kou iwi a nānā iā ia no nā cell plasma ʻē. Hana pinepine ʻia kēia mai ka iwi ʻūhā. ʻOiai hiki ke ʻeha iki, he mea nui loa ia no ka ʻike ʻana.

3. Nā hoʻāʻo kiʻi: Hana ʻia nā hoʻāʻo e like me ka CT scan (Computed Tomography scan) a i ʻole MRI (Magnetic Resonance Imaging) e ʻike ai inā ua hōʻino ka maʻi i nā iwi.

Ma hope wale nō o ka hana ʻana i kēia mau hoʻokolohua a pau hiki i ke kauka ke haʻi pololei iā ʻoe inā he PCL kou a ʻaʻole paha, a inā pēlā, he aha ke ʻano.

Pehea e mālama ʻia ai ka maʻi leukemia cell plasma (PCL)?

Hoʻōla ʻia ka maʻi leukemia cell plasma (PCL) ma ke ʻano pākahi. ʻO ke ʻano kēia, ʻaʻole i hāʻawi ʻia nā kānaka a pau i ka lāʻau like. E nānā pono ke kime lapaʻau i kou kūlana a e paipai i ke ʻano lapaʻau a i ʻole ka hui pū ʻana o nā lāʻau lapaʻau i kūpono loa iā ʻoe.

Hoʻohana pinepine ʻia nā lāʻau lapaʻau like no PCL e like me ka myeloma maha. Eia kekahi o lākou:

• ʻO Chemotherapy: ʻO kēia ka hāʻawi ʻana i nā lāʻau ikaika e pepehi i nā hunaola kanesa. ʻO nā laʻana e komo pū me `Doxorubicin (Adriamycin®), `Cisplatin` a me `Cyclophosphamide (Cytoxan®).`
• Immunotherapy: Pili kēia i ka hoʻoulu ʻana i kāu ʻōnaehana pale ponoʻī e hakakā i nā hunaola kanesa. Hoʻokomo pū kēia me nā lāʻau lapaʻau hou e like me nā monoclonal antibodies (e.g., Daratumumab (Darzalex®)), nā bispecific antibodies (e.g., Teclistamab (Tecvayli®)), a me ka chimeric antigen receptor (CAR) T-cell therapy.
• Lapaʻau i kuhikuhi ʻia: Hana kēia mau lāʻau lapaʻau ma ke kuhikuhi ʻana i nā molekala kikoʻī e kōkua i nā ʻōpū kanesa e ulu a ola, e hoʻōki ana iā lākou mai ka hana ʻana. ʻO kēia mau mea me nā mea hoʻopaʻa proteasome (e.g., Bortezomib (Velcade®), Carfilzomib (Kyprolis®), Ixazomib (Ninlaro®)) a me nā immunomodulators (e.g., Lenalidomide (Revlimid®), Pomalidomide (Pomalyst®).
• Hoʻoili Kelepona Kumu Autologous: Pili kēia i ka hoʻoili ʻana i nā kelepona kumu olakino i lawe ʻia mai ka mea maʻi iā lākou iho ma hope o ka chemotherapy. Eia naʻe, ʻaʻole kūpono nā kānaka a pau no kēia lāʻau. Na ke kauka e hoʻoholo.

Ma waho aʻe o kēia mau lāʻau lapaʻau, hiki i kāu kauka ke ʻōlelo aku i nā lawelawe mālama palliative e kōkua i ka hoʻokele ʻana i kāu mau hōʻailona, ​​​​e hōʻemi i ka ʻeha, a hāʻawi iā ʻoe i ka hōʻoluʻolu noʻonoʻo a me ke kino i kēia huakaʻi paʻakikī.

He mea nui: ʻO ka heluhelu ʻana e pili ana i kēia mau lāʻau lapaʻau a me nā lāʻau lapaʻau e hoʻolilo iā ʻoe i mea huikau iki. Eia nō naʻe, na kāu hui lapaʻau kēia mau mea a pau e hoʻoholo. E wehewehe lākou i nā mea āpau iā ʻoe. Mai makaʻu e nīnau iā lākou i kāu mau nīnau.

He aha ke kūlana o ke ola no ka poʻe me ka maʻi leukemia cell plasma (PCL)?

He kumuhana paʻakikī loa kēia e kamaʻilio e pili ana. ʻO ka maʻi leukemia cell plasma (PCL) he maʻi ʻino loa ia e laha wikiwiki ana, a he maʻi make pinepine ia . ʻOi aku ma mua o 10% o ka poʻe me kēia maʻi kanesa e ola ana ma mua o ʻelima mau makahiki ma hope o ka hōʻoia ʻana. Ma keʻano laulā, ʻoi aku ka lōʻihi o ke ola o ka poʻe me ka PCL mua ma mua o ka poʻe me ka PCL lua.

ʻO ke kūlana o ke ola e pili ana i nā mea he nui, me ke koʻikoʻi o ka maʻi, ke ʻano o ka lāʻau āu e loaʻa ai, a pehea e pane ai kou kino i kēlā mau lāʻau.

ʻO ka poʻe i kūpono no ka hoʻoili ʻana i nā cell stem ua ʻōlelo ʻia e ola ana ma ka awelika o ʻekolu a ʻehā mau makahiki . Eia nō naʻe, hiki i kekahi poʻe ke ola lōʻihi aʻe. Ua hōʻike kekahi noiʻi ua noho kahi maʻi PCL i ka hoʻomaha no ʻeiwa mau makahiki ma mua o ka hoʻi hou ʻana o ka maʻi.

I kēia lā, ua hoʻolōʻihi iki ʻia ke ola o kēia mau maʻi i hoʻohālikelike ʻia me kekahi mau makahiki i hala. ʻOiai he hoʻomaikaʻi iki ia, he mea nui nō naʻe ia. Ke hana nei nā kānaka noiʻi i kēia me ka hoihoi nui.

Hiki ke pale ʻia ka maʻi leukemia cell plasma (PCL)?

ʻO ka mea pōʻino, ʻaʻohe ala e pale aku ai i ka maʻi leukemia cell plasma (PCL). No ka mea, ʻaʻole hiki iā mākou ke kāohi i nā loli genetic e hoʻokumu ai, he mea kakaikahi loa hoʻi ia, e paʻakikī ai ke aʻo ʻana a me ka loaʻa ʻana o nā ala e pale aku ai. Eia nō naʻe, ke hoʻomau nei nā mea noiʻi i ka loaʻa ʻana o nā ala e ʻike mua ai i ka maʻi.

Pehea wau e mālama ai iaʻu iho?

Ke ʻike ʻia ʻoe me kahi maʻi e like me ka plasma cell leukemia (PCL), he mea maʻamau ke kānalua no ka wā e hiki mai ana, a me ka ʻike ʻana i nā ʻano manaʻo like ʻole, me ka makaʻu, ka huhū, ke kaumaha, ka hoʻonāukiuki, a me ka hewa. ʻAʻohe hewa o ka manaʻo ʻana i kēia mau manaʻo. ʻO ka mea nui loa, ʻo ia ke kamaʻilio e pili ana i kou mau manaʻo me kekahi. E kamaʻilio me kekahi āu e hilinaʻi ai, he lālā o ka ʻohana, he hoaaloha, a i ʻole kāu kauka e pili ana i nā lawelawe kākoʻo. Hiki iā lākou ke kōkua iā ʻoe e mālama i kou ola ma hope o kāu hōʻailona a i ka wā o ka mālama ʻana.

Āhea wau e ʻike ai i ke kauka?

E noho pili loa ʻoe me kāu hui lapaʻau i loko o kāu mālama ʻana. Eia nō naʻe, inā loaʻa iā ʻoe nā hōʻailona hou a inā paha e ʻoi aku ka ʻino o kāu mau hōʻailona, ​​​​pono ʻoe e hoʻomaopopo koke i kāu kauka.

He aha nā nīnau e pono iaʻu e nīnau aku i kaʻu kauka?

Inā loaʻa iā ʻoe ka leukemia cell plasma (PCL), nui paha kāu mau nīnau. Eia kekahi mau nīnau koʻikoʻi e nīnau aku ai i kāu kauka:

• Pehea ka lōʻihi o ka laha ʻana o ke kanesa? (Pehea ka holomua o ke kanesa?)
• He aha kaʻu mau koho lapaʻau?
• Ua kūpono anei au no kahi hoʻoili pūnaewele kumu?
• ʻEhia ka lōʻihi e hiki ai iaʻu ke ola me ka lāʻau lapaʻau?
• He aha nā kumuwaiwai i loaʻa iaʻu?

He hanana hoʻololi ola kekahi maʻi kanesa. Akā ke loaʻa iā ʻoe kahi maʻi koʻikoʻi a laha ʻole e like me ka plasma cell leukemia (PCL), hiki ke mehameha loa a hoʻoluhi nui ʻia. Manaʻo paha ʻoe ʻaʻohe mea e maopopo i kāu mea e hele nei. Inā hiki, e hui pū me kahi hui kākoʻo.A laila hiki iā ʻoe ke hālāwai a kamaʻilio me nā poʻe ʻē aʻe e hele nei i nā ʻike like me ʻoe. E hilinaʻi i kāu poʻe aloha, kāu hui lapaʻau. Aia lākou a pau ma laila e kōkua iā ʻoe, e kākoʻo iā ʻoe i ka mālama ʻana i kou ola ma hope o ka hōʻoia ʻana a i ka wā o ka mālama ʻana. ʻAʻole pono ʻoe e hele wale ma kēia huakaʻi.

Leka Lawe-Home

ʻO ka Plasma Cell Leukemia (PCL) kahi ʻano koʻikoʻi a kakaʻikahi o ka myeloma multiple. I kēia ʻano maʻi kanesa, kaʻapuni nā cell plasma maʻamau ʻole i loko o ke koko. Hiki ke ʻokoʻa nā hōʻailona, ​​​​me ka luhi, ka anemia, a me ka ʻeha o ka iwi. ʻOiai ua manaʻo ʻia nā loli genetic ke kumu, ʻaʻole ʻike ʻia ke kumu pololei.

Hana ʻia ka ʻike ma o nā hoʻāʻo koko, ka biopsy iwi iwi, a me nā hoʻāʻo kiʻi. ʻO nā koho lapaʻau e komo pū me ka chemotherapy, immunotherapy, therapy i hoʻolālā ʻia, a me ka hoʻoili ʻana i nā cell stem.

ʻOiai he maʻi koʻikoʻi kēia, ua piʻi iki ka manaʻolana o ke ola me nā lāʻau lapaʻau hou. ʻO ka mea nui loa, ʻo ia ke ʻimi koke i ke aʻo lapaʻau inā loaʻa iā ʻoe nā hōʻailona, ​​​​e loaʻa ka lāʻau lapaʻau kūpono, a e noho ikaika i ka noʻonoʻo. ʻO kāu hui lapaʻau a me nā mea aloha he kumu ikaika nui ia nou ma kēia huakaʻi.

ʻO ka maʻi kanesa o ke kelepona plasma, ka maʻi ʻaʻai, ka myeloma lehulehu, ke kanesa koko, ka iwi iwi, nā hōʻailona o ke kanesa, ka mālama ʻana i ke kanesa