ʻO ke kolesterol kiʻekiʻe? E kamaʻilio kākou e pili ana i kēia mau statins?

He nui o kākou e pilikia nei me ke kolamu kiʻekiʻe. He mea maʻamau ke manaʻo iki i ka makaʻu a me ka hopohopo ke loaʻa iā ʻoe nā hopena o kāu hoʻāʻo koko a ʻike ʻoe ua ʻoi aku kou pae LDL ma mua o ʻekolu mau helu. No laila, ua haʻi aku kāu kauka iā ʻoe e hoʻomaka e lawe i kahi lāʻau i kapa ʻia ʻo statins e kāohi i kāu kolamu? Ke lawe nei paha ʻoe i kēia lāʻau. No laila, he nui paha kāu mau nīnau e pili ana i kēia lāʻau, kona pono, a me kona mau pono a me nā pōʻino. E wehewehe kākou i kāu mau nīnau a pau e pili ana i kēia lā.

I ka ʻōlelo maʻalahi, he aha kēia mau statins?

ʻO nā Statins kahi papa o nā lāʻau lapaʻau hiki ke lawe wale ʻia me ke kauoha a ke kauka. ʻO kā lākou hana nui ka hoʻomaʻamaʻa ʻana i kāu mau pae cholesterol. Ma ke ʻano kūikawā, hiki i kekahi mau statins ke hoʻemi i kāu LDL (Low-Density Lipoprotein) cholesterol, i ʻike ʻia hoʻi ʻo ka "bad" cholesterol, ma 50% a ʻoi aku paha.

Ua kapa nā kauka i ka LDL cholesterol "maikaʻi ʻole" no kekahi kumu. E noʻonoʻo i nā aʻa e lawe ana i ke koko ma loko o kou kino e like me nā paipu wai. ʻO ka hana a kēia LDL cholesterol, ʻo ia ke kau ʻana ma luna o nā paia o kēlā mau paipu wai e like me ka limu. I ka hala ʻana o ka manawa, hōʻiliʻili kēia mau waihona (kapa mākou iā lākou he plaque) a hōʻemi i ka hakahaka i loko o kou mau kīʻaha koko. Hoʻoikaika kēia i ka puʻuwai e hana e pamu i ke koko, a ke ālai nei hoʻi i ke kahe ʻana o ke koko.

ʻAʻole wale nā ​​Statins e hoʻohaʻahaʻa i ka LDL. Hoʻohaʻahaʻa pū lākou i kekahi ʻano momona i loko o kou koko i kapa ʻia ʻo triglycerides. Kōkua pū lākou i kou akepaʻa e hoʻopau i ka cholesterol makemake ʻole ʻia. I kekahi manawa hiki i kēia mau lāʻau ke hoʻonui i kou pae o HDL (High-Density Lipoprotein), i ʻike ʻia ʻo ka cholesterol "maikaʻi" . He "maikaʻi" ka HDL no ka mea hōʻiliʻili ia i ka cholesterol makemake ʻole ʻia mai ke kino holoʻokoʻa a hāʻawi iā ia i ke akepaʻa. A laila lawe ke akepaʻa mai ke kino.

Loaʻa kēia mau lāʻau lapaʻau ma ke ʻano o nā papa a i ʻole nā ​​capsules. Lawe ʻia lākou i hoʻokahi manawa i ka lā. Hiki ke lawe ʻia me ka ʻai a me ka ʻole o ka meaʻai. ʻO ka mea nui loa, ʻo ia ka lawe ʻana iā lākou i ka manawa like i kēlā me kēia lā. E haʻi aku ka lepili ma kāu ʻōmole lāʻau lapaʻau iā ʻoe i ka manawa o ka lā e lawe ai iā lākou. ʻO ka maʻamau, lawe ʻia nā statins hana pōkole i ka pō no ka mea hana ko mākou kino i ka cholesterol hou aʻe i ka pō i ka wā e hiamoe ana mākou. Eia naʻe, ʻaʻole like ka maikaʻi o nā statins hana lōʻihi i kēlā me kēia manawa o ka lā.

ʻAe, e nānā kākou pehea e hana ai kēia lāʻau lapaʻau i loko o ke kino.

He mea maʻalahi loa kēia e hoʻomaopopo. E noʻonoʻo ʻoe ʻo kou akepaʻa ka hale hana nui e hana ai i ka cholesterol. 75% o ka cholesterol e pono ai ko kākou kino e hana ʻia e kēia akepaʻa. ʻO ke koena mai ka meaʻai a kākou e ʻai ai.

No laila, i mea e hana ai kēia hale hana hana cholesterol, pono ia i kahi limahana koʻikoʻi. He enzyme kēlā i kapa ʻia ʻo HMG-CoA reductase. Ua like ia me ka pono o kahi mīkini akamai e kūkulu i kahi kaʻa.

Hana nā Statins i kahi hana maalea loa. Ua like ia me ke kiaʻi palekana ma ka puka o kahi hale hana. Hoʻōki nā Statins i ka enzyme HMG-CoA reductase mai ke komo ʻana i ka hale hana. ʻO ia hoʻi, ke ālai nei lākou iā ia. He aha ka mea e hana ʻia? No ka mea ua nalowale ka "mea hana" nui e hana ana i ka cholesterol, ua emi nui ka hana cholesterol o ke akepaʻa. Penei ke kaohi ʻana o nā statins i nā pae cholesterol i loko o kou koko.

No ke aha mākou e pono ai i kēia mau statins?

ʻO ke kumu nui, ʻo ia ka hōʻemi ʻana i ka pilikia o ka hōʻeha puʻuwai a me ka hahau.

He mea nui ka cholesterol no ko kākou kino e hana i ka wikamina D, nā hormones, a me nā waikawa e kōkua ai i ka hoʻoheheʻe ʻana i ka meaʻai. Akā ʻo ka pilikia, nui ka cholesterol e hōʻiliʻili ana i loko o ke koko.

E like me kaʻu i ʻōlelo ai ma mua, hoʻomaka kēia cholesterol keu e hōʻiliʻili i loko o nā kīʻaha koko. Kāhea mākou i kēia he atherosclerosis. I ka hala ʻana o ka manawa, ʻo kēia mau waihona (plaque) ke kumu o ka wili ʻana o nā kīʻaha koko. A laila, emi ka wahi no ke kahe ʻana o ke koko. Ua like ia me ka paʻa kaʻa ma ke alanui paʻahana.

Hiki ke ʻoi aku ka ʻino o ke kūlana. I kekahi manawa, hiki i nā waihona cholesterol i hōʻiliʻili ʻia i loko o kēlā mau kīʻaha koko ke lilo i mea paʻa ʻole a pohā koke. Inā kū kahi ʻūlū koko ma laila, hiki iā ia ke ālai loa i ke kīʻaha koko. Inā kū kēia ālai ʻana i loko o kahi aʻa e hoʻolako ana i ke koko i ka puʻuwai, hiki iā ia ke hōʻeha i ka puʻuwai . Inā kū ia i loko o kahi aʻa e hoʻolako ana i ke koko i ka lolo, hiki iā ia ke hahau . Hoʻohaʻahaʻa nā Statins i ka cholesterol a pale iā mākou mai kēia mau maʻi koʻikoʻi.

He aha nā ʻano statins i loaʻa ma ka mākeke?

Aia kekahi mau ʻano statins. E loiloi kāu kauka i kou kūlana a hoʻoholo i ke ʻano a me ka nui o ka lāʻau i kūpono loa iā ʻoe.

I kekahi mau hihia, hāʻawi ʻia kahi lāʻau statin i loko o kahi pila i hui pū ʻia me kekahi lāʻau ʻē aʻe.

• ʻO Simvastatin me ka ezetimibe a i ʻole niacin
• ʻO Atorvastatin me ezetimibe a i ʻole amlodipine
• ʻO Lovastatin me ka niacin

ʻO wai ka mea e pono e lawe i nā statins?

He nīnau koʻikoʻi loa kēia. ʻAʻole he lāʻau lapaʻau hoʻokahi nā Statins no nā mea āpau. E kuhikuhi ke kauka i kēia lāʻau lapaʻau ma muli o kou pilikia holoʻokoʻa o ka loaʻa ʻana o nā maʻi puʻuwai a me nā kīʻaha koko.

ʻO ka maʻamau, ua ʻōlelo ʻia nā statins no:

• No ka poʻe hiki ʻole ke kāohi i ko lākou pae cholesterol ma o ka ʻai a me ka hoʻoikaika kino .
• No kekahi poʻe, ma muli o nā kumu hoʻoilina (genes), ʻo ia hoʻi, hoʻoilina, hana ke kino i ka cholesterol ma mua o ka mea e pono ai. No kēlā poʻe.
• No ka poʻe me nā kumu pilikia no ka maʻi puʻuwai, e like me ka maʻi diabetes, ke koko kiʻekiʻe, a me ka hoʻohana ʻana i ka paka.

I ke koho ʻana inā pono ʻoe i nā statins, e noʻonoʻo kāu kauka i nā kumu he nui, me kou makahiki, ke kāne, a me ka mōʻaukala ʻohana. Hiki ke kuhikuhi ʻia nā Statins no nā pākeke a, i kekahi mau hihia, nā keiki ʻōpio.

Eia kekahi mau kūlana e ʻōlelo pinepine ai nā kauka i nā statins:

• No ka poʻe i kiʻekiʻe loa ko lākou pae cholesterol maikaʻi ʻole (LDL), ma luna o 190 mg/dL, a ʻaʻole hiki ke kāohi ʻia e nā loli o ke ʻano o ka nohona.
• ʻO nā kānaka ma waena o 40-75 mau makahiki me ka maʻi diabetes a me nā pae LDL ma mua o 70 mg/dL.
• No ka poʻe i loaʻa i ka hōʻeha puʻuwai ma mua, ka hahau ʻana, a i ʻole ka maʻi peripheral artery (PAD).
• No nā poʻe i piha i nā makahiki 40-75, me nā pae LDL ma mua o 70 mg/dL a me kahi pilikia kiʻekiʻe o ka loaʻa ʻana o nā maʻi puʻuwai.

Loaʻa iā ʻoe nā hopena ʻaoʻao o nā statins?

E like me nā lāʻau lapaʻau āpau, hiki i nā statins ke hana i nā hopena ʻaoʻao. Akā ʻo ka mea nui, ʻaʻole i loaʻa i ka hapa nui o ka poʻe kekahi mau hopena ʻaoʻao. ʻOiai inā loaʻa iā lākou, he mea liʻiliʻi ka hapa nui o lākou.

Eia nō naʻe, he mea nui loa ia e ʻike ʻoe i kēia. Inā loaʻa iā ʻoe kekahi mau hopena ʻaoʻao, pono ʻoe e hoʻomaopopo i kāu kauka. A laila hiki iā ia ke hoʻololi i kāu dosage a hoʻololi paha iā ʻoe i kahi statin ʻē aʻe.

Nā nīnau i nīnau pinepine ʻia e pili ana i nā statins

He aha ka mea e hana ai inā e ho'ōki koke ʻoe i ka lawe ʻana i nā statins?

He mea weliweli loa kēia. Inā ʻoe e hoʻōki i ka lawe ʻana i nā statins me ka ʻole o ke aʻo ʻana a kāu kauka, e hoʻomaka hou ana kāu mau pae cholesterol e piʻi. ʻO ia hoʻi, e piʻi hou ana kou pilikia o ka hōʻeha puʻuwai a me ka hahau. Ua like kēia me ka lawe ʻana i kahi umbrella mai ka makau i ka ua. E nalowale ana ka pale i hāʻawi ʻia e ka lāʻau lapaʻau. No laila , mai hoʻōki i ka lawe ʻana i ka lāʻau lapaʻau no kekahi kumu me ka ʻole o ke noi ʻana i kāu kauka.

Ke hoʻonui nei nā statins i ke kaumaha?

Ua ʻike ʻia kekahi mau noiʻi hiki i nā statins ke hoʻonui iki i ke kaumaha. ʻO kekahi mea ʻē aʻe, ke hoʻomaka kekahi poʻe e lawe i ka lāʻau lapaʻau, no ka mea, ua maikaʻi ko lākou pae cholesterol, manaʻo lākou, "Ua maikaʻi wau i kēia manawa," a hoʻopoina i ka kaohi ʻana i kā lākou ʻai a me ka hoʻoikaika kino. ʻOiai i kēlā manawa, hiki iā lākou ke piʻi i ke kaumaha. E hoʻomanaʻo, ʻoiai inā ʻoe e lawe i nā statins, he mea nui ia e mālama i kahi nohona olakino.

Āhea wau e ʻike ai i ke kauka i ka wā e lawe ana i kēia lāʻau lapaʻau?

Inā ʻike ʻoe i kekahi o kēia mau hōʻailona i ka wā e lawe ana i nā statins, e haʻi koke i kāu kauka:

• ʻEha ʻiʻo a hui paha i hiki ʻole ke hoʻomanawanui
• Nāwaliwali
• kuni
• Melemele o nā maka a i ʻole ka ʻili (Jaundice)
• Mimi ʻeleʻele

Aia kekahi poʻe ʻaʻole pono e lawe i nā statins?

ʻAe. ʻAʻole kūpono nā Statins no kekahi poʻe.

• No nā wahine hāpai
• No nā makuahine hānai
• No nā kānaka me kekahi mau maʻi akepaʻa koʻikoʻi

Inā loaʻa iā ʻoe ka maʻi diabetes, e haʻi i kāu kauka. No kekahi mea i pilikia mua i ka loaʻa ʻana o ka maʻi diabetes, hiki i nā statins ke hoʻonui iki i kēlā pilikia. Eia nō naʻe, no ka mea, ʻoi aku ka nui o ka pilikia o ka poʻe me ka maʻi diabetes i ka loaʻa ʻana o ka maʻi puʻuwai, ʻoi aku ka maikaʻi o nā pono o nā statins ma mua o ka pilikia liʻiliʻi. ʻO kāu kauka ke kanaka maikaʻi loa e hana i kēia hoʻoholo.