Ke lawe nei ʻoe i ka lāʻau lapaʻau e hoʻohaʻahaʻa i kāu cholesterol? Inā pēlā, ke lawe nei paha ʻoe i kahi papa o nā lāʻau lapaʻau i kapa ʻia ʻo 'statins'. Ma hope o ka hoʻomaka ʻana i kēia lāʻau lapaʻau, ke manaʻo nei ʻoe i kekahi manawa ua poniuniu, poina i nā mea, a i ʻole he mea a mākou e kapa nei he 'noe lolo'? He pilikia kēia i loaʻa i nā poʻe he nui. No laila, i kēia lā, e ʻike pono kākou i ke ʻano o ia mea.
ʻO ka mea mua, e nānā kākou, he aha kēia statin?
I ka ʻōlelo maʻalahi, he mea ʻaila a palupalu ka cholesterol i loko o ko kākou koko. Pono ko kākou kino i kēia cholesterol e kūkulu i nā cell a hana i nā hormones, akā ʻo ka nui loa ʻaʻole ia he mea maikaʻi. ʻOiai ke kiʻekiʻe ka cholesterol "maikaʻi ʻole", a i ʻole LDL (Low-Density Lipoprotein) cholesterol , hiki iā ia ke kūkulu ma nā paia o ko kākou mau kīʻaha koko a paʻa iā lākou. He kumu nui kēia o nā maʻi weliweli e like me nā hōʻeha puʻuwai a me nā hahau.
Hana nā lāʻau statin ma ka hoʻēmi ʻana i ka nui o ka cholesterol LDL maikaʻi ʻole i hana ʻia e ke ake. No laila, ʻaʻole hewa ke kapa ʻana i kēia mau lāʻau he mau lāʻau pono a hoʻōla ola no ka poʻe i pilikia i ka maʻi puʻuwai.
No laila, he ʻoiaʻiʻo anei kēia moʻolelo 'noe lolo'?
ʻOiai ua manaʻo ʻia he palekana loa nā statins no ka hapa nui o nā kānaka, e like me nā lāʻau lapaʻau āpau, hiki iā lākou ke hana i nā hopena ʻaoʻao liʻiliʻi. Eia kekahi laʻana, ʻeha nā ʻiʻo, hōʻino ʻia ke akepaʻa, a me ka 'noe lolo', a i ʻole nā pilikia me ka hoʻomanaʻo a me ka nānā ʻana, kekahi o lākou.
ʻO ka 'Brain Fog' kahi kūlana o ka huikau nui a me ka huikau. E noʻonoʻo, poina iā ʻoe kahi āu i waiho ai i kāu mau kī, malia paha e wehe ʻoe i ka pahu hau a waiho i ke kī i loko a laila e ʻimi hou aku ma hope. ʻO kēia nā ʻano mea e hana ʻia ma kēia kūlana.
Ua hoʻokomo pū ka FDA ma ʻAmelika Hui Pū ʻIa i ka nalowale o ka hoʻomanaʻo a me ka huikau ma ke ʻano he mau hopena ʻaoʻao "ʻaʻole koʻikoʻi a hoʻohuli ʻia" ma nā lepili statin. He mea nui ka cholesterol no ka hana o ko kākou lolo. ʻO ka ʻoiaʻiʻo, aia ka 25% o kā kākou cholesterol holoʻokoʻa i loko o ka lolo. No laila, he mea kūpono ke manaʻo e hiki i ka hoʻohaʻahaʻa ʻana i ka cholesterol me nā statins ke loaʻa kekahi hopena i ka lolo.
Eia nō naʻe, ʻōlelo nā loea ʻaʻohe pono e hopohopo nui e pili ana i kēia. ʻAʻole i hōʻoia ʻia kahi pilina pololei ma waena o kēia lāʻau lapaʻau a me ka nalowale o ka hoʻomanaʻo i ka noiʻi nui.
I ka manawa pinepine, hiki i kēia mau hōʻailona ke hōʻailona o kekahi maʻi olakino ʻē aʻe. ʻOi loa aku i ka wā e loaʻa ai nā pilikia hoʻomanaʻo e like me kēia i ka poʻe waena a ʻelemakule paha, he hōʻailona mua paha ia o ka maʻi Alzheimer.
No laila, ʻo ka mea mua a ke kauka e noʻonoʻo ai, "No ka lāʻau lapaʻau anei kēia? A i ʻole he pilikia ʻē aʻe?" No kēlā, hiki iā lākou ke kuhikuhi iā ʻoe i kahi loea neuropsychiatric no ka hoʻokolokolo ʻana.
Kupaianaha!
Ma ka ʻaoʻao ʻē aʻe, hōʻike kekahi mau noiʻi e hiki i ka hoʻohana ʻana i nā statin ke hōʻemi i ka pilikia o ka dementia, a i ʻole ka emi ʻana o ka naʻauao a me ka hoʻomanaʻo e kū mai ana me ka makahiki. Ua ʻike ʻia kekahi noiʻi i mālama ʻia ma luna o 12 mau makahiki he haʻahaʻa ka pilikia o ka poʻe e lawe ana i nā dosis kiʻekiʻe o nā statins i ka dementia. No laila ke hana ʻia nei nā noiʻi hou aku ma kēia.
He aha kāu e hana ai inā loaʻa iā ʻoe kēia mau hopena ʻaoʻao?
Inā ʻoe e lawe ana i ka statin a loaʻa iā ʻoe ka 'noe lolo', ka ʻeha ʻiʻo, a i ʻole kekahi mau hōʻailona ʻē aʻe, ʻo ka mea nui a me ka mea wale nō āu e hana ai, ʻo ia ke hoʻomaopopo i kāu kauka.
Mai ho'ōki koke i ka lawe ʻana i kāu lāʻau lapaʻau me ka ʻole o ke kamaʻilio ʻana me kāu kauka. E hoʻomanaʻo, pale kēia mau lāʻau lapaʻau iā ʻoe mai nā pilikia koʻikoʻi e like me nā hōʻeha puʻuwai a me nā hahau.
E loiloi kāu kauka i kou kūlana a hoʻololi i kāu hoʻolālā lapaʻau inā pono. Hiki iā ia ke hana i kēia mau mea:
- Ke hoʻōki nei i ka lāʻau statin āu e lawe nei no kekahi manawa.
- Ke hoʻololi nei i kahi ʻano statin ʻē aʻe.
- Ka hoʻemi ʻana i ka nui o ka lāʻau lapaʻau.
He aha nā koho ʻē aʻe i nā statins?
I kekahi mau hihia, inā hoʻomau nā statins i nā hopena ʻaoʻao, hiki i kāu kauka ke kuhikuhi i nā lāʻau lapaʻau ʻē aʻe. Aia kekahi o kēia mau mea ma lalo nei.
| Māhele lāʻau lapaʻau | Hana | Nā laʻana (nā inoa lama) |
|---|---|---|
| Nā mea pale ACL | Hoʻemi ia i ka hana ʻana o ka cholesterol e ke akepaʻa. Hoʻopaʻa pū kekahi mau lāʻau lapaʻau i ka omo ʻana o ka cholesterol mai ka ʻōpū liʻiliʻi. | ʻO Nexletol (waikawa bempedoic), Nexlizet (waikawa bempedoic a me ezetimibe) |
| Nā mea pale PCSK9 | He mau inikini kēia. ʻAʻole lākou e komo i ka lolo. Hoʻopau lākou i ka cholesterol LDL maikaʻi ʻole i loko o ke koko a hoʻolalelale i kona wehe ʻana. | ʻO Alirocumab (Praluent), ʻEvolocumab (Repatha) |
Hiki ke ʻoi aku ke kumukūʻai o kēia mau lāʻau lapaʻau ma mua o nā statins a ʻaʻole paha e kūpono no nā mea āpau, no laila he hoʻoholo kēia na kāu kauka e hana ai.
He aha nā mea ʻē aʻe e pono ai ʻoe e ʻike i ka wā e lawe ai i nā statins?
No ka hōʻemi ʻana i nā hopena ʻaoʻao, e mālama pū i kēia mau mea:
- E makaʻala me ka pomelo: Hiki i kekahi mau kemika i loko o ka wai pomelo ke hoʻopilikia i ka hiki o ke kino ke wāwahi i nā lāʻau statin. ʻAʻole pono ʻoe e hoʻōki loa i ka pomelo, akā e nīnau i kāu kauka i ka nui o kāu e ʻai ai/inu ai.
- E haʻi i kāu kauka e pili ana i nā lāʻau lapaʻau ʻē aʻe āu e lawe ai: Hiki i kekahi mau lāʻau lapaʻau ke launa pū me nā statins a hoʻoulu i nā hopena ʻaoʻao. Nā laʻana:
- Nā lāʻau lapaʻau no nā maʻi o ka puʻuwai (e like me Amiodarone)
- Nā lāʻau lapaʻau cholesterol ʻē aʻe (e.g., Gemfibrozil)
- Nā lāʻau lapaʻau i hoʻohana ʻia e mālama i ka maʻi HIV
- ʻO kekahi mau antibiotics a me nā antifungals (e.g. Clarithromycin, Itraconazole)
- Nā lāʻau hoʻopau i ka pale ʻana (e like me Cyclosporine)
- E akahele i ka hoʻoikaika kino: ʻO ka hopena maʻamau o nā statins ka ʻeha o nā ʻiʻo. Inā hoʻomaka koke ʻoe e hana i ka hoʻoikaika kino ikaika i kou wā e lawe ana iā lākou, hiki iā ʻoe ke hoʻonui i kou pilikia o ka hōʻino ʻia ʻana o nā ʻiʻo. Inā he mea hou ʻoe i ka hoʻoikaika kino, e hoʻonui mālie i ka ikaika.
Leka Lawe-Home
- He lāʻau lapaʻau koʻikoʻi loa nā statins, e hoʻōla ola ana e hōʻemi ana i ka pilikia o ka hōʻeha puʻuwai a me ka hahau.
- He hopena ʻaoʻao kakaikahi loa ka 'noe lolo'. ʻAʻole ia he mea koʻikoʻi a nalowale ke hoʻōki ʻia a hoʻololi ʻia paha ka lāʻau lapaʻau.
- ʻOi aku ka nui o nā pilikia hoʻomanaʻo āu e ʻike nei e kumu ʻia e nā kumu ʻē aʻe (makahiki, nā kūlana olakino ʻē aʻe) ma mua o ka lāʻau statin.
- Inā loaʻa iā ʻoe kekahi mau hopena ʻaoʻao, ʻo ka mea maikaʻi loa e hana ai, ʻo ia ke kamaʻilio me kāu kauka.
- Mai ho'ōki i ka lawe ʻana i nā statins no kekahi kumu me ke aʻo ʻole ʻia e ke kauka. ʻOi aku ka maikaʻi o nā pono ma mua o nā pilikia.
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