He hakakā maoli ka noho ʻana me ke kanesa. ʻOiai hiki i nā lāʻau lapaʻau e like me ka chemotherapy ke kōkua i ka luku ʻana i nā hunaola kanesa, i kekahi manawa hiki i kēlā mau lāʻau lapaʻau ke hana i nā pilikia i manaʻo ʻole ʻia. I kēia lā, e kamaʻilio mākou e pili ana i kahi pilikia e pono ai ka nānā koke ʻana a hiki ke hoʻoweliweli i ke ola . Ua kapa ʻia kēia ʻo Tumor Lysis Syndrome.
He aha ka Tumor Lysis Syndrome? E hoʻomaopopo maʻalahi kākou.
I ka ʻōlelo maʻalahi, ʻo Tumor Lysis Syndrome kahi hui o nā maʻi koʻikoʻi e kū mai ana i ka wā e make ai ka nui o nā hunaola kanesa i ka manawa hoʻokahi a hoʻokuʻu ʻia nā mea o loko o kēlā mau hunaola i loko o ke koko. E noʻonoʻo, hiki ke hana ʻia kēia maʻi i loko o kekahi mau hola o ka hoʻomaka ʻana o ka mālama ʻana i ka maʻi kanesa. Hiki iā ia ke ulu koke a lilo i maʻi e pono ai ka mālama lapaʻau ulia pōpilikia. No laila, ke nānā mau nei nā kauka i kēia.
Akā, aia ka nūhou maikaʻi. Loaʻa i nā kauka nā ala e pale aku ai i ka Tumor Lysis Syndrome mai ka hanana ʻana . Hana lākou i kēia ma ka ʻike ʻana i ka mea i ʻoi aku ka pilikia a me ka lawe ʻana i nā hana e hōʻemi ai i kēlā pilikia.
He aha ka mea e hana ʻia i ko mākou kino i kēia kūlana?
Ke hōʻike ʻia nā hunaola kanesa i ke kaumaha, ʻoiai mai nā lāʻau lapaʻau e like me ka chemotherapy, e haki lākou. A laila, hōʻiliʻili koke nā kemika a me nā mea ʻawahia i loko o kēlā mau hunaola i nā nui he nui i loko o ke koko. Hoʻomaka ka pilikia ke hiki ʻole i ko mākou kino ke wehe koke i kēia mau mea. Hiki i kēia maʻi lysis tumor ke hoʻopilikia nui i ko mākou puʻuwai, nā puʻupaʻa, a me nā ʻiʻo. E nānā kākou i kēia mau hopena:
- Hyperuricemia - ʻO ke ʻano kēia o ka hoʻonui ʻia ʻana o ka nui o ka uric acid: Ke piʻi ka uric acid i loko o ke koko, hiki ke waiho ʻia i loko o nā puʻupaʻa, e hana ana i ka hana pono ʻole o nā puʻupaʻa a me ka hāʻule ʻana o nā puʻupaʻa. E noʻonoʻo iā ia e like me kahi paʻa i loko o ka paipu wai.
- ʻO ka Hyperphosphatemia - ʻo ia hoʻi, hoʻonui ʻia nā pae phosphorus: ʻO ka hoʻonui ʻia o nā pae phosphorus i loko o ke koko e hoʻopilikia pū i ka hana o ka puʻupaʻa.
- Hyperkalemia - ʻO ke ʻano kēia o nā pae potassium kiʻekiʻe: Ke kiʻekiʻe nā pae potassium, hiki iā ʻoe ke ʻike i nā hōʻailona e like me ka nausea, ka luaʻi ʻana, a me ka maʻi diarrhea. ʻAʻole wale ia, akā hiki ke loli kou helu puʻuwai, e hana ana i nā arrhythmias, a malia paha he hōʻeha puʻuwai. He mea weliweli iki kēia, ʻeā?
- ʻUremia: Hana ʻia kēia ke pau nā puʻupaʻa i ka kānana ʻana i nā mea ʻawahia mai ke koko. Hiki i ka ʻUremia ke hana i nā pilikia koʻikoʻi me nā iwi, nā ʻiʻo, ka puʻuwai, a me nā kīʻaha koko.
- Hypocalcemia - Nā pae calcium haʻahaʻa: ʻO nā pae calcium haʻahaʻa i loko o ke koko hiki ke hoʻololi i ka ʻōʻō o ka puʻuwai, nā ʻūpā ʻiʻo, ka huikau, ka mae a me ke kani ʻana o nā lālā. I kekahi manawa, hiki ke make mai ka hopu ʻia ʻana o ka puʻuwai.
ʻO ka mea nui loa: Hana ʻia ka Tumor Lysis Syndrome ke hui pū ʻia kekahi a ʻoi aku paha o kēia mau kūlana.
He pilikia anei ka Tumor Lysis Syndrome?
ʻAe, ʻoiaʻiʻo nō! He pilikia olakino ka Tumor Lysis Syndrome e pono ai ka mālama koke ʻana. No laila, he mea nui loa ka makaʻala i kēia.
ʻO wai ka mea hiki ke lilo i mea i hōʻeha ʻia e kēia maʻi?
ʻAʻole nā kānaka a pau e loaʻa ana i ka lāʻau lapaʻau no ka maʻi kanesa e loaʻa i ka Tumor Lysis Syndrome. Inā ʻoe e loaʻa ana i ka lāʻau lapaʻau no ka maʻi kanesa, he manaʻo maikaʻi e nīnau i kāu kauka e pili ana i kēia. Ma keʻano laulā, ʻoi aku ka nui o ka pilikia o ka poʻe e loaʻa ana i ka chemotherapy no kēia mau ʻano maʻi kanesa:
- ʻO ka maʻi leukemia lymphocytic koʻikoʻi
- ʻO ka Lymphoma Non-Hodgkin Aggressive, e like me Burkitt Lymphoma a me Diffuse Large B-cell Lymphoma
- ʻO ka maʻi leukemia myeloid koʻikoʻi (AML)
- ʻO ka maʻi Leukemia Lymphoblastic ʻOʻoleʻa B-cell (ALL)
- Ka maʻi ʻaʻai māmā liʻiliʻi
Eia kekahi, aia kekahi mau ʻano maʻi ʻē aʻe, i ka wā e mālama ʻia ai, he emi iki ka pilikia o ka loaʻa ʻana o kēia maʻi. Akā, ʻaʻole i nalowale loa. Nā Laʻana:
- ʻO Anaplastic Large Cell Lymphoma - He maʻi kanesa laha ʻole kēia o ka ʻōnaehana pale maʻi.
- ʻO ka maʻi leukemia lymphocytic mau loa (CLL)
- ʻO ka Neuroblastoma
- Ka maʻi ʻaʻai umauma
- ʻO ka Sarcoma ʻiʻo palupalu
- ʻO ka Medulloblastoma
- ʻO ke kanesa o ke kelepona Merkel
He aha nā kumu ʻē aʻe o ka Tumor Lysis Syndrome?
Ua ʻike nā kauka he nui ka pilikia o kekahi poʻe i ka loaʻa ʻana o kēia maʻi. Lawe ʻia nā hana palekana kūikawā ma mua o ka hāʻawi ʻana i ka chemotherapy i kēlā poʻe. Eia kekahi mau mea e hoʻonui ai i ka pilikia:
- Loaʻa ka helu kiʻekiʻe o nā hunaola koko keʻokeʻo.
- Ua kiʻekiʻe mua nā pae waikawa uric i loko o ke koko.
- Loaʻa nā pilikia o nā puʻupaʻa.
- Ka emi ʻana o ka wai o ke kino (Dehydration).
- Loaʻa i ke kanesa i kahi pae koʻikoʻi (maʻi kanesa ma hope).
- Loaʻa nā puʻupuʻu nui.
Hiki ke hana i kēia kūlana me ka ʻole o ka chemotherapy?
ʻAe, akā he mea kākaʻikahi loa ia. Ke hana ia, kapa ʻia ia e nā kauka he Spontaneous Tumor Lysis Syndrome.
He aha nā hōʻailona o ka Tumor Lysis Syndrome?
ʻIke pinepine ʻia kēia mau hōʻailona i loko o 12 a 72 mau hola o ka hoʻomaka ʻana o ka chemotherapy. Eia lākou:
- Ka luaʻi a me ka luaʻi.
- Ka maʻi pākī.
- Nā loli i ka nui o ka mimi āu e hoʻohele ai (hiki ke hoʻonui a emi paha).
- Ka nāwaliwali a me ka palaualelo.
- Ke koko i loko o ka mimi (Hematuria).
- Nā kūlana epileptic, ʻo ia hoʻi, nā hopu ʻana.
- ʻŪpē ʻiʻo.
- ʻO ka syncope.
- Puʻuwai kūpono ʻole.
- Ke koko haʻahaʻa (Hypotension).
- ʻEha hui.
Inā ʻike ʻoe i hoʻokahi a ʻoi aku paha o kēia mau hōʻailona i ka wā e mālama ʻia ai ka maʻi kanesa, pono ʻoe e hoʻomaopopo koke i ke kauka.
No ke aha i kū mai ai ka Tumor Lysis Syndrome?
I ka ʻōlelo maʻalahi, hana ʻia kēia kūlana ke make koke a wikiwiki ka nui o nā hunaola kanesa i ka mālama ʻana i ka maʻi kanesa. Hōʻiliʻili koke nā mea i loko o nā hunaola e make ana (e like me ka potassium, phosphorus, a me ka uric acid) i loko o ke koko.
ʻO ka maʻamau, ʻo ko kākou mau puʻupaʻa ka mea e kānana i kēia mau mea makemake ʻole ʻia. Akā, i ka wā e make ai ka nui o nā cell i ka manawa hoʻokahi, ʻaʻole hiki i nā puʻupaʻa ke hana i kēia hana. Ua like ia me kahi paipu e paʻa ana i ka wā e komo mai ai ka nui o nā ʻōpala i ka manawa hoʻokahi. A laila hoʻomaka kēia mau mea ʻawahia e hōʻiliʻili i loko o ke kino.
Pehea e ʻike ai nā kauka i kēia maʻi?
ʻO ke kumu nui o nā kauka ka pale ʻana i ka Tumor Lysis Syndrome. No ka hana ʻana i kēia, e hana mau lākou i nā hoʻokolohua koko a me ka mimi e hōʻoia i ka hana pono ʻana o kou mau puʻupaʻa a ke hoʻoneʻe ʻia nei nā mea ʻawahia mai kou kino.
He aha nā lāʻau lapaʻau no ka Tumor Lysis Syndrome?
ʻO ka hoʻāʻo mua a nā kauka e pale aku i kēia. Hana lākou i kēia ma ka ʻike ʻana i ka poʻe i ʻoi aku ka pilikia a me ka lawe ʻana i nā hana palekana kūikawā no lākou. Akā, inā loaʻa ke kūlana, hoʻomaka koke ka lāʻau.
Nā mea e hana ai e pale aku ai:
- Hoʻomaʻū ʻia i loko o ke kino (IV): Kōkua kēia i ka mālama ʻana i nā pae hydration maikaʻi, hoʻoulu i ka mimi ʻana, a kōkua i ka hoʻopau koke ʻana i nā mea ʻawahia mai ke kino.
- Ke hāʻawi ʻana i nā lāʻau lapaʻau e pale ai i ka waiho ʻana o nā kristal uric acid i loko o nā puʻupaʻa: Aia kekahi mau lāʻau lapaʻau e kōkua ai i ka kaohi ʻana i nā pae uric acid.
Lapaʻau inā loaʻa ke kūlana:
- Ke hāʻawi ʻana i nā diuretics: Kōkua kēia i ka wehe ʻana i nā mea ʻawahia mai ke kino me ka wikiwiki.
- GLISH: Ke hāʻawi nei i nā lāʻau lapaʻau e hoʻopau i ka potassium a me ka phosphorus keu.
- Ke hāʻawi nei i nā lāʻau lapaʻau e hoʻoheheʻe i nā kristal uric acid i hana ʻia i loko o nā puʻupaʻa.
- Dialysis: Inā ʻaʻole hana pono kou mau puʻupaʻa, pono paha ʻoe i ka dialysis e wehe i nā mea ʻawahia mai kou koko. Ua like kēia me ka hana ʻana i ka hana a kou mau puʻupaʻa ma ke ʻano hana.
Hiki ke ho'ōla ʻia ka Tumor Lysis Syndrome?
ʻAe, ʻoiaʻiʻo nō! Kokoke i ka 90 pakeneka o ka poʻe i loaʻa i kēia maʻi e hoʻōla hou ʻia. ʻO ka mea nui loa, ʻo ia ka ʻike mua ʻana a hoʻomaka i ka lāʻau lapaʻau i ka wā mua.
He aha ka mea e hana ʻia ma hope o ka mālama ʻia ʻana o kēia maʻi?
Hiki i ka Tumor Lysis Syndrome ke hōʻino i kou mau puʻupaʻa. No laila, inā loaʻa iā ʻoe kēia ʻano, he mea nui loa ia e nīnau i kāu kauka inā pono ʻoe i ka lāʻau hou a i ʻole ka mālama kūikawā a hiki i ka hoʻōla ʻana o kou mau puʻupaʻa.
Ke holomua nei nā lāʻau lapaʻau maʻi kanesa i kēlā me kēia lā, e hiki ai iā mākou ke luku koke i nā hunaola kanesa. Eia nō naʻe, i kekahi manawa, ke make kēia mau hunaola, hiki i nā kemika a me nā mea ʻawahia a lākou e hoʻokuʻu ai ke hana i kahi maʻi weliweli i kapa ʻia ʻo Tumor Lysis Syndrome. Hiki i kēia ke loaʻa ka hopena nui i ka puʻuwai a me nā puʻupaʻa.
ʻO ka mea hope loa, nā mea e hoʻomanaʻo ai (Leka Lawe-Home)
He paʻakikī ka mālama ʻana i ka maʻi kanesa. I kēia manawa, he mea nui e makaʻala i nā pilikia e like me ka Tumor Lysis Syndrome. Inā ʻoe e mālama ʻia ana i ka maʻi kanesa, e nīnau pono i kāu kauka inā pilikia ʻoe i kēia maʻi. E wehewehe lākou i nā pilikia iā ʻoe a hana i nā mea āpau e hiki ai iā lākou ke pale aku a mālama paha i kēia maʻi inā loaʻa. Mai hoʻowahāwahā i kekahi mau hōʻailona, a e haʻi koke i ke kauka inā ʻike ʻoe i kekahi mea ʻē. ʻO ka mālama ʻana i kou olakino ka mea nui loa!
ʻO ka maʻi lysis tumor, ka mālama ʻana i ka maʻi kanesa, chemotherapy, maʻi puʻupaʻa, hyperkalemia, hyperuricemia, pilikia olakino
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