ʻAʻole hana nā antibiotics? Ua lohe anei ʻoe i nā virus e pepehi i nā bacteria? (Phage Therapy)

No kekahi mau maʻi, e kuhikuhi kāu kauka i nā antibiotics, ʻeā? ʻO lākou ka lāʻau lapaʻau nui a mākou e hoʻohana ai no nā maʻi bacteria. Akā i kekahi manawa, ʻaʻohe mea he antibiotic a mākou e hāʻawi ai, hiki iā mākou ke kūʻē iā lākou, a hiki i nā bacteria weliweli (kapa mākou i kēia mau 'superbugs') ke komo i loko o ko mākou kino. No laila he aha kā mākou e hana ai i nā manawa e like me kēia? I kēia lā e kamaʻilio mākou e pili ana i kahi lāʻau lapaʻau ʻano ʻē akā ikaika loa e hiki ke kōkua i nā manawa e like me kēia. ʻO ia ka Phage Therapy.

I ka ʻōlelo maʻalahi, he aha ka Phage Therapy?

He ʻano huakino ka Phage a i ʻole bacteriophage. Mai makaʻu e nīnau, "He huakino anei ia?" ʻAʻole kēia he huakino e like me Corona a i ʻole Dengue e hoʻomaʻi ai iā kākou. ʻO ka pahuhopu wale nō a me ka meaʻai wale nō o kēia mau huakino phage he bacteria. ʻAʻole lākou e hōʻeha i nā cell kanaka. E noʻonoʻo iā ia e like me kahi commando kūikawā i hoʻomaʻamaʻa ʻia e hahai i nā bacteria.

ʻAʻole he maʻi i hana ʻia e ke kanaka ka Phage. Loaʻa maoli ia ma nā wahi āpau o ka honua - ma ka lepo, ka wai, a, he mea kupanaha, i loko o kou kino. No laila, pili ka phage therapy i ka hoʻohana ʻana i kēia maʻi phage, he 'ʻenemi' kūikawā ia o kēlā bacteria, e hakakā i kahi bacteria ʻaʻole hiki i nā antibiotics ke pepehi.

No laila pehea e hana ai kēia lāʻau lapaʻau?

He hana kūlohelohe hoihoi loa kēia. ʻAʻole hiki i kahi maʻi phage ke hana hou ma kāna iho, ʻo ia hoʻi, e hoʻonui. Pono maoli ia i kahi bacteria e hana pēlā.

1. Ka ʻike ʻana i ka pahuhopu: ʻO ka mea mua, loaʻa i ka maʻi phage kahi bacteria kikoʻī hiki iā ia ke luku a hoʻopili iā ia iho i kona ʻili.

2. Ke hoʻokomo nei i ka DNA: ʻO ka mea aʻe, hoʻokomo ka maʻi phage i kāna ʻike genetic, ʻo ia hoʻi, ka DNA, i loko o ka cell bacteria.

3. Ke kāohi nei: Aia ka cell bacteria i kēia manawa ma lalo o ka mana o ka maʻi phage. Me ka hoʻohana ʻana i ka ikehu āpau o ka bacteria, hoʻomaka ia e hana i nā haneli o nā maʻi phage hou me ka hoʻohana ʻana i ka DNA i komo.

4. Ka luku ʻana a me ka laha ʻana: Ke ʻole kahi hou i loko o ke keena bacteria no nā virus phage hou e hana ai, pahū ke keena bacteria. A laila, puka mai nā haneli he mau tausani o kēlā mau virus phage i hana hou ʻia, loaʻa nā bacteria ʻē aʻe, a hoʻomaka i ke kaʻina hana o ka luku ʻana iā lākou pū kekahi.

Hoʻohana nā kauka i kēia ʻano hana ma ke ʻano penei: Hoʻomaopopo lākou i ka bacteria pololei e hoʻoulu ai i ka maʻi i loko o kou kino. A laila, mai kahi 'hale waihona puke phage' o nā tausani o nā phages like ʻole, koho lākou i ka phage pololei e hoʻouka i kēlā bacteria a hoʻohana iā ia no ka mālama ʻana.

Aia kekahi mau kūlana kahi e hiki ai i kēia lāʻau ke kōkua:

• Nā maʻi puʻuwai e pili ana me ka cystic fibrosis
• Nā maʻi pepeiao i hoʻokumu ʻia e ka bacteria P. aeruginosa
• Nā maʻi ʻē aʻe i hoʻokumu ʻia e ka bacteria E. coli a i ʻole P. aeruginosa
• Nā maʻi o nā ʻeha wāwae e ho'ōla ʻole ʻia
• Nā maʻi maka bacteria
• Sepsis (maʻi koko) i nā keiki hānau hou
• Nā maʻi ʻōpū mimi
• Nā maʻi ʻeha ma hope o ke ʻoki ʻana

He aha nā pōmaikaʻi a me nā pōʻino o ka phage therapy?

E like me nā lāʻau lapaʻau a pau, he mau pono a me kekahi mau pilikia kēia. E nānā kākou i nā mea ʻelua. E kamaʻilio mua kākou e pili ana i nā pono.

Hiki i kēia ke hōʻeha? He aha nā pilikia?

Aia kekahi mau mea a nā kauka e hopohopo nei i ka wā e kamaʻilio ai e pili ana i kēia lāʻau lapaʻau.

• ʻAʻohe ʻike lawa: ʻOiai ua hoʻohana ʻia ka phage therapy no kekahi manawa ma nā ʻāina e like me Rusia a me Polani, aia nō nā hoʻokolohua lapaʻau nui a hou ma ka pae honua i ko lākou mau pae mua. No laila, ʻaʻohe ʻikepili lawa e ʻōlelo me ka 100% maopopo i nā hopena pōkole a me ka lōʻihi o kēia lāʻau.

• Ka Pōpilikia o ka Septic Shock: ʻO kēia ka pilikia nui. Ke wāwahi koke nā virus phage i nā cell bacteria, hiki ke hoʻokuʻu ʻia nā mea ʻawahia i kapa ʻia ʻo endotoxins i loko o kēlā mau cell i loko o ke kino. Hiki i kēia mau mea ke hoʻopilikia i ka ʻōnaehana pale, e hoʻohaʻahaʻa koke i ke koko, a hoʻoulu i ka hāʻule ʻana o nā ʻōkana. Akā e hoʻomanaʻo, ua like kēia pilikia i ka wā e hoʻohana ai i nā antibiotics ikaika.

• ʻO ka pilikia o ka hoʻoili ʻana o ka DNA: Hiki i nā virus Phage ke hoʻoili kūlohelohe i ka DNA mai kekahi bacteria i kekahi. No laila, manaʻoʻiʻo kekahi poʻe e hiki i kēia hoʻoili DNA ke alakaʻi i ka hoʻokumu ʻana o nā ʻano bacteria hou a weliweli. Akā, ʻaʻohe pono e hopohopo, no ka mea, nānā pono nā kānaka ʻepekema i nā phages i hoʻohana ʻia i kēia lāʻau lapaʻau a koho wale i nā mea ʻaʻohe mea ʻawaʻawa a i ʻole nā ​​​​genes ʻino.

Loaʻa kēia lāʻau lapaʻau ma Sri Lanka?

I kēia manawa, ʻaʻole i lilo ka phage therapy i lāʻau lapaʻau nui ma nā ʻāina he nui a puni ka honua, me Sri Lanka. Aia nō ia i ke kahua noiʻi, a i ʻole hāʻule ma lalo o ka māhele o "hoʻohana aloha." ʻO ke ʻano kēia, hiki i nā kauka ke lawelawe i kēia lāʻau lapaʻau i nā pilikia wale nō, ke hāʻule nā ​​​​lāʻau lapaʻau ʻē aʻe a pau a ʻaʻohe koho ʻē aʻe e hoʻopakele i ke ola , me ka ʻae kūikawā.

ʻOi aku ka nui o kēia ʻano lapaʻau ma mua o 100 mau makahiki. ʻOiai ua hoʻohana nui ʻia ma ʻAmelika i nā makahiki 1940, ua nalowale mālie ia me ka ʻike ʻia ʻana o nā antibiotics. Akā i kēia manawa, ʻoiai ua lilo ka pilikia o nā bacteria kūʻē i ka antibiotic i mea hoʻoweliweli nui i ka honua, ua hoʻi hou ka hoihoi i ka phage therapy. No laila, ke hana wikiwiki nei ka noiʻi ʻana i kēia a puni ka honua.