Koj puas xav paub txog qhov kev xeem ANCA thiab? Cia peb tham txog nws kom meej!

Koj puas tau hnov ​​txog qhov kev xeem '(ANCA test)'? Tej zaum koj tus kws kho mob hais kom koj ua qhov kev xeem no, lossis tej zaum koj nyuam qhuav pom lub npe qhov twg thiab xav paub. Yog li, qhov '(ANCA test)' no yog dab tsi? Nws nrhiav dab tsi tiag? Hauv tsab xov xwm no, peb yuav nrhiav cov lus teb rau cov lus nug uas koj xav txog.

Kev kuaj ANCA yog dab tsi? Cia peb nkag siab yooj yim!

Hais yooj yim xwb, kev kuaj ANCA yog kev kuaj ntshav uas coj ib qho qauv ntawm koj cov ntshav thiab nrhiav cov khoom tshwj xeeb hu ua Antineutrophil Cytoplasmic Antibodies, lossis luv luv ANCAs.

Tam sim no tej zaum koj yuav xav paub, cov '(ANCAs)' no yog dab tsi? '(ANCAs)' yog ib hom '(autoantibodies)' . '(Autoantibodies)' yog ib hom protein uas peb lub cev tiv thaiv kab mob tsim tawm (uas yog, lub cev uas tiv thaiv peb ntawm cov kab mob). Txawm li cas los xij, qhov teeb meem nrog cov '(autoantibodies)' no yog tias lawv ua yuam kev tawm tsam cov hlwb thiab cov nqaij noj qab haus huv hauv peb lub cev. Nws zoo li peb cov tub rog tawm tsam peb lub tebchaws.

Cov '(ANCAs)' no tsom mus rau cov protein uas pom muaj nyob rau hauv cov qe ntshav dawb hu ua '(neutrophils) . '(Neutrophils)' zoo li cov tub rog me me hauv peb lub cev. Lawv yog cov uas tawm tsam cov kab mob thiab pab peb tiv thaiv peb tus kheej ntawm kab mob. Yog li, qhov '(ANCA test)' no tuaj yeem nrhiav tau seb koj puas muaj cov '(autoantibodies)' no hauv koj cov ntshav, thiab yog tias muaj, muaj pes tsawg.

Kev kuaj ANCA siv los kuaj mob hom kab mob dab tsi?

Cov kws kho mob siv qhov kev xeem ANCA feem ntau los pab kuaj mob qee yam kab mob autoimmune, uas yog ib pawg kab mob hu ua vasculitis .

Qhov no yog dab tsi (vasculitis)?

Xav txog seb, thoob plaws peb lub cev, muaj tej yam me me zoo li cov raj uas nqa ntshav? Qhov ntawd yog qhov peb hu ua cov hlab ntsha. Hauv qhov mob no hu ua "vasculitis," qhov tshwm sim yog tias peb lub cev tiv thaiv kab mob tawm tsam cov hlab ntsha no thiab ua rau lawv o, uas yog, o . Nws zoo li qhov txhab sab hauv.

Muaj ntau hom vasculitis uas cuam tshuam nrog ANCA:

• `(Granulomatosis nrog polyangiitis)` (yav tas los hu ua `(Wegener granulomatosis)`).
• `(Microscopic polyangiitis)` .
• Eosinophilic granulomatosis nrog polyangiitis (yav tas los hu ua Churg-Strauss syndrome).

Cov hlab ntsha yog cov uas nqa cov ntshav los ntawm peb lub plawv mus rau txhua yam kabmob thiab cov nqaij. Yog li, thaum cov hlab ntsha no o, cov ntshav tsis ntws zoo. Qhov no tuaj yeem ua rau peb cov kabmob tseem ceeb puas tsuaj, thiab qee zaum txawm tias ua rau muaj cov mob txaus ntshai xws li cov hlab ntsha tawg (aneurysm) . Yog vim li ntawd nws thiaj li tseem ceeb kom kuaj pom cov mob zoo li no sai sai.

Puas muaj cov hom tseem ceeb ntawm (ANCA)?

Yog, muaj ob hom ANCA tseem ceeb. Qhov kev kuaj ANCA no tuaj yeem qhia tau tias koj muaj ib lossis ob qho tib si.

• `cANCA` : Qhov no tsom mus rau ib qho protein hu ua `(proteinase 3)` lossis `(PR3)` .
• `pANCA` : Qhov no tsom mus rau ib qho protein hu ua `(myeloperoxidase)` lossis `(MPO)` .

Ob hom '(protein)' no pom muaj nyob hauv cov qe ntshav dawb hu ua '(neutrophils)' uas tau hais ua ntej. Kev paub tias hom '(ANCA)' twg muaj nyob yuav pab tus kws kho mob kuaj mob thiab npaj kev kho mob.

Leej twg ua qhov kev xeem ANCA? Yuav kuaj li cas hauv chav kuaj?

Feem ntau, tus kws tu mob, tus kws kho mob, lossis tus kws tshaj lij hauv chaw kuaj mob yuav coj koj cov ntshav mus kuaj, thiab tom qab ntawd xa mus rau chaw kuaj mob kom kuaj.

Muaj dab tsi tshwm sim hauv chav kuaj mob ('lab')?

Lawv coj ib qho qauv ntawm koj cov ntshav thiab sib tov nrog cov neutrophils ntawm daim slide. Tam sim no, yog tias muaj ANCAs hauv koj cov ntshav, lawv yuav lo rau cov neutrophils. Tom qab ntawd, ib qho xim tshwj xeeb (xim av) raug ntxiv rau daim slide. Tom qab ntawd, thaum koj saib nws hauv qab lub tshuab microscope, koj tuaj yeem pom meej meej cov qauv ntawm ANCAs uas tau txuas rau daim slide.

Lub chaw kuaj mob txheeb xyuas cov hlwb no ua cANCA (tus qauv cytoplasmic) lossis pANCA (tus qauv perinuclear) raws li tus qauv fluorescence tshwj xeeb uas pom hauv cov hlwb no.

Ib lub chaw kuaj mob yuav siv ib lossis ob hom kev kuaj ANCA:

• `(Indirect immunofluorescence) (IIF)` : Qhov kev kuaj no tsuas qhia rau koj seb koj puas muaj cov `(autoantibodies)` ntawd los tsis muaj. Yog li ntawd, qhov tshwm sim yog `(zoo)` lossis `(tsis zoo)`.
• Kev ntsuam xyuas enzyme-linked immunosorbent assay (ELISA) : Txoj kev kuaj no yog siv los txheeb xyuas seb cov protein uas lub hom phiaj (piv txwv li PR3 lossis MPO) nyob sab hauv cov neutrophils yog dab tsi.

Puas muaj kev npaj tshwj xeeb uas yuav tsum tau ua ntej qhov kev xeem ANCA?

Feem ntau , tsis tas yuav npaj tshwj xeeb rau kev kuaj ANCA. Txawm li cas los xij, qee zaum ntau yam yuav raug kuaj nrog tib cov ntshav kuaj. Hauv cov xwm txheej zoo li no, qee qhov kev kuaj yuav xav kom koj yoo mov li 8 txog 12 teev, txhais tau tias koj yuav tsum tsis txhob noj lossis haus dab tsi tsuas yog dej xwb. Txawm li cas los xij, koj tus kws kho mob yuav muab cov lus qhia tshwj xeeb rau koj txog qhov no. Yog li ntawd, tsis txhob txhawj txog nws.

Thaum koj ua qhov kev xeem ANCA, koj yuav tsum xav li cas?

Tsuas siv ob peb feeb xwb los rho koj cov ntshav. Feem ntau ua tiav hauv chaw ua haujlwm, chaw kho mob, lossis chaw kuaj mob. Nov yog li cas rho cov ntshav:

• Ua ntej, ib txoj hlua khi los yog ib txoj hlua khi nruj nreem ncig koj sab caj npab (saum koj lub plab).
• Tom qab ntawd, daim tawv nqaij uas yuav raug rub cov ntshav yuav raug ntxuav nrog tshuaj tua kab mob.
• Tom qab ntawd, yuav muab ib rab koob ntxig rau hauv cov leeg ntshav ze ntawm lub luj tshib. Thaum lub sijhawm no , koj yuav hnov ​​​​​​qhov mob khaus lossis qhov khaus me ntsis . Qhov no yog qhov ib txwm muaj.
• Muaj ib lub raj me me txuas rau ntawm rab koob thiab sau cov ntshav kom txaus.
• Tom qab ntawd, lawv tshem daim kab xev thiab koob, thiab tuav qhov chaw uas koob tau ntxig nrog ib daim paj rwb kom tiv thaiv kev los ntshav.
• Thaum kawg, ib daim ntaub qhwv me me (plaster) raug siv rau thaj chaw ntawd.

Tom qab kuaj ANCA tas, yuav muaj dab tsi tshwm sim?

Koj tus kws kho mob yuav hais kom koj qhwv daim ntaub qhwv rau ob peb teev. Lawv kuj tseem yuav hais kom koj tsis txhob ua si nawv hnyav rau ob peb teev tom qab koj pub ntshav. Dua li ntawd, tsis muaj dab tsi tshwj xeeb.

Puas muaj kev pheej hmoo nrog qhov no (kev xeem ANCA)?

Kev kuaj ntshav muaj kev nyab xeeb heev thiab cov kev pheej hmoo tsawg heev .

Tej zaum koj yuav muaj qhov mob me me ntawm qhov uas koj muab koob txhaj rau hauv. Feem ntau qhov no yuav ploj mus li ob peb hnub xwb. Tsis tshua muaj, cov leeg ntshav yuav o me ntsis. Yog tias qhov no tshwm sim, kev siv cov ntaub sov sov yuav pab tau. Qhov no tsis yog ib yam dab tsi uas yuav tsum txhawj txog.

Yuav siv sijhawm ntev npaum li cas thiaj li tau txais cov txiaj ntsig ntawm kev xeem ANCA?

Qhov kev kuaj ANCA yog ib qho kev kuaj tshwj xeeb, yog li nws ua tiav hauv chav kuaj mob tshwj xeeb. Yog li ntawd, nws yuav siv sijhawm txij li ob peb hnub mus txog ib lub lim tiam kom cov txiaj ntsig rov qab los. Koj tus kws kho mob yuav qhia rau koj paub.

Cov txiaj ntsig ntawm kev xeem ANCA txhais li cas? Kuv nkag siab li cas?

Qhov no yog qhov tseem ceeb tshaj plaws. Koj tus kws kho mob yog tus uas yuav nrog koj tham txog cov txiaj ntsig ntawm kev xeem ANCA thiab lawv cuam tshuam li cas rau koj txoj kev noj qab haus huv.

• Yog tias cov txiaj ntsig yog "tsis zoo": Qhov no feem ntau txhais tau tias koj tsis muaj tus mob "autoimmune vasculitis" uas tau tham ua ntej.
• Yog tias cov txiaj ntsig yog "zoo": Tej zaum nws txhais tau tias koj muaj "autoimmune vasculitis".

Txawm li cas los xij, muaj qee yam tseem ceeb uas yuav tsum nkag siab ntawm no. Kev kuaj ANCA zoo tsis tau txhais hais tias koj muaj tus kab mob. Koj tus kws kho mob yuav xaj kom kuaj ntxiv , xws li kev kuaj nqaij (cov qauv ntawm cov ntaub so ntswg coj mus kuaj), lossis lwm yam kev kuaj ntshav. Tsis tas li ntawd, kev kuaj mob yog ua raws li ntau yam, suav nrog koj cov tsos mob thiab cov txiaj ntsig ntawm lwm yam kev kuaj.

Tseem Ceeb: Cov txiaj ntsig ntawm kev kuaj ANCA tsuas yog ib feem ntawm cov txheej txheem kuaj mob xwb. Nws tsis txiav txim siab seb puas muaj kab mob ntawm nws tus kheej. Koj tus kws kho mob yuav xav txog qhov no ua ke nrog ntau lwm yam, xws li koj cov tsos mob, cov txiaj ntsig ntawm lwm yam kev kuaj mob, thiab koj keeb kwm kev kho mob.

Yog li ntawd, qhov tseem ceeb tshaj plaws uas peb yuav tsum nco ntsoov ntawm qhov no yog dab tsi?

Qhov kev kuaj "Antineutrophil Cytoplasmic Antibodies", lossis "ANCA", yog ib qho kev kuaj ntshav tseem ceeb uas pab cov kws kho mob kuaj pom qee hom "autoimmune vasculitis", cov mob uas peb lub cev tiv thaiv kab mob tawm tsam peb cov hlab ntsha.

Koj tus kws kho mob yuav piav qhia rau koj vim li cas koj thiaj li yuav tsum tau kuaj qhov no thiab cov txiaj ntsig yuav txhais li cas rau koj. Yog li, tsis txhob ntshai lossis ua xyem xyav. Yog tias koj muaj lus nug lossis tsis nkag siab ib yam dab tsi, nug koj tus kws kho mob tam sim ntawd. Nws yog qhov zoo tshaj plaws kom paub thaum txiav txim siab txog koj txoj kev noj qab haus huv.

` (kev xeem ANCA), kev xeem ANCA, kev kuaj ntshav, mob vasculitis, cov kab mob autoimmune, cov tshuaj tua kab mob, neutrophils, o ntawm cov hlab ntsha