Puas muaj teeb meem sab hauv koj cov hlab ntsha? Cia peb kawm txog Endothelial Dysfunction.

Koj puas tau xav txog qhov tseem ceeb ntawm cov hlab ntsha hauv peb lub cev? Lawv zoo li txoj kev me me uas nqa cov lus thiab cov as-ham thoob plaws peb lub cev. Yog li ntawd, yuav ua li cas yog tias muaj qhov tsis muaj zog ntawm cov txheej sab hauv cov kev no, hu ua endothelium? Qhov ntawd yog qhov peb hu ua "Endothelial Dysfunction". Cia peb tham txog qhov no ntxiv me ntsis, puas yog?

Endothelial Dysfunction yog dab tsi?

Hais yooj yim xwb, Endothelial Dysfunction yog thaum cov txheej nyias nyias ntawm cov hlwb hauv koj cov hlab ntsha hu ua endothelium tsis ua haujlwm zoo. Cov hlwb endothelial no feem ntau pab kom koj cov hlab ntsha qhib (dilated) thaum xav tau. Tab sis thaum qhov kev ua haujlwm tsis zoo no tshwm sim, qhov txawv tshwm sim. Ntawd yog, cov hlab ntsha pib cog lus thiab nqaim.

Xav txog nws zoo li ib lub yeeb nkab dej. Yog tias lub txheej sab hauv nws tsis yog, nws yuav nyuaj rau cov dej ntws los, puas yog? Yog li ntawd nws yog. Qhov laj thawj tseem ceeb rau qhov mob no yog ib qho mob hu ua "Vasospasm" uas cuam tshuam nrog cov hlab ntsha ntawm lub plawv. Hauv qhov no, txawm tias tsis muaj dab tsi raug thaiv hauv koj cov hlab ntsha ntawm lub plawv, cov hlab ntsha tsuas yog nqaim. Tsis tas li ntawd, "Endothelial Dysfunction" ua rau muaj kev pheej hmoo ntawm "Atherosclerosis", uas yog kev tso cov rog rau ntawm phab ntsa ntawm cov hlab ntsha thiab ua rau cov hlab ntsha nqaim.

Yog li ntawd, lub luag haujlwm ntawm endothelium no yog dab tsi?

Txhua txoj hlab ntsha hauv peb lub cev (uas yog cov hlab ntsha, cov leeg ntshav, cov hlab ntsha me me) yog ib txheej ntawm cov hlwb hu ua endothelial cells. Koj puas paub, qhov endothelium no yog ib qho ntawm cov kab ke loj tshaj plaws hauv peb lub cev!

Cov hlwb endothelial tso tawm ntau yam tshuaj. Cov tshuaj no tswj qhov qhib thiab kaw ntawm cov hlab ntsha (qhov no hu ua "Vascular Tone". Qhov "Vascular Tone" no txiav txim siab peb cov ntshav siab, thiab lub plawv yuav tsum nqus ntshav npaum li cas.

Tsis yog li ntawd xwb, tab sis koj lub endothelium nws tus kheej ua ntau lwm yam haujlwm tseem ceeb:

• Nws tswj cov kua dej thiab electrolytes hauv koj cov ntshav.
• Pab kom cov ntshav khov thaum xav tau.
• Tiv thaiv cov tshuaj lom kom tsis txhob nkag mus rau hauv cov ntaub so ntswg.
• Tswj kev o ntawm cov ntaub so ntswg.

Xav seb cov hlwb me me no ua haujlwm ntau npaum li cas hauv peb lub cev!

Tus mob no hu ua endothelial dysfunction ntau npaum li cas?

Tau ntev los lawm, cov kws kho mob xav tias endothelium tsuas yog ib qho thaiv sab hauv cov hlab ntsha xwb. Tab sis tom qab ntawd lawv tau paub tias qhov no kuj yog ib qho tseem ceeb ntawm lub cev. Thaum ntawd tus mob no hu ua "Endothelial Dysfunction" tuaj yeem lees paub tias yog ib yam kab mob sib cais.

Cov kev tshawb pom no tau ua nyob rau xyoo 1990s, uas txhais tau tias tus mob no tsis tau raug txheeb xyuas ntev heev. Yog li cov kws tshaj lij tseem tsis tuaj yeem hais meej tias nws kis tau dav npaum li cas ntawm cov neeg.

Vim li cas qhov kev ua haujlwm tsis zoo ntawm endothelial no tshwm sim?

Qhov laj thawj tseem ceeb rau qhov mob no yog tias tsis muaj roj hu ua Nitric Oxide (NO) txaus hauv phab ntsa ntawm koj cov hlab ntsha. Qhov xav tsis thoob yog, cov nitric oxide no yog tsim los ntawm koj lub endothelium nws tus kheej! Cov nitric oxide no yog "(Vasodilator)", uas txhais tau tias nws qhib cov hlab ntsha thiab tso cai rau cov ntshav ntws tau yooj yim.

Yog li, yuav ua li cas thaum cov nitric oxide theem txo qis?

• Cov hlab ntsha nqaim: Qhov no tuaj yeem ua rau muaj ntshav siab.
• Kev o tshwm sim hauv cov phab ntsa ntawm cov hlab ntsha: Qhov no tuaj yeem ua rau atherosclerosis, lossis cov hlab ntsha tawv.
• Platelet ntau ntxiv: Qhov no tuaj yeem ua rau cov ntshav txhaws.
• Cov phab ntsa ntawm cov hlab ntsha ua rau muaj qhov ntxeem tau: Qhov no ua rau cov ntaub so ntswg raug rau cov lipoproteins uas ua rau puas tsuaj thiab lwm yam tshuaj lom.

Cov tsos mob ntawm Endothelial Dysfunction yog dab tsi?

Cov tsos mob tseem ceeb ntawm tus kab mob coronary artery (endothelial dysfunction) yog angina , uas yog mob hauv siab. Qhov mob hauv siab no tshwm sim vim tias koj cov hlab ntsha kaw thaum lawv yuav tsum qhib. Qhov mob hauv siab no feem ntau hnyav dua thaum lub sijhawm ua si.

Tej tus neeg yuav mob hauv siab tas li ('Angina') txawm tias lawv tsis ua dab tsi los xij. Qhov no tuaj yeem yog ib qho cim qhia tias muaj mob plawv nres. Yog tias qhov no tshwm sim, cov tsos mob suav nrog mob hauv siab tas li, qaug zog heev, thiab ua tsis taus pa. Qhov no yog xwm txheej ceev hauv kev kho mob uas yuav tsum tau kho tam sim ntawd.

Leej twg muaj feem yuav muaj qhov teeb meem no tshaj? (Cov Yam Uas Ua Rau Muaj Kev Pheej Hmoo)

Tej yam uas yuav ua rau koj muaj feem yuav mob Endothelial Dysfunction ntau ntxiv. Koj muaj feem yuav mob ntau dua yog tias koj muaj cov mob hauv qab no:

• Kab mob ntshav qab zib ('Diabetes Mellitus')
• Ntshav siab (Tshuaj ntshav siab)
• Ntshav qab zib ntau ('Hyperglycemia')
• Cov roj cholesterol ntau
• Kab mob metabolic syndrome
• Haus luam yeeb
• Kev rog dhau
• Qee cov kab mob autoimmune

Lwm yam mob dab tsi tuaj yeem ua rau Endothelial Dysfunction?

Qhov mob no (Endothelial Dysfunction) ua rau muaj kev pheej hmoo ntawm cov kab mob plawv (Cardiovascular Diseases) thiab ntau yam kab mob ntxiv. Piv txwv li:

• Atherosclerosis thiab Kab Mob Coronary Artery
• Cov Ntshav Txhaws thiab Mob Stroke
• Lub plawv loj (Hypertrophic Cardiomyopathy)
• Mob Plawv Nres thiab Mob Plawv Tsis Ua Haujlwm
• Ntshav siab (Tshuaj ntshav siab)
• Kev Ua Tsis Taus ntawm Lub Raum
• Kab Mob Ntawm Cov Hlab Ntxwm (PAD)
• Kab mob ntshav siab hauv lub ntsws (PH)
• Kab Mob Me Me ntawm Cov Hlab Ntsws (Kab Mob Me Me ntawm Cov Hlab Ntsws ntawm Lub Hlab Ntsws)

Cov teeb meem ntawm tus mob no yog dab tsi?

Kev ua haujlwm tsis zoo ntawm cov hlab ntsha hauv lub plawv (endothelial dysfunction) tuaj yeem ua rau muaj mob hu ua Acute Coronary Syndrome . Qhov no yog kev sib xyaw ua ke ntawm peb hom kab mob ntawm cov hlab ntsha hauv lub plawv. Qhov no ua rau muaj kev pheej hmoo ntawm cov rog (plaque) hauv cov hlab ntsha tawg. Cov roj uas tawg no tuaj yeem thaiv cov ntshav ntws mus rau cov leeg nqaij plawv thiab ua rau mob plawv nres.

Yuav kuaj mob li cas ? (Kev kuaj mob)

Cov kws kho mob siv ntau yam kev kuaj duab los saib ncaj qha seb cov ntshav ntws li cas los ntawm cov hlab ntsha. Cov kev kuaj no tuaj yeem pab tus kws kho mob pom seb puas muaj cov cim qhia txog kev ua haujlwm tsis zoo ntawm cov hlab ntsha hauv lub cev. Cov kev kuaj no suav nrog:

• Kev kuaj mob hluav taws xob (Electrocardiogram - EKG)
• Angiogram, suav nrog Coronary Computed Tomography Angiogram (CCTA).

Tsis tas li ntawd xwb, qee qhov kev kuaj "Stress Imaging" siv tau los saib seb cov ntshav ntws los ntawm koj cov hlab ntsha puas txo qis, uas tej zaum yuav ua rau koj lub plawv ua haujlwm hnyav dua. Piv txwv li:

• Echocardiogram (`Echocardiogram - echo`)
• MRI (MRI)
• Kev Siv Positron Emission Tomography (PET scan)

Yuav kho qhov no li cas? (Kev Kho Mob)

Yog tias koj muaj kab mob plawv lossis kab mob hlab ntsha hauv lub plawv (COPD) vim yog qhov ua haujlwm tsis zoo ntawm cov hlab ntsha hauv lub plawv, koj tus kws kho mob yuav sau ntawv rau koj noj qee yam tshuaj. Piv txwv li:

• Tshuaj aspirin los yog tshuaj thinner rau cov ntshav.
• Cov tshuaj uas tswj cov ntshav siab, xws li cov calcium channel blockers.
• Cov tshuaj txo cov roj cholesterol zoo li statins.
• Cov tshuaj uas qhib cov hlab ntsha, xws li nitrates.

Tsis tas li ntawd xwb, yog tias koj muaj Endothelial Dysfunction, koj tuaj yeem txo koj cov tsos mob los ntawm kev hloov pauv kev noj haus thiab kev ua neej . Cov no suav nrog:

• Noj zaub mov zoo rau lub plawv thiab tawm dag zog tsis tu ncua.
• Txwv kev haus cawv.
• Txo qhov hnyav (yog tias tsim nyog) thiab tswj qhov hnyav kom noj qab nyob zoo.
• Nrhiav txoj hauv kev noj qab haus huv los tswj kev ntxhov siab .
• Nrhiav kev pab kom tso kev haus luam yeeb thiab zam kev haus luam yeeb ntawm lwm tus.
• Tswj tau zoo ntawm cov mob xws li ntshav siab, ntshav qab zib, thiab roj cholesterol siab.

Yuav ua li cas rau cov neeg uas muaj Endothelial Dysfunction?

Kev ua haujlwm tsis zoo ntawm Endothelial tuaj yeem kho tau los ntawm kev hloov pauv hauv lub neej thiab tshuaj.Nws yog ib yam mob uas kho tau yooj yim heev. Txawm li cas los xij, qee tus neeg uas muaj tus kab mob plawv tsis thaiv (NOCAD) tseem yuav mob hauv siab txawm tias tau kho mob lawm los xij.

Hom mob hauv siab no tuaj yeem cuam tshuam rau kev ua ub ua no txhua hnub. Nws kuj tseem tuaj yeem ua rau muaj mob xws li kev ntxhov siab thiab kev nyuaj siab. Kev kho mob hlwb, tshuaj, thiab kev tswj kev ntxhov siab tuaj yeem pab tau.

Kuv yuav tsum mus ntsib kws kho mob thaum twg?

Yog tias koj muaj cov tsos mob nram qab no, mus ntsib kws kho mob tam sim ntawd:

• Mob hauv siab
• Ua pa nyuaj
• Cov tsos mob ntawm kev mob plawv nres (piv txwv li, mob hauv siab hnyav, mob kis mus rau sab caj npab sab laug, mob hauv lub puab tsaig, tawm hws, xeev siab)
• Kev qaug zog ntau dhau tsis muaj laj thawj

Kuv yuav tsum nug kuv tus kws kho mob li cas?

Koj tuaj yeem nug koj tus kws kho mob cov lus nug zoo li no:

• Vim li cas kuv thiaj muaj tus mob no (Endothelial Dysfunction)?
• Kuv puas xav tau tshuaj?
• Kuv yuav tsum hloov pauv txoj kev ua neej thiab kev noj haus li cas?
• Kuv puas muaj feem yuav mob plawv? Kuv yuav ua li cas thiaj txo tau qhov kev pheej hmoo ntawd?
• Kuv puas yuav tsum paub txog cov tsos mob ntawm cov teeb meem?

Cov Lus Qhia Txog Kev Coj Mus Tsev

Kev ua haujlwm tsis zoo ntawm cov hlab ntsha hauv lub plawv (endothelial dysfunction) yog ib hom kab mob ntawm cov hlab ntsha hauv lub plawv. Thaum tsis muaj nitric oxide txaus hauv cov phab ntsa ntawm koj cov hlab ntsha, cov hlab ntsha yuav nqaim. Qhov kev nqaim no ua rau cov ntshav ntws mus rau lub plawv tsis zoo. Qhov mob no ua rau mob angina, lossis mob hauv siab, thiab ua rau muaj kev pheej hmoo ntawm kab mob plawv.

Qhov zoo tshaj plaws yog, yog tias koj kuaj pom thaum ntxov thiab tau txais kev kho mob kom zoo, nrog rau kev hloov pauv koj txoj kev ua neej, koj muaj lub sijhawm zoo los tiv thaiv koj tus kheej ntawm cov kab mob plawv loj. Yog li ntawd, tsis txhob tso tseg cov tsos mob. Yog tias koj tsis paub meej, nws yog ib qho zoo kom nrhiav kev pab kho mob.

Kev Ua Haujlwm Tsis Zoo ntawm Endothelial, Kab Mob Plawv, Cov Hlab Ntshav, Angina, Nitric Oxide, Ntshav Siab, Cholesterol