Wi ɔl no di frayd ɛn wɔri we kin kam we wi yɛri frɔm di dɔktɔ se pɔsin na wi fambul ɔ padi gɛt siriɔs blɔd disɔda ɔ blɔd kansa. Bɔt bikɔs ɔf di tin dɛn we dɔn apin na mɛrɛsin tide, pawaful tritmɛnt dɛn de we go mɛn dɛn kayn sik dɛn de. Wan pan dɛn kayn tritmɛnt ya we de sev layf na in dɛn kɔl "Allogeneic Stem Cell Transplant." Pan ɔl we di nem kin tan lɛk se i kɔmplikt, lɛ wi tɔk bɔt wetin kin apin na dis rili simpul wan.
Wetin rili na allogeneic stem cell transplant?
Fɔ tɔk am simpul wan, dis involv fɔ pul di stem sɛl dɛn we sik, we nɔ de wok fayn na yu bɔdi ɛn put stem sɛl dɛn we gɛt wɛlbɔdi, we go gri wit ɔda pɔsin (we na pɔsin we gi di mɛrɛsin).
Naw lɛ wi ɛksplen dis smɔl mɔ.
- Stem Sεl dεm: Wi kin kכl dεn ya bak "mama sεl dεm" biכs dεn sεl dεm ya lεk di fכktri we de mek כl di כda bכdi sεl dεm na wi bכdi (rεd bכdi sεl dεm, wayt bכdi sεl dεm, pletlet dεm). dis stεm sεl dεm de bכku pan wi bon mכro.
- Allogeneic: Dis wɔd min "dɛn gɛt frɔm ɔda pɔsin." Dis min se di tritmɛnt de yuz sɛl dɛn frɔm pɔsin we gɛt wɛlbɔdi, we go gri fɔ gi am, nɔto yu yon.
Imajin se wi bon mɛro tan lɛk fayn fayn fam we gɛt gud grɔn. Na dis fil wi blɔd sɛl dɛn kin gro. Bɔt pan sik lɛk lukimiya, dis fil kin pwɛl, ɛn gras (kansa sɛl) kin gro instead fɔ di gud tin dɛn we dɛn kin plant. So, insay dis tritmɛnt, dɛn kin pul da dɔti we dɔn pwɛl (di bon mɛrɔ we gɛt sik) kpatakpata ɛn put nyu, wɛlbɔdi, fayn fayn grɔn (di pɔsin in stem sɛl dɛn) insay in ples. Dɔn, wɛlbɔdi blɔd sɛl dɛn kin bigin fɔ gro na da nyu grɔn de.
Dis tritmɛnt na pawaful wan we kin mɛn sɔm siriɔs sik dɛn kpatakpata. Dɔktɔ dɛn kin yuz dis tritmɛnt we ɔda tritmɛnt dɛn nɔ wok ɔ we di sik kam bak.
Us kayn tin dɛn kin yuse dis tritmɛnt fɔ?
Bɔku tɛm dɛn kin yuz am fɔ sik dɛn we gɛt fɔ du wit di blɔd ɛn di imyun sistɛm. Na sɔm pan di men sik dɛn.
| Mɛdikal kɔndishɔn | Wan simpul ɛksplen |
|---|---|
| Akyu Limfoblastik Lukimiya (ALL) . | Limfosayt, we na wan kayn wayt blɔd sɛl we de na di blɔd ɛn bon mɛrɔ, kin bi kansa sɛl. |
| Akyu Maylɔyd Lukimiya (AML) . | Kansa na di bכdi sεl dεm we de divεlכp frכm di mayloid stεm sεl dεm. |
| Aplastik Anemia we dɛn kɔl | We di bon mɛro pwɛl, dat kin mek di bɔdi nɔ ebul fɔ mek inof nyu blɔd sɛl dɛn. |
| Limfoma we dɛn kɔl Limfoma | Wan kansa we kin apin na di limfatik sistɛm. |
| Maylodisplastik Sindrom we dɛn kɔl di sik | di rεgulεr prodakshכn fכ hεlty bכdi sεl dεm na di bon mכro. |
| Siklɔs Sɛl Sik | Na sik we pɔsin kin gɛt frɔm in mama ɛn papa we di rɛd blɔd sɛl dɛn shep kin chenj ɛn dɛn nɔ kin wok fayn. |
Aw yu kin rɛdi fɔ tritmɛnt?
Bikɔs dis na big tritmɛnt, di mɛdikal tim go du sɔm tɛst dɛn bifo tɛm fɔ mek shɔ se yu bɔdi ebul fɔ bia wit am.
- Blɔd tɛst: Dɛn kin du tin dɛn lɛk kɔmplit blɔd kɔnt (CBC) fɔ chɛk di lɛvɛl we di rɛd blɔd sɛl dɛn, wayt blɔd sɛl dɛn, ɛn di pletlɛt dɛn de.
- At test: Echocardiogram (fɔ si aw di at de wok fayn) ɛn electrocardiogram (EKG) fɔ si di at in ritm.
- Dɛn kin du tɛst fɔ chɛk aw di liva ɛn di kidni de wok .
- Bone Marrow Biopsy: If yu gɛt kansa, dɛn kin tek smɔl sɛmpul pan bon marrow ɛn tɛst am fɔ no aw di sik tan ɛn di risk fɔ mek i kam bak.
We dɛn dɔn du ɔl dɛn tɛst ya ɛn dɛn dɔn no se yu na gud kandidet, di impɔtant pat pan di tritmɛnt, we dɛn kɔl "pri-transplant conditioning," kin bigin. Dis involv ay doz kemotɛrapi ɔ redyushɔn tɛrapi to di wan ol bɔdi. Dis kin bi tranga tɛm. Bɔt i rili impɔtant.
Wetin mek dis prɛ-tritmɛnt impɔtant so?
- I de pwɛl ɛni kansa sɛl we lɛf na yu bɔdi.
- I de pul ol, sik sɛl dɛn na yu bon mɛro ɛn mek ples fɔ nyu sɛl dɛn fɔ gro.
- I de mek yu imyun sistɛm wik fɔ sɔm tɛm. Dɛn kin du dis fɔ mek yu bɔdi nɔ atak ɛn rijek di nyu sɛl dɛn we dɛn dɔn gi.
Yu go gɛt fɔ de na ɔspitul fɔ wan ɔ tu wik fɔ dis tritmɛnt.
Wetin kin apin di de we dɛn transplant di sɛl?
Di we aw dɛn kin transplant di sɛl dɛn rili simpul ɛn i nɔ kin mek pɔsin fil pen , jɔs lɛk fɔ gi blɔd.
Di mɛdikal tim go put spɛshal tiub insay wan big vein na yu chɛst we de ɔp. Dɛn kɔl dis Sɛntral Venɔs Kateta (CVC) . di bag we gεt di hεlty stεm sεl dεm frכm di dכna de kכnekt to dis tכb. Dɔn dɛn kin put di sɛl dɛn smɔl smɔl insay yu bɔdi, tru yu blɔd, ɛn go insay yu bon mɛro, lɛk sɔl sɔlvushɔn.
Dis prɔses kin tek lɛk 30 minit to wan awa. Insay dis tɛm, di mɛdikal tim go sidɔm nia yu ɛn wach yu blɔd prɛshɔn ɛn yu at rit. Sɔntɛnde, smɔl smɔl sayd ɛfɛkt dɛn kin apin.
- Fɔ fil kol
- I nɔ kin izi fɔ yu fɔ blo smɔl
- Wan fiva
Bɔt bɔku tɛm dɛn tin ya nɔ kin rili siriɔs.
Wetin kin apin afta dɛn dɔn trit am?
di mכst imכtant rεkכvεshכn tεm de bigin afta di stεm sεl transplant. Yu go nid fɔ de na ɔspitul ɔ nia am fɔ sɔm wiks mɔ.
- Immune control: Dɛn go kɔntinyu fɔ gi yu immunosuppressants fɔ mek yu bɔdi nɔ atak di nyu sɛl dɛn ɛn fɔ mek di nyu sɛl dɛn nɔ atak yu bɔdi.
- Blɔd transfyushɔn: I kin tek sɔm tɛm fɔ mek di nyu stem sɛl dɛn bigin fɔ wok ɛn mek nyu rɛd sɛl ɛn pletlɛt dɛn. Insay da tɛm de, yu go nid fɔ tek blɔd.
- Protekshɔn frɔm infɛkshɔn: Yu imyun sistɛm kin rili wik insay dis tɛm, so dɛn kin pe spɛshal atɛnshɔn fɔ protɛkt yusɛf frɔm baktri ɛn vayral infɛkshɔn.
di prכsεs we di nyu sεl dεm de travul go na di bon mכro, setul de, εn bigin fכ mek nyu bכdi sεl dεm dεn kכl am "engraftment." Dis kin tek lɛk 10 to 14 dez.
Aw lɔng i kin tek fɔ mek i wɛl ɔltogɛda?
Dis na tin we dɛn kin du fɔ lɔng tɛm. I kin tek tu ia ɔ mɔ fɔ mek i wɛl. I kin tek lɛk wan ia so fɔ mek yu imyun sistɛm kam bak.
Speshal risk fɔ no bɔt: Graft vs. Host Disease (GVHD) .
dis na di mכst kכmכn komplikashכn fכ wan allogeneic transplant. Fɔ tɔk am simpul wan, i kin apin we di nyu imyun sɛl dɛn frɔm di pɔsin we gi yu (di graft) atak yu yon bɔdi in yon sɛl ɛn tisu dɛn (di ɔs) . I tan lɛk "gɔst we de atak di ɔs."
Dis kin bi smɔl ɔ i kin rili bad. Na dat mek dɛn kin gi am di mɛrɛsin dɛn we de mek pɔsin nɔ ebul fɔ fɛt di sik ɔltɛm. Yu nid fɔ no gud gud wan bɔt de sayn dɛm fɔ dis sik.
Di sayn dɛm wae yu fɔ ripɔt to yu dɔktɔ kwik kwik wan
We yu go na os afta yu dɔn gɛt tritmɛnt, yu fɔ rili tek tɛm wit sɔm sayn dɛm. If ɛni wan pan dɛn tin ya apin, kɔl yu mɛdikal tim wantɛm wantɛm.
| Kategori fɔ di simptom dɛn | Ficha dɛn we yu fɔ luk fɔ |
|---|---|
| Di sayn dɛm fɔ Graft vs. Host Disease (GVHD) kin inklud: | |
| Na di bɛlɛ | Bɛlɛ de at, nɔs ɛn vɔmit, dayarɛa (blɔt) . |
| Skin ɛn yay | Itchy skin rash, yɔlɔ na di skin ɛn/ɔ di yay (jaundice) . |
| I kin bi sayn fɔ se yu gɛt infekshɔn | |
| Jɛnɛral kwaliti dɛn | Fiva we kin pas 38 Sɛlshiɔs (100.4 Fɛnayt) ɔ pas dat, i kin mek pɔsin kol |
| Di sistɛm we de mek pɔsin ebul fɔ blo | Kɔf, sniz, nɔs we de rɔn, i nɔ izi fɔ blo |
| Ɔda tin dɛn we de apin | Diziz, yu de pis ɔltɛm, ɔ yu de bɔn we yu de pis |
di difrεns bitwin "allogeneic" εn "autologous" transplant
Yu go dɔn yɛri bak bɔt ɔtologous stem cell transplant. di men difrεns bitwin dεn tu na di say we di sεl dεm de kכmכt.
- Allogeneic: dεn kin gεt sεl dεm frכm כda pכsin (wan dכna).
- Autologous: Dɛn kin tek di sɛl dɛn frɔm di pɔsin we sik . Dis min se dɛn kin gɛda di pɔsin in yon wɛlbɔdi stem sɛl dɛn fɔs ɛn afta dat dɛn kin gi am bak to dɛn afta dɛn dɔn gi am ay doz kemotɛrapi.
Wan allogeneic transplant kin mɛn sɔm sik dɛn we kin mek pɔsin in layf de pan denja kpatakpata. Bɔku tɛm, na pipul dɛn we wi nɔ no bɔt we wi nɔ ɛva mit kin du dɛn transplant ya we de sev layf. Sɔntɛnde, pipul dɛn na di famili kin bi pipul dɛn we de gi mɔni. Pan ɔl we prɔblɛm dɛn de fɔ dis tritmɛnt, di bɛnifit dɛn bak kin rili bɔku. Yu dɔktɔ go ɛksplen ɔl dis to yu ɛn ɛp yu fɔ disayd fɔ du di bɛst tin fɔ yu.
Mɛsej we dɛn kin kɛr go na os
- allojenik stεm sεl transplant na di riplesmεnt fכ di bon mכro we sik wit stεm sεl dεm frכm hεlty dכna.
- Dis na pawaful tritmɛnt we dɛn kin yuz fɔ siriɔs blɔd sik lɛk lukimiya, limfoma, ɛn aplastik anemia.
- I impɔtant fɔ pripia di bɔdi wit ay doz kemotɛrapi ɔ redyushɔn tɛrapi bifo dɛn trit am.
- Di men kɔmplikeshɔn we kin apin afta tritmɛnt na Graft vs. Host Disease (GVHD), ɛn i impɔtant fɔ no dis ɔltɛm ɛn di sayn dɛm fɔ infɛkshɔn.
- Dis na lɔng tɛm fɔ mɛn, ɛn i rili impɔtant fɔ tɛl yu dɔktɔ ɔ di mɛdikal tim wantɛm wantɛm bɔt ɛni prɔblɛm.
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