Yu dɔn ɛva tink se fɔ fil taya ɔltɛm, fɔ gɛt swɛlin leg, ɛn fɔ gɛt prɔblɛm fɔ blo na nɔmal tin? Sɔmtɛm, kin gɛt wan mɔr kɔmplikɛt kɔndishɔn biɛn dɛn sik ya wae wi nɔr dɔn yɛri bɔrku bɔt. Tide, wi de tɔk bɔt wan pan dɛn kayn sik ya we nɔ kin bɔku, bɔt wan we yu fɔ no bɔt. Dat na di sik we dɛn kɔl AL Amyloidosis. Dis nem kin tan lɛk se i de mek wi fred smɔl, bɔt lɛ wi tɔk bɔt am simpul wan ɛn klia wan.
Fɔ tɔk am simpul wan, wetin na AL amyloidosis?
Imajin se wi gɛt smɔl smɔl faktri dɛn na wi bɔdi, we wi kɔl plasma sɛl . Dɛn tin ya de na wi bon mɛro. Dɛn men wok na fɔ mek sojaman dɛn we dɛn kɔl antibodi fɔ fɛt di jem dɛn we de kam insay wi bɔdi. Dis na wan impɔtant pat pan wi imyun sistɛm.
bכt insay wan kכndishכn we dεn kכl AL amyloidosis, sכm sכm dεf de na dεn plasma sεl dεm ya. Bikɔs ɔf dis prɔblɛm, dɛn sɛl dɛn de kin mek wan kayn prɔtin we nɔ shep fayn, we brok, ɛn we nɔ shep fayn. Dɛn kɔl dis layt chen protin .
dis layt chen protin dεm we dεn nכ fכld fayn kin kכlכm tכgeda, we de fכm tכngl dεm εn sכm sכm fayv strכkchכ dεm. Dɛn tin ya kin gɛda na difrɛn pat dɛn na wi bɔdi, lɛk di at, kidni, nerv, ɛn insay. Jɔs lɛk aw dɔti kin lɔk paip, we dɛn prɔtin ya kin gɛda, dɛn ɔgan dɛn de nɔ kin ebul fɔ wok fayn. Dis na wetin wi kɔl AL amyloidosis.
Wetin mek dɛn kɔl dis AL?
Difrɛn kayn amyloidosis de. Dɛn gi ɛni kayn in nem to di abnɔmal prɔtin we de mek i gɛt am. Di lɛta A tinap fɔ Amyloidosis ɛn di lɛta L tinap fɔ Layt Chen .
Aw dis sik kin afɛkt di bɔdi?
Bɔku bɔku difrɛn kayn plasma sɛl dɛn de na wi bɔdi. Ɛni kayn de mek wan patikyula kayn antibodi fɔ fɛt wan patikyula jem.
insay AL amyloidosis, wan plasma sεl de divεlכp wan difεkt, εn da sεl de de divayd we dεn nכ ebul fכ kכntrכl, we de mek tכwzin sεl dεm we nכ de wok fayn. Ɛni wan pan dɛn sɛl ya de mek di layt chen protin we nɔ fayn we wi bin dɔn tɔk bɔt.
Dis big big protin de travul tru wi blɔd ɛn bigin fɔ put insay wi ɔgan dɛn. dεn kכl dεn fayv dεm ya we dεn dכn dכn amyloid fibrils . Dɛn tin ya kin mek di ɔgan dɛn tik ɛn nɔ kin wok fayn. As tɛm de go, dis kin mek bad bad tin apin we kin ivin mek pɔsin in layf de pan denja.
Udat kin gɛt dis sik pas ɔlman?
Dis na rili sik we nɔ kin apin so ɔltɛm . Ɔlsay na di wɔl, i kin afɛkt smɔl pipul dɛn, bitwin 5 ɛn 12 pan ɛvri milyɔn.
- Mɔ fɔ man dɛn pas uman dɛnDi tendency fɔ bil up na bit tumɔs.
- Dis sik kin kam pan pipul dɛm wae dɔn pas 60. De avrej ej wae dɛn kin gɛt dis sik na lɛk 64 ia.
Wetin na di sayn dɛm wae dɛn kin no?
Wan prɔblɛm wit dis sik na dat, bɔrku tɛm di sayn dɛm wae i kin gɛt kin tan lɛk ɔda sik dɛm wae kin kam pan pɔrsin. Ɛn dɛn sayn ya kin apia smɔl smɔl. So yu nɔ go notis bɔku difrɛns fɔs. Lɛ wi si wetin na dɛn sayn ya na di tebul we de dɔŋ ya.
| Di pat na di bɔdi we dɛn afɛkt | Di tin dɛn we pɔsin kin si |
|---|---|
| Hed ɛn nɛk |
|
| An ɛn fut | |
| At ɛn di lɔng dɛn | |
| Dijestiv sistɛm | |
| Kidni ɛn urinary system |
Dɛn kin si dɛn sayn ya bak pan bɔrku sik dɛm, so nɔr panik if yu gɛt amyloidosis jɔs bikɔs yu gɛt wan ɔr tu pan dɛn sik ya. Bɔt if yu gɛt pas wan pan dɛn sik ya, yu fɔ rili go to dɔktɔ fɔ advays.
Aw dɔktɔ kin no kɔrɛkt wan bɔt dis sik?
Afta yu dɔn lisin to yu sayn dɛm, if di dɔktɔ sɔspɛkt dis sik, i go du sɔm tɛst fɔ no if yu gɛt am.
Di tɛst we impɔtant pas ɔl fɔ dis na bayɔpsi . Dis min se dɛn kin tek wan rili smɔl pat pan di tisu ɔ ɔgan we dɛn tink se i afɛkt ɛn chɛk am ɔnda maykroskɔp. dis de mek wi si εksakכt if di amyloid protin de. Dɛn kin du bayɔpsi tɛst fɔ:
- Bon mכro bayopsi: dεn kin tek sכm sכm sεmpl frכm di bon mכro insay wan bon.
- Kidni bayɔpsi: Dɛn kin tek sɔm rili smɔl smɔl tisu dɛn frɔm di kidni.
- Hat biopsy: Dɛn kin tek sɔm smɔl smɔl pat dɛn na di at mɔsul.
- di bכdi fεt pad bayopsi: dεn kin tek sכm sכm tisu frכm di fεt layεr כnda di bכdi in skin.
Ɔda tɛst dɛn we dɛn kin du
Apat frɔm dis, dɛn de du mɔ tɛst fɔ no ɔmɔs damej dɔn apin to yu ɔgan dɛn.
- Blɔd tɛst: Dɛn tin ya kin ɛp fɔ si aw di kidni, at, ɛn liva de wok, ɛn fɔ no di layt chen prɔtin we de insay di blɔd.
- Yurin tɛst: Dɛn kin tɛst wan urine sɛmpul, we dɛn kin gɛda fɔ 24 awa, fɔ si if ɛnitin dɔn pwɛl di kidni dɛn.
- ECG (Electrocardiogram): I de mכsu di ilektrikal aktiviti we di at de du.
- Echocardiogram: Na ɔltra saund skan fɔ di at. Dis kin luk pan tin dεm lεk aw di at de muv εn di sayz.
- Cardiac MRI: Dɛn kin du dis tɛst fɔ gɛt wan rili klia, ditayli pikchɔ bɔt di at.
Wetin na di tritmɛnt dɛm fɔ dis?
difrεn men gol dεm de fכ trit AL amyloidosis. Wan pan dɛn na fɔ kɔntrol di sayn dɛn we pɔsin kin gɛt. Di ɔda wan na fɔ manej di ɔgan dɛn we de pwɛl. Ɛn di tin we impɔtant pas ɔl na fɔ stɔp di protin we nɔ de wok .
Bɔku tɛm, dɔktɔ dɛn kin yuz mɛrɛsin dɛn lɛk kemotɛrapi , imyunotɛrapi , ɔ stɛroyd fɔ pwɛl di plasma sɛl dɛn we nɔ fayn, we kin stɔp fɔ mek nyu layt chen protin dɛn.
Impɔtant tin na dat, pan ɔl we dɛn tritmɛnt ya kin stɔp di sik fɔ wɔs, dɛn nɔ kin pul di amyloid fibrils we dɔn ɔlrɛdi de na di ɔgan dɛn. we dεn bigin fכ trit, wi כwn imyun sistεm de bigin fכ pul dεn protin dεm ya we dεn dכn put.
Sɔntɛnde, i kin dipen pan di sikman in kɔndishɔn , dɛn kin advays fɔ transplant bon mɛrɔ ɔ stem sɛl . Na di dɔktɔ we de trit yu kin disayd ɔl dis.
Aw lɔŋ yu kin liv wit dis sik?
Dis na prɔblɛm fɔ bɔku pipul dɛn. Infakt, nyu tritmɛnt dɛn naw dɔn rili inkrisayz di layf we pipul dɛn we gɛt AL amyloidosis de liv. Fɔ sɔm pipul dɛn, i dɔn bi wan sik we nɔ de mɛn ɛn dɛn kin ebul fɔ kɔntrol am wit mɛrɛsin.
Bɔt wi nɔ fɔ fɔgɛt se dis na sik we rili siriɔs. Bɔrku tin kin sho aw di sikman in sik go bi tumara bambay, lɛk aw di ɔgan dɛn kin pwɛl we dɛn no se i gɛt di sik, ɛn aw di bɔdi kin du tin we i gɛt tritmɛnt.
Yu dɔktɔ kin gi yu di bɛst infɔmeshɔn bɔt yu sik, di tin dɛn we go kɔmɔt frɔm yu tritmɛnt, ɛn yu tumara bambay. So nɔ fred fɔ aks am ɛni kwɛstyɔn we yu gɛt.
Yu tink se dɛn go ebul fɔ avɔyd di sik? Aw a go tek kia ɔf misɛf?
כnכfכs, AL amyloidosis nכto sik we wi kin prεvεnt. Na wan random mutation we de na wan plasma sɛl kin mek i apin. Bɔt we dɛn dɔn no di sik, sɔm tin dɛn de we yu kin du fɔ kia fɔ yusɛf.
- Gud it: Sɔm tritmɛnt dɛn kin mek yu nɔ want fɔ it. Bɔt gud it impɔtant fɔ mek yu bɔdi strɔng. Tɔk to yu dɔktɔ bɔt aw fɔ it we fayn fɔ yu.
- Gɛt inof rɛst: Gi yu bɔdi tɛm fɔ wɛl. Gɛt inof slip ɛn rɛst.
- Fɔ ɛksesaiz we fit fɔ du am:Ɛksesaiz fayn fɔ di maynd ɛn bak fɔ di bɔdi. Bɔt aks yu dɔktɔ us ɛgzampul dɛn we nɔ bad ɛn we fayn fɔ yu bɔdi.
- Saikɔlɔjik sɔpɔt: Wae yu gɛt wan sik wae nɔr kin bɔrku lɛk dis, yu kin fil lɛk yu wae yu de fil ɛn yu de fa frɔm ɔda pipul dɛm bikɔs ɔda pipul dɛm nɔr ɔndastand. Dat na nɔmal tin. Aks yu dɔktɔ bɔt sɔpɔt grup fɔ pipul dɛm wae gɛt dis sik. We yu tɛl ɔda pipul dɛn bɔt yu ɛkspiriɛns dɛn, dat kin mek yu gɛt bɔku trɛnk.
Pan ɔl we AL amyloidosis na siriɔs sik, i pɔsibul fɔ manej ɛn liv wit di kɔndishɔn bay we yu no am kwik, gɛt di rayt tritmɛnt, ɛn tek kia ɔf yusɛf gud gud wan.
Mɛsej we dɛn kin kɛr go na os
- AL amyloidosis na sik we nכ kin apin we dεn kin kכz fכ dipכzishכn fכ abnכmal protin dεm (layt chen dεm) we di plasma sεl dεm na di bon mכro insay כgan dεm de prodyuz.
- Dis kin mɔs afɛkt di at ɛn kidni, bɔt i kin afɛkt ɛni ɔda ɔgan na di bɔdi.
- Bikɔs di sayn dɛm lɛk fɔ taya, fɔ swel in leg, ɛn fɔ blo shɔt kin tan lɛk ɔda sik dɛm, i impɔtant fɔ go to dɔktɔ if dɛn kɔntinyu fɔ de fɔ lɔng tɛm.
- Bayɔpsi impɔtant fɔ no di sik kɔrɛkt wan.
- di men gol fכ tritmεnt na fכ stכp di prodyushכn fכ abnכmal protin dεm tru tritmεnt lεk kεmothεrapi.
- E fayn fɔ tɔk to yu dɔktɔ opin wan bɔt aw yu sik ɛn aw fɔ trit yu.
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