Hereditary risk of colon cancer (HNPCC) - lɛ wi tɔk bɔt dis

Yu dɔn yɛri se sɔm pipul dɛn na yu famili dɔn gɛt kansa na dɛn kɔlɔ, mɔ bifo dɛn ol 50 ia? Ɔ yu tink se uman dɛn na yu famili gɛt bɔku kansa na yu bɛlɛ? Na nɔmal tin fɔ fil smɔl fɔ fred ɛn wɔri we wi yɛri tin lɛk dis. Bɔt i impɔtant pas fɔ fred fɔ no bɔt dis. Tide wi go tɔk bɔt wan spɛshal kansa risk kɔndishɔn we dɛn kin pas frɔm wan jɛnɛreshɔn to jɛnɛreshɔn. Wi de kɔl dis HNPCC.

Wetin na HNPCC rili?

Fɔ tɔk am simpul wan, HNPCC na akɔdin fɔ Hɛridit Nɔnpɔlipɔsis Kɔlorɛktal Kansa . Insay Sinhala, i min sɔntin lɛk "Hɛritɛri Nɔnpɔlipɔsis Kɔlɔrektal Kansa." Bɔt dɛn wɔd dɛn de rili kɔmplikt, nɔto so? So mek wi jos memba am as HNPCC.

dis na kεnsar risk we wi kin gεt frכm jεnereshכn to jεnereshכn bikoz fכ sכm chenj dεm (mכtεshכn) na wi jin dεm. Dis kin mɔs afɛkt di big intestinal, we na di las pat pan yu intestin. Bɔt di nem "Nɔn-pɔlipɔsis" min "nɔ-pɔlipɔsis". di rizin fכ dis na dat, כltεm, sכm sכm growth dεm we dεn kכl "polyps" de fכm na di intestin bifo kכlon kεnsar de divεlכp. Bɔt pɔsin we gɛt HNPCC nɔ kin gɛt bɔku bɔku pan dɛn kayn polip ya, bɔt i kin gɛt bɔku kansa.

So na Lynch syndrome na HNPCC bak?

Yɛs, bɔku tɛm dɛn kin yuz dɛn tu nem ya fɔ di sem sik. Bɔt smɔl difrɛns de pan tɛknik. Lynch syndrome na di jenɛtik kɔndishɔn we de mek i gɛt am. Dat min se if pɔsin gɛt jin muteshon we gɛt fɔ du wit Lynch syndrome, i gɛt ay risk fɔ gɛt wan kansa kɔndishɔn we dɛn kɔl HNPCC.

Jɛnɛral wan, if pɔsin we nɔ rich 50 ia yet gɛt kansa we gɛt fɔ du wit Linch sindrom, lɛk kɔlon kansa, ɛndometrial kansa, smɔl intestin kansa, ɔ ureteral kansa, dɛn kin se di famili gɛt wan sik we dɛn kɔl HNPCC. Dɛn kansa ya kin apin mɔ na di rayt say na di big intestinal.

Aw dis sik kin kɔmɔn? Wetin na di sayn dɛm we de sho se yu gɛt dis sik?

HNPCC de mek 2% to 4% pan ɔl di kɔlɔrɛktal kansa dɛn ɔlsay na di wɔl. dis min se lεk 2 to 4 pan εvri 100 kכlכrektal kεnsar dεm na dis jεnεtik fכktכ de kכz dεm. Pan ɔl we i kin afɛkt ɛnibɔdi, bɔku tɛm dɛn kin no am pan pipul dɛn we nɔ rich 50 ia yet.

Na di fɔs stej, bɔku tɛm HNPCC nɔ kin kɔz ɛni sayn. Dat na di pat we de mek pɔsin fred pas ɔl. Bɔt as di kansa de big, yu kin bigin fɔ gɛt sayn dɛn lɛk dis.

Wetin mek HNPCC de divɛlɔp? Yu tink se i kin pas?

Di men rizin fɔ dis na wi jin dɛn. Imajin se wi bɔdi tan lɛk big buk, ɛn jin na di instrɔkshɔn dɛn we dɛn rayt insay da buk de. Ɛvri sɛl na wi bɔdi de wok akɔdin to dɛn instrɔkshɔn ya. Sɔntɛnde, spɛlin mistek (muteshɔn) kin de na dɛn instrɔkshɔn ya.

Nɔmal wan wi bɔdi kin gɛt spɛshal jin dɛn we kin no ɛn kɔrɛkt dɛn mistek ya. Lɛk pɔsin we de pruf wan buk. Insay Lynch sindrom, dɛn tin ya na MLH1, MSH2, MSH6, PMS2, ɛn EPCAM.we dεn jin dεm ya we dεn kכl "kכrekt" de fכm, dεn nכ de ebul fכ kכrekt כda mistek dεm we di sεl dεm de sheb. As tɛm de go, dɛn sɛl ya we nɔ fayn kin gɛda ɛn bi kansa sɛl.

Dis nɔto sik we pɔsin kin pas. Yu nɔ go ebul fɔ kech am bay we yu it it ɔ yu de wit pɔsin we gɛt HNPCC. Bɔt di jin we de mek i chenj kin pas frɔm wan jɛnɛreshɔn to ɔda jɛnɛreshɔn. Imajin se di mama ɔ di papa gɛt dis jin we de chenj. Dɔn 50% chans de fɔ mek wan pan dɛn pikin dɛn gɛt da jin de. Dat min se if tu pikin dɛn de, wan pan dɛn kin gɛt dis risk jin. Na dat mek bɔku pipul dɛn na dɛn kayn famili dɛn de kin gɛt kansa.

Aw dɔktɔ kin no se i gɛt HNPCC?

We yu go to dɔktɔ wit di sayn dɛm we yu bin dɔn tɔk bɔt, di fɔs tin we i go du na fɔ tek tɛm lisin to yu sayn dɛm ɛn du yu bɔdi ɛgzam. Dɔn, dɛn go aks bɔku kwɛstyɔn bɔt yu famili in mɛdikal istri .

• "Yu mama, papa, brɔda ɛn sista dɛn dɔn gɛt kansa?"
• "If na so, wich kain kansa i bi? Na wich ej i de divelop?"
• "Aw many pipul fo yu famili don get kansa?"

Dɛn kwɛstyɔn ya rili impɔtant bikɔs if sɔm famili mɛmba dɛn dɔn gɛt kansa na dɛn kɔlon ɔ uterin, mɔ we dɛn yɔŋ, di dɔktɔ kin sɔprayz se HNPCC de.

Neks, di men tɛst fɔ no if yu gɛt kansa na yu kɔlon na we yu de du kɔlon skɔpi . Dis min se yu fɔ chɛk yu wan ol kɔlon yuz wan tiub we gɛt smɔl kamɛra we dɛn tay. If dɛn fɛn ɛnitin we dɛn nɔ biliv, dɛn kin tek wan smɔl tisu ɛn sɛn am na lab fɔ mek dɛn tɛst am (bayopsi).

Fɔ kɔnfɔm HNPCC stetɔs, dɛn nid fɔ du sɔm spɛshal tɛst dɛn:

1. Jɛnɛtik Tɛst: Dɛn kin tek wan sɛmpul pan yu blɔd ɛn tɛst fɔ si if di jɛnɛtik chenj dɛn we gɛt fɔ du wit Lynch sindrom.

2. tכmכro tisu tεst: if kεnsar de, dεn de tεst di kεnsar sεl dεm fכ spεsifi k mak dεm we riliyt to HNPCC.

3. Fכ pul כda kכndyushכn dεm: כda kכndyushכn de we dεn kin gεt fכ bכn we dεn kכl Familial Adenomatous Polyposis (FAP) . insay FAP, כndrεd כ tawzin polip dεm de divεlכp na di kכlon. Dis nɔ kin apin na HNPCC. So, yu dɔktɔ go chɛk fɔ si uswan pan dɛn tu tin ya yu gɛt.

Wetin na di tritmɛnt dɛm fɔ HNPCC?

If di kɔlon kansa kam bikɔs ɔf HNPCC, di men tritmɛnt na ɔpreshɔn fɔ pul di kansa ɛn di tisu we de rawnd am. Dɛn kɔl dis ɔpreshɔn kɔlektɔmi . Dɛn kin du am difrɛn we dɛn.

• Patɛl Kɔlektɔmi: Na di pat pan di kɔlon nɔmɔ usay di kansa de, dɛn kin pul am.
• Tɔtɔl Kɔlektɔmi: .Dɛn kin pul di wan ol kɔlon. Bɔku tɛm dɛn kin se dɛn fɔ du dis ɔpreshɔn fɔ pɔsin we gɛt HNPCC fɔ ridyus di risk fɔ gɛt ɔda kansa tumara bambay.
• Proktεktomi: dεn de pul di rεktum wit di big intestin.

Ɔda tritmɛnt dɛn

If di kansa dɔn skata (metastasized) to ɔda pat dɛn na di bɔdi, dɛn kin nid ɔda tritmɛnt dɛn apat frɔm ɔpreshɔn.

• Kimotɛrapi: Fɔ gi pawaful mɛrɛsin fɔ pwɛl di kansa sɛl dɛn.
• Immunotherapy: I de mek wi bɔdi in yon imyun sistɛm fɔ fɛt di kansa sɛl dɛn. Bɔku tɛm dis tritmɛnt kin wok fayn fɔ di kansa dɛn we HNPCC kin mek.

Tin dɛm we pɔsin we de liv wit HNPCC fɔ no

If dɛn no se yu gɛt HNPCC, dat min se yu de pan ay risk pas di avɛrej pɔsin fɔ gɛt nɔto jɔs kansa na yu bɔdi, bɔt yu gɛt sɔm ɔda kayn kansa dɛn bak. So, fɔ de chɛk yu dɔktɔ ɔltɛm fɔ bi pat pan yu layf.

Yu dɔktɔ kin advays yu fɔ de chɛk yu ɔltɛm fɔ dɛn kansa ya:

• Uterus we de na di bɛlɛ
• Ovarian
• Bɛlɛ
• Kidni ɛn urinary sistɛm
• Bren
• Kanda

Dis kin tan lɛk se i de mek pɔsin fred. Bɔt di bɛst tin we de ya na fɔ no am kwik kwik wan . If dɛn de chɛk am ɔltɛm, ivin if kansa bigin fɔ kam, dɛn kin kech am kwik kwik wan. Dɔn di chans fɔ mek dɛn trit am ɛn wɛl ɔltogɛda kin bɔku pasmak.

Lynch syndrome nɔ go ebul fɔ mɛn, bikɔs na sɔntin we de insay wi jin. Bɔt dɛn kin mɛn di kansa dɛn we HNPCC kin mek. Ɔpreshɔn lɛk fɔ pul ɔl di kɔlektɔmi kin mek bak nɔ gɛt kansa na di kɔlon.

Aw a go ebul fɔ kɔntrol mi risk?

If yu gɛt famili histri bɔt HNPCC ɔ Lynch syndrome, di fɔs tin we yu fɔ du na fɔ tɔk to yu dɔktɔ bɔt am. Na in go disayd if yu nid fɔ du yu jenɛtik tɛst.

If dɛn kɔnfyus se yu gɛt di Lynch syndrome jin muteshon, yu dɔktɔ go mɔs advays yu fɔ bigin fɔ chɛk fɔ kɔlon kansa, lɛk kɔlon skɔpi, we yu ol 20 ia.

Apat frɔm dat, yu kin ridyus di risk fɔ gɛt kansa mɔ bay we yu de liv fayn layf:

• Nɔ smok kpatakpata.
• It fayn it we gɛt fayn fayn tin dɛn fɔ it (inklud mɔ vɛjitebul, frut, ɛn it dɛn we gɛt fayv).
• Ɛksesaiz ɔltɛm.
• Limit fɔ drink rɔm.
• Mek yu gɛt wɛlbɔdi bɔdi wet.
• Mek dɛn du ɔl di tɛst dɛn we di dɔktɔ tɛl yu fɔ du di rayt tɛm.