Yu gɛt siriɔs pwɛl hat sik bak, ɔr lɛk aw wi kin kɔl am pan mɛrɛsin, Major Depressive Disorder (MDD)? Ivin afta yu dɔn yuz wan ɔ tu mɛrɛsin we di dɔktɔ gi yu, yu stil nɔ de fil ɛni impɔtant tin ɔ chenj? "Wetin a de du naw?" Sɔntɛm yu de tink wit big pwɛl at. I rili nɔmal fɔ fil se yu de yu wan ɛn nɔ ebul fɔ du natin pan tɛm lɛk dis. Bɔt nɔ fred. Nɔto yu wan de. As sayɛns de go bifo, nyu op dɛn de kam bak. Tide wi de tɔk bɔt dis kayn nyu op.
Fɔs, lɛ wi mɛmba yu smɔl bɔt di kɔmɔn mɛrɛsin dɛn we dɛn kin gi yu fɔ mek yu nɔ fil bad.
If yu dɔn bigin fɔ trit yu pwɛl hat, yu dɔktɔ go dɔn gi yu wan kayn mɛrɛsin fɔs we dɛn kɔl ‘traditional antidepressant.’ Bɔku men kayn dɛn de. Dɛn mɛrɛsin ya kin wok bay we dɛn de balans di wok we di kemikal mɛsenja dɛn na di bren, we dɛn kɔl nyurotransmitta , de du, we kin afɛkt di we aw wi de fil ɛn aw wi de fil. Dɛn tin ya na sɛrotonin , norepinephrine , ɛn dopamin .
Bɔt sɔm prɔblɛm dɛn de wit dɛn mɛrɛsin ya. Wan na dat dɛn kin tek sɔm tɛm fɔ bigin fɔ wok. Bɔku tɛm yu kin wet fɔ lɛk 4 to et wiks fɔ si di rizɔlt. Wan ɔda wan na dat, dɛn mɛrɛsin ya nɔ de wok di sem fɔ ɔlman. Stɔdi dɔn sho se lɛk tu pan ɛvri tri pipul dɛn we de yuz dɛn nɔ kin wɛl ful wan .
Fɔ mek i izi fɔ yu fɔ ɔndastand, lɛ wi luk sɔm pan di mɛrɛsin dɛn we dɛn kin yuz mɔ na tebul lɛk dis.
| Drug Klas we dɛn de yuz | Kɔmɔn Ɛgzampul dɛn |
|---|---|
| SSRI dɛn (Sɛlektiv Sɛrotonin Riuptek Inhibitɔ dɛn) . | Sitalopram, Essitalopram, Fluoxetin, Paroxetin, Sɛtralin |
| SNRI dɛn (Serotonin-Norepinephrine Riuptek Inhibitɔ dɛn) . | Duloxetin, Venlafaksin, we dɛn kɔl Venlafaxine |
| Atypical Antidipreshɔn dɛn | Bupropion, Mirtazapin, Trazodɔn, ɛn ɔda pipul dɛn |
If yu dɔn tray wan ɔr mɔ pan dɛn mɛrɛsin ya ɛn stil nɔr de fil fayn, nɔr wɔri. Nɔto yu fɔlt. Na tɛm lɛk dɛn tɛm ya, dɔktɔ dɛn kin tink bɔt nyu tritmɛnt dɛn we dɔn go bifo.
So wetin na dɛn nyu NMDA tritmɛnt ya?
Fɔ tɔk am simpul wan, dis na difrɛn we fɔ trit pwɛl hat. Dis tritmεnt nכ lεk di mεdikeshכn dεm we bin de bifo, de tכk bכt di rεsεpכta dεm na di bren we dεn kכl N-methyl-D-aspartate (NMDA) .
Tink bɔt am dis we. pan pɔrsin wae gɛt big pwɛl hat sik, sɔm impɔtant pat dɛm na in bren kin nɔr de woke smɔl, lɛk wae dɛn de ‘slip’ (underactive). wetin NMDA tritmεnt dεn de du na fכ kכntrכl di akshכn fכ כda pawaful nyurotransmitta we dεn kכl glutamate , εn strכng di kכnektiviti bitwin dεn ‘slip’ bren sεl dεm (nyuron dεm). Dat min se dɛn kin mek di mɛsej dɛn we de bitwin di bren sɛl dɛn chenj kwik kwik wan .
Masta sabi bukman dɛn biliv se dis wek we di kɔnekshɔn bitwin di bren sɛl dɛn kin wek wantɛm wantɛm, na in kin mek di sayn dɛn we de sho se pɔsin gɛt pwɛl at kin ridyus kwik kwik wan we kin mek i sɔprayz.
Di big bɛnifit fɔ dis na fɔ spid. Pan ɔl we kɔmɔn mɛrɛsin kin tek sɔm wiks fɔ wok, sɔm NMDA tritmɛnt dɛn kin bigin fɔ gi bɔku rilif ɛn chenj to di pɔsin insay sɔm awa .
Wetin na di tritmɛnt dɛm wae de tɔch NMDA? Ɛni risk dɛn de we kin apin?
Kεtamin na wan ki dכg we dεn kin yus fכ trit diprεshכn we de rεsistεnt tritmεnt bay we dεn de tכk bכt di NMDA rεsεpכta dεm.
Dɛn kin gi dis to di pɔsin tru wan vein (intravenous ɔ IV) wit salin . Bɔt sɔntin de we yu rili nid fɔ mɛmba na ya.
Dis nɔto di fɔs tritmɛnt we dɔktɔ go tɛl pɔsin fɔ gɛt pwɛl at.
Dɛn kin yuse dɛn tin ya fɔ pipul dɛm wae gɛt siriɔs pwɛl hat sik wae dɔn tray ɔl ɔda tin dɛm wae dɛn kin du ɛn nɔr dɔn gɛt ɛni sakrifays. Dɔn bak, dɛn kin rili du dis tritmɛnt na ɔspitul, ɛn spɛshal dɔktɔ dɛn ɛn pipul dɛn we dɛn dɔn tren kin wach dɛn gud gud wan . Dis nɔto mɛrɛsin we pɔsin kin bay na famasi ɛn kɛr am go na os.
Wetin mek yu de du dat? Bikɔs lɛk ɔl di mɛrɛsin dɛn, sɔm kayn bad bad tin dɛn de we kin apin to pɔsin. We yu de trit yu, yu kin gɛt chenj na yu blɔd prɛshɔn, yu kin gɛt diziz, yu kin gɛt nɔys, ɛn sɔntɛnde yu kin lɛf smɔl fɔ lɛ yu nɔr de wit di rial tin. Medikal supavayshɔn impɔtant fɔ mek dɛn ebul fɔ manej ɔl dis.
Aw a go no if a fit fɔ gɛt dis tritmɛnt?
Dis na di kwɛstyɔn we impɔtant pas ɔl. Na di dɔktɔ we de trit yu nɔmɔ go ebul fɔ no di ansa to dis. If yu na gud kandidet fɔ advans tritmɛnt lɛk NMDA tɛrapi go dipen pan sɔm tin dɛn:
- Us kayn mɛrɛsin wae yu dɔn yuse bifo?
- Aw lɔng dɛn bin yuz dɛn, ɛn di rayt doz?
- Aw yu bɔdi bin de du dɛn?
- De kayn pwɛl hat sik wae de kam naw.
- Yu ɔl yu wɛl bɔdi (ɔda sik dɛm, ɔda mɛrɛsin dɛm wae yu de tek, ɛn ɔda tin dɛm).
So, di bɛst tin we yu go du na fɔ tɔk opin wan wit yu dɔktɔ bɔt ɔltin we de na yu maynd. Nɔ fred fɔ aks kwɛstyɔn dɛn lɛk, "Dɔkta, a dɔn de tek dis mɛrɛsin fɔ mɔnt naw, bɔt a stil nɔ notis ɛni difrɛns," ɔ "No ɔda we nɔ de fɔ mek a ebul fɔ pas dis?" Di mɔ yu de tɔk bɔt aw yu de fil ɛn ɛkspiriɛns, na di mɔ i go izi fɔ yu dɔktɔ fɔ pik di bɛst tritmɛnt fɔ yu.
Mɛsej we dɛn kin kɛr go na os
- Major depression disorder (MDD) na siriɔs sik wae nid fɔ gɛt tritmɛnt. Kɔmɔn antidipreshan (SSRI, SNRI) nɔr de woke fayn fɔ ɔlman.
- Fɔ di wan dɛn we nɔ de ansa to kɔmɔn mɛrɛsin, naw dɛn gɛt mɔdan tritmɛnt dɛn lɛk Ketamine, we de tɔch di NMDA riseptɔ dɛn.
- Dɛn tin ya kin afɛkt di glutamate na di bren, i kin mek di kɔnekshɔn bitwin di bren sɛl dɛn strɔng kwik kwik wan, ɛn i kin mek i wɛl kwik kwik wan.
- Dɛn tritmɛnt ya na spɛshal tritmɛnt, ɛn dɛn kin gi dɛn to pasɛnt dɛn nɔmɔ we nɔ ebul fɔ du ɔda tritmɛnt, ɔnda strikt mɛdikal sɔpɔtishɔn na ɔspitul.
- If yu nɔr de gɛt rilif frɔm di tritmɛnt dɛm wae yu de gi yu naw, nɔr giv ɔp ɛn tɔk opin wan wit yu dɔktɔ bɔt ɔl di opshɔn dɛm.
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