Yu de wɔri bɔt blɔd we de klɔt? Yu kin wɔri bɔt yu at atak ɔr strok. Fɔ pipul dɛm wae de pan denja, dɔktɔ kin gi dɛn wan kayn mɛrɛsin wae dɛn kɔl "blɔd thinner." So tide wi go tɔk bɔt wan nyu, bɔt rili impɔtant, klas fɔ mɛrɛsin. Dat na Dairekt Thrombin Inhibitors.
Fɔ tɔk am simpul wan, wetin na dɛn Dairekt Thrombin Inhibitors ya?
Na dɛn tin ya wi kin kɔl mɛrɛsin dɛn we de mek blɔd tan, ɔ antikɔagulant we wi de tɔk bɔt mɛrɛsin. Dɛn wok na fɔ stɔp di blɔd we nɔ nid fɔ klɔt na di bɔdi. Jɔs tink bɔt dat, bɔku pipul dɛn na di wɔl kin day bikɔs dɛn gɛt at sik. So dɛn kayn mɛrɛsin ya kin rili ɛp fɔ mek di blɔd nɔ klɔg di blɔd vesel dɛn we de gi impɔtant ɔgan dɛn lɛk di at ɛn di bren.
Pan ɔl we trade, dɛn bin de yuz tin dɛn we fiba wan prɔtin we de na di saliva fɔ lich, dɛn de mek dɛn mɛrɛsin ya, naw dɛn de yuz di mɛrɛsin dɛn we dɛn de mek na lɛbɔretri dɛn tide.
Us kɔndishɔn dɛn kin yuz dis mɛrɛsin fɔ?
Dɔktɔ dɛn kin se dɛn fɔ tek dis kayn mɛrɛsin, we dɛn kɔl dairekt thrombin inhibitor, fɔ mek dɛn nɔ gɛt ɛn kɔntrol bɔku tin dɛn. Lɛ wi luk wan tebul lɛk dis fɔ mek i izi fɔ ɔndastand dis infɔmeshɔn.
| Kɔndishɔn | Simpul ɛksplen |
|---|---|
| Akyu Koronari Sindrom we pɔsin kin gɛt | Di blɔd we de flɔ we de go dɔŋ ɔ stɔp wantɛm wantɛm bikɔs wan vein we de kɛr blɔd go na di at dɔn blok. |
| Thrombocytopenia we di hεparin indyuz (HIT) . | Wan kɔmpleks kɔndishɔn we di ɛparin we de mek di blɔd tan kin mek di pletlɛt dɛn go dɔŋ, ɛn dis kin mek di blɔd klɔt. |
| Venɔs Tromboɛmbolizm (VTE) . | Blɔd klɔt kin fɔm ɛn stɔp insay wan vein na di bɔdi. |
| Struk Prɛvenshɔn na Atrial Fibrilɛshɔn (Afib) . | Prɛvɛnt strok pan pasɛnt dɛn we nɔ gɛt at valv prɔblɛm bɔt we gɛt at bit we nɔ de bit ɔltɛm (Afib). |
| Afta dɛn dɔn du ɔpreshɔn fɔ riples di hip | Ridyus di risk fɔ mek blɔd klɔt na di leg dɛn afta dɛn dɔn ɔpreshɔn. |
| Dip Vein Trombosis (DVT) we de mek pɔsin gɛt sik . | Blɔd we de klɔt, mɔ na dip vein na di leg dɛn. |
| Pɔlmonari Ɛmbolizm | Wan blɔd we de na di leg kin brok ɛn i kin lod insay wan vein we de na di lɔng dɛn. |
pan tap dat, dεn kin gi dis mεdikeshכn bak as injεkshכn we dεn de trit dεm lεk angioplasty, we de opin di at dεm na di at.
Aw dis mɛrɛsin de wok insay di bɔdi?
Dis na tin we rili simpul fɔ ɔndastand. Bɔku tin dɛn de we kin mek di blɔd klɔt na wi bɔdi. Pan dɛn , "Thrombin" tan lɛk di chif injinia fɔ wan faktri we de mek blɔd klot. Na in de gi ɔda lɔ fɔ mek di blɔd klɔt.
So wetin dis Dairekt Thrombin Inhibitor de du na dat i de tay dairekt to da tin we dεn kכl thrombin εn stכp am fכ du in wok. I tan lɛk se pɔsin de jomp bifo pɔsin we de mek blɔd klot ɛn ambɔg dɛn wok. we di trombin stכp fכ wok, di כl prכsεs we de mek di bכdi kכlכt de stכp.
Bɔt sɔntɛnde dis mɛrɛsin kin mek pɔsin blɔd pasmak. If na so i bi, wan injɛkshɔn de we dɛn kɔl Idarucizumab fɔ rivɛns di ifɛkt dɛn we di pil we dɛn kɔl Dabigatran . Bɔt no patikyula mɛrɛsin nɔ de fɔ di mɛrɛsin dɛn we dɛn kin put insay di bɛlɛ (IV). Bɔt we dɛn dɔn stɔp di mɛrɛsin, di tin dɛn we i kin du kin west na di bɔdi as tɛm de go.
Wetin na di bɛnifit dɛn we dis mɛrɛsin de gi?
If yu kɔmpia am to ol blɔd tin dɛn, dis nyu kayn mɛrɛsin gɛt bɔku bɛnifit dɛn.
- Di rizulyt dɛn na mɔ spɛshal wan:Bikɔs dis drɔg kin jɔs tay pan trombin, di tin dɛn we kin kɔmɔt frɔm am kin kɔnsistɛns. Dis min se yu kin ɛkspɛkt di sem rizɔlt ɛvri tɛm we yu tek di sem doz. Yu nɔ nid fɔ chenj di doz ɔltɛm lɛk aw yu go chenj wit warfarin.
- I nɔ de ridyus di blɔd pletlɛt: Dɛn tin ya nɔ de ridyus di blɔd pletlɛt lɛk sɔm mɛrɛsin dɛn.
- Nɔ nid fɔ du blɔd tɛst ɔltɛm: We yu de tek Warfarin, yu nid fɔ du blɔd tɛst ɔltɛm fɔ chɛk yu blɔd klɔt rit (INR tɛst). Bɔt dis mɛrɛsin nɔ nid dat.
- Lɔw risk ɛn kɔvinant: Dabigatran, we dɛn tek as pil, gɛt smɔl risk fɔ blɔd we yu kɔmpia am wit Warfarin. I nɔ gɛt bɛtɛ intarakshɔn bak wit ɔda mɛrɛsin dɛn. I rili fayn bak fɔ yuz bikɔs yu kin tek am wan ɔ tu tɛm insay di de.
- Wan gud ɔda we fɔ du am: Dis na fayn ɔda we fɔ di wan dɛn we nɔ ebul fɔ tek di mɛrɛsin we dɛn kɔl Heparin.
Aw dis mɛrɛsin de wok? Ɛni risk de?
Risach dɔn sho se dis mɛrɛsin sef ɛn i wok lɛk Warfarin ɔ Heparin. Bɔt wan impɔtant tin de we wi fɔ no bɔt. Dis mɛrɛsin nɔ fayn fɔ pipul dɛn we gɛt mɛkanikal at valv. Yu dɔktɔ go advays yu bɔt dis.
Di big difrɛns pan dɛn mɛrɛsin ya na dat dɛn kin de na di bɔdi fɔ shɔt tɛm.
Imajin, we yu tek wan doz fɔ Warfarin, lɛk af pan am kin de na yu bɔdi fɔ 20-60 awa. Bɔt we yu tek drɔg lɛk Dabigatran, af pan am kin kɔmɔt na yu bɔdi insay 12-14 awa.
Di impɔtant tin we wi nid fɔ ɔndastand frɔm dis na dat i nɔ fayn fɔ skip wan doz fɔ mɛrɛsin fɔ ɛni rizin . If yu mis wan doz, di ifɛkt we di mɛrɛsin gɛt go west kwik, ɛn di risk fɔ mek yu gɛt blɔd klɔt kin bɔku wantɛm wantɛm.
Wetin na di sayd ɛfɛkt ɛn prɔblɛm dɛn we kin apin?
Lɛk ɛni mɛrɛsin, dɛn tin ya kin gɛt bad bad tin dɛn. Pan ɔl we sɔm na nɔmal tin, ɔda wan dɛn nid wi fɔ rili tek tɛm.
Di men ɛn denja sayd ɛfɛkt na we yu de blɔd pasmak (Bleeding complications). Apat frɔm dat, dɛn tin ya kin apin:
- Bɛlɛ nɔ kin fil fayn, inflamɛns (Dyspepsia) .
- Bɛlɛ de at
- Brawn ɔ pink urine
- Ed de at
- Lɔw blɔd prɛshɔn (Hypotension) .
- Chɛst de pen
- Diziz we pɔsin kin gɛt
- I nɔ kin izi fɔ yu fɔ blo
- Fiva
- Sepsis (na wan bad bad tin we di bɔdi kin du we i gɛt infɛkshɔn) .
- Di at we de mek di at nɔ de wok
Ustɛm a fɔ kɔl di dɔktɔ?
If yu gɛt ɛni sayd ɛfɛkt we yu de yuz dis mɛrɛsin, tɛl yu dɔktɔ wantɛm wantɛm.
Ɛspɛshali if sayn dɛn de fɔ se pɔsin de blɔd bɔku, na imejensi.Fɔ ɛgzampul, if wund nɔ stɔp fɔ blɔd, if yu stɔl blak, if yu vɔmit blɔd, ɔ if yu gɛt bad bad ed pen, go na di ɔspitul we de nia yu in Imejɛnsi Dipatmɛnt (ETU) wantɛm wantɛm. Nɔ delay.
Mɛsej we dɛn kin kɛr go na os
- Direct Thrombin Inhibitors na wan kayn mɛrɛsin we rili pawaful we de mek blɔd nɔ klɔt. Tek di doz we yu dɔktɔ tɛl yu ɔltɛm, di rayt tɛm.
- Nɔ skip wan doz fɔ mɛrɛsin fɔ ɛni rizin. We yu du dat, i kin mek yu blɔd klɔt mɔ ɛn mɔ. If yu fɔgɛt fɔ tek wan doz, aks yu dɔktɔ wantɛm wantɛm bɔt wetin fɔ du nɛks.
- Yu fɔ no di sayn dɛm we de sho se yu de blɔd bɔku (blak stɔl, yu de vɔmit blɔd, yu de blɔd ɔltɛm). If dis apin, go na di ETU wantɛm wantɛm.
- Dis mɛrɛsin nɔ fayn fɔ ɔlman (especially di wan dɛn we gɛt mɛkanikal at valv), so mek shɔ se yu tɛl yu dɔktɔ yu ful mɛdikal histri.
- We yu de du ɛni ɔda tritmɛnt (ivin fɔ pul yu tut), tɛl di dɔktɔ se yu de tek dis mɛrɛsin.
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