Yu kin tink bɔt wi bɔdi as big buk we de tich wi. wi kכl di sכm sכm instrכkshכn dεm na dis instrכkshכn buk "jin" . Dɛn jin ya de sho ɔltin na wi bɔdi, fɔ ɛgzampul, di kɔlɔ we wi yay gɛt, di we aw wi ia tan. So, sɔm tɛm dɛn kin mek smɔl mistek na wan pan di instrɔkshɔn dɛn we de na dis instrɔkshɔn buk, dat na, if dɛn chenj lɛta, i kin mek pɔsin gɛt siriɔs sik. Tide wi de tɔk bɔt wan rili advans mɛrɛsin we de kɔrɛkt dɛn kayn kɔrɛkt instrɔkshɔn ya, ɔ put nyu kɔrɛkt instrɔkshɔn insay. Dɛn kɔl dis jin tɛrapi.
Wetin na jin tɛrapi simpul wan?
Fɔ tɔk am simpul wan, jin tɛrapi na spɛshal we fɔ trit di sik dɛn we de na di jɛnɛtiks. di jin dεm na wi bכdi de gi instrכkshכn fכ mek protin dεm. If wan jin chenj ɔ i nɔ fayn, dɛn kin mek di prɔtin we i de mek di rɔŋ we ɔ dɛn kin stɔp am ɔltogɛda. Dis na wetin kin mek pipul dɛn gɛt prɔblɛm wit dɛn jɛnɛtiks.
Jin tɛrapi kin chenj di fɔlt jin we de mek di sik , ɔ gi yu sɛl dɛn nyu wok kɔpi fɔ wan jin . Bɔku tɛm, dis na tritmɛnt fɔ wan tɛm nɔmɔ. Afta dis tritmɛnt, yu bɔdi kin ebul fɔ mek di prɔtin dɛn we i nid kɔrɛkt wan, we kin mek yu nɔ gɛt di sik.
Aw dis tritmɛnt kin wok?
Tri men we dɛn de we di jin tɛrapi de wok. Lɛ wi luk di tebul we de dɔŋ fɔ ɔndastand dis klia wan.
| Di we aw dɛn kin trit am | Fɔ tɔk am simpul wan... | Wetin yu de du? |
|---|---|---|
| Jin Adishɔn | Fɔ put nyu gud jin insay. | if wan protin we nid nכ de na di bכdi bikoz fכ difεkt na wan patikyula jin, dεn de put wan kכpi fכ wan hεlty jin we kin mek da protin de insay di sεl dεm. |
| Jin Ɛditin | Fɔ kɔrɛkt di jin we nɔ fayn. | Sayɛnsman dɛm de yuz spɛshal tul dɛm lɛk CRISPR/cas9 fɔ "kɔt ɛn pas" di fɔlt jin we de mek di sik. Dɔn, da jin de kin bigin fɔ mek di kɔrɛkt prɔtin. |
| Jin Saylɛns | Fɔ ɔf di rɔng jin. | Sɔm jin dɛn nɔ de wok fayn ɛn dɛn de mek prɔtin dɛn we de ambɔg di bɔdi. Dis we ya de stɔp di wok we wan jin we de gi dɛn kayn kɔrɛkt instrɔkshɔn ya de du. Dat min se, dɛn dɔn sɛt mɔt. |
Aw yu kin put dɛn jin ya we dɛn dɔn chenj insay di bɔdi?
Okay, naw yu gɛt wan kwɛstyɔn: Aw yu kin mek dɛn modifyed jin ya kam na di bɔdi? Sayɛnsman dɛn kin pak dɛn jin ya insay sɔntin lɛk pasɛl. Dɛn kɔl dis pasɛl "vɛktɔ." Bɔku tɛm dis vektɔ na spɛshal vayrɔs we dɛn dɔn chenj.
Nɔ wɔri! Dis nɔto vayrɔs we de mek wi sik. I dɔn pul di pawa we i gɛt fɔ mek wi sik kpatakpata, ɛn bifo dat, dɛn dɔn put am wit wi wɛlbɔdi jin dɛn. lεk di dεlivεri motoka, dis kεriכn in כnli wok na fכ kכri di jin dεm εn delivεr dεm to di rayt sεl dεm.
Insay sɔm tritmɛnt dɛn, dɛn kin tek sɔm pan yu yon blɔd stem sɛl dɛn, chenj dɛn na lab, dɔn dɛn kin put dɛn bak na yu bɔdi. כda kes dεm, dεn kin gi wan kכriכ we gεt dεn jin dεm ya as injεkshכn כ as infushכn insay wan vein. As tɛm de go, di sɛl dɛn we gɛt dɛn nyu jin ya kin sheb ɛn bɔku, ɛn dɛn kin tek di sɛl dɛn we sik. So di tin dɛn we dis tritmɛnt kin du fɔ lɔng tɛm.
Us sik dɛn kin mɛn wit jin tɛrapi?
Bɔku tɛm, di jin tɛrapi kin wok fayn fɔ sik dɛn we wan jin nɔ fayn. Na sɔm pan di sik dɛm wae dɛn dɔn gri fɔ dis tritmɛnt fɔ naw:
- Sik dɛm wae kin kam wit jɛnɛtiks wae kin afɛkt di bren, lɛk Cerebral Adrenoleukodystrophy .
- Di sik dɛn we pɔsin kin gɛt frɔm in blɔd: Fɔ ɛgzampul , siklɛt sik, thalassemia, ɛn ɛmofilia .
- Di sik dɛm we pɔsin kin gɛt frɔm di nyuromɔskular: Kɔndishɔn dɛm lɛk Duchenne Muscular Dystrophy ɛn Spinal Muscular Atrophy.
- Di sik dɛn we pɔsin kin gɛt frɔm in yay: Na sik dɛn we kin afɛkt di we aw pɔsin de si, lɛk Leber’s Congenital Amaurosis.
- Ɔda jɛnɛtik sik dɛm lɛk Mɛtachromatic Leukodystrophy.
Apat frɔm dis, kansa ɛn HIVSayɛnsman dɛn stil de du risach if dɛn kin yuz jin tɛrapi fɔ sik dɛn lɛk...
Wetin na di bɛnifit ɛn bad tin dɛn we pɔsin kin gɛt we i de mɛn pipul dɛn we gɛt jin?
Lɛk ɛni tritmɛnt, jin tɛrapi gɛt in bɛnifit dɛn ɛn sɔm risk ɛn bad tin dɛn bak. I impɔtant fɔ no bɔt dɛn tin ya.
| Di gud tin dɛn we pɔsin kin du | Di bad tin dɛn ɛn di tin dɛn we nɔ izi fɔ du |
|---|---|
| Nyu Op: De gi nyu tritmɛnt opshɔn fɔ bɔku sik dɛn we ɔda tritmɛnt opshɔn nɔ de fɔ. | I nɔ izi fɔ gɛt: Bikɔs ɔf di ay kɔst ɛn di limiteshɔn fɔ di teknɔlɔji, nɔto ɔlman kin gɛt dis tritmɛnt. |
| I izi fɔ yu: Bɔku pan di jin tritmɛnt dɛn na tritmɛnt dɛn we dɛn kin du wan tɛm nɔmɔ insay yu layf. Yu nɔ nid fɔ tek mɛrɛsin ɛvride. | Sayd ɛfɛkt: Jɔs lɛk ɔl tritmɛnt, risk de fɔ gɛt sayd ɛfɛkt. fכ egzampl, di bכdi in imyun sistεm kin riak to di jin kכriכ (vayrus). |
| Tritmɛnt kwik: If dɛn kin gɛt dis tritmɛnt bifo di sik mek di bɔdi pwɛl bad bad wan, dɛn kin ebul fɔ avɔyd da damej de. | Di we aw dɛn kin pripia: Sɔm jin tritmɛnt dɛn kin nid ɔda tritmɛnt, lɛk kemotɛrapi, bifo dɛn trit am, we kin mek pɔsin gɛt bad bad sayd ɛfɛkt. |
| Fɔ trit di rut fɔ di sik: Bifo wi jɔs trit di sayn dɛm, wi kin trit di ɔndalayn kɔz fɔ di sik, we na di jenɛtik dɛfɛkt insɛf. | I stil na nyu wok: Pan ɔl we dɛn dɔn de du risach fɔ dis fɔ bɔku bɔku ia, di we aw dɛn de yuz am fɔ mɛn pipul dɛn stil na nyu tin. Bɔku tin stil de fɔ lan. |
Jɛnɛral tritmɛnt gɛt big prɔmis fɔ pipul dɛm wae gɛt jɛnɛtik sik. I kin trit di rut fɔ wan sik, pas fɔ jɔs trit di sayn dɛm. Pan ɔl we dis stil na fild we de kam, i gɛt di potenshal fɔ gi layf-chenj rizulyt fɔ di pasɛnt dɛn we nɔ bin gɛt bɛtɛ tritmɛnt opshɔn dɛn trade. If yu ɔ sɔmbɔdi na yu famili gɛt wan sik we de kɔmɔt frɔm yu jɛnɛtiks, i go fayn fɔ mek yu tɔk to yu dɔktɔ bɔt dis ɛn lan mɔ.
Mɛsej we dɛn kin kɛr go na os
- Jin tɛrapi na wan advans tritmɛnt we de kɔrɛkt di ɔndalayn jenɛtik dɛfɛkt we de mek sɔm jɛnɛtik sik dɛn.
- Dis kin kɔrɛkt wan jin we nɔ fayn ɔ put kɔpi fɔ wan wɛlbɔdi jin insay di bɔdi.
- Pan ɔl we bɔku tɛm dis na tritmɛnt fɔ wan tɛm nɔmɔ, naw i nɔ kin apin ɔlsay na di wɔl ɛn i kin dia.
- Lɛk ɛni tritmɛnt, bɛnifit dɛn de, prɔblɛm dɛn de, ɛn bad tin dɛn de we kin apin to am.
- I impɔtant ɔltɛm fɔ tɔk bɔt dis wit yu dɔktɔ bifo yu disayd fɔ du ɛnitin bɔt dɛn kayn tritmɛnt ya.
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