Yu dɔn ɛva yɛri bɔt Lynch Syndrome? Dis nem kin bi nyu tin to yu smɔl. Bɔt na wan jɛnɛtik kɔndishɔn we kin pas frɔm wan jɛnɛreshɔn to jɛnɛreshɔn we kin rili mek wi gɛt kansa. Dis kin mek yu gɛt kansa mɔ ɛn mɔ bifo yu ol 50. I nɔmal fɔ mek yu fil fred smɔl we yu yɛri di wɔd dɛm "yu kin gɛt kansa". Bɔt di tin we impɔtant pas ɔl na fɔ no gud gud wan bɔt dɛn kayn tin ya. So tide wi go tɔk bɔt dis simpul wan, di we we yu go ɔndastand.
Fɔ tɔk am simpul wan, wetin na Lynch Syndrome?
Imajin se wi bɔdi tan lɛk kɔmpleks mashin we de wok akɔdin to wan big instrɔkshɔn buk (DNA). Wi jin dɛn tan lɛk di lɛta dɛn we de na dis instrɔkshɔn buk. Sɔntɛnde, mistek kin de na dis instrɔkshɔn buk, ɔ ‘tayp mistek’. Insay mɛrɛsin, dɛn kin kɔl dis jɛnɛtik muteshɔn.
Lynch syndrome na wan sik wae de kam wit wan jenɛtik mutation. Wi bɔdi gɛt wan spɛshal kayn jin we de no ɛn mek mistek dɛn we de na wi DNA. dis dεn kכl am di ``mismatch ripa (MMR)`` jin. I tan lɛk ''ripa tim'' na wi bɔdi. Pɔsin we gɛt Lynch syndrome gɛt difrɛns na wan pan di jin dɛm na dis ''ripa tim''. So, dɛn nɔ kin mek mistek dɛn we de na DNA fayn fayn wan. di sεl dεm we gεt dεn mistek ya kin kכmכt εn as tεm de go, dεn kin bi kεnsar.
Dis sik kin afɛkt ɛnibɔdi. Na bikɔs na tin we pɔsin kin gɛt we i kam pan jɛnɛtiks. Sɔntɛnde, yu kin gɛt dis jin we nɔ fayn frɔm yu mama ɔ papa. Na sכm tεm we dis jεnεtik mכtεshכn kin apin na nyu pכsin in bכdi we nכ de na di famili. If yu luk di statystik na kɔntri lɛk Amɛrika, dɛn se na lɛk wan pan ɛvri 279 pipul dɛn gɛt dis sik.
Us sayn dɛm wae pɔrsin wae gɛt Lynch syndrome kin gɛt?
De impɔtant tin fɔ no ya na dat, Lynch syndrome nɔr gɛt ɛni patikyula sayn. Bifo dat, na sayn fɔ de kansa wae de kam wit de sik. Di wan we kin bɔku pan dɛn na kɔlorektal kansa.
So, na sɔm kɔmɔn sayn dɛm wae kin gɛt fɔ du wit kɔlorektal kansa:
| Di sayn we de sho se di sik de | Tɔk bɔt |
|---|---|
| Blɔd we de na di stɔl | Di stɔl kin rɛd ɔ dak blak wit blɔd we dɛn miks insay. |
| Bɛlɛ pen ɔ nɔs | Bɛlɛ kin at ɔ nɔ kin fil fayn ɔltɛm. |
| Chenj na di abit dɛn we pɔsin kin gɛt na di bɔdi | Wantɛm we pɔsin kin gɛt kɔnstipɛshɔn ɔ dayarɛa, ɔ stɔl we kin tan lɛk aw i kin tan lɛk aw i kin tan. |
| Fɔ taya ɔltɛm | I kin taya ɔltɛm pan ɔl we i kin rɛst fayn. |
| Bloating ɔ bloating | Fɔ fil ful ɔ blo ivin afta yu dɔn it smɔl. |
| Nɔs ɔ vɔmit | Nɔs ɔ vɔmit we nɔ gɛt klia rizin. |
De impɔtant tin na dat nɔr to ɔlman kin gɛt dɛn sik ya. Sɔntɛnde, di kansa nɔ kin sho ɛni sayn te i dɔn rili go bifo. So, if yu kɔntinyu fɔ gɛt wan ɔ mɔ pan dɛn sik ya, mek shɔ se yu go to yu dɔktɔ fɔ advays.
Us kayn kansa kin kam bikɔs ɔf dis sik?
Lynch syndrome nɔto wan sik we de opin di domɔt fɔ jɔs wan kayn kansa. I kin mek di risk fɔ gɛt kansa na bɔku difrɛn pat dɛn na di bɔdi. di כgan dεm we de pan denja kin difrεn dipכnt pan di fכlt jin. `MLHL`, `MSH2`, `MSH6`, `PMS2` εn `EPCAM` na di fayv men jin dεm we de involv.
Dis dɔŋ ya na sɔm kayn kansa wae Lynch syndrome kin mek pɔrsin gɛt mɔr sik.
| Di kayn kansa we yu gɛt | Pat we gɛt fɔ du wit di bɔdi |
|---|---|
| Kɔlɔn ɛn rɛktal kansa | Dijestiv sistɛm |
| Kansa we de na di uterin/Endometrial | di uman in riprodaktiv sistεm |
| Kansa na ovarian | di uman in riprodaktiv sistεm |
| Bɛlɛ kansa | Dijestiv sistɛm |
| Smɔl intestinal kansa | Dijestiv sistɛm |
| Kansa na di pankrias | Dijestiv sistɛm |
| Kansa na di urinary tract we de ɔp | Yurinari sistɛm |
| Bren kansa | Nɛvɔ sistɛm |
| Kansa na di skin | Kanda |
Kɔlɔn kansa wae kin kam wit Lynch syndrome kin difrɛn smɔl. Dɛn kin gro kwik kwik wan pas kansa dɛn we kin gɛt nɔmal wan.Pan ɔl we i kin tek lɛk 10 ia fɔ mek nɔmal pɔsin in smɔl polyp gɛt kansa, i kin tek lɛk wan ɔ tu ia fɔ pɔsin we gɛt Lynch syndrome.
Dɔn bak, bikɔs ɔf dis kɔndishɔn, pɔsin we dɔn gɛt kɔlorektal kansa wan tɛm ɛn we dɔn wɛl kin gɛt di sem kayn kansa bak.
Tink bɔt, lɛk 15% risk de fɔ mek kansa kam bak insay 10 ia afta dɛn dɔn ɔpreshɔn di fɔs kansa. Dis risk kin go ɔp to 40% afta 20 ia, ɛn to 60% afta 30 ia. Dis de sho aw i impɔtant fɔ mek dɛn de chɛk pɔsin ɔltɛm.
Aw dis kin pas fɔ lɔng lɔng tɛm?
Lynch syndrome na wan kכndyushכn we de pas dכn frכm jεnereshכn to jεnereshכn insay ``autosomal dominant`` we. Dis jɔs min se ivin if na wan mama ɔ papa nɔmɔ , we na di mama ɔ di papa, gɛt di jin we nɔ fayn, 50% chans de fɔ mek di pikin gɛt am. Dis min se ɛni pikin gɛt 50% chans fɔ gɛt am ɛn 50% chans fɔ nɔ gɛt am.
So, if yu ɔ sɔmbɔdi na yu famili gɛt Lynch syndrome, i rili impɔtant fɔ tɛl di ɔda pipul dɛn na yu famili. Ɛspɛshali yu brɔda ɛn sista dɛn, pikin dɛn, ɛn mama ɛn papa dɛn fɔ tɛl dɛn bɔt dis prɔblɛm. If yu rifer dɛn to tɛst ɛn advays bɔt dɛn jɛnɛtiks, dat kin ivin sev dɛn layf.
Aw a go no if a gɛt dis sik? Us tɛst dɛn a fɔ du?
Di bɛst we fɔ no if yu gɛt Lynch syndrome na fɔ du jenɛtik tɛst . Bɔku tɛm, dis kin min fɔ tek blɔd sɛmpul. Ɔ dɛn kin tek bɔkal swab frɔm insay yu mɔt. dis tεst kin kכrekt fכ no if yu gεt mכtεshכn na di jin dεm we wi bin tכk bכt, lεk MLHL εn MSH2.
If dɛn no se yu gɛt Lynch syndrome, di nɛks tin we impɔtant pas ɔl na fɔ gɛt skrinin ɔltɛm fɔ no kansa kwik kwik wan. Yu dɔktɔ go mek wan schedule fɔ screening we go fayn fɔ yu.
| Tɛst | Aw fɔ du am ɛn di tɛm we dɛn kin yuz fɔ du am |
|---|---|
| Kolonoskopi we dɛn kin du | Kolonoskopi na we dεn kin put wan tin tכb wit kεmεra tru di an fכ egzamin di kכlon. Bɔku tɛm dɛn kin advays am ɛvri ia ɔ tu ia . |
| Transvaginal Ultrasound we dɛn kin yuz | Fɔ uman dɛn, dɛn kin se dɛn fɔ du ɛgzam na di bɛlɛ, we na fɔ put wan tin fɔ skan tru di vagina ɛn chɛk di uterus ɛn ovaria, ɛvri ia ɔ tu ia . |
| Urinalysis we dɛn kin du | Gɛt wan bɛsik ɔndastandin bɔt kansa dɛn we gɛt fɔ du wit kidni bay we yu tɛst wan urine sampul. I fayn fɔ du dis ɛvri ia . |
| Ɔpa Ɛndoskopi | tכb we gεt kεmεra we dεn put tru di mכt fכ egzamin di bεlε εn כp pat pan di sכmכl intestin. Rikɔmɛnd am ɛvri 3-5 ia . |
| Bayopsi we dɛn kin du | If dɛn fɛn tisu ɔ tumbu we dɛn tink se de apin we dɛn de du di tɛst we wi dɔn tɔk bɔt, dɛn kin tek smɔl sampul ɛn tɛst fɔ si if i gɛt kansa sɛl dɛn. |
Aw dɛn kin trit Lynch syndrome?
Naw, no mɛrɛsin nɔ de fɔ di jenɛtik kɔndishɔn we dɛn kɔl Lynch syndrome. So, di men tin we di tritmɛnt de pe atɛnshɔn pan na fɔ no ɛn ɔpreshɔn fɔ pul di kansa sɛl dɛn na di bɔdi. If dɛn kin no di kansa ɛn pul am bifo i go na ɔda pat dɛn na di bɔdi, di tin dɛn we kin apin kin rili fayn.
Dis nid fɔ gɛt wan tim we gɛt bɔku bɔku dɔktɔ dɛn. Fɔ ɛgzampul, di wan dɛn we de mɛn di bɛlɛ, di dɔktɔ dɛn we de du ɔpreshɔn, di wan dɛn we de mɛn uman dɛn we gɛt kansa, ɛn di wan dɛn we de mɛn kansa kin wok togɛda fɔ trit dis sik.
sכm pipul dεm, spεshal uman dεm we dεn kכmplit dεn famili, kin disayd fכ mek dεn hysterectomy כ oophorectomy bifo εni sik kam fכ ridyus dεn risk fכ gεt uterin כ ovarian kansa tumara bambay. Semweso, di wan dɛn we gɛt ay risk fɔ gɛt kansa na dɛn kɔlon kin disayd fɔ mek dɛn pul di kɔlektɔmi. Dɛn tin ya na tin dɛn we pɔsin kin disayd fɔ du, ɛn yu fɔ disayd fɔ du am afta yu dɔn tɔk bɔku tɛm wit yu dɔktɔ.
Yu tink se Lynch syndrome ɛn HNPCC na di sem tin?
Yu kin dɔn yɛri bak di nem `HNPCC (Hɛritɛri Nɔn-Polipɔsis Kɔlorektal Kansa)`. Bɔku tɛm dɛn kin yuz Lynch syndrome ɛn HNPCC fɔ chenj, bɔt smɔl tɛknikal difrɛns de bitwin di tu.
Fɔ tɔk am simpul wan, dɛn kin yuz di nem HNPCC bay famili istri. Dat min se if sɔm pipul dɛn na wan famili dɔn gɛt dis kayn kansa, dɛn kin se da famili de gɛt HNPCC. Bɔt Linch sindrom na di nem we dɛn gi afta dɛn dɔn no di patikyula jin we de mek i chenj. So, ɔl di mɛmba dɛm na wan famili we gɛt HNPCC kin gɛt di Lynch syndrome jin muteshon. Dɔn bak, dɛn kin se pɔsin we gɛt nyu jin muteshon we nɔ gɛt ɛni ɔda pɔsin na di famili, i gɛt Lynch syndrome bak.
Nɔbɔdi nɔ lɛk fɔ yɛri di wɔd dɛn we se, "Yu gɛt kansa." Sɔmbɔdi wae gɛt Lynch syndrome kin gɛt fɔ yɛri dɛn wɔd ya sɔmtɛm na in layf. Bɔt nɔto di ɛnd fɔ di wɔl. If yu no bɔt yu sik, wok wit yu dɔktɔ, ɛn gɛt kansa skrinin ɔltɛm, dɛn kin no ɛn mɛn ɛni kansa we i bigin. Fɔ no am kwik kwik wan ɛn fɔ trit am na di bɛst we fɔ liv wɛlbɔdi ɛn gladi at.
Mɛsej we dɛn kin kɛr go na os
- Lynch syndrome na wan sik wae de kam wit jεnεtiks wae de pas dכn tru jεnereshכn εn i de mek di risk fכ gεt kansa bכku.
- Ivin if na wan mama ɔ papa nɔmɔ gɛt dis jin we nɔ fayn, pikin gɛt 50% chans fɔ gɛt am.
- If yu ɔ sɔmbɔdi na yu famili gɛt dis sik, i rili impɔtant fɔ tɛl ɔda pipul dɛn we de nia yu fambul bɔt dis.
- Pan ɔl we dɛn nɔ go ebul fɔ mɛn dis jenɛtik kɔndishɔn, di bɛst we fɔ mek dɛn nɔ gɛt kansa ɔ fɔ no if pɔsin gɛt kansa kwik na fɔ go to dɔktɔ ɔltɛm.
- If yu no bɔt kansa kwik kwik wan ɛn trit yu, dat kin mek yu gɛt fayn fayn tin dɛn ɛn i kin mek yu liv fayn layf.
- Ɔltɛm, tɔk to yu dɔktɔ fɔ mek dɛn mek wan tɛm fɔ du di tɛst we go fayn fɔ yu ɛn fɔ sɔlv ɛnitin we de mɔna yu.
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