Yu dɔktɔ dɔn gi yu wan kayn mɛrɛsin we dɛn kɔl MAOI? Ɔ yu dɔn yɛri bɔt dis mɛrɛsin sɔnsay ɛn yu want fɔ no ustɛm i bi? MAOI na rili wan kayn mɛrɛsin wae dɛn kin gi fɔ trit mɛntɛl hεlth kɔndishɔn lɛk pwɛl hat. Bɔt, dɔktɔ dɛn nɔ kin tɛl dɛn fɔ du dɛn bɔku tɛm dɛn tɛm ya. Bɔku patikyula rizin dɛn de fɔ dis. Lɛ wi tɔk bɔt dis frɔm di biginin, rili simpul wan, insay wan we we yu go ɔndastand.
Us kayn mɛrɛsin na MAOI?
Fɔ tɔk am simpul wan, MAOIs (Monoamine Oxidase Inhibitors) na di fɔs klas fɔ drɔgs we dɛn dɔn fɛn fɔ mɛn pwɛl hat. Bɔt yu nid fɔ rili tek tɛm wit wetin yu de it we yu de yuz dɛn. Dɔn bak, bikɔs ɔf sɔm sayd ɛfɛkt ɛn prɔblɛm wit ɔda mɛrɛsin, bɔku tɛm dɔktɔ dɛn kin tɛl dɛn fɔ du am as las tin, we ɔda kayn mɛrɛsin dɛn we de mek pɔsin fil bad nɔ kin wok.
Dat min se, if dɛn dɔn gi yu nyu mɛrɛsin lɛk SSRI ɛn yu sik nɔ dɔn bɛtɛ, yu dɔktɔ kin tek MAOI as di nɛks tin we yu fɔ du.
Wetin na di men kayn MAOI dɛm we dɛn de yuz na di wɔl?
Bɔku men kayn MAOI dɛn de we dɛn de yuz naw. If ɔl dɛn tin ya de na wi kɔntri, i kin difrɛn, bɔt i fayn fɔ mek wi no bɔt dɛn nem ya.
- Isokarboksazid (Marplan®) we dɛn kɔl .
- Fɛnɛlzin (Nardil®) we dɛn kɔl .
- Sɛlɛgilin (Emsam®) we dɛn kɔl .
- Tranilsaypromin (Parnate®) we dɛn kɔl di .
Us kɔndishɔn dɛn kin gi MAOI mɛrɛsin fɔ?
Pan ɔl we dɛn kin gi dis mɛrɛsin mɔ fɔ pwɛl hat, dɛn kin yuse am bak fɔ ɔda mental wɛlbɔdi prɔblɛm dɛn.
Di we dɛn we ɔfishal gri fɔ yuz
Dis na kes dɛm we di ɔtoriti dɛm we gɛt fɔ du wit am dɔn ɔfishal wan gri fɔ dis mɛrɛsin as i fayn fɔ dɛn sik ya.
- Major Depression Disorder: Dɛn dɔn gri fɔ ɔl tu di Isocarboxazid ɛn Tranylcypromine fɔ dis sik.
- Disɔda wae nɔr kin gɛt tritmɛnt: Dɛn kin yuse Phenelzine fɔ trit pwɛl hat, panik disɔda, ɛn sɔshal wɔri disɔda wae nɔr kin ansa ɔda tritmɛnt.
- Pakinsin sik: Selegiline na mɛrɛsin wae dɛn kin yuse fɔ trit pwɛl hat ɛn dɛn kin yuse am bak as ɔda mɛrɛsin fɔ Pakinsin sik.
"Off-label" de yuz
Sɔntɛnde, dɔktɔ kin gi dɛn dis mɛrɛsin bay aw dɛn no bɔt mɛrɛsin ɛn ɛkspiriɛns fɔ wan sik we ɔfishal nɔ gri fɔ. Dɛn kɔl dis "ɔf-lɛbul" yus. Fɔ ɛgzampul:
- Sɔntɛnde dɛn kin gi wan mɛrɛsin we dɛn kɔl tranylcypromine fɔ sɔshal wɔri ɛn panik disɔda we nɔ de tek tritmɛnt.
- Sɔntɛnde, dɛn kin gi di mɛrɛsin we dɛn kɔl Selegiline fɔ pɔsin we gɛt atɛnshɔn dɛfisit haypa aktiviti disɔda (ADHD).
Aw dis mɛrɛsin de wok insay di bɔdi?
Dis na tin we rili simpul fɔ ɔndastand. Imajin se wi bren gɛt kemikal dɛn we de kɔntrol tin dɛn lɛk aw wi de fil, aw wi gladi, ɛn aw wi de pe atɛnshɔn. Wi kin kɔl dɛn nyurotransmitta ya . Dɛn tin ya tan lɛk smɔl mɛsenja dɛn we de kɛr mɛsej dɛn insay di bren.
naw, wi bכdi gεt wan εnzym we dεn kכl "Monoamine Oxidase." di wok we dis εnzym de du na fכ brok dכn εn pul dεn mεsenja dεm (nyurotransmitta dεm) afta dεn dכn yuz dεm.
Pɔsin wae gɛt pwɛl hat kin gɛt bɔrku bɔrku mɛsenja ya na in bren. wetin wan MAOI dכg de du na fכ stכp (inhibit) di akshכn fכ da ‘klin’ εnzym de fכ sכm tεm. Wetin kin apin da tɛm de?
sεvεra imכtant nyurotransmit dεm na di bren de de na di bren fכ lכng tεm we dεn nכ de brok dכn, we min se dεn lεvεl dεm de go כp.
di men nyurotransmit dεm we di MAOI dεm de inkrεs na:
- Serotonin: I rili impɔtant fɔ di we aw pɔsin de fil, fɔ slip, fɔ want fɔ it, ɛn fɔ biev wit ɔda pipul dɛn.
- Norepinephrine: I impɔtant fɔ mek yu de wach, fɔ pe atɛnshɔn, ɛn fɔ du sɔntin.
- Dopamine: I gɛt fɔ du wit gladi at, satisfayshɔn, ɛn atɛnshɔn.
- Tyramine: Dis na wan kayn nyurotransmit bak. Bɔt di men wok we i de du na fɔ ɛp fɔ kɔntrol blɔd prɛshɔn. Dis na di men rizin we mek yu nid fɔ tek tɛm wit wetin yu de it we yu de tek MAOI. Wi go tɔk bɔt am mɔ ditayli insay smɔl.
Wetin na di difrɛns bitwin MAOI ɛn SSRI?
SSRI (Selective Serotonin Reuptake Inhibitors) na ɔda kayn mɛrɛsin wae dɛn kin yuse fɔ trit pwɛl hat. Yu go dɔn yɛri bɔt nem dɛn lɛk Prozac ɛn Sertraline. Pan ɔl we dɛn ɔl tu na mɛrɛsin dɛn we dɛn kin yuz fɔ mɛn pwɛl hat, dɛn kin wok difrɛn we.
- SSRI: Dɛn wan ya tan lɛk snaypa. Dɛn kin jɔs de tɔch di nyurotransmitta we dɛn kɔl sɛrotonin . Dɛn kin jɔs mek in lɛvɛl dɛn go ɔp.
- MAOIs: Dis wan dem laik shotgun. dεn kin afekt sεvεra nyurotransmitta dεm (sεrotonin, norepinephrine, dopamine) wan tεm.
Bikɔs SSRI mɛrɛsin nɔ gɛt bɛtɛ sayd ɛfɛkt ɛn no spɛshal lɔ nɔ de bɔt it ɛn drink, dɔktɔ dɛn kin tɛl yu fɔ tek SSRI mɛrɛsin fɔs.
Wetin na di kɔmɔn sayd ɛfɛkt dɛm we MAOI kin gɛt?
Lɛk ɔl di mɛrɛsin dɛn, dis wan kin gɛt sayd ɛfɛkt. Bɔt nɔto ɔlman kin gɛt dɛn. Sɔm pipul dɛn kin gɛt wan ɔ tu, ɛn sɔm nɔ kin gɛt ɛni wan pan dɛn atɔl. If yu gɛt ɛni nyu diskɔmfɔt afta yu dɔn bigin dis mɛrɛsin, tɔk to yu dɔktɔ bɔt am.
| Kɔmɔn sayd ɛfɛkt dɛn | Tɔk bɔt |
|---|---|
| Diziz ɔ layt ed | Dis kin kam bikɔs di blɔd prɛshɔn nɔ bɔku. Yu kin kɔntrol dis bay we yu grap sloslo frɔm we yu tinap ɔ sidɔm. |
| Dray mɔt | Yu kin gɛt fridɔm bay we yu drink mɔ wata ɛn chew gɔm we nɔ gɛt shuga. |
| Vɔmit | Dis kin ridyus if yu tek di mɛrɛsin wit it. |
| Flatulence ɔ kɔnstipɛshɔn | Dis kin difrɛn difrɛn wan bay aw yu de it ɛn di wata we yu de drink. |
| Di we aw pɔsin kin slip | Di dɔktɔ kin advays yu fɔ tek di mɛrɛsin na nɛt. |
| Nɔ ebul slip | If na so i bi, dɛn kin advays yu fɔ tek di mɛrɛsin na mɔnin. |
Siriɔs risk dɛn we gɛt fɔ du wit yus MAOIs!
Yu fɔ no mɔ bɔt dis pat. MAOI na drɔg we dɛn fɔ tek tɛm yuz.
1. I de tink mɔ bɔt fɔ kil insɛf
Di tink ɔ bihayvya fɔ kil dɛnsɛf kin bɔku, mɔ pan yɔŋ pipul dɛn we nɔ rich 25 ia yet, we dɛn fɔs bigin dis mɛrɛsin ɔ we dɛn chenj di doz.
If yu ɔ yu pikin bigin fɔ fil se yu nɔ gɛt op afta yu dɔn bigin fɔ tek dis mɛrɛsin, nɔ shem fɔ kɔntak di dɔktɔ we gi yu di mɛrɛsin wantɛm wantɛm.Yu kin gɛt sɔpɔt kwik bak bay we yu kɔl di nashɔnal mental wɛlbɔdi ɛplayn nɔmba na Sri Lanka, 1926 .
2. Sεrotonin Sindrכm
Dis na tin wae nɔr kin apin so ɔltɛm, bɔt kin mek pɔrsin in layf de pan denja . I kin apin we di sɛrotonin lɛvɛl na di bɔdi kin denja pasmak. Dis risk kin go ɔp if yu tek MAOI we yu de tek ɔda mɛrɛsin dɛn we de mek di sɛrotonin lɛvɛl go ɔp (e.g., ɔda antidipreshan, sɔm kɔf srɔp, ɛn pen kil).
So, bifo yu bigin tek MAOI, yu fɔ tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn we yu de tek naw (inklud vaytamɛn ɛn tradishɔnal mɛrɛsin dɛn).
| Di simptom dɛm fɔ Serotonin Syndrome | |
|---|---|
| Di kɔmɔn sayn dɛm |
|
| Siriɔs ɛn we kin apin kwik kwik wan |
|
| If yu gɛt ɛni wan pan dɛn siriɔs sayn ya, go na di ɔspitul Imejɛnsi Dipatmɛnt (ETU) we de nia yu wantɛm wantɛm! | |
3. Antidipreshan Diskɔntinyueshɔn Sindrom
If yu tek MAOI fɔ pas 6 wik ɛn afta dat yu stɔp am wantɛm wantɛm, yu kin gɛt sayn fɔ lɛf fɔ tek am. Dis nɔto adikshɔn, bɔt na we fɔ mek di bɔdi ansa di mɛrɛsin as i de yus to am.
Karakta:
- Bɔdi de at, taya, ɛn swet, lɛk se yu gɛt fiva
- Nɔ ebul slip
- Vɔmit
- Diziz we pɔsin kin gɛt
- Fɔ fil lɛk se kɔrɛnt de go tru yu bɔdi
- Fɔ wɔri, fɔ vɛks
Nɔ stɔp fɔ tek dis mɛrɛsin wantɛm wantɛm fɔ ɛni rizin we yu nɔ go to yu dɔktɔ. If yu stɔp fɔ tek di mɛrɛsin, du am smɔl smɔl fɔ lɛk wan mɔnt so, ridyus di doz, ɛn na ɔnda yu dɔktɔ in sɔpɔtishɔn nɔmɔ.
4. Denja riakshכn wit it (Tyramine Reaction) .
Dis na di mɔs impɔtant ɛn denja risk wit MAOI.
As wi bin dɔn tɔk, MAOI mɛrɛsin dɛn de blok di ɛnzaym we de brok wan kemikal we dɛn kɔl tyramine. Tayramine kin de na sɔm it dɛn we wi kin it. Insay pɔsin we nɔ de tek di mɛrɛsin, di bɔdi kin brok izi wan ɛn pul dis tayramin.
Bɔt if pɔsin we de tek MAOI it it we gɛt bɔku tayramin, di bɔdi nɔ go ebul fɔ brok am. Dɔn di lɛvɛl we di tayramin de na di blɔd kin go ɔp bad bad wan, ɛn dis kin mek di blɔd prɛshɔn go ɔp wantɛm wantɛm (Hypertensive Crisis) . Dis na tin we rili denja. Sɔntɛnde, dis kin mek in bren blɔd ɛn ivin day.
Fɔd fɔ ‘absolutely’ avɔyd we yu de tek MAOI!
If yu de tek MAOI, yu fɔ avɔyd di it dɛn we de na di list we de dɔŋ ya kpatakpata. Tɔk to yu dɔktɔ bɔt dis fɔ no mɔ.
| Di kayn it we dɛn kin it | Tin dɛn we yu fɔ avɔyd ɛn wetin mek |
|---|---|
| Chiz | Nɔ it chiz dɛn we dɔn ol ɔltogɛda. Fɔ ɛgzampul: Chɛda, Blu chiz, Pamɛsan. (Di tyramine lεvεl dεm de inkrεs ova tεm). Fresh chiz lek Cottage cheese, Mozzarella fayn. |
| Mit ɛn fish we dɛn dɔn prosɛs | Sosish, salami, dray mit, mit we dɛn dɔn mɛn, ɛn smok mit/fish. |
| Sos dɛn we dɛn kin yuz | Soya sos ɛn ɔda sos dɛn we dɛn dɔn fɛmɛnt. |
| Frut ɛn vɛjitebul dɛn we dɛn dɔn fɛmɛnt | Banana we rili rayp , avokado, fig. Fava bins (wan kayn ligɛm). |
| Rum | Tap bia (draft bia) ɛn bia dɛn we dɛn dɔn fɛmɛnt. Sɔm wayn dɛn kin gɛt bɔku tayramin bak. |
| Ɔda | Sɔdo bred, liva, ɛn ɔda tin dɛn (tayramin kin bɔku kwik kwik wan if nɔto fresh). |
Di tin we impɔtant pas ɔl: It it jɔs afta i dɔn kuk. Put di tin dɛn we lɛf na frij ɛn nɔ ɔt am bak. As di it de ol, di tyramine lɛvɛl kin go ɔp.
Aw lɔng i kin tek fɔ fil di tin dɛn we di mɛrɛsin kin du?
Bɔku tɛm, i kin tek tu to tri wik fɔ mek dɛn fil di ful ifɛkt we di mɛrɛsin gɛt. If yu nɔ si ɛni impɔtant tin pan yu sik dɛn da tɛm de, tɔk to yu dɔktɔ.
Ustɛm yu fɔ kɔl yu dɔktɔ?
If yu de tek MAOI, yu fɔ go to yu dɔktɔ ɔltɛm fɔ si if di mɛrɛsin de wok ɛn if yu gɛt ɛni prɔblɛm. Apat frɔm dat, mek shɔ se yu tɔk to yu dɔktɔ bɔt dɛn tin ya:
- If di sayd ɛfɛkt dɛn de mɔna yu.
- If yu sik nɔr de bɛtɛ ɔr de wɔs.
- If yu fil se yu nid fɔ stɔp fɔ tek di mɛrɛsin.
Fɔ dɔn, as pɔsin we de tek MAOI, i impɔtant fɔ tɛl ɛni dɔktɔ we yu si (ivin dɛntist) se yu de tek dis mɛrɛsin, bikɔs sɔm anestetik ɛn ɔda mɛrɛsin dɛn kin mek yu gɛt denja riakshɔn wit MAOI.
Mɛsej we dɛn kin kɛr go na os
- MAOI na wan kayn mɛrɛsin fɔ pwɛl hat wae nɔr de yuse bɔrku bɔrku igen, bɔt i kin rili woke pan sɔm kayn tin dɛm.
- Yu fɔ avɔyd it dɛn we gɛt tayramin (lɛk chiz we dɔn ol, mit we dɛn dɔn prosɛs, soya sos) ɔltogɛda we yu de tek dis mɛrɛsin. Dis kin mek pɔsin in layf de pan denja.
- I rili impɔtant fɔ tɛl yu dɔktɔ bɔt ɛni ɔda mɛrɛsin we yu de tek.
- Nɔ ɛva stɔp fɔ tek mɛrɛsin wantɛm wantɛm we yu nɔ go to yu dɔktɔ.
- If yu gɛt siriɔs simptom dɛm fɔ sɛrotonin sindrom (kɔnfyushɔn, ay fiva, sizhɔ) ɔr yu de tink bɔt fɔ kil yusɛf, go na imejensi rum (ETU) wantɛm wantɛm.
- Tɛl ɛvri wɛlbɔdi biznɛs pɔsin we yu de trit se yu de tek MAOI.
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