Yu go dɔn yɛri se nyu, advans tritmɛnt dɛn de fɔ siriɔs sik dɛn lɛk kansa. Sɔntɛnde di dɔktɔ kin se, "Spɛshal mɛrɛsin de fɔ dis we de yuz wi yon imyun sistɛm." Tide, wi go tɔk bɔt wan tritmɛnt we dɔn mek big big chenj pan mɛrɛsin. Dɛn kɔl dɛn tin ya monoklɔnal antibodi. Pan ɔl we di nem kɔmplikt smɔl, di stori rili simpul. Lɛ wi si wetin na dis.
Wetin na dɛn monoklɔnal antibodi ya?
Fɔ tɔk am simpul wan, dɛn tin ya na spɛshal prɔtin dɛn we dɛn mek na lab we de wok di sem we lɛk di antibodi dɛn we wi bɔdi kin mek bay insɛf.
Naw tink bɔt am, wi bɔdi tan lɛk kɔntri. Ami de fɔ protɛkt dis kɔntri. Dat ami na wi imyun sistɛm . Jɛm ɛn tin dɛn we de mek pɔsin sik (wi kɔl dɛn antijen ya ) we kɔmɔt na do tan lɛk ɛnimi dɛn we de kam na wi kɔntri. Dɛn antibodi ya na di spɛshal sojaman dɛn na wi ami. Dɛn wok na fɔ fɛn, kech, ɛn pwɛl dɛn ɛnimi ya.
Sɔntɛnde, pan ɔl we tin dɛn lɛk kansa sɛl dɛn kin gro na wi yon bɔdi, wi imyun sistɛm nɔ kin ebul fɔ no dɛn. Na da tɛm de wi kin aks fɔ ɛp frɔm ɔda pipul dɛn.
di monoklonal antibodi dεm na, fכ put am simpul, lεk spεshal tren, supa-smat, klon sojaman dεm we dεn mek na lab. "Mono" min "wan." "Klɔnal" min "kɔpi." dat min se dεn de pik wan singl supεr-smat antibodi εn dεn mek plεnti εksakεt kכpi dεm fכ am na di lab. Dɔn dɛn kin injɛkt dis ami we gɛt antibodi dɛn insay wi bɔdi as mɛrɛsin. Dɛn kin go stret to di sɛl dɛm we de kɔz di sik (e.g., kansa sɛl dɛm), dɛn kin atak dɛn, ɛn ɛp wi yon imyun sistɛm fɔ pwɛl dɛn.
If di nem fɔ dis kayn mɛrɛsin we dɛn gi yu gɛt di tri lɛta dɛn "mab" na di ɛnd (e.g. Trastuzumab, Rituximab), i min se na Monoclonal Antibody.
Wetin na di difrɛns bitwin monoklɔnal ɛn polyklɔnal?
Dis na tin bak we rili simpul.
- Monoclonal: Dis na lɛk snaypa. Na wan target nɔmɔ de. dεn mek dεn antibodi dεm ya fכ atak wan antijen n כmכ . So, dɛn rili spɛshal ɛn dɛn nɔ go mis di target.
- Poliklɔnal: "Poly" min "bɔku." dis na wan kכlekshכn fכ difrεn antibodi dεm. Lɛk ami we gɛt difrɛn wɛpɔn dɛn, dɛn kin atak bɔku kayn antijen dɛn .
di monoklonal antibodi dεm dεn kin yus fכ tritmεnt biכs dεn de tכk dεm spεshal wan.
Wetin dɛn kin yuz dɛn tin ya fɔ?
Dis tritmɛnt we dɛn de yuz naw fɔ bɔku tin. Frɔm risach to fɔ mɛn sik dɛn.
| Fild fɔ yuz | Wan simpul ɛksplen |
|---|---|
| Fɔ mek dɛn no di sik | Dɛn kin yuz am na lɛbɔraytri fɔ no wan tin. Fɔ ɛgzampul, di bɛlɛ tɛst kit we yu kin yuz na os kin wok bak wit dis teknɔlɔji. |
| Tisu ɛn blɔd klasification | dεn kin yuz dεn tin ya fכ chεk if di tisu dεm fכ di dכna εn di rεsεpεnt de kכmpεt we dεn de transplant כgan. |
| Fɔ mɛn sik dɛn | Dis na di tin we impɔtant pas ɔl. Dɛn kin yuz dɛn tin ya fɔ mɛn bɔku sik dɛn lɛk kansa ɛn at at. |
Us sik dɛn kin trit wit monoklɔnal antibodies?
Dis tritmɛnt we dɛn de yuz naw fayn fayn wan fɔ bɔku sik dɛn. Sɔm pan dɛn na:
- Kansa: Fɔ difrɛn kayn kansa lɛk bɔdi kansa, kɔlon kansa, ɛn blɔd kansa.
- fכ mek dεn nכ rijek כgan transplant: Stכp di bכdi fכ rijek כgan we dεn transplant (lεk kidni, liva).
- Awtoimyun dizayd: Fɔ sik dɛm wae di bɔdi in imyun sistɛm de atak in yon sɛl dɛm, lɛk rεumatoid at at ɛn Kron sik.
- Alɛji: Fɔ siriɔs asma ɛn ɔda alɛji.
- Infɛkshɔn: Dɛn dɔn yuz dɛn bak fɔ trit sɔm vayral infɛkshɔn, lɛk COVID-19.
- Ɔstioporosis we pɔsin kin gɛt
- Di kɔndishɔn dɛn we de na di yay
- Maygren we kin kam
- Kɔlestɔl we bɔku
Aw dɛn kin gi di tritmɛnt?
Bɔku tɛm dɛn kin gi dis tritmɛnt as wata we tan lɛk salin insay wan vein (intravenous ɔ IV infusion). Dɛn kin gi dis na spɛshal yunit (infusion center) na ɔspitul ɔ klinik. Bɔku ɔda pipul dɛn kin de gɛt tritmɛnt de di sem tɛm we dɛn de trit yu.
If dis na di fɔs tɛm fɔ gɛt dis tritmɛnt, yu dɔktɔ kin aks yu fɔ kam wit yu fambul so dat dɛn go lan bɔt di tritmɛnt ɛn wetin fɔ ɛkspɛkt afta dɛn dɔn du am. We dɛn de du di fɔs tritmɛnt, di wan dɛn we de wok na di dɔktɔ go wach yu gud gud wan fɔ si if yu gɛt ɛni siriɔs alɛji .
na sכm tεm we dεn kin gi sכm mכnoklכnal antibodi dεm bak as injεkshכn we dεn kin gi sכbkutan. If na so i bi, dɛn go tich yu aw fɔ gi yusɛf di vaysin.
Difrɛn kayn tritmɛnt de fɔ dis tritmɛnt?
Yes, dɛn "klon" sojaman ya kin du difrɛn difrɛn opareshɔn dɛn. Fɔ fala dis, tri men kayn dɛn de.
| Kayn | Fɔ tɔk am simpul wan... |
|---|---|
| Naked Monoklonal Antibodi dɛn we de na di wɔl | Dɛn sojaman dɛn ya de wok dɛn wan. Dɛn kin go stret to di ɛnimi sɛl ɛn gi signal to di imyun sistɛm fɔ pwɛl am. |
| Konjugεt Monoklכnal Antibodi dεm | Dɛn sojaman ya nɔ de go dɛn wan. Dɛn kin kɛr "bɔm." Dat min se, wan redioaktiv patikyula ɔ wan anti-kansa drɔg de atak dis antibodi. Di sojaman go rayt na di ɛnimi sɛl ɛn bɔn dis bɔm. Dɔn di damej na di ɛnimi sɛl nɔmɔ. |
| Bispɛsifi k Monoklɔnal Antibodi dɛn | Dis na di sojaman dɛn we sabi du di wok pas ɔlman. I tan lɛk se dɛn gɛt tu an. We yu grap wan ɛnimi sɛl wit wan an, yu grap wan sɛl frɔm wi yon imyun sistɛm wit di ɔda an ɛn se, "Na di ɛnimi ya, atak." Dɛn kin kɔnɛkt dairekt wan. |
Wetin na di bɛnifit dɛn we dis we fɔ trit pɔsin gɛt?
- Targeted therapy: Dis na di big advantej. Dis tritmɛnt nɔ tan lɛk kemotɛrapi we dɛn kin gi ɔltɛm, i nɔ kin pwɛl di sɛl dɛn we gɛt wɛlbɔdi. Bikɔs na di pɔsin nɔmɔ we i want fɔ atak, i nɔ kin gɛt bɔku sayd ɛfɛkt dɛn.
- Ay sakses rεt: Dis tritmɛnt mεtכd dɔn gi rili saksesful rizulyt fɔ sik dεm lεk sɔm kayn kεnsar.
- Kwaliti: Bikɔs dɛn mek am na lɛbɔtri, ɔl di mɛrɛsin dɛn we dɛn mek na di sem standad.
- Mas prodakshɔn: Naw dɛn kin mek dɛn tin ya bɔku bɔku wan.
Ɛni risk ɔr prɔblɛm de wit dis tritmɛnt?
Jɔs lɛk ɛni tritmɛnt, sɔm prɔblɛm dɛn de we kin apin. Bɔt nɔ wɔri, yu dɔktɔ go ɛksplen ɔltin to yu.
Di tin we impɔtant pas ɔl na fɔ tɛl di dɔktɔ dɛn wantɛm wantɛm if yu gɛt ɛnitin we nɔ kɔmɔn we yu de du dis tritmɛnt ɔ afta yu dɔn gɛt dis tritmɛnt.
Di prɔblɛm dɛn we kin apin na:
- Infushon riakshכn: Dis kin apin di tεm כ sכm tεm afta dεn gi di dכg insay wan vein. Bɔku tɛm, dɛn tin ya nɔ kin siriɔs.
- Skin rash we de kɔmɔt na di skin
- Fiva
- Shivering bikɔs ɔf kol
- I nɔ kin izi fɔ yu fɔ blo
- We pɔsin de swet
- Blɔd prɛshɔn kin chenj
- Di at rit we de go ɔp
If sɔntin lɛk dis apin, dɛn kin kɔntrol am bay we dɛn slo di rit we dɛn de gi di mɛrɛsin ɔ stɔp am fɔ sɔm tɛm.
- Mɔr siriɔs (bɔt nɔr kin si) riakshɔn:
- Akyu Anafylaksis: Dis na bad bad alɛji we kin apin wantɛm wantɛm ɛn i kin mek pɔsin in layf de pan denja. Dis na di rizin we mek dɛn nid fɔ tek tɛm wach di tritmɛnt fɔs.
- Cytokine Release Syndrome (CRS): Dis na wan kכndyushכn we di imyun sistεm de bi ova aktiv εn de mek "storm." Dis kin pwɛl di ɔgan dɛn.
- Sεrum sik: Wetin kin apin pan dis na we wi bכdi kin bigin fכ atak di very protin (antibodi) we dεn bin gi as tritmεnt.
Sɔm risk kin bi fɔ di sik we dɛn de trit. Fɔ ɛgzampul, tumor lysis syndrome in kansa tritmɛnt.Dis kin apin we di kansa sɛl dɛn kin pwɛl kwik kwik wan, ɛn di kidni dɛn nɔ kin ebul fɔ ol di dɔti tin dɛn we dɛn kin mek.
Aw lɔng e kin tek fɔ wɛl afta dɛn dɔn trit am?
Di tɛm we i kin tek fɔ mek dɛn gi di mɛrɛsin insay di bɛlɛ kin difrɛn. Fɔ ɛgzampul, insay sɔm tritmɛnt dɛn fɔ COVID-19, dɛn bin de gi di mɛrɛsin fɔ lɛk wan awa so, dɔn dɛn bin de wach am lɛk wan awa so.
Na dat mek yu fɔ kam wit yu famili di fɔs de. If nɔr sayd ɛfɛkt nɔr de, yu kin kam yu wan fɔ di nɛks tritmɛnt dɛm. If yu nɔ taya afta di tritmɛnt, aks yu dɔktɔ if yu kin kɔntinyu fɔ du yu nɔmal tin dɛn (wok, skul). I dipen pan yu kɔndishɔn ɛn ɔl yu wɛlbɔdi.
A fɔ tɔk to di dɔktɔ bɔt dis?
Fɔ tru, na yɛs.
- If yu dɔn ɔlrɛdi de gɛt monoklɔnal antibodi tritmɛnt ɛn yu gɛt ɛni ɔda kayn sik we nɔ kɔmɔn (lɛk di riakshɔn dɛn we wi bin dɔn tɔk bɔt bifo tɛm), kɔl yu dɔktɔ wantɛm wantɛm ɔ go to di Imejɛnsi Dipatmɛnt (ETU).
- If yu gɛt wan sik we dɛn dɔn no se na di tritmɛnt we yu kin gɛt, tɔk to yu dɔktɔ bɔt if dis monoklɔnal antibodi tritmɛnt rayt fɔ yu. I go chɛk yu sik, ɛksplen di gud ɛn bad tin dɛn, ɛn ɛksplen if i fayn fɔ yu.
Mɛsej we dɛn kin kɛr go na os
- Monoclonal antibodies na spɛshal tritmɛnt we de yuz kɔpi fɔ wi yon antibodi dɛm, we dɛn mek na lɛbɔraytri.
- dis na "targeted therapies" so na sכm damej de pan hεlty sεl dεm.
- Naw dɛn de yuz dɛn tin ya fayn fayn wan fɔ mɛn bɔku siriɔs sik dɛn lɛk kansa, at at, ɛn alɛji.
- Bɔku tɛm dɛn kin gi dis tritmɛnt as salin sɔlvushɔn insay wan vein. Sɔm riakshɔn kin apin we dɛn de du di tritmɛnt ɛn afta di tritmɛnt.
- I rili impɔtant fɔ ripɔt ɛnitin we nɔ kɔmɔn to yu dɔktɔ wantɛm wantɛm.
- Na yu dɔktɔ nɔmɔ go disayd if dis tritmɛnt fayn fɔ yu, so tɔk bɔt ɔltin wit am.
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