Imajin, sɔmbɔdi nɔ kin fil fayn fɔ sɔm dez, in mɛmori nɔ kin fayn smɔl, sɔntɛnde dɛn jɔyn dɛn kin at, ɛn in skin kin bigin fɔ it. So we yu go to dɔktɔ fɔ sɔntin lɛk dis, ɛn dɛn du difrɛn tɛst dɛn, dɛn kin kam fɔ no se di rut fɔ ɔl dis na kansa we ayd insay di bɔdi. Yu nɔ tink se i wɔndaful? Di kansa de na wan ples, bɔt bikɔs ɔf di tin dɛn we i kin du, di sayn dɛn we kin tan lɛk se dɛn nɔ gɛt ɛnitin fɔ du wit am kin apin na difrɛn pat dɛn na di bɔdi atɔl. Na dat wi kin kɔl Paraneoplastic Syndrome na mɛrɛsin.
Fɔ tɔk am simpul wan, wetin na Paraneoplastic Syndrome?
Dis kin tan lɛk se i at fɔ ɔndastand smɔl, bɔt lɛ wi kip am simpul. We wan bad bad tumbu kam na yu bɔdi, i kin gɛt dairekt ifɛkt dɛn. Fɔ ɛgzampul, if yu gɛt kansa na yu lɔng, yu kin gɛt kɔf. If yu gɛt kansa na yu kɔlon, yu kin gɛt blɔd na yu stɔl. Dis na di dairekt sayn dɛm fɔ kansa.
Bɔt Paraneoplastic Syndrome na sɔntin we difrɛn. Wetin kin apin ya na dat yu bɔdi kin mek wan kɔlekɛshɔn fɔ ɔda sayn dɛm fɔ ansa di kansa. Dat min se, nɔto sɔntin we di kansa de du dairekt wan, bɔt bikɔs di kansa de na di bɔdi, ɔda sistɛm dɛn na di bɔdi de go haywire as ‘response’ to am.
Tu men we dɛn de we dis kin apin:
1. Awtoimyun Rispɔns: Tink bɔt wi bɔdi in imyun sistɛm lɛk ami we de fɛt fɔ wan kɔntri. Kansa sɛl na ɛnimi we dɔn kam insay di kɔntri. So wi ami (immune system) bigin fɔ fɛt dis ɛnimi (kansa). Fɔ dat, dɛn kin mek spɛshal wɛpɔn dɛn, dat na , antibodies . Bɔt sɔntɛnde, we dɛn de fɛt dis fɛt, wi sojaman dɛn kin mek mistek. Dɛn nɔ kin bigin fɔ atak ɛnimi sɛl dɛn nɔmɔ, bɔt dɛn kin bigin fɔ atak gud, wɛlbɔdi sɛl dɛn na wi yon bɔdi, ɛn tink se dɛn na ɛnimi. Fɔ ɛgzampul, dɛn kin atak di sɛl dɛn we de na di nervɔs sistɛm, di sɛl dɛn we de na di skin, ɔ di sɛl dɛn we de na di jɔyn dɛn. Na da tɛm de di sayn dɛn we gɛt fɔ du wit dɛn ɔgan dɛn de kin apia.
2. di ɔmon we di kansa sɛl dɛn de mek: Sɔm kayn kansa kin mek bɔku tin dɛn lɛk ɔmon dɛn we wi bɔdi nɔ kin mek, ɔ we i nɔ kin mek bɛtɛ. Dɛn ɔmon dɛn ya we nɔ fayn kin gɛda na di blɔd ɛn travul ɔlsay na di bɔdi, ɛn dis kin mek difrɛn pat dɛn nɔ wok fayn. Fɔ ɛgzampul, dɛn ɔmon ya kin mek di blɔd prɛshɔn go ɔp pasmak, ɔ di kalsiɔm lɛvɛl go ɔp na di blɔd.
Di impɔtant tin na dat sɔmtɛm, ivin bifo dɛn no se yu gɛt kansa, di sayn dɛm wae gɛt fɔ du wit dis Paraneoplastic Syndrome kin apia fɔs. So, e fayn fɔ no bɔt dɛn kayn sik ya.
Us pat na di bɔdi we dis sik kin afɛkt?
Paraneoplastic syndrome kin afɛkt ɔlmost ɛni sistɛm na di bɔdi. Bɔt dɛn kin si dɛn mɔ na dɛn sistɛm ya. Lɛ wi tek wan luk pan wetin dɛn bi ɛn us kɔndishɔn kin apin we gɛt fɔ du wit dɛn.
| Di bɔdi sistɛm we dɛn afɛkt | Posisibul mεdikal kכndyushכn dεm (εgzampl dεm) . |
|---|---|
| Nεv sεstem (bren, spεnal kכd, nεv dεm) . | Kכndishכn dεm lεk Sεribεl dεjεnεreshכn, εnsefalaytis, Lambert-Eaton myasthenic sεndrכm, Myasthenia gravis, Pεrifεral nyuropathy, Stiff pכsin sεndrכm. |
| di εndokrin sistεm (hכmon dεm) . | Kכndishכn dεm lεk Cushing syndrome, Hypercalcemia (di kalsiכm we de bכku na di bכdi), εn Carcinoid syndrome. |
| di kכnektiv tisu (bon dεm, jכint dεm, mכsul dεm) . | Dεmatomyosaytis, Paranioplastik polyarthritis (jɔyn inflameshn), Hypertrophic osteoarthropathy. |
| Blɔd | Anemia fɔ sik we nɔ de mɛn, Paraneoplastic erythrocytosis, Paraneoplastic thrombocytosis. |
| Kanda | Acanthosis nigricans (di skin de tik ɛn tik na say dɛn lɛk di armpit ɛn di nɛk), Dɛmatomyositis, Swit sindrom, Paraneoplastic pemphigus. |
Wetin na di kɔmɔn ɛn patikyula sayn dɛm?
Bɔrku kɔmɔn sayn dɛm de wae dɛn kin si fɔs pan paraneoplastic syndrome. Dɛn kin si dɛn tin ya bak pan ɛni ɔda sik, so i nɔ fayn fɔ mek yu fred jɔs we yu si dɛn tin ya.
Di sayn dɛn we kin apin:
- Fiva we nɔ gɛt rizin
- Fil fɔ it
- Fɔ swet pasmak na nɛt
- Unusual weight loss we yu nɔ tray fɔ du am
Apat frɔm dɛn kɔmɔn sayn ya, lɛk aw wi bin dɔn tɔk, sɔm patikyula sayn dɛn kin apin dipen pan di bɔdi sistɛm we dɛn afɛkt.
| Sistɛm we dɛn afɛkt | Spɛshal sayn dɛm wae yu kin si |
|---|---|
| Nɛvɔ sistɛm | I nɔ kin izi fɔ waka, i nɔ kin balans, i kin gɛt diziz, i kin si tu tɛm, i nɔ kin mɛmba tin, i kin gɛt dis maynia sik, di mɔsul dɛn kin wik, i nɔ kin izi fɔ tɔk. |
| di εndokrin sistεm | Ay blɔd prɛshɔn, we yu nɔ ebul fɔ ɛksplen, we yu gɛt ay shuga na yu blɔd, we yu taya pasmak. |
| Tisu we de kכnekt | Joyn pen, joyn swel, mɔsul pen ɛn wik. |
| Blɔd | wan abnכmal dכn כ inkrεs pan wan kayn bכdi sεl (e.g. anemia, כ inkrεs tεndens fכ blכd fכ kכlכt). |
| Kanda | Lump dɛn we nɔ gɛt kansa na di skin, di skin kin rɛd, i kin it pasmak, ɛn di skin in kɔlɔ kin chenj. |
Udat de pan big risk fɔ gɛt dis sik?
Paraneoplastic syndromes na tiori posbul fɔ ɛnibɔdi we gɛt kansa. Bɔt dɛn kin apin mɔ wit sɔm kayn kansa. Akɔdin to sɔm statystik, lɛk 8 pan 100 pipul dɛm wae gɛt kansa (8%) kin gɛt dis sik.
De kayn kansa wae kin kam wit dis sik na:
- Lɔng kansa (dɛn kin si am mɔ wit dis kayn) .
- Brɔst kansa
- Kansa dɛn we gɛt fɔ du wit blɔd (lɛk limfoma, lukimiya) .
- Kansa na ovarian
Aw dɔktɔ kin fɛn dis?
We yu go to dɔktɔ wit dɛn sik ya, di fɔs tin we i go du na fɔ tek wan gud istri ɛn du wan ɛgzam pan in bɔdi. Dɔn, dɛn go ɔda fɔ du bɔku tɛst fɔ no if na kansa ɔ ɔda sik we de mek pɔsin gɛt di sik.
- Blɔd tɛst: Rutin blɔd tɛst kin chɛk fɔ ɔda tin dɛn we kin mek yu gɛt di sik (e.g., infɛkshɔn, ɔmon imbalans). Dɔn bak, sɔm spɛshal blɔd tɛst dɛn kin luk fɔ antibodi ɔ tumor mak dɛn we gɛt fɔ du wit paraneoplastic syndrome.
- Imajin: Dɛn kin yuz tɛst lɛk CT skan , MRI skan , ɔ ɔltra saund fɔ no if kansa de insay di bɔdi.
- Nyurolɔjik ɛgzam: If dɛn tink se yu sik gɛt fɔ du wit di nervɔs sistɛm, yu dɔktɔ go du difrɛn tin dɛn fɔ tɛst yu trɛnk, mɛmori, balans, ɛn kɔdineshɔn.
- Spinal tap/Lumbar Puncture: Dis involv f tek sכm sכm sכm sεribrospinal fluid, di wata we de rawnd yu spεnal kכd, εn tεst am fכ si if εni abnכmal antibodi dεm de insay dis fluid we de atak hεlty sεl dεm.
Aw dɛn kin trit am?
Di impɔtant ɛn impɔtant tin fɔ trit wan paraneoplastic syndrome na fɔ trit di kansa we mek ɔl dis. Wae dɛn dɔn kɔntrol ɔr dɔn wɛl di kansa, di sayn dɛm wae gɛt fɔ du wit di paraneoplastic syndrome kin stɔp fɔ dɛnsɛf.
Na di sem tɛm, we dɛn de trit kansa, dɛn kin gi tritmɛnt dɛn bak fɔ kɔntrol di sayn dɛn we dɔn kam. Di men gol fɔ dɛn tritmɛnt ya na fɔ mek di imyun sistɛm we de mistek atak di sɛl dɛn we gɛt wɛlbɔdi, kol.
- Kɔtikosterɔyd: Drug dɛn lɛk Prednisolone. Dɛn tin ya de wok bay we dɛn de ridyus di inflamɛns ɛn swel na di bɔdi.
- Di tin dɛn we de mek di bɔdi nɔ ebul fɔ fɛt di sik:Dɛn drɔgs ya de ridyus di wok we di imyun sistɛm de du ɛn stɔp am fɔ atak di sɛl dɛn we gɛt wɛlbɔdi.
- Intravenous immunoglobulin (IVIG): Dis involv fכ gi wan tin we gεt antibodi dεm we dεn tek frכm hεlty pipul dεm intravenous. Dɛn antibodi ya de ɛp fɔ pwɛl di bad bad antibodi dɛm we de pwɛl di bɔdi.
- Plasmapheresis: Dis na tin we fiba di we aw dɛn de klin di blɔd. Dɛn kin tek yu blɔd, dɛn kin separet di wata pat (plasma), dɛn kin filta di antibodi dɛn we de ambɔg yu, ɛn dɛn kin put di plasma we dɛn dɔn klin bak insay yu bɔdi.
- Fyzikal, wok ɛn tɔk tritmɛnt: If di nervɔs sistɛm dɔn afɛkt ɛn i nɔ izi fɔ waka, tɔk ɔ du ɛvride wok, dɛn tritmɛnt ya kin ɛp fɔ bil dɛn abiliti dɛn de bak.
Ustɛm yu fɔ go to dɔktɔ?
If yu gɛt ɛni ɔda kayn sik lɛk di wan dɛn we wi dɔn tɔk bɔt na dis atikul, mɔ if i rili bad ɔ i kin las pas tu wiks, yu fɔ rili go to dɔktɔ.
Mɛmba se nɔto ɔlman we gɛt dɛn sik ya gɛt kansa. Bɔrku pan dɛn sik ya kin kam bak wit ɔda tin dɛm wae nɔr kin siriɔs lɛk kansa. So nɔ tink se na di wɔs tin ɛn panik. Bɔt, i impɔtant fɔ no di rayt tin we de mek yu gɛt am. So mek shɔ se yu go to dɔktɔ fɔ advays.
If yu dɔn gɛt tritmɛnt fɔ kansa trade, lɛ wi se insay di las fayv ia, ɛn naw yu de gɛt sɔm kayn sik lɛk dis, i rili impɔtant fɔ mek dɛn du tɛst bak. Dis kin ɛp fɔ no if di kansa dɔn kam bak.
Wae yu de liv wit kansa, e nɔrmal fɔ fil pasmak wae yu gɛt kɔmbayn sik lɛk dis. Bɔt i impɔtant fɔ ɔndastand se di bɛst tritmɛnt fɔ dis paraneoplastic syndrome na di sem wit di tritmɛnt fɔ di kansa. If yu fala yu kansa tritmɛnt plan gud gud wan, dat go ɛp yu fɔ kɔntrol dɛn sik ya. Bɔku tritmɛnt dɛn de we kin mek yu fil fayn. Tɔk opin wan wit yu dɔktɔ bɔt dɛn.
Mɛsej we dɛn kin kɛr go na os
- Paraneoplastic syndrome nɔto dairekt ifɛkt we kansa gɛt, bɔt na indaykt ifɛkt we di bɔdi in imyun sistɛm ɔ ɔmon dɛn we de ansa kansa kin mek.
- Sɔntɛnde, di sayn dɛm wae gɛt fɔ du wit dis sik kin apia fɔs , ivin bifo dɛn no se yu gɛt kansa.
- Di men we fɔ trit dis sik na fɔ trit di kansa we de ɔnda am.
- If yu gɛt sɔm kayn sik dɛn we nɔ kɔmɔn (e.g. we yu de lɔs yu wet, yu mɔsul dɛn wik, yu skin de chenj) we de sho fɔ natin ɛn we de las fɔ pas tu wik, go to dɔktɔ we yu nɔ de te.
- Bikɔs bɔku ɔda sik dɛn kin kam wit dɛn sik ya, i rili impɔtant fɔ mek yu nɔ fred ɛn go to dɔktɔ fɔ chɛk yu fayn fayn wan .
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