I at fɔ put insay wɔd wetin yu de fil we yu kam fɔ no se yu ɔ pɔsin we yu lɛk gɛt kansa. Na nɔmal tin fɔ mek yu fred ɛn want fɔ no mɔ we yu dɔktɔ tɛl yu bɔt nyu tritmɛnt, lɛk PRRT, we na wɔd we yu nɔ no. Bɔt nɔ wɔri. Pan ɔl we dis na sɔm kɔmpleks tɔpik, tide wi go tɔk bɔt wetin na PRRT, wetin i de du, ɛn wetin na in bɛnifit ɛn bad tin dɛn, insay wan rili simpul we we yu go ɔndastand.
Wetin PRRT jɔs min?
Fɔ tɔk am simpul wan, PRRT na wan tritmɛnt we rili advans we de tɔch, fɛn, ɛn pwɛl kansa sɛl dɛn, jɔs lɛk ‘gayded missile’ . dεn kin yus am spεshal fכ trit wan kayn kεnsar we dεn kכl `Neuroendocrine Tumors (NETs).'
Di spɛshal tin we dis tritmɛnt de du na dat di redioaktiv matirial (raydioaktiviti) we i de pul de go dairekt insay di kansa sɛl dɛn ɛn pwɛl dɛn. So, di damej we di sɛl dɛn we gɛt wɛlbɔdi kin du nɔ kin bɔku pas di wan we dɛn kin yuz redyushɔn tɛrapi ɔltɛm.
Aw dis tritmɛnt de wok insay di bɔdi?
Fɔ ɔndastand dis, lɛ wi yuz wan simpul ɛgzampul. imajin se yu kansa sel dεm na do dεm we gεt plεnti spεshal ‘kihol’ (`rεsεptor`). Ɛni domɔt kin jɔs fit wan ki we gɛt wan patikyula shep.
Dis drɔg we dɛn kɔl PRRT, dɛn kin mek am bay we dɛn jɔyn tu tin dɛn:
1. Di Ki: Dis na prɔtin. dis ki kin כnli fit insay di ‘kihol’ fכ di kεnsar sεl dεm. I nɔ kin fit insay sɛl dɛn we gɛt wɛlbɔdi.
2. Di Redioaktiv Pasenja: Dis ki gɛt wan rili smɔl redioaktiv ɛlimɛnt (`radionuclide`) we dɛn tay pan am.
So, we yu gi dis drɔg to yu bɔdi, dis ‘ki’ de travul ɔlsay na di bɔdi, fɛn di ‘kihol’ dɛn na di kansa sɛl dɛn, ɛn atak insɛf to dɛn. afta dat, di ‘raydioaktiv pasenja’ we de na di ki de go insay di kansa sεl, i de pwεl di DNA fכ da sεl de, εn i de pwεl di sεl frכm insay.
dis mכtכd de alaw fכ sεlektiv dεstrukshכn fכ כnli kεnsar sεl dεm, we nכ de mek bכku damej to hεlty sεl dεm. Dis na di big big bɛnifit fɔ dis tritmɛnt.
di PRRT dכg we dεn kin yus mכst tide na `lutetium Lu 177 dotatate (LUTATHERA®)`.
Udat dɛn kin advays fɔ gi PRRT tritmɛnt?
Dis tritmɛnt nɔ fayn fɔ ɔl di wan dɛn we gɛt kansa. naw, dεn kin mεnli rεkomεnd am fכ kεnsar dεm we dεn kכl `gastroenteropancreatic NETs`, we na kεnsar dεm na di dijestiv trakt (intestines, bεlε, rεktum) εn pankrias. Bɔrku tin kin de wae dis tritmɛnt kin fayn fɔ yu.
| Pozishɔn | Fɔ ɛksplen |
|---|---|
| Nɔ fayn fɔ ɔpreshɔn | If di kansa dɔn skata ( metastasized ) to bɔku pat dɛn na di bɔdi, i nɔ go izi fɔ mek dɛn du ɔpreshɔn nɔmɔ i go mɛn am ɔl. Bɔrku pipul dɛm wae gɛt NET kin dɔn ɔlrɛdi spre di kansa wae dɛn no se dɛn gɛt am. |
| Ɔda tritmɛnt dɛn nɔ dɔn wok fayn | If dɛn nɔ ebul fɔ du ɔpreshɔn, dɛn kin gi dɛn tin dɛn lɛk ɔmon tɛrapi. Bɔt sɔntɛnde, dɛn tritmɛnt dɛn de kin mek di kansa sɛl dɛn kɔntinyu fɔ gro we dɛn nɔ ebul fɔ kɔntrol. Fɔ dɛn pipul dɛn de, PRRT na gud opshɔn. |
| Kansa sel dεm gεt da ‘kihol’ de. | Dis na di tin we impɔtant pas ɔl. fכ mek di PRRT dכg rich di ‘ki’ εn kכnekt, i fכ gεt 'kihol' dεm we dεn kכl somatostatin rεsεp כta dεm na di sεf fכ di kεnsar sεl dεm. Yu dɔktɔ go du spɛshal skan, lɛk ɔktreɔtayd skan ɔ PET skan , fɔ si if yu kansa sɛl dɛn gɛt dɛn tin ya. |
Wetin kin apin bifo ɛn we dɛn de trit am?
Bifo dɛn trit am
If yu de tek ɔda mɛrɛsin fɔ NET (especially somatostatin analogs), yu dɔktɔ go mɔs advays yu fɔ stɔp fɔ tek dɛn sɔm wiks bifo PRRT. I go mɔs bi se yu dɔktɔ go du blɔd tɛst bak lɛk wan wik bifo yu tritmɛnt fɔ chɛk aw yu kidni de wok ɛn di blɔd sɛl dɛn fɔ mek shɔ se yu bɔdi de fayn fɔ gɛt di tritmɛnt.
Na di de we dɛn de trit am
Dɛn kin gi dis tritmɛnt ɛvri tu mɔnt fɔ 4 sɛshɔn fɔ 8 mɔnt. Dis na ɔutpatient prosidur, we nɔ nid fɔ de na ɔspitul. di ol prosidכs de tek lεk 5-6 awa.
- Fɔs, dɛn kin put smɔl tiub (kanula) insay wan vein na yu an ɛn mek wan salin layn.
- Lɛk wan awa bifo di tritmɛnt bigin, dɛn kin gi am mɛrɛsin fɔ mek i nɔ gɛt nays ɛn vɔmit.
- afta dat, dεn go gi yu wan salin sכlushכn we gεt amino asid fכ protεkt yu kidni dεm fכ lεk 4 awa. Dis rili impɔtant.
- lεk 30 minit afta dεn bigin fכ gi di amino asid dεm, dεn de gi di PRRT dכg to di bכdi tru di salin fכ 30-45 minit.
- We dɛn dɔn gi ɔl di salin, dɛn kin pul di tiub we de na di an.
Di de afta di tritmɛnt, yu go gɛt ɔda skan fɔ chɛk usay di redioaktiv mɛrɛsin dɔn go na yu bɔdi, mɔ usay di kansa tumbu dɛn de.
Wetin na di sayd ɛfɛkt ɛn risk dɛm?
Jɔs lɛk ɛni tritmɛnt, sɔm sayd ɛfɛkt dɛn kin de.
Di sayd ɛfɛkt dɛn we kin apin mɔ:
Di sayd ɛfɛkt dɛm we kin apin pas ɔl na fɔ nɔs ɛn vɔmit , bɔt bɔku pan dɛn kin kɔntrol dɛn tin ya if yu trit yu kwik kwik wan.
Ɔda prɔblɛm dɛn we kin apin:
- Ɛni ifɛkt pan di kidni ɔ liva wok.
- di nכmba fכ di bכdi sεl dεm (wayt blכd sεl dεm, rεd blכd sεl dεm, pletlεt dεm) dכn dכn. Dis kin mek i nɔ izi fɔ blo, i kin mek i gɛt infɛkshɔn mɔ ɛn mɔ, ɛn i kin mek i gɛt blɔd ɔ brus.
- Na smɔl tɛm nɔmɔ, i kin rili smɔl fɔ mek yu gɛt ɔda blɔd kansa lɛk myelodysplastic syndrome ɔ leukemia.
Yu dɔktɔ go de wach yu blɔd lɛvɛl ɔltɛm ɔl di tɛm we yu de trit yu. If ɛni prɔblɛm kam, dɛn kin disayd fɔ chenj di doz ɔ stɔp yu tritmɛnt.
Wan rili siriɔs tin we nid fɔ pe atɛnshɔn to am wantɛm wantɛm!
Carcinoid crisis na wan sik wae nɔr kin bɔrku bɔt kin mek pɔrsin in layf de pan denja wae kin apun wae dɛn de trit am. I kin kam bikɔs bɔku bɔku ɔmon dɛn we de kɔmɔt na di kansa sɛl dɛn kin kɔmɔt na di blɔd wantɛm wantɛm. Di sayn dɛm kin sho insay di fɔs 48 awa afta dɛn dɔn gɛt di tritmɛnt.
If yu gɛt ɛni wan pan dɛn sik ya, go na di ɔspitul Imejɛnsi Dipatmɛnt (ETU) we de nia yu wantɛm wantɛm ɔ kɔl 1990:
* I nɔ izi fɔ blo
* yu fes ɔ yu nɛk de rɛd, yu de fil wam ɔ yu de bɔn na yu bɔdi (Flushing) .
* Blɔd prɛshɔn go dɔŋ wantɛm wantɛm (we yu de fil lɛk yu ed de tɔn) .
* Di at we de blo
* I kin gɛt siriɔs dayarɛa
Ɛvride layf afta tritmɛnt
Bɔrku pipul dɛn kin telɛ dis tritmɛnt fayn fayn wan ɛn dɛn kin wɛl kwik kwik wan.
Redioaktiviti ɛn sef:
Di tritmɛnt de yuz smɔl smɔl raytin. Dis go pas kɔmɔt na yu bɔdi insay yu urine ɛn stɔl insay di nɛks sɔm dez. Insay dis tɛm, yu dɔktɔ go gi yu instrɔkshɔn fɔ mek ɔda pipul dɛn nɔ gɛt raytin.
- I impɔtant mɔ fɔ de fa frɔm uman dɛn we gɛt bɛlɛ ɛn yɔŋ pikin dɛn fɔ sɔm dez.
- Wash yu an fayn fayn wan wit sop afta yu dɔn yuz tɔylɛt.
We yu de travul:
Na smɔl smɔl raytin kin de na yu bɔdi fɔ te 3 mɔnt afta yu dɔn trit yu. Dis kin mek dɛn bigin fɔ yuz redyushɔn ditektɔ dɛn na di aypɔt ɔ na di bɔda dɛn. So, kip di spɛshal kad we yu de gɛt frɔm di ɔspitul ɛn yu tritmɛnt ditil dɛn wit yu ɔltɛm. Dis rili impɔtant fɔ mek yu nɔ gɛt ɛni prɔblɛm we yu de travul.
Mɛsej we dɛn kin kɛr go na os
- PRRT na wan advans tritmεnt we de gi rεdyushכn we dεn spεshal tכk to kansa sεl dεm. Dɛn kin yuz am spɛshal fɔ Nyuroɛndokrin Tumɔs (NET).
- Pan ɔl we dis nɔto tritmɛnt we de mɛn kansa ɔltogɛda, i de ɛp fɔ mek di tumbu dɛn smɔl ɔ stɔp fɔ gro, kɔntrol di sik dɛn we de sho se i gɛt sik, ɛn mek in layf bɛtɛ bay we i de mek di tɛm we pɔsin de liv bɛtɛ.
- Fɔ sɔm dez afta di tritmɛnt, fala di instrɔkshɔn dɛm we dɛn gi fɔ protɛkt ɔda pipul dɛm frɔm redyushɔn (espɛshali fɔ de fa frɔm yɔŋ pikin dɛm ɛn uman dɛm we gɛt bɛlɛ).
- Yu fɔ no di sayn dɛm wae de sho se yu gɛt kansa (di at fɔ blo, yu de flash, yu gɛt siriɔs dayarɛa, yu at de rit pasmak). If yu gɛt ɛni wan pan dɛn sik ya, go na ɔspitul in ETU wantɛm wantɛm.
- Nɔ shek fɔ tɔk to yu dɔktɔ bɔt ɛni sayd ɛfɛkt ɔ prɔblɛm we yu go gɛt.
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