We dɛn no se yu ɔ pɔsin we yu lɛk gɛt kansa, i nɔmal fɔ mek yu fred smɔl ɛn fred we yu dɔktɔ tɔk bɔt tritmɛnt lɛk R-CHOP. Bɔku kwɛstyɔn dɛn kin kam na wi maynd, lɛk wetin dɛn wɔd ya min, aw dis tritmɛnt tan, ɛn wetin go apin bikɔs ɔf dat. Na dat mek, lɛk se yu padi de tɛl yu bɔt am insay simpul wɔd, wi go tɔk bɔt ɔltin bɔt R-CHOP tritmɛnt tide.
Fɔ tɔk am simpul wan, wetin na R-CHOP?
R-CHOP na wan tritmɛnt fɔ kansa. Fɔ tɔk di kɔrɛkt tin, na fayv drɔgs dɛn we dɛn jɔyn togɛda. Dɛn kin yuz am spɛshal fɔ mɛn wan kayn kansa we dɛn kɔl Nɔn-Hɔdgkin Limfoma . Dis kɔmbayn drɔgs inklud tri kemotɛrapi drɔgs, wan targeted therapy drug, ɛn wan kɔtikosterɔyd.
Ɛni lɛta we de na dis nem tinap fɔ wan kayn mɛrɛsin. I rili simpul, si.
| Lɛta | Nem fɔ di drɔg | Wetin kin apin wit dis? |
|---|---|---|
| R | Rituximab we dɛn kɔl Rituximab | Dis na tritmɛnt we dɛn kin yuz fɔ mɛn pipul dɛn. Dis min se di drɔg de atak wan patikyula prɔtin we de na di kansa sɛl dɛn. Dɔn wi bɔdi in imyun sistɛm kin ebul fɔ fɛn ɛn pwɛl dɛn kansa sɛl ya izi wan. |
| C. C | Sayklɔfosfamid | Dis na wan mɛrɛsin we dɛn kin yuz fɔ mɛn pipul dɛn we gɛt kemotɛrapi. Dɛn drɔgs ya de wok bay we dɛn de pwɛl di sɛl dɛn we de sheb kwik kwik wan (lɛk di kansa sɛl dɛn). |
| H | Dɔksorubisin Haydroklɔrayd | Dis na kemotɛrapi mɛrɛsin bak. |
| O | Vinkristin Sɔlfɛt we dɛn kɔl Vincristine | Dis na ɔda kemotɛrapi mɛrɛsin. |
| P | Prednison we gɛt di sik | Dis na wan kayn stɛroyd (kɔtikosterɔyd). I de ɛp fɔ kil di kansa sɛl dɛm ɛn i de ɛp bak fɔ ridyus di alɛji we kin apin wit ɔda mɛrɛsin dɛm. |
Bikɔs bɔku pan dɛn mɛrɛsin ya na kemotɛrapi drɔgs, sɔm pipul dɛn kin kɔl dis tritmɛnt bak "R-CHOP kemo." Bɔt bikɔs di mɛrɛsin we dɛn kɔl Rituximab de ɛp wi imyun sistɛm, yu dɔktɔ kin kɔl am bak "immuno-chemotherapy."
Us kayn sik dɛn kin yuz R-CHOP tritmɛnt fɔ?
Dɔktɔ dɛn kin yuz R-CHOP mɔ fɔ trit wan kayn kansa we dɛn kɔl non-Hodgkin lymphoma . I de trit bak we rili fayn fɔ wan pan di kayn limfoma we dɛn kin kɔl difyuz big B-sɛl limfoma (DLBCL) .
Apat frɔm dat, dɛn kin yuz R-CHOP bak pan dɛn tin ya:
- Advans folikul limfoma
- Mantɛl sɛl limfoma
- Waldenstrom makroglobulinemia
Aw di tritmɛnt kin apin? (Tritmɛnt Saykl) .
Yu go gɛt R-CHOP tritmɛnt insay saykl dɛn. εvri saykl kin tek tri wik (21 dez). Dis saykl gɛt tu pat:
1. Tritmɛnt de: Na di de dɛn we dɛn de gi yu mɛrɛsin.
2. Rɛst de: De fɔ alaw yu bɔdi fɔ wɛl, dat na fɔ wɛl, bifo di nɛks rawnd.
Aw di tritmɛnt de dɛn de go?
Yu go nid fɔ tek mɛrɛsin fɔ fayv dez. Dɛn kin tek di stɛroyd we dɛn kɔl Prednisone (P) as pil. Dɛn kin gi yu di ɔda 4 mɛrɛsin dɛn (R, C, H, O) bay we dɛn put yu insay yu bɛlɛ (IV). Dis min se dɛn kin gi dɛn insay wan vein lɛk salin. Yu go nid fɔ go na ɔspitul ɔ klinik fɔ dis.
We dɛn de du dis tritmɛnt, dɛn go sidɔm na chia. Wan mashin go gi yu di mɛrɛsin tru wan plastic tiub insay wan vein na yu an, an, ɔ chɛst. Sɔntɛnde, fɔ mek i izi fɔ kɔntinyu fɔ gɛt tritmɛnt, dɛn kin put wan smɔl tin we dɛn kɔl kemo pɔt ɔnda di skin na yu chɛst.Dɛn kin kɔl am bak wan.
Di fɔs raun fɔ tritmɛnt kin go lɛk dis:
- Bifo di tritmɛnt bigin, dɛn go gi yu mɛrɛsin fɔ stɔp fɔ vɔmit ɛn nɔs .
- Dɔn bak, dɛn kin gi mɛrɛsin fɔ mek pɔsin nɔ gɛt alɛji . I kɔmɔn fɔ gɛt smɔl riakshɔn (e.g., fil wam, diziz) we dɛn gi yu di drɔg Rituximab (R). Bɔt di mɛrɛsin we dɛn bin dɔn gi am trade kin mek i nɔ gɛt siriɔs riakshɔn.
Di impɔtant tin fɔ rɛst de
Insay wan tipik saykl fɔ R-CHOP, yu kin gɛt 16 dez fɔ rɛst afta fayv dez tritmɛnt. Dis tɛm rili impɔtant. Bikɔs we R-CHOP de pwɛl di kansa sɛl dɛn, i kin rili taya bak fɔ di bɔdi. So na nɔmal tin fɔ mek yu fil taya bad bad wan afta yu dɔn gɛt tritmɛnt. Insay dɛn rɛst de ya, i go fayn fɔ aks yu fambul ɔ padi fɔ ɛp yu wit di wok dɛn we yu de du ɛvride.
We yu de wɛl, if yu ebul fɔ du tin wit yu bɔdi, yu dɔktɔ go tɛl yu fɔ du smɔl smɔl tin dɛn lɛk fɔ waka, drink bɔku wata, ɛn it tin dɛn we gɛt fayn fayn tin dɛn fɔ du.
Aw lɔng dɛn fɔ du dis tritmɛnt?
Bɔku pipul dɛn kin gɛt siks saykl dɛn fɔ R-CHOP. Ɛni saykl kin tek tri wik, so di ɔl tritmɛnt tɛm na lɛk 18 wik. Bɔt di nɔmba fɔ di saykl dɛn we yu nid kin dipen pan di sik we yu gɛt. Sɔm pipul dɛn kin nid et saykl. Sɔm dɔktɔ dɛn kin se yu fɔ tek tu wiks saykl instead fɔ tri wik saykl.
Yu dɔktɔ na di bɛst pɔsin fɔ disayd dis . I go ɛksplen klia wan di tritmɛnt plan we yu nid.
Wetin na di bɛnifit dɛn we R-CHOP tritmɛnt kin gi?
Di big bɛnifit fɔ dis na dat i nɔto wan mɛrɛsin, bɔt na fayv mɛrɛsin dɛn we dɛn jɔyn togɛda. Ɛni wan pan dɛn mɛrɛsin ya kin kil di kansa sɛl dɛn difrɛn we dɛn. So, insted fo wan sojaman fait, e bi laik se wan ol ami de kam togeda fo fait kansa.
Di sakses ret fɔ R-CHOP tritmɛnt rili ay . fכ egzampl, te to 70% pan di pipul dεm we gεt wan kayn kεnsar we dεn kכl DLBCL kin rich komplit rεmishכn. Dis min se ɔl di sayn dɛm kin dɔn. If di sik nɔ kam bak fɔ fayv ia, dɛn kin tek di kansa se i nɔ go kam bak.
Na tru se dis tritmɛnt nɔ go ebul fɔ gi garanti se i go pul di kansa kpatakpata ɔ stɔp am fɔ kam bak na ɔlman. Bɔt dɛn kin tek R-CHOP as wan pan di tritmɛnt dɛn we sef ɛn we go wok fayn fɔ di nɔ-Hɔdgkin limfoma.
Sayd Ifɛkt ɛn Risk dɛn
Lɛk ɛni tritmɛnt, R-CHOP gɛt sayd ɛfɛkt. Bɔt nɔ wɔri. Yu dɔktɔ go gi yu mɛrɛsin fɔ mek yu nɔ gɛt dɛn big big sayd ɛfɛkt ya (lɛk fɔ vɔmit) ɛn fɔ kɔntrol tin dɛn lɛk we di wayt blɔd sɛl dɛn nɔ de bɔku. E fayn fɔ tɔk opin wan bɔt dɛn prɔblɛm ya wit yu dɔktɔ bifo yu bigin fɔ trit yu.
Riakshɔn dɛn we pɔsin kin du wit infushɔn
Bɔku pipul dɛn kin gɛt smɔl riakshɔn to Rituximab di tɛm we dɛn de tek dɛn fɔs raun fɔ tritmɛnt. Dis na di rizin we mek dɔktɔ dɛn kin gi di mɛrɛsin smɔl smɔl fɔs. Na kɔmɔn tin fɔ mek yu gɛt diziz ɔ wam, ɛn i go dɔn afta sɔm tɛm. Bɔt if yu gɛt sayn dɛn we de sho se yu gɛt siriɔs riakshɔn, yu fɔ go to dɔktɔ wantɛm wantɛm . Dɛn sayn ya na:
- Skin rash we de kɔmɔt na di skin
- I de it
- Di mɔt ɔ di lip dɛn we de swel
- Fɔ fil lɛk se yu trot dɔn kɔnstrikt
Di mɛdikal wokman dɛm go wach yu we dɛn de gi yu di mɛrɛsin. Bɔt if yu gɛt ɛni wan pan dɛn sik ya afta yu dɔn go na os, go na di ɔspitul in Imejɛnsi Dipatmɛnt (ETU) wantɛm wantɛm.
Kɔmɔn sayd ɛfɛkt dɛn
Ɔl di mɛrɛsin dɛn we de na R-CHOP kin mek pɔsin gɛt sayd ɛfɛkt. Bɔt nɔto ɔlman kin gɛt dɛn. I kin difrɛn frɔm wan pɔsin to ɔda pɔsin. Lɛ wi luk di sayd ɛfɛkt dɛm wae kin kam ɛn aw fɔ dil wit dɛm.
| Sayd ɛfɛkt we pɔsin kin gɛt | Simpul ɛksplen ɛn manejmɛnt |
|---|---|
| Rɛd/pink urine | Dɔksorubisin (H) na wan rɛd mɛrɛsin. So yu urine kin tɔn rɛd/pink fɔ lɛk 48 awa afta yu dɔn trit yu. Dis na nɔmal tin, nɔ wɔri. |
| Nɔs ɛn vɔmit | Ilɛksɛf dɛn gi yu mɛrɛsin fɔ mek yu nɔ vɔmit, sɔntɛnde yu kin fil lɛk yu nɔs. Tek di mɛrɛsin jɔs lɛk aw yu dɔktɔ tɛl yu fɔ tek am. Dɔn bak, nɔ it big it ɛn it tin dɛn we gɛt ɔyl/spaysi. |
| Di ia we de lɔs | Dis na wan kɔmɔn sayd ɛfɛkt we kemotɛrapi kin gɛt. di ia we de lכs kin bigin lεk tri wik afta di fכs doz fכ mεdikeshכn. BɔtI go gro bak afta di tritmɛnt dɔn. |
| Fɔ gɛt kol ɛn gɛt fiva | Kimotɛrapi kin mek di wayt blɔd sɛl dɛn nɔ bɔku. Dis kin mek di risk fɔ gɛt di sik bɔku. Dɛn go gi yu wan shot we dɛn kɔl G-CSF, we de ɛp fɔ mek wayt blɔd sɛl dɛn. Bɔt if yu gɛt fiva, tɛl yu dɔktɔ wantɛm wantɛm. |
| Trade wok ɛn tray tranga wan | R-CHOP tritmɛnt kin mek di rɛd blɔd sɛl dɛn go dɔŋ (anemia). Dis kin mek yu fil taya bad bad wan. Aks fɔ ɛp fɔ du wok dɛn we yu de du ɛvride. Layt ɛksesaiz, lɛk fɔ waka fɔ lɛk 30 minit so insay di de, fayn, bɔt rɛst if yu fil taya. |
| I izi fɔ mek yu blɔd ɛn brus | As di nɔmba fɔ di pletlɛt dɛn de go dɔŋ, ivin smɔl injuri kin mek i blɔd ɛn brus. Tek tɛm mek yu nɔ wund yusɛf. Tɛl yu dɔktɔ if yu gɛt dɛn sik ya. |
| Di limb dɛn we de na di an ɛn fut dɛn kin swɛla | Yu kin gɛt swɛt ɔ yu kin swɛt na yu an ɛn fut. Dɛn kɔl dis periferik nyuropathy. If yu gɛt dɛn sik ya, tɛl yu dɔktɔ. |
Apat frɔm dat, ɔda bad bad tin dɛn kin apin:
- Sɔl dɛn na yu mɔt
- Ed de at
- Kɔnstipɛshɔn ɔ dayarɛa
- At bɔn
- Di mɔsul dɛn we wik
- Nɔ ebul slip
- Di we aw pɔsin de fil kin chenj
- Di at we de blo
Pɔsin kin gɛt lɔng tɛm ifɛkt afta tritmɛnt
Bɔrku sayd ɛfɛkt kin go as tɛm de go afta di tritmɛnt dɔn.
Bɔt i dipen pan tin dɛn lɛk di trɛnk we di mɛrɛsin we yu de gɛt, R-CHOP tritmɛnt kin mek yu gɛt at sik ɔ ɔda kayn kansa smɔl tumara bambay. I kin afɛkt bak di we aw pɔsin kin bɔn pikin . Dis min se if yu de plan fɔ bɔn pikin tumara bambay, tɔk to yu dɔktɔ bɔt dis bifo tɛm. Yu kin ebul fɔ tɔk bɔt di tin dɛn we yu kin du lɛk fɔ friz yu eg ɔ yu sperm.
Wetin na di difrɛns bitwin R-CHOP ɛn CHOP?
Fɔ tɔk am simpul wan, R-CHOP na wan impɔtant vɛshɔn fɔ di CHOP tritmɛnt. Dɛn bin introduks CHOP insay di 1990 dɛm ɛn na bin di bɛst tritmɛnt fɔ non-Hodgkin lymphoma da tɛm de.
Bɔt insay di fɔs 2000 dɛm, di risach pipul dɛm ad di targeted therapy drug Rituximab (R) to di CHOP regimen. Dis addɛshɔn bin inkrisayz di rit rɛt mɔ ɛn mɔ. Tide, R-CHOP na di tritmɛnt we de wok fayn pas ɔl, we de tek CHOP in ples.
Mɛsej we dɛn kin kɛr go na os
- R-CHOP na pawaful kɔmbaynshɔn fɔ fayv drɔgs we de atak kansa sɛl dɛn frɔm difrɛn say dɛn.
- Dɛn kin gi dis tritmɛnt insay saykl dɛn. Ɛni saykl gɛt tritmɛnt de ɛn rɛst de.
- Sɔm bad tin kin apin, bɔt dɛn kin kɔntrol bɔku pan dɛn. Nɔr frayd fɔ tɛl yu dɔktɔ bɔt ɛni diskɔmfɔt we yu gɛt.
- If yu gɛt fiva, i nɔ izi fɔ yu fɔ blo, ɔ ɔda bad bad tin dɛn, go to dɔktɔ wantɛm wantɛm.
- R-CHOP tritmɛnt gɛt rili ay sakrifays rɛt fɔ nɔ-Hɔdgkin limfoma. Dis joyn kin tranga, bɔt yu mɛdikal tim ɛn di wan dɛn we yu lɛk de wit yu.
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