Yu tink se di mɛrɛsin we yu de tek kin mek yu layf de pan denja? Lɛ wi tɔk bɔt di sik we dɛn kɔl Serotonin Syndrome

Yu na pɔsin we de tek mɛrɛsin fɔ pwɛl at, fɔ gɛt maygren, ɔ fɔ gɛt bad bad pen? Ɔ yu kin tek mɛrɛsin frɔm bɔku dɔktɔ dɛn fɔ di sem sik? Dɔn dis stori go rili impɔtant to yu. Tide wi de tɔk bɔt wan kɔndishɔn we kin apin na wi bɔdi bikɔs ɔf sɔm kayn mɛrɛsin, we kin mek wi layf de pan denja if wi nɔ ɔndastand am fayn. Wi kin kɔl dis ‘Serotonin Syndrome’ . Nɔr wɔri, if wi no bɔt dis fayn fayn wan, wi kin avɔyd big risk.

Fɔ tɔk am simpul wan, wetin na Serotonin Syndrome?

Fɔ ɔndastand dis, wi fɔs nid fɔ no wetin na ‘Serotonin’. Tink bɔt am lɛk smɔl mɛsenja we de kɛr mɛsej bitwin wi bren ɛn di ɔda pat dɛn na wi bɔdi. insay mεdisin, wi kin kכl dεn kεmikכl mεsenja dεm ya ‘nyurotransmitta dεm’. Serotonin na wan impɔtant nyurotransmit bak fɔ wi bɔdi, we de kɔntrol bɔku tin dɛn lɛk wi maynd, slip, ɛn we wi want fɔ it.

Nɔmal wan, we yu tek di mɛrɛsin we dɔktɔ gi yu, di lɛvɛl we di sɛrotonin de na di bɔdi kin balans. כltu, if fכ sכm rizin dis kεmikכl we dεn kכl sεrotonin inkrεs tu mכch na wi bכdi , dat na if i kכlכm insay wan כmכnt we di bכdi nכ ebul fכ hεndl, dεn kכl am di riakshכn we wi bכdi de du to am ‘sεrotonin sεndrכm’. Dis kin bi wan denja riakshɔn we wan kayn mɛrɛsin kin kam wit (drug reaction).

Udat kin gɛt dis sik?

Infakt, ɛnibɔdi we ol ɛni ej we de yuz mɛrɛsin, sɔpɔtmɛnt, ɔ drɔgs we nɔ rayt we de afɛkt di sɛrotonin lɛvɛl, de pan denja. Dis kכndyushכn kin mכst si pan tin dεm lεk dis:

• We yu bigin fɔ tek nyu mɛrɛsin: As yu bigin fɔ tek nyu mɛrɛsin we de mek di sɛrotonin lɛvɛl go ɔp.
• We yu de inkrisayz di doz fɔ wan mɛrɛsin: If yu dɔktɔ inkrisayz di doz fɔ wan mɛrɛsin we yu dɔn ɔlrɛdi de tek.
• We yu de yuz sɔm mɛrɛsin dɛn togɛda: Dis na di tin we de mek yu denja pas ɔl ɛn we yu kin gɛt. Imajin, yu gɛt yu jɔyn dɛn we de at. Yu tek pen kil frɔm wan dɔktɔ fɔ am. Insay da tɛm de, bikɔs yu de wɔri smɔl, yu go si ɔda dɔktɔ ɛn tek mɛrɛsin fɔ dat bak. Bɔt yu nɔ de tɛl di fɔs dɔktɔ bɔt di sɛkɔn mɛrɛsin, ɔ di sɛkɔn dɔktɔ bɔt di fɔs mɛrɛsin. Dis na we chans de fɔ mek yu nɔ no se yu yuz tu mɛrɛsin dɛn we de mek yu gɛt sɛrotonin togɛda ɛn mek dis tin apin.
• If yu tek bɔku mɛrɛsin: If yu tek mɔ mɛrɛsin pas di doz we dɛn tɛl yu fɔ tek, bay wilful ɔ aksidɛntli.

Wetin na di sayn dɛm we de sho se yu gɛt dis sik? Aw wi no dis?

De sayn dɛm wae de sho se yu gɛt sɛrotonin syndrome kin difrɛn frɔm wan pɔrsin to ɔda pɔrsin. Sɔm pipul kin gɛt sɔm kayn sik wae nɔr kin pasmak, wae ɔda pipul dɛn kin gɛt siriɔs sik wae kin mek pɔrsin in layf de pan denja. Dɛn sayn ya kin bigin insay sɔm awa afta yu tek nyu mɛrɛsin ɔ chenj di doz.

Fɔ mek i izi fɔ ɔndastand, lɛ wi sheb dɛn sik ya to tri pat.

Wetin na dɛn mɛrɛsin ya we de mek di sɛrotonin lɛvɛl go ɔp?

Dis list lɔng smɔl, bɔt i rili impɔtant fɔ mek yu sef fɔ no bɔt dis.

Di mɛrɛsin dɛn we de mek pɔsin nɔ fil bad

Dis na di mɛrɛsin dɛm wae kin gɛt fɔ du wit sɛrotonin syndrome. Di risk kin bɔku mɔ we dɛn tek dɛn tin ya wit ɔda mɛrɛsin (e.g., maygren mɛrɛsin).

• SSRI dεm (Sεlektiv sεrotonin riuptek inhibito dεm): Mεdikeshכn dεm lεk Fluoxetine, Sertraline, Citalopram, Escitalopram, Paroxetine.
• SNRI dεm (Serotonin-norepinephrine riuptake inhibitors): Mεdikeshכn dεm lεk Venlafaxine, Duloxetine, Desvenlafaxine.
• Trisayklik antidipreshan: Mεdikeshכn dεm lεk Amitriptyline, Nortriptyline, Imipramine.
• MAOIs (Monoamine oxidase inhibitors): Pan ɔl we dɛn nɔ kin yuz dɛn tin ya igen, dɛn kin gi dɛn insay sɔm kes dɛm.

Ɔda mɛrɛsin dɛn

• Mɛrɛsin fɔ mek pɔsin fil bad bad wan: Dɛn kin yuz mɛrɛsin fɔ mɛn pen lɛk Tramadol, Pethidine (Meperidine), Fentanyl, ɛn Methadone.
• Kɔf mɛrɛsin: Sɔm kɔf srɔp dɛn we dɛn kin gɛt na famasi dɛn gɛt wan tin we dɛn kɔl Dextromethorphan . Dis kin afɛkt di sɛrotonin lɛvɛl bak.
• Maygren mɛrɛsin: Triptan mɛrɛsin lɛk Sumatriptan ɛn Rizatriptan.
• Mɛrɛsin fɔ vɔmit: Mɛrɛsin lɛk Metoclopramide ɛn Ondansetron.
• Sɔm antibayɔtiks: Di antibayɔtik linezolid.
• Di mɛrɛsin fɔ kɔntrol di we aw pɔsin de fil: Litiɔm.

Ɔda tin dɛn

• Ɛrbal supamakit: Tin dɛn lɛk Sɛnt Jɔn wɔt ɛn Ginseng.
• Ilɛgal drɔgs: Tin dɛn lɛk Ɛkstasi (MDMA), LSD, Kɔkɛyn, Amfɛtamin.

Nɔ mek yu fred wit dis list. Nɔto ɔlman go gɛt dis sik afta dɛn dɔn tek wan pan dɛn mɛrɛsin ya. Di risk kin jɔs kam we yu yuz sɔm pan dɛn tin ya togɛda, inkrisayz di doz, ɔ if yu bɔdi de fil fɔ dɛn.

Aw dɔktɔ kin no dis?

Nɔ patikyula blɔd tɛst ɔ skan nɔ de fɔ kɔnfirm serotonin syndrome. Dɔktɔ go no di sik bay sɔm tin dɛn:

1. Yu sayn dɛm: Tek tɛm lisin to wetin yu de fil.

2. Fɔ chɛk yu bɔdi: Dɛn go chɛk yu at rit, blɔd prɛshɔn, bɔdi tɛmpracha, ɛn yu mɔsul kɔndishɔn.

3. List fɔ di mɛrɛsin dɛn we yu de tek: Dis na di tin we impɔtant pas ɔl.

Apat frɔm dat, yu kin gɛt blɔd ɛn urine tɛst bak, ɛkstrem rayt na yu chɛst, ɔr CT skan fɔ mek shɔ se yu nɔ gɛt ɔda tin dɛn (e.g., infɛkshɔn) we de mek yu gɛt di sem kayn sik.

Wetin na di tritmɛnt dɛm fɔ dis?

Di tritmɛnt de dipen pan aw yu sik bad bad wan.

• If yu gɛt sɔm kayn sik: De tritmɛnt wae yu kin gɛt na fɔ stɔp fɔ tek di mɛrɛsin wae mek yu gɛt de sik. Dis go ɔltɛm sɔlv di sik dɛn kpatakpata insay 24-72 awa.
• If yu gɛt smɔl smɔl sik dɛn: Dɛn go kip yu na ɔspitul ɛn wach yu fɔ at le 24 awa. Insay dis tɛm, dɛn go gi yu salin (IV fluid) ɛn mɛrɛsin lɛk bɛnzodiazepin fɔ wɔri.
• If yu gɛt siriɔs sik: Dis na mɛdikal imejensi. Dɛn go admit yu na di intensiv kia yunit (ICU) ɛn gi yu tritmɛnt lɛk sɔpɔt fɔ mek yu nɔ ebul fɔ blo fayn, fɔ kɔntrol yu ay fiva, ɛn mɛrɛsin fɔ kɔntrol yu at rit ɛn blɔd prɛshɔn. Sɔntɛnde, dɛn kin gi am bak wan mɛrɛsin we dɛn kɔl Cyproheptadine, we de blok di wok we di sɛrotonin de du.

Aw wi go protɛkt wisɛf frɔm dis kayn tin?

Sɔm tin dɛn de we simpul, bɔt we rili impɔtant we wi kin du fɔ mek wi nɔ gɛt dis denja.

1. Eduket yusɛf bɔt yu mɛrɛsin dɛn: Kip di nem, di doz, ɛn di rizin fɔ ɛni mɛrɛsin we yu de tek.

2. Tɛl ɛni dɔktɔ di ful ditil: If sɔm dɔktɔ dɛn de trit yu, mek shɔ se yu tɛl wan dɔktɔ bɔt di mɛrɛsin dɛn we di ɔda wan dɛn gi yu.

3. Nɔ stɔp fɔ tek mɛrɛsin we yu nɔ aks yu dɔktɔ: Ivin if yu fil ɛni prɔblɛm, nɔ stɔp fɔ tek mɛrɛsin ɔ chenj di doz we yu nɔ tɔk to dɔktɔ.

4. Tek tɛm we yu de bay mɛrɛsin na di famasi: We yu de bay mɛrɛsin fɔ tin dɛn lɛk kɔf ɛn kol, aks fɔ mɛrɛsin we go gri wit di mɛrɛsin we yu dɔn de tek.

5. Pe atɛnshɔn to di sayn dɛm: Pe atɛnshɔn gud wan to ɛni chenj na yu bɔdi, mɔ we yu bigin fɔ tek nyu mɛrɛsin ɔ yu de ad di doz.