Dɔktɔ dɔn gi yu wan kayn mɛrɛsin we dɛn kɔl SNRI fɔ yu pwɛl hat ɔr wae yu de wɔri ɔltɛm? Sɔntɛm wan pan yu padi dɛn de yuz dis mɛrɛsin. Sɔntɛm yu bin de fred smɔl we yu yɛri dis nem. Yu go mɔs gɛt bɔku kwɛstyɔn dɛn na yu maynd lɛk, "Wetin na dis mɛrɛsin? Dɛn tin ya gud fɔ di bɔdi?" So tide, lɛ wi tɔk bɔt dis kayn mɛrɛsin we dɛn kɔl SNRI rili simpul, lɛk se yu de tɔk to yu padi.
Fɔ tɔk am simpul wan, wetin na dɛn SNRI ya?
di ful minin fכ SNRI na Serotonin εn Norepinephrine Riuptek Inhibitors . Okay, di nem soun likli komplikayt, no bi so? Lɛ wi brok am ɛn ɔndastand am simpul wan.
Insay wi bren, spɛshal kemikal mɛsenja dɛn de we de kɔntrol bɔku tin dɛn, lɛk aw wi de fil, aw wi de tink, aw wi de slip, ɛn aw wi want fɔ it. wi kכl dεn ya ``Nyurotransmitta dεm.'' lεk postman, dεn mεsεn dεm ya kin kכri mεsej frכm wan pat na di bren to כda wan.
Tu pan dɛn mɛsenja ya na sɛrotonin ɛn norepinephrine .
- Serotonin rili impɔtant fɔ tin dɛn lɛk aw wi de fil, aw wi de slip, ɛn aw wi de digest. We di sɛrotonin lɛvɛl bɔku, wi kin fil gladi ɛn rilaks.
- Norepinephrine de ɛp wi fɔ kɔntinyu fɔ pe atɛnshɔn, gɛt trɛnk, ɛn du tin dɛn.
wetin kin apin na dat afta dεn mεsεn dεm ya de gi dεn mεsej, di bren sεl dεm de abzכp dεm bak insay.Dεn kכl dis ``Reuptake.'' Jεs lεk aw di postman de go bak na di post כfis afta i dεn delivεr lεta.
Bɔt pan pipul dɛm wae gɛt sik lɛk pwɛl hat ɔr wɔri, di wok wae dɛn sɛrotonin ɛn norepinephrine mɛsenja ya kin du kin ridyus smɔl na dɛn bren.
Dis na di say we SNRI drɔgs kin kam in. Wetin dɛn drɔgs ya kin du na fɔ blok fɔ sɔm tɛm fɔ mek dɛn mɛsenja dɛn de tek bak. I tan lɛk se yu tɛl di postman fɔ "wet smɔl ɛn sɛn sɔm mɔ mɛsej dɛn." Dɔn dɛn gud mɛsenja ya (serotonin ɛn norepinephrine) kin de na di bren fɔ lɔng tɛm ɛn du dɛn gud wok. Dis kin bigin fɔ mek wi fil fayn, nɔ kin wɔri, ɛn mek wi gɛt mɔ trɛnk.
Fɔ tɔk am simpul wan, SNRI na wan kayn mɛrɛsin we de ɛp wi fɔ fil fayn bay we wi de balans di lɛvɛl dɛn we di natura l kemikal dɛn de na wi bren we de kɔntrol "gladi ɛn ɛnaji."
Us kɔndishɔn dɛn kin yuz SNRI mɛrɛsin fɔ?
Pan ɔl we dɛn kin gi dɛn mɛrɛsin ya mɔ fɔ pipul dɛn we gɛt prɔblɛm wit dɛn maynd, dɔktɔ dɛn kin gi dɛn bak fɔ sɔm ɔda tin dɛn we kin apin to pɔsin in bɔdi. Lɛ wi tek wan luk pan wetin dɛn bi.
| Sik | Wan simpul ɛksplen |
|---|---|
| Mɔs pan di tɛm dɛn we dɛn kin rɛkɔmɛnd | |
| Major Dipreshɔn Disɔda | Fɔ mek yu nɔr gɛt sɔm kayn sik lɛk wae yu de fil bad fɔ lɔng tɛm, nɔr de intres pan ɛnitin, ɛn wae yu de bost wit layf. |
| Jɛnɛralized Anxiety Disɔda | Fɔ kɔntrol frayd, wɔri, ɛn nɔr de rɛst we kin kam na yu maynd ɔltɛm fɔ no patikyula rizin. |
| Sɔshial Wɔri Disɔda | Fɔ ridyus di fred pasmak ɛn shem fɔ tɔk ɛn du pɔfɔm bifo ɔda pipul dɛn. |
| Panik Disɔda | Fɔ mek yu nɔ gɛt panik atak wantɛm wantɛm, we yu nɔ go ebul fɔ kɔntrol. |
| Pen we nɔ de dɔn | Fɔ mek yu nɔr gɛt pen we nɔr de dɔn we kin kam wit tin dɛm lɛk nyuropathy we gɛt fɔ du wit dayabitis ɛn fibromyalgia. |
| Ɔda kes dɛn (Off-label use) . | |
| Obsesiv-Kɔmpulsiv Disɔda (OCD) . | Fɔ kɔntrol di we aw pipul dɛn kin tink bɔt tin dɛn we dɛn nɔ want ɔltɛm ɛn we dɛn kin ripit sɔm tin dɛn fɔ ansa dɛn. |
| Di Simptom dɛn we pɔsin kin gɛt we i dɔn lɛf fɔ liv | Fɔ kɔntrol di sayn dɛm lɛk wam wam wam wam wam wam wam wam wam wam wam wam wam wam wam wam ia de kam wit mɛnɔpauz. |
| Maygren we kin kam | As tritmɛnt fɔ mek yu nɔ gɛt maygren. |
Yu kin de wɔnda wetin "ɔf-lɛbul yuz" min. I min se dɔktɔ, bikɔs ɔf in mɛrɛsin ɛn ɛkspiriɛns, kin tɛl pɔsin fɔ tek wan mɛrɛsin fɔ ɔda sik, apat frɔm di men sik we dɛn gri fɔ tek am. Dis na sɔntin we pipul dɛn kin du.
Wetin na di kayn SNRI dɛm we kɔmɔn pas ɔl na Sri Lanka?
Bɔku kayn SNRI mɛrɛsin dɛn de. Yu dɔktɔ go pik di mɛrɛsin we go fayn fɔ yu bay aw yu sik, yu ej, ɛn ɔda wɛlbɔdi prɔblɛm dɛn.
- Venlafaxine (lɛk di brand nem Effexor®) .
- Duloxetine (lɛk di brand nem Cymbalta®) .
- Desvenlafaxine (na di nem fɔ di brand Pristiq®) .
- Milnacipran (di nem fɔ di brand Savella®) .
- Levomilnacipran (lɛk di brand nem Fetzima®) .
Di mɛrɛsin we yu gɛt kin gɛt wan pan dɛn tin ya we wi dɔn tɔk bɔt.
Wetin na di sayd ɛfɛkt dɛn we pɔsin kin gɛt we i yuz dis mɛrɛsin?
Lɛk ɔl di mɛrɛsin dɛn, dis wan kin gɛt smɔl smɔl sayd ɛfɛkt dɛn. Bɔt fɔ bɔku pipul dɛn, dɛn tin ya nɔto siriɔs tin. Dɛn kin apin insay di fɔs wik dɛn we yu tek di mɛrɛsin ɛn afta dat dɛn kin go as yu bɔdi de ajɔst to di mɛrɛsin.
| Sayd ɛfɛkt we pɔsin kin gɛt | Tɔk bɔt |
|---|---|
| Prɔblɛm dɛn we de na di dijestiv sistɛm | Nɔs, vɔmit, bɛlɛ kramp, kɔnstipɛshɔn, ɔ dayarɛa. |
| Diziz (vɛrtigo) . | Diziz, mɔ we yu tinap ɔ chenj yu pozishɔn. |
| Dray mɔt | Wan filin we saliva de pul na yu mɔt. Yu kin kɔntrol dis bay we yu drink smɔl mɔ wata. |
| We pɔsin de swet pasmak | Di swet kin bɔku, mɔ na nɛt. |
| Prɔblɛm dɛn we pɔsin kin gɛt we i de slip | Sɔm pipul dɛn kin gɛt dis sik we dɛn nɔ kin ebul fɔ slip. Ɔda pipul dɛn kin fil lɛk se dɛn de slip pasmak. |
| Prɔblɛm dɛn we gɛt fɔ du wit mami ɛn dadi biznɛs | Tin dɛn lɛk we pɔsin nɔ want fɔ du mami ɛn dadi biznɛs igen ɛn i nɔ kin izi fɔ mek i kɔmɔt na in bɔdi kin apin. Nɔ shem fɔ tɔk to yu dɔktɔ bɔt dis. |
Di tin we impɔtant pas ɔl na dat, if yu gɛt sayd ɛfɛkt lɛk dis, ɛn i tumɔs fɔ bia, nɔ ɛva stɔp fɔ tek di mɛrɛsin fɔ yusɛf. Mek shɔ se yu tɔk to yu dɔktɔ fɔ advays.
Speshal risk situeshɔn fɔ pe atɛnshɔn to
Pan ɔl we SNRI na jɔs sef mɛrɛsin, i fayn fɔ no bɔt sɔm siriɔs risk dɛn, pan ɔl we dɛn kin apin smɔl smɔl.
1. Sεrotonin Sindrכm
Dis na di tin we impɔtant pas ɔl we yu fɔ wach fɔ. We dɛn tek SNRI ɛn ɔda mɛrɛsin dɛn we de afɛkt di sɛrotonin lɛvɛl togɛda, di sɛrotonin lɛvɛl na di bren kin ay pasmak. Dis na siriɔs mɛdikal imejensi .
- Di sayn dɛm: Kɔnfyushɔn we yu nɔ ɛksplen, at kin bit kwik kwik wan, fiva ay, mɔsul dɛn kin stif ɔ bit, ɛn yu kin swet pasmak.
- Wetin fɔ du: If yu ɔ pɔsin we yu sabi gɛt dɛn sik ya wantɛm wantɛm, go to dɔktɔ wantɛm wantɛm ɔ go na di ɔspitul we de nia yu in Imejɛnsi Dipatmɛnt (ETU).
2. Di sayn dɛm wae kin kam wae yu stɔp fɔ tek di mɛrɛsin (Antidepressant Discontinuation Syndrome) .
If yu tek dis mɛrɛsin fɔ lɔng tɛm ɛn stɔp wantɛm wantɛm, yu bɔdi kin gɛt diskɔmfɔt as riakshɔn to am.
- Karakta:Diziz, ed we de at, nɔs, bɔdi we de at (lɛk we yu gɛt fiva), ɛn wɔri bad bad wan.
- Fɔ mek yu nɔ gɛt dis sik: Nɔ ɛva stɔp fɔ tek mɛrɛsin if yu nɔ go to yu dɔktɔ. If yu nid fɔ stɔp, yu dɔktɔ go ridyus di doz smɔl smɔl fɔ wan ɔ tu mɔnt, mek yu bɔdi ajɔst, dɔn sho yu aw fɔ stɔp am sef wan.
3. Tin dɛn we pɔsin kin tink bɔt fɔ kil insɛf
Dis na tɔpik we rili sɛnsitiv, bɔt na sɔntin we nid fɔ tɔk bɔt. Stɔdi dɔn sho se na smɔl risk de fɔ mek dɛn tink mɔ bɔt fɔ kil dɛnsɛf, mɔ pan yɔŋ pipul dɛn we nɔ rich 25 ia yet , insay di fɔs wik dɛn we dɛn de yuz dis mɛrɛsin.
- Impɔtant: If yu gɛt dɛn tin ya, duya nɔ sɔfa yu wan. Dis nɔto yu fɔlt, i kin bi wan sayd ɛfɛkt fɔ di mɛrɛsin. Tɛl yu dɔktɔ wantɛm wantɛm. Tɛl yu fambul ɔ padi we yu trɔst. Fɔ aks fɔ ɛp kin mek pɔsin gɛt trɛnk.
Ɔda tin dɛn fɔ tink bɔt we yu de tek SNRI
Fɔ drink rɔm
I bɛtɛ fɔ avɔyd fɔ drink rɔm we yu de tek mɛrɛsin fɔ mek yu nɔ fil bad lɛk SNRI. Alkol na wan tin bak we de mek di sɛntral nervɔs sistɛm pwɛl. So, i kin ambɔg di wok we di mɛrɛsin de du. Sɔntɛnde, rɔm kin mek di sayn dɛm fɔ pwɛl hat wɔs.
Ɔda mɛrɛsin dɛn
If yu de tek SNRI, tɛl yu dɔktɔ bɔt ɔl di ɔda mɛrɛsin dɛn we yu de tek (dɛn mɛrɛsin fɔ mɛn pen, kɔf mɛrɛsin, vaytamɛn, ivin ɛbul mɛrɛsin). Sɔm mɛrɛsin kin intarakt wit SNRI dɛm.
- Di mɛrɛsin dɛn we de mek pɔsin fil pen lɛk NSAID (e.g. Ibuprofen, Diclofenac) .
- Mεdisin dεm we de mek bכdi nכ kכlכt (e.g. Aspirin, Clopidogrel) .
- Triptan na mɛrɛsin fɔ maygren.
- Herbal prodak dɛm lɛk Sɛnt Jɔn Wɔt
Bεlε εn we i de gi pikin in bεlε
If yu de plan fɔ gɛt bɛlɛ, yu dɔn gɛt bɛlɛ, ɔ yu de gi pikin in bɛlɛ, yu fɔ rili tɔk to yu dɔktɔ bɔt aw fɔ yuz dis mɛrɛsin. Sɔm SNRI kin afɛkt di pikin we de na di bɛlɛ. Dɔn bak, if yu stɔp di mɛrɛsin wantɛm wantɛm, dat kin ambɔg di mama. Yu dɔktɔ kin ɛp yu fɔ disayd wetin na di bɛst tin fɔ yu ɛn yu pikin.
Aw lɔng i kin tek fɔ mek di mɛrɛsin wok?
Dis na kwɛstyɔn we bɔku pipul dɛn kin aks. SNRI nɔto drɔg we de wok wantɛm wantɛm lɛk Panadol. I kin tek sɔm tɛm fɔ mek di kemikal dɛn we de na di bren balans.
- Bɔrku pipul dɛn go si sɔm impɔtant (progres) pan di sayn dɛm insay 4 to 6 wik .
- I kin tek bitwin 9 ɛn 12 wik (2-3 mɔnt) fɔ mek sɔm pipul dɛn gɛt di ful bɛnifit fɔ di mɛrɛsin.
So, nɔr stɔp fɔ tek di mɛrɛsin jɔs bikɔs yu nɔr de fil bɔrku difrɛns na di fɔs wik.Na fɔ peshɛnt. If yu stil nɔ fil ɛni difrɛns afta da tɛm de, tɔk to yu dɔktɔ bak. I kin ebul fɔ ajɔst di mɛrɛsin ɔ chenj yu to ɔda mɛrɛsin.
Mɛsej we dɛn kin kɛr go na os
- SNRI na fayn mɛrɛsin wae de ɛp fɔ kɔntrol pwɛl hat, wɔri, ɛn sɔm pen kɔndishɔn bay wae dɛn de balans di akshɔn wae natura kemikal mɛsenja dɛm na yu bren.
- Dis mɛrɛsin nɔ de wok wantɛm wantɛm. Yu fɔ peshɛnt ɛn wet fɔ sɔm wiks fɔ si di rizɔlt.
- Jɔs lɛk ɔl di mɛrɛsin dɛn, smɔl smɔl sayd ɛfɛkt dɛn kin de. Bɔku tɛm, dɛn kin stɔp as tɛm de go. If yu gɛt ɛni prɔblɛm we yu nɔ go ebul fɔ bia, tɛl yu dɔktɔ.
- Nɔ ɛva, fɔ ɛni rizin, stɔp fɔ tek dis mɛrɛsin wantɛm wantɛm we yu nɔ go to yu dɔktɔ. If yu du dat, i kin mek yu gɛt sayn dɛn we nɔ fayn.
- I impɔtant fɔ tɛl yu dɔktɔ bɔt ɔl di ɔda mɛrɛsin dɛn we yu de tek, if yu de drink rɔm, ɛn if yu gɛt bɛlɛ.
- If yu gɛt ɛni kwɛstyɔn, wɔri, ɔ dawt bɔt yu mɛrɛsin, tɔk bɔt am opin wan wit yu dɔktɔ. Na in na di bɛst advaysa we yu kin abop pan.
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