Dɔktɔ dɔn ɛva gi yu wan ol mɛrɛsin fɔ pwɛl hat ɔ ɔda sik? I kin bi wan pan di trisayklik antidipreshan (TCA). Pan ɔl we di nem kin tan lɛk se i de mek pɔsin fred smɔl, dɛn mɛrɛsin ya stil rili yusful mɛrɛsin dɛn we dɛn kin yuz fɔ bɔku sik dɛn. So tide, lɛ wi tɔk bɔt dɛn TCA mɛrɛsin ya na simpul, izi fɔ ɔndastand.
Fɔ tɔk am simpul wan, wetin na dɛn trisayklik antidipreshan (TCA) ya?
Tricyclic antidepressants, ɔr TCA fɔ shɔt, na wan klas ɔf mɛrɛsin wae de ɛp fɔ kɔntrol di sayn dɛm wae de sho se pɔrsin gɛt maynd sik wae dɛn kɔl major depressive disorder . Bɔt dɛn tɛm ya, dɔktɔ dɛn kin gi dɛn mɛrɛsin ya fɔ ɔda sik dɛn pas fɔ jɔs pwɛl at.
Dɛn TCA ya na bin wan pan di fɔs klas dɛm fɔ drɔgs we dɛn bin fɛn fɔ trit pwɛl hat. Na dat mek wi kin kɔl dɛm "fɔs-jɛnɛreshɔn" antidipreshan. Bɔt naw we nyu mɛrɛsin dɛn we nɔ bad (lɛk SSRI) dɔn kam fɔ trit pwɛl hat, dɔktɔ dɛn nɔ kin gi dɛn TCA ya as fɔs layn mɛrɛsin fɔ pwɛl hat.
dεn kכl dεn dכg dεm ya "tricyclics" biכs fכ dεn kεmikכl strכkchכ. Dɛn gɛt tri ring dɛn. Na dat di nem min, natin nɔ de fɔ tink bɔt.
Us kayn drɔgs de insay di TCA grup?
Dis na sɔm pan di men TCA mɛrɛsin dɛm we dɛn kin yuz na Sri Lanka ɛn ɔlsay na di wɔl, wit dɛn brand nem. Si if di mɛrɛsin we yu dɔktɔ dɔn gi yu na wan pan dɛn mɛrɛsin ya.
| Jɛnɛrik Nem | Kɔmɔn Brand Nem dɛn |
|---|---|
| Amitriptaylin we dɛn kɔl | Elavil®, Vanatrip®, ɛn ɔda pipul dɛn |
| Amoxapin we dɛn kɔl am | Asendin® we gɛt fɔ du wit am |
| Desipramin we gɛt di sik | Norpramin® we dɛn kɔl |
| Dɔksɛpin we dɛn kɔl | Silenor®, Sinequan®, we de wok fɔ di ɔda wan dɛn |
| Imipramin we dɛn kɔl imipramin | Tofranil®, Tofranil-PM®, ɛn ɔda pipul dɛn |
| Nɔtriptaylin we dɛn kɔl | Aventyl®, Pamelor®, ɛn ɔda pipul dɛn |
| Protriptyline we dɛn kɔl | Vivactil® we gɛt di sik |
| Trimipramin we dɛn kɔl trimipramin | Surmontil® we dɛn kɔl |
| Klɔmipramin we dɛn kɔl | Anafranil® we dɛn kɔl |
Apat frɔm dat, dɛn kin yuz di TCA drɔg we dɛn kɔl Clomipramine (Anafranil®) spɛshal wan fɔ trit wan sik we dɛn kɔl obsessive-compulsive disorder (OCD) .
Us kɔndishɔn dɛn kin yuz TCA mɛrɛsin fɔ?
Dɛn mɛrɛsin ya na dɛn fɔs fɔ mɛn pwɛl hat. Bɔt lɛk aw a bin dɔn tɔk bifo tɛm, dɔktɔ dɛn dis tɛm ya nɔ de gi dɛn fɔs fɔ dipreshɔn. Na if ɔda nyu mɛrɛsin dɛn (lɛk SSRI) nɔ wok, sɔntɛm dɛn kin bigin fɔ yuz TCA. Na bikɔs tɛm kin de we dɛn ol mɛrɛsin ya kin wok fayn pas di nyu mɛrɛsin fɔ sɔm pipul dɛn.
Bɔt naw, na di TCA dɛn we pipul dɛn lɛk pas ɔl fɔ trit ɔda kɔndishɔn dɛn pas di wan dɛn we dɛn dɔn gri fɔ. Wi de kol dis "off-label" yus. Dat min se, pan ɔl we di Food and Drug Administration nɔ dɔn gri fɔ di mɛrɛsin fɔ da sik de, di mɛdikal risach dɔn sho se di mɛrɛsin fayn fɔ da sik de.
Di tin we impɔtant pas ɔl na, nɔ ɛva yuz dis kayn mɛrɛsin fɔ ɛnitin we yu want we yu nɔ gɛt dɔktɔ in prɛskrishɔn.
Na sɔm "ɔf-lɛbul" yus dɛm fɔ TCA dɛm:
- Fɔ mek yu nɔ gɛt maygren: Fɔ di wan dɛn we de sɔfa wit maygren ɔltɛm, dis mɛrɛsin de ɛp fɔ kɔntrol aw i de apin.
- Inshɔmnia: Sɔm TCA, we dɛn gi yu smɔl, kin ɛp yu fɔ slip fayn.
- Wae pɔrsin kin wɔri: Dɛn kin yuse dɛn tin ya bak fɔ kɔntrol difrɛn kayn wɔri hat sik.
- Pen we nɔ de dɔn: Dis na wan pan di men tin dɛn we dɛn kin yuz TCA tide. Dɛn kin wok fayn mɔ fɔ nyuropatik pen . Fɔ ɛgzampul:
- Nyuropathy we gɛt fɔ du wit dayabitis
- Postherpetic neuralgia (pen we kin apin afta chikinpoks) .
- Fibromyalgia kɔndishɔn we pɔsin kin gɛt
- Bedwetting: Sɔntɛnde dɛn kin gi dis mɛrɛsin insay smɔl dos fɔ kɔntrol di we aw pikin dɛn kin pis na nɛt.
Wetin na di difrɛns bitwin di nyu mɛrɛsin dɛn (SSRI) ɛn dɛn ol mɛrɛsin ya (TCA)?
Dɛn tu na klas dɛm fɔ drɔgs wae de mɛn pwɛl hat. Bɔt sɔm impɔtant tin dɛn de we difrɛn. Yu kin ɔndastand dis izi wan bay we yu luk di tebul we de dɔŋ ya.
| Di kwaliti we pɔsin gɛt | Trisayklik Antidipreshɔn (TCA) . | Sεlektiv Sεrotonin Riuptek Inhibitor (SSRI) . |
|---|---|---|
| Pipul dɛn | Fɔs jɛnɛreshɔn (ol) drɔgs. | Sɛkɔn jɛnɛreshɔn (nyu) drɔgs. |
| Di sayd ɛfɛkt dɛn we kin apin | Relatively high en som of dem kin bi bit harsh. | I rili smɔl ɛn i de na wan lɛvul we pɔsin kin ebul fɔ bia wit. |
| Risk fɔ mek yu tek am pasmak | Rili ay. If yu tek am pasmak, dat kin mek yu layf de pan denja. | Nɔ. Much sef pas TCA. |
| Men yus (tide) . | Fɔ kɔndishɔn lɛk pen we nɔ de dɔn, maygren, ɛn we pɔsin nɔ de slip. | Fɔ pwɛl hat ɛn sik dɛm wae gɛt fɔ du wit wɔri. |
Aw dis TCA mεdikeshכn de wok insay di bכdi?
Dis na tin we rili simpul fɔ ɔndastand. di nεv sεl dεm na wi bren de yuz kεmεkal dεm we dεn kכl nyurotransmitta fכ sεnd mεsej to dεn wan dεm. Lɛk di postman dɛn. Tu pan dɛn nyurotransmitta ya rili impɔtant fɔ kɔntrol wi maynd. Dɛn tin ya na norepinephrine ɛn sɛrotonin .
pan kכndyushכn lεk diprεshכn, di lεvεl dεm fכ dεn kεmεkal dεm na di bren de dכn. TCA mεdikeshכn dεm de wok bay we dεn de inkrεs di lεvεl dεm fכ norepinephrine εn sεrotonin na di bren. dis kin mek di nεv sεl dεm bεtε kכmכnikεshכn, εn i de mek di mכd bεtεh.
Risach pipul dɛn dɔn kam fɔ no bak aw dɛn mɛrɛsin ya kin mek pɔsin nɔ fil pen. Dɛn se dɛn drɔgs ya kin mek di sayn dɛn we de sho aw pɔsin de fil nɔ travul tru wi spɛnal kɔd to di bren, ɛn dis kin mek wi nɔ fil pen.
Aw a fɔ tek di mɛrɛsin ɛn wetin na di sayd ɛfɛkt dɛm?
TCA dɛn kin de as tablɛt ɔ kapsul. I rili impɔtant fɔ tek di rayt doz we yu dɔktɔ tɛl yu fɔ tek.
Bikɔs di risk bɔku fɔ tek dɛn mɛrɛsin ya pasmak, dɔktɔ dɛn kin bigin ɔltɛm wit di doz we smɔl pas ɔl. Dɔn, if nid de, dɛn kin ad di doz smɔl smɔl. Nɔ ɛva chenj di doz fɔ yusɛf if yu dɔktɔ nɔ advays yu.
Kɔmɔn sayd ɛfɛkt dɛn
Lɛk ɔl di mɛrɛsin dɛn, dis wan gɛt sayd ɛfɛkt dɛn. Bɔt nɔto ɔlman kin gɛt dɛn. Sɔm pipul dɛn kin gɛt wan ɔ tu, ɛn ɔda wan dɛn nɔ kin gɛt ɛni wan.
| Tayp fɔ di sayd ɛfɛkt | Tɔk bɔt |
|---|---|
| Kɔmɔn sayd ɛfɛkt dɛn |
|
| Ɔda sayd ɛfɛkt dɛn we pɔsin kin gɛt |
If dɛn sayd ɛfɛkt ya de mɔna yu, tɔk to yu dɔktɔ ɛn nɔ stɔp di mɛrɛsin. Dɛn kin ebul fɔ kɔntrol dɛn bay we dɛn chenj di doz ɔ yuz ɔda we.
Udat fɔ tek tɛm mɔ bɔt TCA mɛrɛsin dɛn?
Dɔktɔ dɛn kin rili tek tɛm we dɛn de gi sɔm pipul dɛn dis mɛrɛsin. If yu gɛt ɛni wan pan dɛn sik ya, yu fɔ rili tɛl yu dɔktɔ bifo yu bigin fɔ tek di mɛrɛsin.
- If yu gɛt at sik: TCA mɛrɛsin kin mek sɔm at sik dɛn wɔs, so yu dɔktɔ kin ɔda fɔ mek dɛn tek ilɛktrokardiogram (EKG) fɔ chɛk aw yu at de wok bifo yu bigin fɔ tek di mɛrɛsin.
- If yu gɛt ɛpilepshi: Dis mɛrɛsin kin mek yu gɛt smɔl sik fɔ mek yu gɛt sik.
- If yu gɛt bɛlɛ ɔ yu de plan fɔ gɛt bɛlɛ: TCA mɛrɛsin nɔ kin rili sef we yu gɛt bɛlɛ. Sɔm stɔdi dɛn dɔn sho se dɛn kin afɛkt di pikin we de na di bɛlɛ. So mek shɔ se yu tɔk to yu dɔktɔ bɔt dis.
Wan wɔnin we rili impɔtant
Sɔntɛnde, pikin dɛn we nɔ rich 25 ia yet, yɔŋ pikin dɛn, ɛn yɔŋ pipul dɛn kin tink ɔ biev lɛk fɔ kil dɛnsɛf mɔ ɛn mɔ we dɛn bigin fɔ yuz dis mɛrɛsin, mɔ insay di fɔs wik dɛn.
If yu ɔ yu pikin gɛt dɛn tin ya, kɔl di dɔktɔ we gi yu di mɛrɛsin wantɛm wantɛm ɛn nɔ de te. Ɔ go na di Imejɛnsi Dipatmɛnt (ETU) na di ɔspitul we de nia yu.
I pɔsibul fɔ ɔvados pan TCA mɛrɛsin?
Yɛs, yu kin ebul. Infakt, pan di kayn mɛrɛsin dɛn we dɛn kin gi fɔ mek dɛn nɔ gɛt pwɛl hat, TCA na di grup fɔ drɔgs we gɛt di ay risk fɔ tek ɔvados. Na dat mek yu nɔ fɔ ɛva tek pas di doz we yu dɔktɔ tɛl yu fɔ tek.
Ɔvados kin apin bay mistek, i nɔ no natin, ɔ bay wilful. So ɔltɛm kip yu mɛrɛsin sef wan usay pikin ɛn animal dɛn we yu de mɛn nɔ go ebul fɔ rich.
Di sayn dɛn we de sho se pɔsin dɔn tek am pasmak
- Di at bit abnɔmaliti (di chenj na di ritm) .
- Blɔd prɛshɔn kin go dɔŋ tumɔs
- I kin slip bad bad wan
- Di sik dɛn we kin mek pɔsin sik
- Di we aw pɔsin kin shek shek
- Kɔnfyus
- Kɔma
TCA ovados na mɛdikal imejensi . I kin kil pɔsin if dɛn nɔ trit am kwik kwik wan. If yu gɛt ɛni saspek se dis dɔn apin to yu ɔ ɔda pɔsin, go na di ɔspitul Imejɛnsi Dipatmɛnt (ETU) we de nia yu wantɛm wantɛm. If nid de, yu kin kɔl bak di Nashɔnal Pɔyzin Infɔmeshɔn Sɛnta na di Kɔlɔmbɔ Nashɔnal Ospital fɔ advays.
Ustɛm fɔ tɔk to di dɔktɔ
If yu de yuz TCA mɛrɛsin, i impɔtant fɔ de kɔntakt yu dɔktɔ ɔltɛm. Mek shɔ se yu tɔk to yu dɔktɔ if yu gɛt ɛni wan pan dɛn tin ya:
- If di sayd ɛfɛkt dɛn de mɔna yu bɔku: If yu fil se "dis na smɔl tin fɔ bia," tɛl yu dɔktɔ.
- If yu sik nɔr de bɛtɛ ɔr de wɔs: If nɔr impɔtant afta lɛk 4 wik ɔr if i tan lɛk se de sik de wɔs, tɛl yu dɔktɔ.
- If yu de tink fɔ stɔp di mɛrɛsin: Nɔ ɛva stɔp fɔ tek dis mɛrɛsin wantɛm wantɛm. If yu du dat, i kin mek yu gɛt sayn dɛn fɔ lɛf fɔ drink. If yu stɔp, du am lɛk aw yu dɔktɔ tɛl yu, ɛn smɔl smɔl yu fɔ ridyus di doz.
Pan ɔl we dis mɛrɛsin ol, i rili fayn if dɛn yuz am di rayt we . So, if yu gɛt ɛni kwɛstyɔn, fred, ɔ dawt bɔt dis mɛrɛsin, aks yu dɔktɔ bɔt am. I rɛdi ɛn rɛdi fɔ ɛp yu.
Mɛsej we dɛn kin kɛr go na os
- Pan ɔl we TCA na wan ol klas fɔ drɔgs we dɛn bin dɔn mek fɔs fɔ trit pwɛl hat, dɛn stil de yuz am fayn fayn wan tide fɔ bɔku tin dɛn, lɛk pen we nɔ de dɔn ɛn maygren.
- Di sayd ɛfɛkt dɛm we dɛn mɛrɛsin ya kin gɛt kin tranga smɔl pas di nyu mɛrɛsin dɛm, ɛn di risk fɔ mek dɛn tek am pasmak kin rili bɔku.
- Fɔ fala di doz jɔs lɛk aw yu dɔktɔ tɛl yu. Nɔ ɛva chenj di doz fɔ yusɛf ɔ stɔp fɔ tek di mɛrɛsin wantɛm wantɛm.
- If yu gɛt tin dɛn lɛk at sik, ɛpilepshi, ɔ yu gɛt bɛlɛ, mek shɔ se yu tɛl yu dɔktɔ bifo yu bigin fɔ tek di mɛrɛsin.
- TCA ɔvados na imejensi we kin mek pɔsin in layf de pan denja. If yu sɔprayz, go na di ɔspitul imejensi dipatmɛnt (ETU) we de nia yu wantɛm wantɛm.
- If yu gɛt ɛni kwɛstyɔn bɔt di mɛrɛsin, nɔ fred fɔ aks yu dɔktɔ.
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