Maygren we de fil lɛk se yu ed go bɔm, layt de apia bifo yu yay, ɛn yu fil lɛk se yu de kam fɔ vɔmit... Yu sabi dis ɛkspiriɛns? Sɔntɛnde, yu kin gɛt fɔ de na dak ɛn kwayɛt rum ɔl di de, nɔto so? Maygren nɔto jɔs ed we de at, na sɔntin we na di pɔsin nɔmɔ we gɛt am no. So tide wi go tɔk bɔt wan rili impɔtant kayn mɛrɛsin we dɛn kin yuz fɔ mɛn maygren. Dat na Triptans.
Wetin na Triptan dɛn?
Fɔ tɔk am simpul wan, Triptan na wan kayn mɛrɛsin we dɛn kin gi fɔ stɔp maygren atak wans i dɔn bigin . Dɛn kin tek dɛn as di fɔs layn tritmɛnt fɔ maygren. Bɔku tɛm, dɛn mɛrɛsin ya nɔ kin mek pɔsin nɔ gɛt maygren, bɔt dɛn kin ɛp fɔ kɔntrol di pen ɛn ɔda sayn dɛn we i dɔn bigin .
Maygren nɔto jɔs ed we de at. Na wan nyurolɔjik kɔndishɔn we de afɛkt wi bren. Dis na di rizin we mek, apat frɔm di ed we de at, tin dɛn de lɛk fɔ chenj di we aw wi de si, fɔ si layt bifo wi yay (aura), nɔs, vɔmit, ɛn fɔ fil lɛk layt ɛn sawnd. Fɔ sɔm, dɛn sik ya kin so bad dat dɛn nɔ kin ebul fɔ du natin pas fɔ ledɔm na dak ɛn kwayɛt ples te di maygren dɔn.
Triptan, we dɛn bin fɛn insay di 1980 dɛm, bin chenj di tritmɛnt fɔ maygren. Di fɔs triptan, `(Sumatriptan),` bin introdyus insay di 1990s. Leta, dɛn bin kam wit bɔku ɔda triptan dɛn.
Us kayn triptan dɛn de?
Naw, sɛvin kayn triptan dɛn de. Dɛn ɔl kin trit maygren, bɔt dɛn kin gri fɔ sɔm pan dɛn fɔ sɔm patikyula kayn maygren ɛn fɔ yuz fɔ pikin ɛn yɔŋ pipul dɛn. Di izi we fɔ no dɛn mɛrɛsin ya na fɔ luk fɔ di sɔfix "-triptan" na dɛn nem.
Di tebul we de dɔŋ ya de sho di kayn triptan dɛn ɛn aw dɛn kin gɛt dɛn.
| Triptan Drug Nem fɔ di mɛrɛsin | Aw fɔ gɛt (Fɔm) . |
|---|---|
| Almotriptan we dɛn kɔl | Pil we dɛn kin yuz fɔ it |
| Eletriptan we dɛn kɔl | Pil we dɛn kin yuz fɔ it |
| Frovatriptan we dɛn kɔl Frovatriptan | Pil we dɛn kin yuz fɔ it |
| Naratriptan we de na di wɔl | Pil we dɛn kin yuz fɔ it |
| Rizatriptan we dɛn kɔl | Pil we dɛn kin yuz fɔ it |
| Sumatriptan we dɛn kɔl Sumatriptan | Oral, Nasal spray/pauda, Injɛkshɔn we dɛn kin put ɔnda di bɔdi |
| Zolmitriptan we dɛn kɔl Zolmitriptan | Tablɛt dɛn we dɛn kin tek bay mɔt, we dɛn kin sprɛy na yu nos |
Aw dɛn mɛrɛsin ya we dɛn kɔl Triptans kin rili wok?
Fɔ ɔndastand aw dis mɛrɛsin de wok, wi nid fɔ ɔndastand smɔl bɔt aw wi kin fil pen ɛn aw maygren kin apin.
Lɛ wi tek wan luk pan aw wi kin fil pen.
Imajin se yu nak yu finga sɔmsay. Di pen nɔ kin rili fil di finga. di nεv dεm na di finga de sεnd signal to di bren se, "Sכmtin dεn at ya." di bren de translet da signal de to "pen" εn mek yu fil am.
Wi bren nɔ gɛt pen-sensing nerve endings, na dat mek sayɛnsman dɛn stil nɔ ɔndastand gud gud wan aw maygren kin apin. Bɔt naw dɛn dɔn fɛn bɔku we dɛn we go mek dis apin.
Di stori biɛn maygren
Dɛn biliv se tri men tin dɛn kin mek pɔsin gɛt maygren:
1. Nyuron aktibכshכn: Wi bren, spεnal kכd, εn nεv dεm na sεl dεm we dεn kכl nyuron. We maygren apin, sɔm nyuron dɛn na di bren kin faya wan patikyula we. Dis aktiveshɔn na di bren na in de mek wi fil pen ɛn ɔda sayn dɛm fɔ maygren.
2. Chenj dεm na di bכdi we de kכmכt: We maygrεn de, di bכdi we de na di bren de kכnstrikt εn dilayt. Dis kin chenj di we aw di blɔd de flɔ. Bikɔs triptan kin afɛkt dɛn blɔd vesel ya, dɛn kin tink bak se dis kin mek pɔsin gɛt maygren.
3. Inflameshɔn: .Inflameshɔn na wan tin we wi bɔdi de yuz fɔ protɛkt ɛn wɛl insɛf. Dɛn dɔn si bak se di kemikal dɛn we kin mek pɔsin gɛt inflamɛns kin kɔmɔt we pɔsin gɛt maygren.
Aw triptans kin afɛkt dis prɔses?
Naw lɛ wi si aw Triptan dɛn de intavyu dis. di sεl dεm na wi nεv sεstem de kכnεkt to wan an tru kεmikכl dεm we dεn kכl nyurotransmitta. Dɛn tin ya tan lɛk ki. di nεv sεl dεm gεt pat dεm we dεn kכl rεsεpכta dεm. Dɛn tin ya tan lɛk ki. we di rayt ki (nyurotransmitta) kכnekt to di rayt ki (rεsεptor), di sεl go aktibכt.
di triptan dεm de wok bay we dεn de miks di nyurotransmitta sεrotonin na di bren. dis min se dεn dכg dεm ya de biεn εn aktibכt rεsεpכta dεm fכ sεrotonin. dεn kin afekt tri kayn rεsεpכta dεm mεntal:
- 5HT1B rεsεpכta dεm: dεn de fכnshכn na di bכdi vεsul dεm na di bren. we triptan dεm de aktibכt dεn rεsεpכta dεm ya, di bכdi vεsul dεm we dεn dכn dilayt we nכ nid bikoz fכ maygrεn de kכnstrikt. Dis kin mek pɔsin nɔ fil pen.
- 5HT1D rεsεpכta dεm: dεn ya de insay di ``Trigeminal`` nεv sεstem, we de involv fכ si wi pen. We triptan dɛn de mek dɛn tin ya wok, dɛn kin stɔp di kεmεkal dεm we de mek yu fil pen.
- 5HT1F rεsεpכta dεm: dεn ya de εp bak fכ limited di transmishכn fכ pen signal to di bren.
Fɔ tɔk am simpul wan, triptan dɛn de wok bay we dɛn de rilaks di blɔd vesel dɛn na di bren, mek di kemikal dɛn we de mek pɔsin fil pen nɔ kɔmɔt, ɛn i nɔ de mek di pen signal dɛn go na di bren. Ɔl dɛn tri tin ya kin ɛp fɔ kɔntrol di sik dɛn we de sho se pɔsin gɛt maygren.
Wetin na di bɛnifit dɛn we pɔsin kin gɛt we i yuz Triptan?
Triptan gɛt bɔku bɛnifit we yu kɔmpia am wit di mɛrɛsin dɛn we dɛn bin de yuz fɔ mɛn maygren trade.
- Smɔl sayd ɛfɛkt: Triptan nɔ gɛt bɛtɛ sayd ɛfɛkt pas ol mɛrɛsin, ɛn dɛn nɔ kin rili bad.
- Nɔto adikshɔn: Sɔm pen kil fɔ maygren, mɔ di opioid, kin mek yu adikshɔn. Bɔt, triptan nɔ kin adikshɔn.
- Rili sef: Triptan na jɛnɛral wan rili sef klas fɔ mɛrɛsin. Mɛrɛsin lɛk `(Sumatriptan)` so sef dat na sɔm kɔntri dɛn kin bay dɛn na kɔwnta na famasi we yu nɔ gɛt dɔktɔ in prɛskrishɔn.
- Dɛn kin gɛt am difrɛn we dɛn: As wi bin si na di tebul we dɔn pas, dɛn kin gɛt dɛn tin ya difrɛn we dɛn lɛk pils, sprɛy na yu nos, ɛn injɛkshɔn. Sprɛy na in nos kin izi fɔ pɔsin we nɔ kin izi fɔ swɛla pil ɔ we de vɔmit.
Ɛni bad tin de, ɛni bad bad tin we kin apin to am, ɛn prɔblɛm dɛn de we kin apin?
Lɛk ɛni mɛrɛsin, Triptan gɛt sɔm sayd ɛfɛkt ɛn tin dɛn we yu fɔ no bɔt.
Di bad tin dɛn we Triptan dɛn gɛt
Di men tin we nɔ fayn na dat dɛn nɔ de mek pɔsin nɔ gɛt maygren . Dɛn kin yuz dɛn as rɛskɔ mɛrɛsin fɔ "stɔp" maygren afta i dɔn bigin. Bɔt wan spɛshal kes de, ɛn dat na maygren we pɔsin kin gɛt we i de gɛt mɔnt. Sɔm triptan kin ɛp fɔ mek yu nɔ gɛt maygren if yu tek am lɛk tu dez bifo yu prɛgnɛshɔn. Yu dɔktɔ go advays yu bɔt dis.
Wan ɔda tin na dat i nɔ fayn fɔ yuz dɛn tumɔs . Sɔm pipul dɛn nid mɔ pas wan doz fɔ di mɛrɛsin fɔ ridyus maygren. Bɔt if yu tek Triptans tumɔs, dɛn nɔ go wok fayn igen. Nɔto dat nɔmɔ, bɔt yu kin gɛt ``medication-overuse headache'' bak bikɔs yu de yuz di mɛrɛsin pasmak. So, i rili impɔtant fɔ yuz dɛn tin ya jɔs di doz ɛn frɛkuɛns we dɛn tɛl yu fɔ yuz, lɛk aw di dɔktɔ se .
Kɔmɔn sayd ɛfɛkt dɛn
Pan ɔl we nɔto ɔlman kin gɛt dɛn sayd ɛfɛkt ya we dɛn de tek triptan, sɔm pipul dɛn kin gɛt dɛn.
| Sayd Ifɛkt we i kin gɛt | Tɔk bɔt |
|---|---|
| Diziz we pɔsin kin gɛt | Diziz we pɔsin kin gɛt |
| Fɔ slip ɔ taya | Fɔ slip ɔ taya |
| Vɔmit | Vɔmit |
| Tingling na di an ɛn fut | Tingling ɔ numbness na an/fut `(Paresthesia)` |
| Nek de pen | Nek de pen |
| Chest pen (we nɔ kin apin so ɔltɛm) . | Chɛst pen (rare) . |
Ustɛm yu nɔ fɔ tek triptan?
Triptan nɔ fayn fɔ pipul dɛn we gɛt sɔm kayn wɛlbɔdi prɔblɛm (Contraindications).
- Intarakshɔn wit ɔda mɛrɛsin: If yu de tek ɔda mɛrɛsin we gɛt ``Ergotamine`` fɔ maygren ɔ fɔ ɔda kɔndishɔn, dɛn kin intarakt wit Triptans. So, i impɔtant fɔ tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn, vaytamɛn dɛn, ɛn sɔpɔtmɛnt dɛn we yu de tek .
- At sik ɔr prɔblɛm wit di blɔd we de kɔmɔt na di blɔd: Triptan nɔ fayn if yu gɛt at sik, ay blɔd prɛshɔn we yu nɔ ebul fɔ kɔntrol (haypa blɔd prɛshɔn), ɔ sik we de na di periferik at. Dɔktɔ dɛn nɔ kin tɛl yu bak fɔ tek dɛn mɛrɛsin ya if yu dɔn gɛt ɔ yu de pan denja fɔ gɛt at ritm disɔda, at atak, strok, ɔ TIA.
- Bεlε εn bεlε: If yu bεlε, yu de tray fכ bεlε, כ yu de gi bεlε, yu fכ rili tכk to yu dכkta bכt yus triptan.
Ustɛm yu fɔ go to dɔktɔ?
Ustɛm fɔ kɔl di dɔktɔ
If yu gɛt siriɔs sayd ɛfɛkt frɔm triptan, if i de ambɔg yu ɛvride aktiviti, ɔ if yu fil lɛk se wan mɛrɛsin we yu dɔn de tek fɔ lɔng tɛm nɔ de wok igen, tɔk to yu dɔktɔ. I kin ebul fɔ gi yu difrɛn triptan ɔ ɔda tritmɛnt.
Situeshɔn dɛn we nid fɔ gɛt tritmɛnt kwik kwik wan
Triptan dɛn kin mek siriɔs sayd ɛfɛkt dɛn we nɔ kin apin so ɔltɛm (lɛs dan 1%), bɔt if yu gɛt ɛni wan pan dɛn sayn ya we de sho se yu gɛt at sik ɔ strok, yu fɔ go na ɔspitul in imejensi dipatmɛnt (ETU) wantɛm wantɛm .
Di sayn dɛm wae gɛt fɔ du wit at sik:
- Chest pen ɔ diskɔmfɔt
- Hat bit fast fast (Tachycardia) ɔ at bit sloslo (Bradycardia) .
- I nɔ izi fɔ blo (Dyspnea) .
Di sayn dɛm wae gɛt fɔ du wit strok:
Wan pan de men sayn dɛm wae de sho se pɔrsin gɛt strok na fɔ paralayz, fɔ nɔr de fil fayn, ɔr wik na wan say na in bɔdi (hemiplegia). Dɛn sayn ya kin apin bak pan sɔm kayn bad bad kes dɛm wae gɛt maygren.
I nɔr pɔsibul fɔ no na os if dis sik na bikɔs ɔf maygren ɔr strok. So, if yu fil se wan say na yu bɔdi de lɔs pawa, go to di Imejɛnsi Dipatmɛnt (ETU) wantɛm wantɛm ɛn nɔ de te . Insay strok, ɛvri sɛkɔn we di tritmɛnt delay kin mek yu bren pwɛl fɔ ɔltɛm.
If yu nɔr ɛva gɛt maygren bifo ɛn yu gɛt siriɔs ed pen wit sɔm kayn sik lɛk dis, tek am se na imejensi.
Us Triptan bɛtɛ fɔ mi?
Dis na kwɛstyɔn we bɔku pipul dɛn kin aks. Notin nɔ de we dɛn kɔl "best triptan." Wan drɔg we de wok fayn fɔ wan pɔsin nɔ kin wok fayn fɔ ɔda pɔsin. Yu dɔktɔ go disayd us triptan we bɛtɛ fɔ yu ɛn aw fɔ tek am (pil ɔ sprɛy) bay bɔku tin dɛn, lɛk aw yu maygren tan, yu ɔda wɛlbɔdi prɔblɛm dɛn, ɛn ɔda mɛrɛsin dɛn we yu de tek .
Bifo dɛn fɛn triptan, pipul dɛn we gɛt maygren bin gɛt layf we nɔ bin izi fɔ dɛn. Tide, bikɔs ɔf dɛn mɛrɛsin ya, bɔku bɔku pipul dɛn nɔ gɛt di pen we dɛn kin gɛt we dɛn gɛt maygren ɛn dɛn kin liv nɔmal layf. If yu gɛt maygren, nɔ jɔs bia di pen. Tɔk to yu dɔktɔ ɛn si if triptan kin ɛp yu. Dɛn mɛrɛsin ya kin ɛp yu fɔ liv yu de nɔmal wan, instead fɔ mek yu paralayz bikɔs ɔf maygren.
Mɛsej we dɛn kin kɛr go na os
- Triptan na wan kayn mɛrɛsin we dɛn kin gi fɔ kɔntrol di pen ɛn di sayn dɛm we pɔsin kin gɛt we i gɛt maygren wans i dɔn bigin.
- Dɛn tin ya nɔ de mek yu nɔ gɛt maygren (eksept fɔ maygren we yu de gɛt we yu de gɛt mɔnt). Dɛn kin akt lɛk "rɛskɔ" mɛrɛsin.
- Triptan dɛn de wok bay we dɛn de rilaks di blɔd vesel dɛn na di bren, blok di pen signal dɛn, ɛn kɔntrol maygren.
- Dis mɛrɛsin rili sef, i nɔ de mek pɔsin adikshɔn, ɛn i nɔ gɛt bɛtɛ sayd ɛfɛkt.
- Dɛn tin ya nɔr fayn fɔ pipul dɛm wae gɛt sik lɛk at sik ɔr ay blɔd prɛshɔn we dɛn nɔr kin kɔntrol. Tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn we yu de tek.
- Yuz dɛn tin ya jɔs di doz ɛn frɛkuɛns we yu dɔktɔ tɛl yu fɔ du. If yu yuz am pasmak, dat kin mek yu ed at mɔ ɛn mɔ.
- If yu gɛt siriɔs sik lɛk aw yu chɛst de pen ɔ yu wik na wan say na yu bɔdi, go na imejensi rum (ETU) wantɛm wantɛm.
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