We wi kam fɔ no se wi gɛt kansa, wi ɔl kin fred bad bad wan. Na di sem tɛm, wi kin tink bɔt tritmɛnt dɛn lɛk kemotɛrapi. Kimotɛrapi kin pwɛl di sɛl dɛn we de sheb kwik kwik wan. Bɔt nɔto jɔs di kansa sɛl dɛn nɔmɔ, bɔt di wɛlbɔdi sɛl dɛn na wi bɔdi, fɔ ɛgzampul, di ia sɛl dɛn, di sɛl dɛn we de mek wi gɛt ɔlsa na wi mɔt, ɛn di sɛl dɛn we de na di intestinal dɛn, kin pwɛl. Na dat mek kemo kin mek yu ia lɔs, yu mɔt kin gɛt ɔlsa, ɛn yu bɛlɛ kin pwɛl. Bɔt, imajin... aw i go fayn if wan kayn mɛrɛsin de we go ebul fɔ tɔch ɔl di kansa sɛl dɛn, lɛk snaypa rayf? Na dat wi go tok abaut tide. Dɛn kɔl dɛn tin ya Tyrosine Kinase Inhibitors , ɔ TKI fɔ shɔt tɛm.
Simply put, wetin na dis TKI dem?
TKI na wan kayn tεrapi we dεn kin yuz fכ trit kansa. Dɛn kin wok bay we dɛn kin blok sɔm tin dɛn insay di kansa sɛl dɛn we kin ɛp dɛn fɔ gro ɛn sheb. in oda wod, di kεnsar sεl dεm gεt wan signal sistεm we de tεl dεm fכ "grכw εn divayd." TKI dεm de wok bay we dεn de intafεr wit da signal sistεm de εn stכp am.
Dɛn mɛrɛsin ya nɔ kin mɛn kansa ɔl, bɔt dɛn kin ɛp di wan dɛn we sik fɔ kɔntrol di kansa fɔ lɔng tɛm (rɛmishɔn), ɔ ivin liv gud kwaliti layf wit di kansa.
Aw dis mɛrɛsin kin rili wok? Lɛ wi tek wan luk insay smɔl mɔ.
Fɔ ɔndastand dis, wi fɔs nid fɔ no smɔl bɔt di nɔmal we aw di sɛl dɛn kin sheb na wi bɔdi. Imajin se wi bɔdi na big faktri. Dɛn kɔl di wan dɛn we de wok na dis faktri sɛl.
1. Di tin dɛm we de mek pɔsin gro: Dis na di mɛsenja dɛm we kɔmɔt na do na di faktri we de briŋ di mɛsej "Start production now."
2. Tyrosine kinases: dis na di enzym dεm we de insay di sεl dεm we de tek di mεsej εn tεl כda pipul dεm fכ "OK, lε wi go wok."
Na dis na wetin kin apin na nɔmal wɛlbɔdi sɛl. di mεsenja (growth factor) de kam εn gi di mεsej to di manija (tyrosine kinase). Di manija tek da mɛsej de ɛn tɛl di sɛl fɔ sheb. Afta di sɛl dɛn dɔn sheb as dɛn nid, di manija kin ɔf di swich. Dis na tin we dɛn kin rili kɔntrol.
Bɔt insay kansa sɛl dɛn, dis sistɛm kin go haywire. pan sɔm kayn kansa, mɔ, dɛn manija ya (Tyrosine kinases) kin kray. Dɛn switch de on fɔ ɔltɛm. Dɛn nɔ nid mɛsej frɔm ɔdasay, dɛn jɔs de kɔntinyu fɔ tɛl di sɛl dɛn fɔ "divayd, divayd, divayd." Dis divεlכpmεnt fכ di sεl dεm we dεn nכ de kכntrol na in wi kכl kεnsar.
Wetin TKI dɛn de du na fɔ go na da krayzi, pɔrmanent ‘on’ manija (Tyrosine kinase) wokples ɛn disrɔb am so dat i nɔ go ebul fɔ du in wok. Dɔn da kɔnstant "divayd" signal de stɔp. Di kansa sɛl dɛn kin stɔp fɔ sheb, ɛn di tumbu kin bigin fɔ smɔl.
Di bɛst ɛgzampul: Kronik Maylɔyd Lukimiya (CML) .
Dis na wan kayn blɔd kansa. Trade, we CML bin de divɛlɔp, na bin sik we kin kil pɔsin. Bɔt afta dɛn dɔn fɛn TKI, naw CML dɔn bi wan sik we nɔ de mɛn we dɛn kin kɔntrol wit mɛrɛsin lɛk dayabitis ɛn ay blɔd prɛshɔn.
insay di sεl dεm na di bon mכro fכ CML pasεnshכn dεm, di Tyrosine kinase εnzym we wi mεnshכn de fכm abnכmal wan, εn in swich de ‘on’ fכ כltεm. So di bon mɛro de mek wayt blɔd sɛl dɛn we nɔ de kɔntrol. Dis kin mek dɛn nɔ gɛt wɛlbɔdi rɛd blɔd sɛl dɛn, wayt blɔd sɛl dɛn, ɛn pletlɛt dɛn. TKI dεm, lεk Imatinib (Gleevec®) , de tכk to da abnכmal εnzym de εn tכn in ‘on’ switch ‘כf’. Dis na big rivɔlɔshɔn na di istri bɔt kansa tritmɛnt.
Us kayn kansa dɛn kin yuz TKI fɔ?
Naw dɛn de yuz dis tritmɛnt we dɛn dɔn tɔk bɔt fɔ bɔku kayn kansa. I nɔ de wok fɔ ɔl di kansa dɛn. dis na biכs nכto כl kεnsar dεm gεt di ‘turn on’ Tyrosine kinase. Dɔktɔ dɛn kin tek bayɔpsi pan di kansa sɛl dɛn ɛn si if dɛn gɛt dis mɔlyul we dɛn kin tɔch. Na if i du am, na in dɛn go gi dis mɛrɛsin.
Dis dɔŋ ya na sɔm pan di men kayn kansa dɛm we dɛn kin trit wit TKI.
| Di kayn kansa we yu gɛt | Tɔk bɔt |
|---|---|
| Blɔd kansa (Lukemia) . | Tayp dεm lεk krεse maylכyd lukimiya (CML) εn krכnik limfosaytik lukimiya (CLL). |
| Kansa na di Lɔng | εspεshali fכ di sik pipul dεm we gεt nכn sכm sכl lכng kεnsar (NSCLC) εn jεnεtik mכtεshכn lεk EGFR εn ALK. |
| Brɔst Kansa | fכ spεsifi k tכp dεm lεk HER2-positiv brεst kεnsar. |
| Gastrointestinal Kansa dɛn we de na di bɔdi | fכ kεnsar lεk di gεstrointestinal stromal tumor (GIST) we de apin na di bεlε εn di intestinal. |
| Kidni Kansa | Ɛspɛshali fɔ advans kidni kansa. |
| Kansa na di skin | Fɔ skin kansa lɛk mɛlanoma wit BRAF jin muteshɔn. |
Naw, di US FDA dɔn gri fɔ mek dɛn yuz pas 50 TKI fɔ trit difrɛn kayn kansa dɛn. Di fɔs drɔg we dɛn dɔn gri fɔ, Imatinib (Gleevec®), dɛn kin yuz fɔ trit 7 kayn kansa.
Aw a go gɛt dis tritmɛnt? Aw lɔng i kin tek?
Dis na ɔda big tin we kin izi fɔ dis tritmɛnt. Mɔs pan di TKI dɛn kin kam insay pil ɔ likwid fɔm. So yu nɔ nid fɔ de na ɔspitul ɛn mek dɛn injɛkt di mɛrɛsin tru wan salin sɔlvushɔn. Yu jɔs gɛt fɔ tek wan ɔ tu pils di sem tɛm ɛvride frɔm os.
Aw lɔng yu nid fɔ tek tritmɛnt dipen pan di kayn kansa we yu gɛt, di stej we di sik de, ɛn aw yu bɔdi de ansa di mɛrɛsin. Fɔ ɛgzampul, if yu gɛt CML, yu kin nid fɔ tek di mɛrɛsin fɔ di res ɔf yu layf. Fɔ ɔda kayn kansa, yu dɔktɔ kin disayd fɔ stɔp di mɛrɛsin wans dɛn dɔn kɔntrol di kansa.
Lɛ wi no bak bɔt di bad tin dɛn we kin apin to wi.
Bikɔs TKI na targeted therapies, dɛn kin jɔs gɛt smɔl sayd ɛfɛkt pas kemotherapy. Dis na bikɔs dɛn nɔ kin mek di sɛl dɛn we gɛt wɛlbɔdi nɔ pwɛl bɛtɛ. Bɔt i nɔ pɔsibul fɔ se dɛn nɔ gɛt "nɔ gɛt ɛni sayd ɛfɛkt atɔl." dis na biכs di mכlikul we dεn de tכk bכt, we dεn kכl Tyrosine kinase, nכ de nכmכ de insay kεnsar sεl dεm, bכt i de insay sכm hεlty sεl dεm. So dɛn sɛl dɛn de kin afɛkt bak.
Di sayd ɛfɛkt dɛn kin difrɛn frɔm wan pɔsin to ɔda pɔsin ɛn i kin dipen bak pan di TKI drɔg we dɛn yuz.
Di kɔmɔn sayd ɛfɛkt dɛn:
- Taya: Dis na kɔmɔn tin wae bɔrku pipul kin gɛt.
- Daya: I kin kam bikɔs di sɛl dɛn we de na di intestinal dɛn dɔn pwɛl.
- Nɔs ɛn Vɔmit: Sɔm pipul dɛn kin gɛt dis sik.
- Skin Rash: Skin rash, dray, ɛn it kin bɔku.
- Di wet fɔ it ɛn wet kin chenj: Sɔm pipul dɛn kin lɔs dɛn wet, ɔda wan dɛn kin gɛt wet bikɔs dɛn kin blo.
- Fiva
Sɔm siriɔs sayd ɛfɛkt dɛn we pɔsin kin gɛt:
Sɔm TKI kin mek sayd ɛfɛkt pan di at, liva, ɔr lɔng. Dɛn kin mek bak pɔsin gɛt siriɔs sik dɛn na di skin, ivin we kin mek pɔsin in layf de pan denja, lɛk Stevens-Johnson syndrome , we kin afɛkt di skin. Bɔt dɛn tin ya nɔ kin apin so ɔltɛm. Ay blɔd prɛshɔn (haypa prɛshɔn) na ɔda tin we de mɔna pipul dɛn.
De tin wae impɔtant pas ɔl na fɔ aks yu dɔktɔ bɔt di patikyula sayd ɛfɛkt dɛm wae de mɛrɛsin wae yu de tek bifo yu bigin tritmɛnt. If yu gɛt ɛni ɔda sayn we nɔ kɔmɔn, nɔ ignore am ɛn tɛl yu dɔktɔ wantɛm wantɛm.
Wetin a go du fɔ mek dis tritmɛnt izi fɔ mi?
Di tritmɛnt fɔ kansa kin tranga, pan ɔl we yu bɔdi ɛn maynd. Sɔm tin dɛn de we yu kin du fɔ mek dis tɛm izi smɔl.
1. Rɛst: Taya na big sayd ɛfɛkt. So slip bɔku tɛm, rɛst smɔl insay di de, ɛn lisin to yu bɔdi.
2. Nyutrishɔn: Fɔ it kin tranga bikɔs ɔf tin dɛn lɛk fɔ lɛf fɔ it ɛn fɔ nɔs. Tray fɔ it smɔl smɔl bɔku tɛm insay di de. Drink bɔku wata lɛk wata, frut jus, pɔrit, ɛn sup. If yu de lɔs yu wet ɔ yu de gɛt bɔku bɔku bɔdi we yu nɔ nid, i rili impɔtant fɔ aks pɔsin we sabi bɔt it.
3. Sayd ɛfɛkt mɛnejɛmɛnt: If yu gɛt dayarɛa, it tin dɛn lɛk ɔyl, we nɔ gɛt bɔku spays, vɛjitebul we dɛn dɔn stim, rays, ɛn banana. Drink drink lek Jeevani na rili gud tin. If yu gɛt rash na yu skin, yuz mɔstizayza we nɔ gɛt sop ɛn we nɔ gɛt sɛnt. Tɔk to yu dɔktɔ bɔt dis ɛn gɛt di rayt mɛrɛsin.
4. Ɔganayz: Kip yu dayari fɔ di sayn dɛm ɛn di sayd ɛfɛkt dɛm. Sho am to yu dɔktɔ we yu si am. Mɛmba fɔ tek yu mɛrɛsin dɛn jɔs di tɛm we yu nid fɔ tek am.
5. Mental hεlth: I rili impɔtant fɔ mek yu maynd strɔng insay dis tɛm. Tɔk to yu fambul ɛn padi dɛn. Tɔk bɔt yu prɔblɛm dɛn. If nid de, aks fɔ advays.
6. Palliative Care: Dis nɔ min se di sik nɔ go ebul fɔ mɛn. Dis na wan tim fɔ spɛshal pipul dɛm wae de ɛp yu fɔ liv fayn fayn wan bay wae dɛn de kɔntrol di sayn dɛm lɛk pen, nɔs, ɛn taya wae kin kam wit kansa tritmɛnt. Yu kin tɔk bak to yu dɔktɔ bɔt dis savis.
Wetin na de risk dɛm wae dis tritmɛnt kin gɛt?
Pan ɔl we TKI kin wok fayn fɔ bɔku kansa, sɔmtɛm prɔblɛm kin kam as tɛm de go. Di men wan na di divɛlɔpmɛnt fɔ di resistans .
Fɔ tɔk am simpul wan, kansa sɛl dɛn na sɛl dɛn we rili kɔni. We dɛn gi dɛn di sem mɛrɛsin as tɛm de go, dɛn kin chenj fɔ mek dɛn nɔ gɛt da mɛrɛsin de. Jɔs lɛk aw baktri dɛn kin ebul fɔ bia wit antibayɔtiks. We dat apin, wan TKI drɔg we bin wok fayn fɔs nɔ kin wok igen.
Bɔt nɔto di ɛnd fɔ di wɔl. biכs sayɛnsman dεm no dis, naw "sεkכn jεnereshכn" εn "tכd jεnereshכn" TKI dεm de we dεn kin gi we rεsistεns de divεlכp. So if wan mɛrɛsin nɔ wok, yu dɔktɔ kin chenj yu to difrɛn TKI.
Mɛsej we dɛn kin kɛr go na os
- Tyrosine Kinase Inhibitors (TKI) na wan spεsifi k tכp dכg we de tכk εn blכk wan signal sistεm we de kכmand di gכd εn divεlכpmεnt fכ di kεnsar sεl dεm.
- Bikɔs dɛn tritmɛnt ya na tritmɛnt dɛn we dɛn kin yuz fɔ mɛn pipul dɛn, dɛn nɔ kin pwɛl di sɛl dɛn we gɛt wɛlbɔdi ɛn dɛn nɔ kin gɛt bɛtɛ sayd ɛfɛkt pas di tradishɔnal kemotɛrapi.
- Bikɔs dɛn mɛrɛsin ya kin kam insay pil ɔ likwid, i kin rili izi fɔ mek yu ebul fɔ gɛt tritmɛnt frɔm os.
- Ivin kansa we de kil pipul lɛk CML dɔn bi sik dɛn we nɔ de mɛn naw we dɛn kin kɔntrol bikɔs ɔf dɛn mɛrɛsin ya.
- Sɔm sayd ɛfɛkt lɛk taya, dayarɛa, ɛn skin rɔsh kin apin. Ripɔt ɛnitin we nɔ kɔmɔn to yu dɔktɔ wantɛm wantɛm.
- As tɛm de go, di kansa sɛl dɛn kin ebul fɔ bia wit di mɛrɛsin, bɔt nyu TKI dɛn de fɔ dɛn kayn kes ya.
- Pan ɔl we dɛn mɛrɛsin ya nɔ kin mɛn kansa ɔltogɛda, dɛn kin rili ɛp pipul dɛn fɔ kɔntrol di sik ɛn liv lɔng wit gud kwaliti layf.
💬 Comments (0)
No kɔmɛnt nɔ de yet. Ad yu kɔmɛnt ya fɔ di fɔs tɛm.
Ad yu kɔmɛnt