We dɔktɔ tɛl yu se brɔst kansa dɔn skata to ɔda pat dɛn na di bɔdi, dat na, i dɔn bi ‘mɛtastatik’, i nɔmal fɔ fil bɔku fred ɛn wɔri. Bɔt we di mɛrɛsin dɛn we dɛn de yuz tide dɔn go bifo, tritmɛnt dɛn de we rili fayn fɔ dɛn kayn sik ya tide. Verzenio na wan pan dɛn kayn drɔgs dɛn de we de mek pɔsin gɛt op. So tide, lɛ wi tɔk smɔl bɔt dis mɛrɛsin we dɛn kɔl Verzenio, aw i de wok, ɛn us tin dɛn fɔ tek tɛm wit we yu de yuz am.
Aw Verzenio de wok insay di bɔdi?
Fɔ tɔk am simpul wan, Verzenio na wan drɔg we de insay wan klas ɔf drɔgs we dɛn kɔl ``kinase inhibitors.`` Tink bɔt am lɛk se ɛnzaym dɛn de na wi bɔdi we de wok lɛk ``mɛsenja`` we de kɛr infɔmeshɔn bak ɛn go bifo bitwin sɛl dɛn. dis na wetin wi kכl ``kinases.`` di kεnsar sεl dεm na dεn spεshal mεsenja dεm we de tεl dεm fכ divayd εn gro kwik kwik wan.
vεrzenio de wok bay we i de blכk di akshכn fכ mεsenja dεm we dεn kכl `sayklin-dipεndεnt kinaz 4 εn 6 (CDK4 εn CDK6)`, we de sεnd signal to kεnsar sεl dεm fכ gro. Fɔ tɔk di kɔrɛkt tin, i kin blok dɛn mɛsej dɛn de af-af di waka. dis we ya, we di CDK4 εn CDK6 εnzym dεm stכp fכ wok, di kεnsar sεl dεm de lכs di signal fכ divayd εn gro. Dis kin mek di kansa sɛl dɛn we de gro kin stɔp ɔ slo . Dis kin ɛp bak fɔ mek di tumbu dɛn smɔl.
Us kayn bɔdi kansa dɛn kin yuz fɔ Verzenio?
Dɛn nɔ kin gi dis mɛrɛsin fɔ ɔl kayn bɔdi kansa. Dɛn kin yuz am mɔ fɔ:
- Hכmon rεsεptכr (HR)-positiv εn
- di hכman εpidamal gכt fכktכ rεsεptכr 2 (HER2)-nεgεtiv
Dɛn kin yuz am fɔ wan kayn bɔdi kansa we dɛn kɔl mɛtastatik bɔdi kansa. Dɛn kin gi am bak we di kansa dɔn skata na do na di bɔdi to ɔda pat dɛn na di bɔdi lɛk di liva, di lɔng, ɔ di bon dɛn.
Sɔntɛnde, dɛn kin gi dis mɛrɛsin togɛda wit ɔda ɔmon tritmɛnt dɛn. Bɔt if di kansa dɔn skata ɛn di sik nɔ ansa ɔl tu di kemotɛrapi ɛn ɔmon tritmɛnt dɛn, dɛn kin gi Verzenio in wan . Na di dɔktɔ we de trit yu kin disayd ɔl dis.
Aw a go tek Verzenio? Wetin a fɔ no bɔt?
Verzenio na wan pil. Yu fɔ no dɛn tin ya we yu de yuz am.
- Yu fɔ tek dis pil tu tɛm insay di de .
- Yu kin tek am bifo ɔ afta yu it, bɔt tray fɔ tek am lɛk di sem tɛm ɛvride .
- Di tablɛt fɔ swɛla ɔl . Nɔ brok am, krɔs am, ɔ it am.
- Nɔ tek ɛni pils we dɔn brok, we dɔn chip, ɔ we dɔn pwɛl.Da tɛm de, kɔl yu dɔktɔ ɛn tɛl am bɔt am.
- If yu vɔmit afta yu tek di mɛrɛsin, skip da doz de. Nɔ tek ɛkstra pil . Tek di nɛks pil di tɛm we yu dɔn plan fɔ tek.
Yu dɔktɔ go advays yu fɔ kɔntinyu fɔ tek dis mɛrɛsin te dɛn kɔntrol yu kansa ɔ te yu gɛt siriɔs sayd ɛfɛkt. If yu gɛt sɔm sayd ɛfɛkt dɛn, yu dɔktɔ go disayd fɔ ridyus di doz we yu de tek, stɔp fɔ tek am fɔ sɔm tɛm, ɔ stɔp am kpatakpata.
Aw Verzenio rili wok fayn? (Klinik Trial Rizɔlt)
Dɛn dɔn gri fɔ dis mɛrɛsin bay di rizɔlt dɛn fɔ sɔm klinik trial dɛn we dɔn rili wok fayn. Lɛ wi tek wan kwik luk pan di tin dɛn we dɔn kɔmɔt frɔm dɛn tray dɛn de.
| Klinik ɛgzamin we dɛn kin du | Di grup we dɛn trit | Men rizulyt |
|---|---|---|
| MONARCH 3. Di wan dɛn we de wok | Di wan dɛn we nɔ bin dɔn gɛt tritmɛnt bifo fɔ gɛt kansa we dɔn go bifo. (Verzenio + ɔmon tɛrapi) | Progression-Free Survival (PFS) na bin 28.2 mɔnt fɔ di wan dɛn we bin de tek Verzenio, we yu kɔmpia am wit 14.8 mɔnt fɔ di wan dɛn we bin de tek ɔda drɔgs. |
| MONARCH 2. Di wan dɛn we de wok | Di pasɛnt dɛn we bin dɔn gɛt ɔl di ɔmon tɛrapi (Verzenio + Fulvestrant) bifo tɛm. | Di wan dɛn we tek Verzenio bin gɛt 16.4 mɔnt we di kansa nɔ bin de skata (9.3 mɔnt fɔ di ɔda wan dɛn), ɛn ɔl di tɛm we dɛn bin de liv na 46.7 mɔnt (37.3 mɔnt fɔ di ɔda wan dɛn). |
| MONARCH 1. Di wan dɛn we de wok | Di wan dɛn we sik we dɛn nɔ bin dɔn kɔntrol dɛn sik wit ɔl tu di kemotɛrapi ɛn ɔmon tɛrapi bifo. (Na Verzenio nɔmɔ) | 17.4% pan di pasɛnt dɛn sho signifyant shrinkage ɔ kɔmplit disappearance of tumor cells. |
Dɛn statystik ya sho se Verzenio na drɔg we de mek big kɔntribyushɔn fɔ kɔntrol di prɛd we kansa de skata ɛn fɔ mek di sik pipul dɛn layf lɔng.
Aw di dɔktɔ kin wach aw di tritmɛnt de go bifo?
We yu bigin fɔ tek di mɛrɛsin, di dɔktɔ go de wach yu ɔltɛm.
- Skan: Dɛn kin du skan lɛk 6 wik afta dɛn dɔn bigin fɔ tek mɛrɛsin fɔ si aw di kansa de ansa di mɛrɛsin.
- Blɔd Tɛst: Dis rili impɔtant. Dɛn kin chɛk di sɛl dɛn we de na yu blɔd, lɛk wayt blɔd sɛl, nyutrofil, ɛn pletlɛt ɔltɛm fɔ mek shɔ se di mɛrɛsin de wok fayn fɔ yu bɔdi.
Aw fɔ kɔntrol di sayd ɛfɛkt dɛn if dɛn apin?
Di sayd ɛfɛkt dɛn kin apin we pɔsin de tek kansa mɛrɛsin. De tin wae impɔtant pas ɔl na fɔ tɛl yu dɔktɔ bɔt ɛni chenj ɔr pwɛl hat wae yu fil, ilɛksɛf na smɔl tin.
- Fɔ tɛst blɔd ɔltɛm: Sɔntɛnde, Verzenio kin mek di wayt blɔd sɛl dɛn go dɔŋ. dεn kכl dis ``nyutropenia.'' Dis kin mek yu gεt siriכs infεkshכn. Na dat mek i impɔtant fɔ mek yu du ɔl di blɔd tɛst dɛn we yu dɔktɔ tɛl yu fɔ du.
- Bɛlɛ at: Nɔs, vɔmit, ɛn dayarɛa na tin dɛn we kin apin. Yu kin kɔntrol dɛn tin ya bay we yu it tin dɛn we nɔ gɛt bɔku fat, ɛn it smɔl smɔl tin dɛn pas big it dɛn. Bɔt if yu dayarɛa bad bad wan, yu fɔ tɛl yu dɔktɔ wantɛm wantɛm . I go gi yu di advays we yu nid.
- Ɔda siriɔs sayd ɛfɛkt: If yu si ɛni sayn we de sho se blɔd de klɔt (we de swel ɔ brus na yu leg) we de afɛkt yu lɔng, lɛk fɔ kɔf, fɔ mek i nɔ izi fɔ blo, ɔ fɔ blo shɔt, yu fɔ tɛl yu dɔktɔ bak wantɛm wantɛm.
Ɛni ɔda spɛshal tin dɛn de we wi fɔ no?
Yɛs, sɔm ɔda tin dɛn de.
- It grepfruit, nɔto jus: Grepfruit de stɔp di bɔdi fɔ brok Verzenio. Dis kin mek di lɛvɛl fɔ di drɔg na di bɔdi go ɔp we nɔ nid, ɛn dis kin mek di sayd ɛfɛkt dɛn bɔku.
- Sɔm mɛrɛsin dɛm: If yu tek antifungal mɛrɛsin lɛk ketoconazole wit dis mɛrɛsin kin mek yu gɛt denja sayd ɛfɛkt. So, tɛl yu dɔktɔ bɔt ɔl di mɛrɛsin dɛn we yu de tek (inklud vaytamɛn ɛn sɔpɔtmɛnt dɛn) .
- Ɔda sik dɛn:If yu gɛt ɔda wɛlbɔdi prɔblɛm, lɛk liva sik, yu go nid fɔ ajɔst yu Verzenio doz. Tɔk to yu dɔktɔ bɔt yu kɔmplit wɛlbɔdi istri.
Mɛsej we dɛn kin kɛr go na os
- Verzenio na wan tεrapi we dεn tכk bכt fכ mεtastas εn sכm kayn brεst kεnsar (HR-positiv, HER2-negative).
- Fɔ fala yu dɔktɔ in instrɔkshɔn dɛn di rayt we. Tek di mɛrɛsin di rayt tɛm ɛn di rayt doz.
- Ripɔt ɛni sayd ɛfɛkt we yu gɛt, ilɛksɛf i smɔl, to yu dɔktɔ wantɛm wantɛm.
- I rili impɔtant fɔ mek dɛn du blɔd tɛst ɛn skan di rayt tɛm.
- Nɔ it grep frut ɔltogɛda. Tɛl yu dɔktɔ bɔt ɔl di ɔda mɛrɛsin dɛn we yu de tek.
- Dis nɔto waka we yu de go tru yu wan. Yu mɛdikal tim de ɔltɛm fɔ ɛp yu. So nɔ fred fɔ aks kwɛstyɔn ɛn mek yu dawt klia wan.
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