Yu no bɔt di rɛd blɔd sɛl dɛn we de na yu blɔd. Bɔku tɛm, dɛn kin rawnd, dɛn kin ebul fɔ chenj, lɛk smɔl smɔl rɔba bɔl dɛn. Dis kin mek dɛn ebul fɔ muv izi wan tru di smɔl smɔl blɔd vesel dɛn na yu bɔdi ɛn kɛr ɔksijɛn go ɔl di pat dɛn na yu bɔdi. Bɔt pan sɔm pipul dɛn, dɛn rɛd blɔd sɛl ya kin tan lɛk sikle (C-shaped), stif ɛn stika. Dis na wetin wi kin kɔl siklɛt sik (SCD). Dis nɔto sik we pɔsin kin gɛt frɔm in mama ɛn papa, bɔt na tin we pɔsin kin gɛt frɔm in bɔdi.
Wetin rili na sikɛl sɛl sik (SCD)?
Fɔ tɔk am simpul wan, siklɛt sik na wan sik we wi kin gɛt we kin afɛkt wi rɛd blɔd sɛl dɛn. Insay dɛn rɛd blɔd sɛl ya, wan prɔtin de we dɛn kɔl ɛmoglobin . di men wok we i de du na fכ pik כksijεn frכm di lכng dεm εn sheb am כlsay na di bכdi. Di ɛmoglobin mɔlyul fɔ pɔsin we gɛt wɛlbɔdi kin rawnd ɛn i kin smɔl. Na dat mek di rɛd blɔd sɛl dɛn kin rawnd fayn fayn wan.
Bɔt pan pɔsin we gɛt siklɛt sik, bikɔs ɔf in jenɛtik dɛfɛkt, di shep fɔ dis ɛmoglobin mɔlyul kin chenj. Bikɔs ɔf dis abnɔmal ɛmoglobin, di rɛd blɔd sɛl dɛn kin tan lɛk sikle, dɛn kin stif, ɛn dɛn kin stika. Imajin, wetin go apin if yu tray fɔ sɛn blɔd we at ɛn we tan lɛk sikɛl tru wan tint tiub, instead fɔ sɛn rawnd bɔl dɛn we de muv along am? Dɛn go klɔmp togɛda ɛn stɔp na di tiub, nɔto so? Semweso, dɛn sɛl dɛn ya we tan lɛk sikl kin stɔp na wi tint blɔd vesel dɛn, ɛn dis kin mek blɔd nɔ ebul fɔ flɔ. Dis na wetin kin mek difrɛn prɔblɛm dɛn lɛk bad bad pen ɛn blɔd blɔd .
Wetin na di kɔmɔn sayn dɛm fɔ dis sik?
di pikin dεm we dεn bכn wit sik sεl sik kin bigin fכ sho di simptom dεm arawnd 5 mכnt. Dɛn sayn ya kin difrɛn frɔm wan pɔrsin to ɔda pɔrsin. Dɛn kin chenj bak as tɛm de go.
| Di sayn we de sho se di sik de | Wan simpul ɛksplen |
|---|---|
| Anemia we nɔ gɛt bɛtɛ blɔd | Siklɔs sɛl dɛn kin rili brok. pan ɔl we nכmal rεd bכdi sεl de liv fכ lεk 120 dez, dεn sεl dεm ya de day insay 10-20 dez. Dis kin mek di bɔdi nɔ gɛt rɛd blɔd sɛl, ɛn dis kin mek yu fil taya ɛn taya ɔltɛm. |
| Pen Krays dɛn | Dis na di men ɛn bad bad sayn fɔ dis sik. We siklɛt sɛl dɛn gɛda ɛn blok di dilik blɔd vesel dɛn na di chɛst, bɛlɛ, an ɛn an, ɛn bon dɛn, i kin mek pɔsin fil pen we i nɔ go ebul fɔ bia. If dis pen rili bad, yu kin nid fɔ go na ɔspitul ɛn go na di ETU (Emergency Treatment Unit) . |
| An ɛn fut kin swel | We di fayn fayn vein dɛn we de gi blɔd to di an ɛn fut kin blok, dɛn say dɛn de kin bigin fɔ swel. |
| Infekshɔn dɛn we kin kam bɔku tɛm | sכmtεm dεn sik sεl dεm ya kin pwεl כgan dεm lεk di splin. di splin na wan rili imכtant כgan na wi bכdi in imyun sistεm. We i dɔn pwɛl, di risk fɔ gɛt infɛkshɔn kin bɔku. |
| Di yay ɛn di skin we de yɔlɔ | As bɔku bɔku sik dɛn we dɔn pwɛl de brok, di skin ɛn di wayt pat na di yay kin bi yɔlɔ (lɛk janda). |
| Di we aw pɔsin nɔ de si fayn | If dɛn sɛl ya blok na di blɔd vesel dɛn we de gi blɔd to di yay, di retina na di yay kin pwɛl ɛn prɔblɛm kin apin we i de si. |
| Di we aw pɔsin nɔ de gro fayn | Pikin dɛn we gɛt dis sik kin bigin fɔ gro sloslo pas ɔda pikin dɛn, ɛn dɛn kin de te bak fɔ mek dɛn bɔn pikin. |
Wetin mek dis sik kin apin? Udat dɛn de pan denja pas ɔlman?
Di men tin we kin mek pɔsin gɛt dis sik na bikɔs in jɛnɛtiks nɔ fayn. i kin kכz fכ difεkt na wan jin (hεmoglobin-beta jin) na wi kromozom 11, we de involv fכ mek hεmoglobin.
Di tin we impɔtant pas ɔl na dat fɔ mek pikin gɛt dis sik, i fɔ gɛt dis jin we nɔ fayn frɔm in mama ɛn papa.
If mama ɛn papa ɔl tu gɛt dis jin we nɔ fayn, we min se dɛn nɔ gɛt di sik bɔt dɛn gɛt di jin we de mek dɛn gɛt di sik na dɛn bɔdi, dɛn pikin gɛt 1 pan 4 (25%) chans fɔ bɔn wit di sik.
If na wan mama ɔ papa nɔmɔ gɛt di jin, di pikin kin bi pɔsin we gɛt di sik. Bɔrku tɛm, dɛn nɔr kin sho sɔm kayn sik, bɔt dɛn kin pas di jin to dɛn pikin dɛm.
Ɔlsay na di wɔl, dis sik de mɔna pipul dɛn we kɔmɔt na Afrika, Midul Ist, Sawt Yurop, ɛn Eshian Indian.
Aw fɔ no di sik? (Diagnosis) .
Wan rili simpul we de fɔ no dis. Wan simpul blɔd tɛst kin no if dis kayn ɛmoglobin we nɔ fayn de. Insay bɔku kɔntri dɛn, dɛn kin tɛst ɛni pikin we dɛn jɔs bɔn fɔ dis.
If dɛn no se yu ɔ yu pikin gɛt dis sik, yu dɔktɔ kin tɛl yu fɔ du ɔda tɛst (lɛk fɔ du spɛshal skan fɔ chɛk fɔ no if i gɛt strok). Ɛn, bikɔs na jɛnɛtik kɔndishɔn, dɛn kin sɛn yu bak to jɛnɛtik advaysa.
If yu ɔ yu patna gɛt siklɛt sik ɔ na pɔsin we gɛt di sik, yu kin mek dɛn tɛst yu pikin in amniotic fluid we i gɛt bɛlɛ fɔ si if dɛn gɛt di sik. Aks yu dɔktɔ fɔ no mɔ.
Wetin na di tritmɛnt dɛn?
Tri men gol dɛn de fɔ trit siklɛt sik:
- Fɔ mek yu nɔ gɛt pen kraysis
- Kɔntrol di sayn dɛm ɛn gi rilif
- Fɔ mek dɛn nɔ gɛt ɔda prɔblɛm dɛn
Difrɛn tritmɛnt dɛn de fɔ dis.
Di mɛrɛsin dɛn we dɛn kin yuz
- Hydroxyurea: Dis mɛrɛsin, we yu tek ɛvride, kin ridyus di atak ɛn ridyus prɔblɛm dɛn lɛk anemia ɛn infɛkshɔn. Bɛlɛ uman dɛn fɔ avɔyd fɔ tek dis mɛrɛsin.
- Di mɛrɛsin dɛn we de mek pɔsin fil pen: We pɔsin de fil pen, di mɛrɛsin dɛn we di dɔktɔ gi am fɔ mɛn di pen kin ɛp fɔ kɔntrol di pen.
- Ɔda mɛrɛsin dɛm: Dɛn de yuz drɔgs lɛk `Crizanlizumab` (wan injɛkshɔn) ɛn `L-glutamine` (wan paoda) naw fɔ ridyus pen atak, ɛn drɔgs lɛk `Voxelotor` fɔ anemia.
Ɔda tritmɛnt dɛn
- Blɔd Transfyushɔn: If yu gi wɛlbɔdi blɔd, dat kin mek yu nɔ gɛt prɔblɛm dɛn lɛk we yu nɔ gɛt bɛtɛ blɔd ɛn we yu nɔ ebul fɔ waka.
- Stem Sεl Transplant: Dis na bon mכro transplant. Sɔm pikin ɛn yɔŋ pipul dɛn gɛt di potenshal fɔ wɛl frɔm di sik ɔltogɛda tru dis. Bɔt dɛn fɔ fɛn pɔsin we de gi mɔni we mach gud gud wan (bɔku tɛm na in fambul we de nia am) fɔ dis.
Di Latest We fɔ Trit: Jin Tɛrapi
Wit di advansment of medikal saiens, plenti saksesful en promising tritment fo dis sik don kom out nau. `Casgevy` ɛn `Lyfgenia` na tu kayn laytst jin tɛrapi dɛm. Fɔ tɔk am simpul wan, dɛn we ya de yuz stem sɛl dɛn we dɛn tek frɔm di pɔsin in yon bon mɛro, we dɛn ‘ɛdit’ yuz jɛnɛtik tɛknɔlɔji lɛk `CRISPR`, dat na fɔ kɔrɛkt di difrɛns, tɔn to wɛlbɔdi sɛl dɛn we de mek rɛd blɔd sɛl, ɛn afta dat dɛn put am bak insay di bɔdi. Dis na tritmɛnt we rili advans we kin mɛn di sik.
Wetin na di rilayshɔn bitwin siklɛt sik ɛn malaria?
Dis na stori we rili strenj. Malaria na siriɔs sik we mɔskito kin pas. Sayɛnsman dɛn biliv se di siklɛt jin bin kam fɔ protɛkt pipul dɛn frɔm malaria. Aw dat kin pɔsibul? If pɔsin we gɛt siklɛt sik (nɔto di sik, jɔs di jin) gɛt malaria, i nɔ kin rili bad. Dis na bikɔs di rɛd blɔd sɛl dɛn we tan lɛk sikl de mek di malaria parasayt nɔ gro fayn fayn wan insay di bɔdi. Dis na di rizin we mek pipul dɛn we gɛt dis jin bin de liv na say dɛn we malaria bin bɔku, lɛk Afrika.
Mɛsej we dɛn kin kɛr go na os
- Siklɔs sik nɔto sik we pɔsin kin gɛt, bɔt na sik we dɛn kin gɛt frɔm in mama ɛn papa.
- Di men prɔblɛm we de ya na dat di shep we di rɛd blɔd sɛl dɛn gɛt kin chenj ɛn dɛn kin lɔk na di blɔd vesel dɛn.
- Bɔrku pen, taya ɔltɛm (anemia), ɛn infekshɔn na di men sayn dɛm.
- If yu fala di rayt tritmɛnt ɛn advays, yu go ebul fɔ kɔntrol di sik dɛn we yu gɛt ɛn liv nɔmal layf. I rili impɔtant fɔ de tɔk to yu dɔktɔ ɔltɛm.
- Tɛnki fɔ di mɔdan tritmɛnt dɛm lɛk jin tɛrapi, naw bɔku gud op de fɔ dis sik.
💬 Comments (0)
No kɔmɛnt nɔ de yet. Ad yu kɔmɛnt ya fɔ di fɔs tɛm.
Ad yu kɔmɛnt