Ka tumanye ku ddaala lyo erya AST. (Aspartate Transferase - AST) Ekyo kitegeeza ki?

Oboolyawo olabye omuwendo oguyitibwa AST ku lipoota y’okukebera omusaayi, oba owulidde omusawo ng’ayogera ku nsonga eyo. Kale, osanga weebuuza nti, "AST kitegeeza ki?" Tofaayo, ka tukyogereko mu ngeri ennyangu. Nga bwe wandiyogedde ne mukwano gwo.

AST kye ki? Mu ngeri ennyangu...

AST lye linnya ettono eriyitibwa enzyme Aspartate Transferase . Oluusi era kiyitibwa Aspartate Aminotransferase . Kati oyinza okuba nga weebuuza nti, "Enzyme eno kye ki?"

Teebereza, waliwo abakozi abatonotono abawerako munda mu mibiri gyaffe abayamba ebintu eby’enjawulo okukola obulungi. Enziyiza bwe zityo. Mu butuufu zino kika kya puloteyina. Enziyiza eno eyitibwa AST esangibwa mu bifo bingi mu mibiri gyaffe. Kisinga kusangibwa mu kibumba . Naye okugatta ku ekyo, enziyiza eno eya AST esangibwa mu bitundu ebirala bingi ng’omutima, obwongo, olubuto, ensigo, n’ebinywa. Wabula ebiseera ebisinga bwe twogera ku AST, esinga kwekuusa ku bulamu bw’ekibumba kyaffe.

Kale okukebera omusaayi gwa AST kye ki?

Okukebera omusaayi gwa AST kupima obungi bwa AST mu musaayi gwo. Mu budde obwabulijjo, obutoffaali bw’omubiri gwaffe bwe gwonoonese, enziyiza eno eya AST esobola okuzimba mu musaayi. N’olwekyo, omuwendo gwa AST omungi mu musaayi kabonero akalaga nti waliwo ekikyamu munda mu mubiri. Ebiseera ebisinga (naye si bulijjo) kino kiyinza okuba obulwadde bw’ekibumba.

Wabula AST tesangibwa mu kibumba kyokka. N’olwekyo, kizibu omusawo okumanya ddala ekika ky’obulwadde bw’olina okusinziira ku miwendo gya AST gyokka. Ebiseera ebisinga, okukebera kwa AST kukolebwa nga kukwataganye n’okukebera okulala okuwerako. Okugeza, kikolebwa ng’ekitundu ky’ekibiina ekigatta enziyiza z’ekibumba (HFP) oba ekibiina ekikwata ku nkyukakyuka y’emmere (comrehensive metabolic panel) (CMP) . Kino kikusobozesa okupima ebintu bingi mu musaayi gumu n’ofuna ekifaananyi ekijjuvu eky’obulamu bwo.

Ekigezo kya AST kirina amannya amalala agawerako:

• Ekirungo kya Aspartate transferase (AST).
• Ekirungo kya aspartate aminotransferase (AST) eddagala eriyitibwa Aspartate aminotransferase (AST).
• Serum Glutamic-Oxaloacetic Transaminase (Ekiwuka ekiyitibwa SGOT).
• SGOT.
• Ekirungo kya aspartate transaminase.

Njawulo ki eriwo wakati wa AST ne ALT?

Oyinza okuba nga wali owulidde ku muwendo omulala oguyitibwa ALT wamu ne AST. ALT (Alanine Transferase) ye enzyme endala epimibwa mu kibumba. Bino byombi bifulumizibwa mu musaayi ng’obutoffaali bw’ekibumba bwonoonese.

Wabula obutafaananako AST, ALT enzyme esinga kusangibwa mu kibumba. AST esangibwa mu bitundu by’omubiri ebirala bingi. N’olwekyo, emiwendo gya ALT egy’okulinnya gitwalibwa ng’ekiraga obulwadde bw’ekibumba okusinga emiwendo gya AST egy’okulinnya . Wabula omusawo bw’aba atunuulira obulamu bw’ekibumba, batera okukebera AST ne ALT zombi wamu.

Lwaki nneetaaga okukeberebwa AST?

Ekigendererwa ekikulu eky’okukebera AST kwe kuzuula obutoffaali obuli mu mubiri gwaffe okwonooneka. Kino kiyamba okuzuula obuzibu mu kibumba naddala singa obutoffaali mu kibumba bwonoonese, anti AST ekuŋŋaanyizibwa mu musaayi. Ate era nga bwe kyayogeddwako emabegako, emiwendo gya AST giyinza okulinnya ne bwe kiba nti obutoffaali bwonoonese awalala mu mubiri.

Omusawo ayinza okukusaba okukeberebwa AST (ebiseera ebisinga ng’ekitundu ku kakiiko) olw’ensonga nga:

1. Okukebera ng’obubonero tebunnalabika

Abantu abamu bali mu bulabe bwa maanyi okukwatibwa obulwadde bw’ekibumba. Bw’oba ​​olina ekimu ku bintu bino eby’obulabe, osobola okukeberebwa kuno okukebera obulamu bw’ekibumba kyo ng’obubonero tebunnalabika. Ebintu bino eby’obulabe mulimu:

• Okunywa omwenge ekisusse.
• Okubeera n’obulwadde bw’ekibumba mu maka.
• Ekirwadde ekya sukaali.
• Omugejjo (okweyongera kw’amasavu mu mubiri).
• Okufuyira eddagala n’empiso ezikozesebwa abalala.

Oluusi, okukeberebwa kwa AST kuteekebwa mu Comprehensive Metabolic Panel (CMP) ng’ekimu ku bitundu by’okukebera obulamu okwa bulijjo, kale oyinza okwetaaga okukeberebwa kuno ne bw’oba ​​toli mu bulabe bwa bulwadde bwa kibumba.

2. Londoola embeera (Okulondoola) .

Bw’oba ​​olina dda obulwadde bw’ekibumba, omusawo ayinza okulagira okukeberebwa kuno okwa AST okulaba oba butereera, bweyongera okusajjuka oba bwe bukola obulungi n’obujjanjabi. Ekirala bw’oba ​​omira eddagala eriyinza okukosa ekibumba, okukebera kuno nakyo kukolebwa okulaba oba eddagala lino lyonoona ekibumba.

3. Nga ekiyamba mu kuzuula (Diagnosing) .

Bw’oba ​​olina obubonero bw’obulwadde bw’ekibumba, okukeberebwa kwa AST kuyinza okuteekebwa mu kukeberebwa okukuyamba okuzuula. Wadde ng’emiwendo gya AST gyokka tegisobola kuzuula bulwadde, kitundu kikulu nnyo mu nkola y’okuzuula.

Obumu ku bubonero bw’obulwadde bw’ekibumba bwe buno:

• Okuziyira ne/oba okusiiyibwa.
• Okulumwa olubuto (okulumwa olubuto).
• Olususu olusiiwa.
• Jaundice (olususu okufuuka ekya kyenvu n’amaaso okweru).
• Okuwulira ennyo ng’okooye (okukoowa).
• Emmere tewooma.

Ani akebera omusaayi gwa AST? Kikolebwa kitya?

Ebiseera ebisinga, omuntu atendekeddwa mu ngeri ey’enjawulo okutwala omusaayi, ayitibwa omusawo w’omusaayi, akwata omusaayi guno. Kyokka omusawo yenna atendekeddwa okumira omusaayi asobola okukikola. Olwo sampuli eno esindikibwa mu laabu. Eyo, omukugu mu laboratory y’ebyobujjanjabi yeetegereza sampuli n’apima omutindo gwa AST ng’akozesa ebyuma eby’enjawulo (analyzers).

Waliwo kye nneetaaga okukola nga sinnakeberebwa?

• Okusiiba: Singa okukeberebwa kwo okwa AST kuba kitundu ku Comprehensive Metabolic Panel (CMP), oyinza okusabibwa okusiiba (tolya oba kunywa kintu kyonna okuggyako amazzi) okumala essaawa 10-12 nga tonnakeberebwa musaayi. Wabula bw’oba ​​okeberebwa AST yokka oba Hepatic Function Panel (HFP) yokka, ebiseera ebisinga teweetaaga kusiiba. Naye,Goberera ddala ebiragiro by’omusawo wo.
• Ebikwata ku ddagala: Olina okutegeeza omusawo wo ku ddagala lyonna, vitamiini, n’ebirungo ebiyamba omubiri gw’omira. Eddagala erimu liyinza okukosa emiwendo gya AST. Omusawo ayinza okukusaba okukomya okuzimira ng’ebula ennaku ntono okukeberebwa, okuggyako nga bakugambye. Tolekera awo kumira ddagala lyonna nga tolina magezi ga musawo.

Kiki ekibaawo ng’owaayo omusaayi?

Kino kyangu nnyo.

• Ojja kutuula mu ntebe. Olwo omusuwa ogusaanira gujja kusangibwa mu mukono gwo (ebiseera ebisinga wansi w’enkokola, munda).
• Omusuwa bwe guzuulibwa, ekitundu ekyo kiyonjebwa ne kitta obuwuka.
• Oluvannyuma, empiso entono eteekebwa mu musuwa ogwo ne bagiggyamu omusaayi. Kino kiyinza okuluma katono, ng’okulumwa enseenene.
• Oluvannyuma lw’okuyingiza empiso, omusaayi omutono gukuŋŋaanyizibwa mu ttanka y’okukebera.
• Bw’omala okukung’aanya omusaayi ogumala okukeberebwa, ggyamu empiso osse puleesa mu kifo we wavudde omusaayi n’akatundu ka ppamba oba gaasi okukomya omusaayi.
• Olwo ne basiiga pulasita mu kifo ekyo era omulimu ne gukolebwa.

Enkola eno yonna etera okutwala eddakiika ezitakka wansi wa ttaano.

Kiki ekibaawo oluvannyuma lw’okugaba omusaayi?

Oluvannyuma lw’omusaayi okusindikibwa mu laabu, ebyavaamu bijja kuzuulibwa mu lunaku nga lumu oba bbiri. Oluusi kiyinza okutwala ekiseera ekiwanvuko katono. Omusawo wo ajja kukubuulira ebinaavaamu nga biyingidde.

Waliwo akabi konna mu kino?

Okukebera omusaayi kwekebejja kwa bulijjo nnyo era kukulu. Obulabe buno butono nnyo. Wayinza okubaawo ebiwundu n’okulumwa omusaayi we guggyibwa. Naye ekyo kijja kuggwaawo mangu.

Ebyava mu kukeberebwa kwa AST bitegeeza ki?

Lipoota y’okukebera omusaayi etera okubaamu amawulire gano wammanga wamu n’ebyava mu AST:

• Erinnya ly'okukebera omusaayi (kiyitibwa AST).
• Omuwendo (omuwendo) gwa AST mu musaayi gwo.
• Range eyabulijjo ey’okugezesebwa okwo.
• Oba ebyavaamu byo bya bulijjo oba si bya bulijjo (waggulu oba wansi).

Range eyabulijjo eri AST eri etya?

Ekigero ekya bulijjo ekya AST kiyinza okwawukana katono okuva ku laabu emu okudda ku ndala. Ekigero ekya bulijjo ekya bulijjo kiri 8 okutuuka ku 33 U/L (units/liter) . Wabula kikulu okutunuulira ebanga erya bulijjo ku lipoota yo.

Ate era, jjukira, tewali ddaala lya AST "erya bulijjo" likola ku buli muntu. Omutindo gwa AST omulamu guyinza okwawukana okusinziira ku bintu nga:

• emyaka gyo.
• Obukyala/obusajja bwo.
• Eggwanga lyo.
• Obuzito bwo.

Omusawo wo ajja kulowooza ku bino byonna era asalewo ku bigenda okuvaamu.

Kitegeeza ki singa AST level yange eba waggulu?

Singa emiwendo gya AST girinnya, kiyinza okuba akabonero k’obulwadde bw’ekibumba.Singa omusaayi omulala naddala ogwekuusa ku kibumba nabwo tebiba bya bulijjo, kiyinzika okuba ng’olina obulwadde bw’ekibumba. Wabula nga bwe kyayogeddwako emabegako, emiwendo gya AST nagyo giyinza okulinnya singa obutoffaali mu bitundu by’omubiri ebirala byonoonese naddala mu kibumba.

Emiwendo gya AST egy’okulinnya giyinza okulaga embeera z’obulwadde bw’ekibumba nga:

• Ekibumba okwonooneka olw’omwenge.
• Obulwadde bw’ekibumba.
• Enkovu mu kibumba (Cirrhosis).
• Okumira eddagala ery’obulabe (obutwa) eri ekibumba.
• Ekizimba ky’ekibumba oba kookolo w’ekibumba.
• Okukendeera kw’omusaayi mu kibumba (Liver Ischemia) (kino kiyinza okuvaako ebitundu by’ekibumba okufa).

Okugatta ku ekyo, embeera ezitakwatagana butereevu na kibumba nazo zisobola okuleeta emiwendo gya AST okulinnya:

• Okukuŋŋaanyizibwa kw’ekyuma ekisusse mu mubiri (Hemochromatosis) (kino kyonoona omutima, ekibumba, n’olubuto).
• Obulwadde bw’omutima (Myocardial Infarction).
• Obulwadde bwa Mononucleosis musujja.
• Endwadde z’ebinywa.
• Okuzimba kw’olubuto (Pancreatitis).

Ng’oggyeeko ebintu bino, emiwendo gya AST nagyo giyinza okweyongera okumala akaseera oluvannyuma lw’ebintu nga:

• Okwokya okw’amaanyi.
• Okukonziba.
• Okulongoosa oba enkola ezikwata ku mutima.
• Okuloongoosa.
• Dduyiro ow’amaanyi.
• Bwoba oli lubuto.

Ekikulu kiri nti omutindo gwa AST ogw’amaanyi tekitegeeza nti olina obulwadde obw’amaanyi. Ensonga endala nnyingi ziyinza okukosa kino. Omusawo wo ajja kutunuulira ebikeberebwa omusaayi ebirala, ebyafaayo byo eby’obujjanjabi, n’ebirala byonna okusobola okusalawo.

Nsaana okweraliikirira singa ebyava mu AST byange biba bingi?

Singa omutindo gwa AST gwo guba waggulu okusinga ku mutindo ogwa bulijjo oguweereddwa ku lipoota yo ey’okukebera AST, tekitegeeza nti olina obulwadde obwetaaga obujjanjabi. N’omuntu alina ekibumba ekiramu era ekikola obulungi asobola okuba n’omutindo gwa AST ogutali ku mutindo ogwa bulijjo. Kino kiyinza okuba nga kiva ku nsonga nnyingi, okugeza:

• emyaka gyo.
• Obukyala/obusajja bwo.
• Eggwanga lyo.
• Endya yo.
• Dduyilo.
• Okumira eddagala erikosa emiwendo gya AST.
• Oli lubuto.

Omusawo wo ajja kulowooza ku nsonga zino zonna, awamu n’ebyava mu musaayi gwo ebirala, era asalewo oba weetaaga okwongera okukeberebwa.

Singa ebyava mu AST byange biba si bya bulijjo, kinanneetaaga okwongera okukeberebwa?

Yee, singa omutindo gwa AST gwo guba gwa bulijjo, omusawo ayinza okulagira okukeberebwa okulala okutonotono. Ebigezo bino mulimu:

• Ddamu okukebera omusaayi gwa AST.
• Okukebera omusaayi okulala (e.g. ALT, Bilirubin).
• Okukebera ebifaananyi (e.g. Ultrasound scan).
• Okukebera omubiri (biopsy).

Ddi lwe nnina okuyita omusawo?

• Bw’oba ​​olina obubonero bw’ekibumba okwonooneka (e.g. jaundice, okulumwa olubuto), kuba essimu y’omusawo mu bwangu.
• Bw’oba ​​omanyi dda nti olina obulwadde bw’ekibumba, tegeeza omusawo wo bw’ofuna obubonero obupya oba obweraliikiriza.
• Bw’oba ​​olina ekibuuzo kyonna ku bivudde mu AST, totya kubuuza musawo wo.

Ekintu ekisinga obukulu okukuuma mu birowoozo (Take-Home Message)

Kya bulijjo okuwulira nga weeraliikirira katono ng’olaba omuwendo ogutali gwa bulijjo ku lipoota y’okukebera omusaayi. Naye jjukira nti olw’okuba AST level yo eri waggulu tekitegeeza nti olina obulwadde oba weetaaga obujjanjabi. Ensonga nnyingi ziyinza okukosa emitendera gya AST. Abantu nga omu ku buli bantu 20 abalamu ayinza okuba n’ebivaamu ebitali bya bulijjo.

Omusawo wo ajja kusalawo oba olina okwongera okukola oba nedda okukeberebwa okuzuula ekivaako omuwendo guno ogutali gwa bulijjo. Kale, totya kwogera na musawo wo ku nsonga eno. Baliwo okukuyamba. Okukifuna?

` AST, ekibumba, enzymes, okukebera omusaayi, SGOT, obulwadde bw'ekibumba, okukebera obulamu