Ka tuyige ebisingawo ku busimu bwa Leptin obukuyamba okufuga obuzito bwo.

Wali weebuuzizzaako lwaki enjala etuluma, engeri gye tuwulira nga tujjudde oluvannyuma lw’okulya, era lwaki kyangu abamu okugejja ate nga kizibu abalala okugejja? Leero tugenda kwogera ku kabaka akatono aka kemiko akakolebwa munda mu mibiri gyaffe akakwatagana ne bino byonna. Kiyitibwa Leptin. Okubeera omutuufu, leptin busimu obufulumizibwa obutoffaali bwaffe obw’amasavu (adipose tissue) obutuyamba okukuuma obuzito bw’omubiri gwaffe mu bbanga eggwanvu.

Leptin kye ki? Ka tulabe mu ngeri ennyangu.

Teebereza ng’amasavu g’omubiri gwo gakola obusimu obuyitibwa Leptin. Kale, omulimu omukulu ogwa Leptin kwe kufuga enjala yaffe n'okutuwa okuwulira nti "enough, I'm full" (satiety) oluvannyuma lw'okulya. Kiringa aka maneja akatono akafuga obuzito bw’omubiri gwaffe.

Bannasayansi baazuula obusimu obuyitibwa leptin mu 1994. Ekyo kitegeeza nti wakyaliwo bingi eby’okubuzuula. Batandise dda okunoonyereza oba leptin esobola okukozesebwa okujjanjaba okukendeeza ku buzito, obulwadde bwa Alzheimer, obulamu bw’okuzaala n’obutazaala.

"Ah... singa leptin efuga obuzito, naffe tetulina kusobola kufuga leptin?" oyinza okulowooza nti. Naye, ekituufu kiri nti, obusimu buno si bwangu kufuga nga bwe twagala.

Leptin ekola ki ku mubiri gwaffe?

Omulimu gwa Leptin omukulu kwe kuyamba okukuuma obuzito bw’omubiri gwaffe nga tegukyukakyuka. Okusingawo, kiyamba okukuuma bbalansi ey’ekiseera ekiwanvu wakati w’obungi bw’emmere gye tulya n’engeri omubiri gwaffe gye gukozesaamu amaanyi. Kwe kugamba, kiyamba okutulemesa okuwulira enjala ng’omubiri gwaffe tegwetaaga maanyi (calories).

Leptin okusinga akola ku hypothalamus, ekitundu ky’obwongo bwaffe ekifuga enjala yaffe n’amaanyi gaffe. Kyokka, ebirungo ebikwata leptin-sensitive receptors nabyo bisangibwa mu bitundu by’omubiri gwaffe ebirala.

Naye wuuno ekintu ky'olina okutegeera. Leptin si busimu obutuleetera okulumwa enjala oluvannyuma lw’okulya emmere emu. Mu kifo ky’ekyo, kituyamba okukuuma obuzito bwaffe nga kikyusa obungi bw’emmere gye tulya okumala ekiseera , kifuga engeri gye tukozesaamu amaanyi, era kituyamba okufuga obuzito bwaffe.

Ebikolwa bya Leptin biwulirwa naddala ng’ogezaako okugejja. Lowooza ku kino, amasavu mu mubiri gwo bwe gakendeera, leptin nayo ekendeera. Olwo obwongo ne bufuna akabonero akagamba nti, "Oh, omubiri tegulina mmere emala, kiringa bwe tusiiba." Eno y’ensonga lwaki oluusi owulira enjala nnyo n’okwegomba emmere ey’enjawulo. Olwo n’okemebwa okulya ennyo. Kino kiyinza n’okukaluubiriza okugejja.

Bannasayansi bakyanoonyereza ku Leptin. Balowooza nti Leptin era ekosa:

• Enkyukakyuka y’ebirungo
• Enkola ya endocrine - kwe kugamba, enkola yaffe ey’obusimu
• Abaserikale b’omubiri - enkola ekuuma endwadde

Emiwendo gya leptin gifugibwa gitya?

Leptin ekolebwa era n’efulumizibwa ebitundu by’amasavu ebyeru mu mibiri gyaffe. Ekitundu kino ekyeru eky’amasavu kye kika ky’amasavu ekisinga mu mibiri gyaffe. Mu ngeri ennyangu, ge masavu agaterekeddwa ku mubiri gwo.

Olw’okuba Leptin ekolebwa obutoffaali bw’amasavu, obungi bwa Leptin mu musaayi gwo bukwatagana butereevu n’obungi bw’amasavu mu mubiri gwo. Ekyo kitegeeza nti bw’oba ​​n’amasavu matono mu mubiri, oba olina Leptin mutono. Bw’oba ​​n’amasavu mangi mu mubiri, olina Leptin omungi. Kyangu, nedda?

Singa amasavu mu mubiri gwo geeyongera okumala ekiseera, emiwendo gya leptin gyo gijja kweyongera. Okwawukana ku ekyo, singa amasavu mu mubiri gwo gakendeera, emiwendo gya leptin gyo gijja kukendeera.

Kiki ekibaawo singa leptin yeeyongera?

Leptin etera okuba waggulu mu bantu abagejjulukuka. Kino kiyitibwa hyperleptinemia. Emiwendo gya leptin bwe giba mingi buli kiseera, obwongo bwaffe buyinza obutaddamu bulungi leptin. Kino kiyitibwa okuziyiza leptin .

Waliwo embeera endala eziwerako eziyinza okuba nga zeekuusa ku hyperleptinemia:

• Ennaku
• Omuze gw’emmere
• Obuzibu bw’obusimu obuyitibwa neurodegenerative disorders
• Obulwadde bw’ekibumba obw’amasavu obutali bwa mwenge
• Rabson-Mendenhall syndrome - Eno mbeera ya buzaale etali ya bulijjo nnyo.

Obuziyiza bwa Leptin kye ki?

Bw’oba ​​olina Leptin Resistance, obwongo bwo tebuddamu Leptin mu ngeri eya bulijjo. Teebereza, Leptin asigala aweereza obubonero ku bwongo ng'agamba nti "Nfunye emmere emala, nzijudde," naye obwongo bulabika tebufaayo. Kale, towulira ng’ojjudde. Olw’ensonga eno, osigala olya wadde ng’olina amasavu mangi agaterekeddwa mu mubiri gwo.

Si ekyo kyokka, wabula olw’okuba Leptin takola bulungi, obwongo bulowooza nti omubiri gufa enjala era nti gufa enjala. Olwo, okukuuma amaanyi, obwongo bukendeeza ku maanyi gaffe, era ne bukendeeza ku muwendo gwa kalori ze tukozesa nga tuwummudde. Mu ngeri ennyangu, Basal Metabolic Rate (BMR) yaffe ekendedde.

Kale olaba, okuziyiza leptin kukuleetera okuwulira enjala buli kiseera, era nakyo kikendeeza ku BMR yo. Ebintu bino ebibiri bwe bikwatagana, okugejja kweyongera okusajjuka.

Mu kiseera kino bannassaayansi bali mu kunoonyereza ku ddagala eriyinza okujjanjaba obulwadde bwa leptin.

Bubonero ki obulaga obulwadde bwa Leptin Resistance?

Obubonero obukulu obw’okuziyiza leptin kwe kuwulira enjala esukkiridde buli kiseera (hyperphagia) n’okulya ennyo. Obubonero buno bubaawo ne bwe wabaawo amasavu amangi agaterekeddwa mu mubiri.

Kyokka waliwo ensonga endala n’embeera eziyinza okuvaako obubonero buno. Obuziyiza leptin si bwe bwokka. Nga bannassaayansi bakyayiga ku leptin, kisoboka okuba nti obubonero obulala obw’okuziyiza leptin bujja kuzuulibwa mu biseera eby’omu maaso.

Kiki ekibaawo singa leptin ekendeera?

Obutabeera na leptin mbeera etali ya bulijjo nnyo. Obulwadde obukulu obukwatagana nabwo bwe butabeera na leptin obuzaaliranwa. Eno mbeera ya buzaale ebeerawo ng’azaalibwa. Abantu abalina embeera eno tebakola leptin okuva mu masavu gaabwe.

Leptin bw’aba taliiwo, omubiri gulowooza nti mu mubiri temuli masavu. Kino kireeta enjala etafugibwa, esukkiridde n’okwegomba okulya. Olw’ensonga eno, abaana abazaalibwa nga tebalina leptin bafuna omugejjo ogw’amaanyi (omugejjo ogw’ekika kya III) ku myaka emito ennyo, era okuvubuka kulwawo.

Endwadde endala eziyinza okuba nga zeekuusa ku mbeera eno:

• Dyslipidemia - obutakwatagana mu masavu nga kolesterol ne triglycerides
• Obulwadde bw’ekibumba obulimu amasavu
• Obulwadde bwa bakitiriya obutera okukwatibwa
• Hyperinsulinemia - ekitegeeza okufulumya insulini mungi
• Hypogonadotropic hypogonadism - ekitegeeza nti obusimu bw’okwegatta buba butono

Okukebera kwa ngeri ki okukolebwa okukebera emiwendo gya leptin?

Omuwendo gwa leptin gusobola okupimibwa n’okukebera omusaayi. Wabula abasawo tebatera kukebera bungi bwa leptin buli muntu. Bakuwa amagezi okukebera leptin mu mbeera zino wammanga:

• Singa omwana wo omuto alina omugejjo gwa class III .
• Bwoba omugejjo ate nga buli kiseera enjala ekuluma .

Emiwendo gya leptin egya bulijjo girina kuba gitya?

Mu budde obutuufu emiwendo gya leptin giyinza okuva ku:

• Ku bakyala: Nanograms 0.5 ku 15.2 buli mililita (ng/mL) .
• Ku basajja: Nanograms 0.5 ku 12.5 buli mililita (ng/mL) .

Naye jjukira nti ensengekera zino eza bulijjo zisobola okwawukana katono wakati wa laboratory ez’enjawulo. Kale, kirungi okukebera range eyabulijjo ku lipoota yo. Oba, kirungi okubuuza omusawo wo ku nsonga eno.

Nnyinza ntya okwongera ku muwendo gwa leptin?

Mu butuufu, waliwo kitono nnyo kye tuyinza okukola okwongera ku leptin levels zaffe okukendeeza enjala n’okwagala okulya. Kubanga nga bwe kyayogeddwako emabegako, emiwendo gya leptin gyo gikwatagana butereevu n’obungi bw’amasavu g’olina mu mubiri gwo.

Okunoonyereza okumu kwazuula nti abantu abafuna otulo obutono balina obusimu obuyitibwa ghrelin obulumwa enjala bungi ate obusimu obuyitibwa leptin buba butono. Kale, okufuna otulo otumala, ow’omutindo kiyinza okuyamba okutereeza obusimu bwo.

Bannasayansi era banoonyereza ku nkolagana eriwo wakati wa leptin n’ekika ky’amasavu agayitibwa triglycerides. Okunoonyereza okumu kulaga nti omuwendo gwa triglyceride omungi gukosa engeri leptin gy’ekola. Naye wakyaliwo endowooza ez’enjawulo ku nsonga eno. Bannasayansi abamu balowooza nti enteekateeka y’okulya ekendeeza ku triglycerides esobola okuyamba okulongoosa omuwendo gwa leptin. Naye abalala tebakkiriziganya na kino.

Mmere ki erimu ekirungo kya Leptin ekingi?

Wano abantu bangi we bakola ensobi. Leptin busimu obukolebwa mu mibiri gyaffe, so si kiriisa kye tusobola okufuna mu mmere nga vitamiini C oba puloteyina. N’olwekyo, tewali kintu kiyitibwa mmere erimu leptin.

N’ekisembayo, ebimu ku bintu ebikulu bye tulina okujjukira

Mu butuufu leptin kipya ekizuuliddwa, n’olwekyo bannassaayansi bakyayiga ebisingawo ku nsonga eno naddala engeri gy’akosaamu omugejjo n’okugejja. Nga bw'olaba, omubiri gwo bwe gukendeeza amasavu, emiwendo gya leptin gikendeera, ekiraga nti omubiri gwo "gusiiba," ekizibuwalira okugejja.

Bw’oba ​​weeraliikirira omugejjo gwo oba nga weetaaga okulambika ku ngeri y’okugejja mu ngeri ennungi, kirungi okwogera n’omusawo wo. Osobola n’okwogera n’omusawo w’endwadde z’omu lubuto ku nteekateeka z’okukendeeza ku buzito.

Jjukira nti bino byonna bikuyamba okubeera omulamu obulungi. Kikulu okubeera nga omanyi omubiri gwo.

` Leptin, okufuga obuzito, obusimu, enjala, omugejjo, amasavu, enkyukakyuka mu mubiri