Ka tuyige ku Human Growth Hormone (HGH) mu bigambo ebyangu.

Owulira ng’omwana wo takula muwanvu nga bwe balina? Oba bulijjo owulira ng’okooye era ng’okooye? Mpozzi ensonga lwaki kino kibeera mubaka wa kemiko omutono mu mubiri gwo. Ekimu ku busimu obwo obukulu mu kukula kw’omubiri gwaffe n’ebintu ebirala bingi kiyitibwa human growth hormone . Tugiyita HGH (Human Growth Hormone) mu bufunze. Abamu era bagiyita somatotropin . Kale leero, ka twogere ku HGH eno mu bujjuvu, mu ngeri ennyangu ennyo.

HGH kye ki? Kikolebwa kitya mu mubiri gwaffe?

Mu ngeri ennyangu, HGH busimu bwa butonde emibiri gyaffe bwe gikola. Kikolebwa akatundu akatono akasangibwa wansi ddala w’obwongo bwaffe, nga kali nga akagumba akatono. Tugiyita enseke y'omubiri ( pituitary gland ) . Obusimu buno obwa HGH bukosa ebitundu by’omubiri byaffe bingi. Kyetaagisa nnyo naddala mu kukula kw'abaana . HGH eyamba nnyo mu bintu ng’okufuula omwana wo omuwanvu n’okunyweza amagumba ge.

Naye bwe tumala okukula, kwe kugamba, oluvannyuma lw’ebipande ebikula mu magumba gaffe (epiphyses) okuggalawo, HGH tekyatufuula bawanvu. Naye ekyo si kye kyokka HGH ky’ekola. Ne bwe tumala okukula, HGH eyamba okukuuma ensengekera y’omubiri gwaffe eya bulijjo n’okukuuma omubiri gwaffe nga gutambula bulungi. Enkyukakyuka eno mu mubiri y’efuula emmere gye tulya amaanyi. HGH era ayamba okukuuma ssukaali (glucose) mu musaayi gwaffe ku mutindo ogugere.

Obusimu ddagala mu mibiri gyaffe. Beeyisa ng’ababaka. Zitambula mu musaayi ne zitegeeza ebitundu byaffe, ebinywa n’ebitundu ebirala eby’okukola ne ddi lwe tulina okukikola. Mu mibiri gyaffe mulimu obusimu buno obusukka mu 50!

Ensigo y’omubiri (pituitary gland) gye nnayogeddeko emabegako esangibwa wansi w’obwongo, wansi w’ekitundu ekiyitibwa hypothalamus . Hypothalamus eno efuga ebintu bingi nga puleesa yaffe, okukuba kw’omutima, ebbugumu ly’omubiri, n’okugaaya emmere. Kale, hypothalamus eno y’egamba enseke y’omubiri (pituitary gland) okufulumya HGH. Obusimu obuyamba ku ekyo buyitibwa GHRH (obusimu obufulumya obusimu bw’okukula) . Ate era, obusimu obulala (somatostatin) buva mu hypothalamus okuyimiriza okufulumya HGH. Eno y’engeri HGH gy’efugibwamu.

Oluusi abasawo bakozesa ekirungo kya HGH ekikoleddwa mu ngeri ey’ekikugu okujjanjaba endwadde ezimu. Naye jjukira nti tokozesangako HGH ya sintetiki nga tolina ddagala lya musawo.

Bintu ki ebikosa okufulumya HGH?

Ensigo yaffe eya pituitary mu budde obutuufu efulumya HGH mu bungi obutono olunaku lwonna, eyitibwa pulses . Kino kifugibwa okusinga obusimu bubiri okuva mu hypothalamus obuyitibwa GHRH ne somatostatin.

Si ekyo kyokka, naye n’obusimu obulala bwe buzingirwamu. Okugeza nga,Ensonga y’okukula eringa insulini 1 (IGF-1) ekendeeza ku kukola HGH, ate obusimu nga thyroxine , glucocorticoids , ne ghrelin byongera ku kufulumya HGH.

IGF-1, efulumizibwa ekibumba kyaffe, kye kimu ku biva mu mirimu gya HGH. IGF-1 eno y’efuga okukola ennyo kwa HGH. Kwe kugamba, HGH ereetera IGF-1 okukolebwa, era IGF-1 ekoleddwa nate okukendeeza ku kukola HGH. Kiba ng’enkulungo.

Mu muntu omulamu obulungi, okufulumya HGH kuziyizibwa ssukaali omungi mu musaayi (hyperglycemia) . Okugatta ku ekyo, okufulumya HGH kusikirizibwa ebintu nga otulo, situleesi, dduyiro, ssukaali omutono mu musaayi (hypoglycemia) , ne amino acids .

Mirimu ki emikulu egy’obusimu bwa HGH?

HGH erina emirimu ebiri emikulu:

1. Okusitula okukula (naddala mu baana) .

2. Okukosa enkyukakyuka mu mubiri (engeri gye tukyusaamu emmere gye tulya okugifuula amaanyi) .

HGH n’okukula

HGH eyamba buli kitundu n’ekitundu ky’omubiri mu mubiri gwaffe okukula. Naye esinga kumanyika olw’okuyamba amagumba n’amagumba okukula. Kino kikulu nnyo naddala mu myaka gy’obutiini. Obutoffaali obuyitibwa chondrocytes mu cartilage ne osteoblasts mu magumba bufuna obubonero okuva mu HGH okweyawulamu n’okukula.

Wabula nga bwe nnagambye emabegako, HGH teyongera buwanvu oluvannyuma lw’obupande bw’okukula (epiphyses) mu magumba g’omwana okuggalwa. Wabula HGH eyamba okukuuma ensengeka y’omubiri eya bulijjo mu bulamu bwonna.

HGH n’enkyukakyuka mu mubiri

Enkyukakyuka y’emmere y’enkola y’eddagala erifuula emmere gye tulya okufuuka amaanyi. Buli katoffaali mu mubiri gwaffe bwetaaga amaanyi okusobola okukola obulungi.

HGH ekosa enkyukakyuka mu mubiri okusinga ng’eyongera ku kukola IGF-1, ekikyusa engeri gy’akosaamu obutoffaali bw’omubiri gwaffe. IGF-1 busimu obulina ensengekera efaananako ne insulini . Insulin busimu bukulu obukolebwa olubuto lwaffe obukendeeza ku sukaali (glucose) mu musaayi . IGF-1 nayo erina obusobozi okukendeeza ku sukaali mu musaayi.

Mu budde obwabulijjo, emibiri gyaffe gifuga n’obwegendereza glucose mu musaayi gwaffe. Glucose oba ssukaali mu musaayi kye kika kya ssukaali ekikulu mu musaayi gwaffe. Tugifuna mu mmere erimu ebirungo ebizimba omubiri (carbohydrate) bye tulya. Ssukaali ono y’awa ebitundu byaffe, ebinywa n’obusimu amaanyi.

Insulin ye hormone enkulu ekendeeza sukaali mu musaayi ng’ali mungi. Era obusimu obuyitibwa glucagon byongera ku sukaali mu musaayi ng’ali mutono. Wabula HGH etera okwongera ku ssukaali mu musaayi ng’ali mutono. Naye,Singa obungi bwa HGH mu mubiri gwo bweyongera nnyo, asobola okutaataaganya enkola ya insulini n’okuleetera ssukaali okweyongera mu musaayi.

Ddala HGH ekufuula omuwanvu?

Yee, HGH esobola okwongera ku buwanvu bw’abaana. Naye ekyo kibaawo nga obupande bw’okukula mu magumba gaabwe tebunnakwatagana. HGH tesobola kukufuula muwanvu nga ebipande ebikula bimaze okwegatta. Wabula bw’omala okutuuka ku buwanvu bwo obusingako, HGH eyamba okukuuma ensengekera y’omubiri gwo n’enkyukakyuka y’omubiri gwo.

Mitendera ki egya bulijjo egya HGH?

Nga bwe nnagambye emabegako, enseke z’omubiri (pituitary gland) zifulumya HGH mu kubutuka olunaku lwonna. Emitendera gino gyawukana okusinziira ku ssaawa y’olunaku, emyaka n’ekikula ky’omuntu. N’olwekyo, okukebera omusaayi omulundi gumu okupima HGH si kya mugaso nnyo mu kuzuula embeera. Wabula abasawo batunuulira emiwendo gya HGH nga bayita mu kukeberebwa okw’enjawulo (okukebera okusikirizibwa oba okunyigiriza).

Emiwendo gya HGH egya bulijjo giri bwe giti:

• Ensajja enkuze: Nanograms 0.4 ku 10 buli mililita (ng/mL) .
• Abakyala abakulu: Nanograms 1 okutuuka ku 14 buli mililita (ng/mL) .
• Abaana: Nanograms 10 ku 50 buli mililita (ng/mL) .

Naye jjukira nti emiwendo gino giyinza okwawukana katono okuva ku laabu okudda ku ndala. Kale zigeraageranye ku range eyabulijjo ku lipoota yo eya laabu. Bw’oba ​​olina ekikweraliikiriza, kakasa nti oyogera n’omusawo wo.

Kiki ekibaawo singa emiwendo gya HGH gikendeera? (Okubulwa obusimu bw’okukula) .

Emiwendo gya HGH bwe giba wansi okusinga ku gya bulijjo, tugiyita Growth Hormone Deficiency . Kino kitera okuva ku buzibu obumu oba okwonooneka kw’endwadde z’omubiri (pituitary gland). Kino kiyinza okuvaako embeera eyitibwa hypopituitarism . Kino kitegeeza nti obusimu bumu oba obusingawo obukolebwa enseke z’omubiri (pituitary gland) bukendeera. HGH nayo busimu obusobola okukosebwa mu ngeri eno.

Obutabeera na HGH buno bukosa abantu abakulu n’abaana mu ngeri ez’enjawulo.

Singa emiwendo gya HGH gikendeera mu bantu abakulu:

Singa emiwendo gya HGH gy’omuntu omukulu gikendeera, ebizibu bino wammanga biyinza okubaawo:

• Okukendeera kw’essanyu n’okumatizibwa mu bulamu.
• Okwongera amasavu mu mubiri.
• Okwongera ku bulabe bw’okufuna endwadde z’omutima.
• Okunafuwa kw’omutima, ebinywa n’amagumba.

Mu bantu abakulu, embeera eno eyinza okuva ku pituitary adenoma (kino si kookolo, wabula kizimba) oba okwonooneka kw’ennywanto/hypothalamus.

Singa abaana baba n’ekirungo kya HGH ekitono:

Singa emiwendo gya HGH gy’omwana gikendeera, okukula kujja kukendeera. Akabonero akakulu kwe kukula mpola ng’omwana awezezza amazaalibwa ag’okusatu. Kwe kugamba, ezitakka wansi wa yinsi emu n’ekitundu buli mwaka. Ng’ekyokulabirako, omwana wo bw’aba alabika ng’omumpi ennyo okusinga abaana abalala abali mu kibiina, olina okweraliikirira.

Okugatta ku ekyo, omwana alina obuzibu bwa HGH naye ayinza okuba n’obubonero nga:

• Feesi eringa ento nnyo okusinga emyaka gyayo.
• Enviiri okulemererwa okukula.
• Okulwawo okutuuka mu myaka gy’obuvubuka.

Abaana basobola okuzaalibwa n’embeera eno. Oluusi ekivaako tekimanyiddwa (idiopathic), kiyinza okuba eky’obuzaale, oba kiyinza okuva ku kwonooneka kw’endwadde z’omubiri (pituitary gland) ng’oli lubuto oba ng’ozaalibwa. Oluusi era kiyinza okuva ku kwonooneka kw’endwadde ya pituitary gland oba hypothalamus ng’omuntu ayise mu bulamu.

Kiki ekibaawo singa emiwendo gya HGH gyeyongera?

Embeera enkulu ekwatagana n'emiwendo gya HGH egya waggulu okusinga egya bulijjo ye acromegaly . Kino nakyo kikosa abantu abakulu n’abaana mu ngeri ya njawulo. Embeera etatera kubaawo nnyo.

Acromegaly mu bantu abakulu

Abantu abakulu abalina obulwadde bwa acromegaly batera okufuna emikono n'ebigere ebinene oba ebizimba n'enkyukakyuka mu ngeri ya ffeesi .

Era ziyinza okuba n’amagumba amanene n’ebitundu by’omunda ebinene. Batera okufuna embeera nga puleesa , sukaali ow’ekika eky’okubiri, n’endwadde z’omutima. Ebitundu ebisoba mu 99% eby’abalwadde ba acromegaly biva ku bizimba ebitali bya kookolo mu nseke eziyitibwa pituitary adenomas . Ebizimba bino bisobola okuvaamu HGH omungi ennyo. Acromegaly esinga kubeerawo oluvannyuma lw’emyaka egy’omu makkati, ng’okukula kuwedde. N’olwekyo, abantu abakulu abalina obulwadde bwa acromegaly tebakula. Mu kifo ky’ekyo, amagumba gaabwe gayinza okugonza.

Obulwadde bwa Acromegaly (Gigantism) mu baana

Tekitera nnyo, abaana basobola okuba n’emiwendo gya HGH egya waggulu nga tebannatuuka ku buwanvu bwabwe obujjuvu. Kino kiyinza okuvaako amagumba amawanvu okukula ekisusse, ekivaako abaana abawanvu mu ngeri etaali ya bulijjo. Embeera eno eyitibwa juvenile acromegaly . Oluusi kiyitibwa gigantism . Singa tebajjanjabwa, abaana bano basobola okukula ne batuuka ku ffuuti musanvu oba okusingawo. Era bayinza okufuna obubonero ng’okukoowa, okulwawo okutuuka mu myaka gy’obuvubuka, n’okulumwa omutwe.

Kino nakyo kitera okuva ku bulwadde bwa pituitary adenoma.

Emiwendo gya HGH gipimibwa gitya?

Singa ggwe oba omwana wo mulina obubonero obulaga nti balina ebizibu ebikwata ku HGH, omusawo ayinza okulagira okukeberebwa omusaayi emirundi egiwerako okukebera emiwendo gya HGH.

Nga bwe nnagambye emabegako, enseke eziyitibwa pituitary gland efulumya HGH mu musaayi emisana gyonna ate ekiro mu biseera ebitali bimu. N’olwekyo, kizibu okutegeera obulungi embeera ng’omira omusaayi n’okukebera HGH omulundi gumu gwokka.

N’olwekyo, abasawo batera okukozesa enkola eziyitibwa growth hormone stimulation and suppression tests okuzuula embeera eziva ku bbula lya HGH oba okuyitirira.

Okugatta ku ekyo, okukebera omusaayi kuyinza okukolebwa okukebera emiwendo gya IGF-1 (insulin-like growth factor 1) .

HGH ekozesebwa etya ng’eddagala?

Ekitongole kya Amerika ekivunaanyizibwa ku by’emmere n’eddagala ekya FDA kikkirizza ekirungo kya HGH ekikolebwa mu ngeri ey’ekikugu okujjanjaba embeera ezimu. HGH eno ey’obutonde osobola okugifuna ng’omusawo agiwandiikiddwa, era eweebwa ng’empiso.

HGH ewandiikibwa abaana olw’embeera zino wammanga:

• Obutabeera na busimu bw’okukula.
• Embeera ezireetera omuntu okubeera omumpi, gamba ng’obulwadde bw’ekibumba obutawona , Turner syndrome , ne Prader-Willi syndrome .

HGH ewandiikibwa abantu abakulu olw’embeera zino wammanga:

• Obutabeera na busimu bw’okukula.
• Okufiirwa ebinywa olw'akawuka ka siriimu .
• Obulwadde bw'ekyenda ekimpi .

Kikulu nnyo: Tokozesangako HGH ya sintetiki okuggyako ng’omusawo akulagira.

Biki ebiva mu HGH ey’obutonde?

Ebimu ku biyinza okuvaamu ng’okozesa HGH ey’obutonde ng’eddagala. Bino bye bino:

• Carpal tunnel syndrome (obusimu obunyiga mu ngalo).
• Okwongera ku buziyiza bwa insulini ne/oba ssukaali ow’ekika eky’okubiri.
• Okuzimba emikono n’ebigere (edema) .
• Obulumi mu binywa n’ebinywa.
• Okugaziwa kw’ebitundu by’amabeere mu basajja (gynecomastia) .
• Okwongera ku bulabe bw’okufuna ebika bya kookolo ebimu.

Abanoonyereza n’okutuusa kati tebalina mawulire gamala ku bikolwa eby’ekiseera ekiwanvu eby’obujjanjabi bwa HGH obw’obutonde.

Ddi lwe nnina okulaba omusawo ku miwendo gya HGH?

Bw’oba ​​ggwe oba omwana wo mulina obubonero obukwatagana n’obutaba na HGH oba okuyitiridde (e.g., okukula mpola, ebitundu by’omubiri okugaziwa), kakasa nti olaba omusawo wo.

Bw’oba ​​wajjanjabwa dda olw’obutabeera bwa bulijjo mu miwendo gya HGH, kikulu nnyo okulaba omusawo wo buli kiseera okukakasa nti obujjanjabi bwo bukola bulungi.

HGH busimu bwa maanyi era obwetaagisa mu nkola nnyingi enkulu mu mubiri gwaffe. Oluusi endwadde yaffe eya pituitary esobola okugikola ekisusse oba ekitono. Ggwe oba omwana wo bw’oba ​​olina obubonero buno, kirungi okwogera n’omusawo. Baliwo okukuyamba.

Obubaka Obusembayo Okutwala Awaka

Okay, kale twayogedde nnyo ku HGH leero, si bwe kiri? Ka tuddemu mu bufunze:

• HGH busimu bukulu nnyo mu kukula kwaffe naddala mu buto, n’enkyukakyuka y’omubiri gwaffe.
• Kino kikolebwa ekitundu ekiyitibwa pituitary gland mu bwongo bwaffe.
• Singa emiwendo gya HGH gikendeera, abaana bayinza okuba nga tebakyakula, era n’abantu abakulu bayinza okufuna ebizibu by’obulamu eby’enjawulo.
• Singa emiwendo gya HGH gyeyongera, embeera nga acromegaly zisobola okubaawo.Mu baana, kino kiyinza okweyoleka nga gigantism, ekitegeeza okukula obuwanvu mu ngeri etaali ya bulijjo.
• Bw’oba ​​oteebereza nti ggwe oba omwana wo muyinza okuba n’ekizibu kya HGH, tolwawo kunoonya magezi ga musawo.
• Tokozesangako HGH ya sintetiki nga tolina ddagala lya musawo.

Jjukira nti bino byonna bigendereddwamu kukusomesa. Bw’oba ​​olina ekikweraliikiriza mu by’obulamu, omusawo wo yekka y’asobola okukuwa eky’okugonjoola ekisinga obulungi. Sigala nga oli mulamu bulungi!

` Obusimu bw’okukula kw’omuntu, HGH, Enseke z’omubiri (Pituitary Gland), Okukula kw’omwana, Okweyongera mu buwanvu, Enkyukakyuka mu mubiri, Obutakwatagana mu busimu