Glucagonoma kye ki? Ka twogere ku mbeera eno etali ya bulijjo!

Olubuto kitundu kitono naye nga kikulu nnyo mu mubiri gwo. Kikola obusimu obuwerako omubiri gwaffe bwe gwetaaga. Kale, oluusi, ekika kya kookolo ekitali kya bulijjo ekikula mu lubuto kiyinza okuleeta obuzibu. Ekyo embeera eno kye bayita Glucagonoma . Mpozzi ng’ofunye obulwadde bwa sukaali mu bwangu, oba ng’ofunye ekintu ng’ekizimba ekyewuunyisa ku lususu lwo, kikulu nnyo okukimanya kino.

Glucagonoma kye ki? Mu ngeri ennyangu...

Glucagonoma kizimba kya kookolo ekitatera kulabika nnyo ekikula mu lubuto lwo. Ekizimba kino kikola obusimu obuyitibwa glucagon obuyitiridde. Kati oyinza okuba nga weebuuza glucagon ono kye ki.

Glucagon busimu bukulu nnyo obuyamba okufuga ssukaali mu mubiri gwaffe, kwe kugamba, glucose mu musaayi . Kikolebwa obutoffaali bwa alpha, ekika ky’obutoffaali obw’enjawulo mu lubuto lwo. Teebereza bw’oba ​​omaze akaseera nga tolya, bw’okola dduyiro nnyo, oba bw’olya emmere erimu ebirungo ebizimba omubiri, ssukaali mu musaayi asobola okukka, nedda? Wano glucagon ono w’ayingira, n’afulumya ssukaali aterekeddwa mu kibumba kyo, kwe kugamba, glycogen , n’azza ssukaali mu musaayi waggulu. Kiringa omuntu ayamba okukuuma bbalansi ya ssukaali mu mubiri gwaffe.

Kyokka bwe wabaawo ekirungo kya glucagonoma, obusimu buno obwa glucagon bukolebwa mu ngeri esukkiridde. Olwo omubiri gwaffe tegusobola kugukwata. Obubonero obukwatagana obuva ku kino buyitibwa Glucagonoma Syndrome . Kino kiyinza okuvaako ebizibu bingi ng’obuzibu bw’olususu ne ssukaali.

Ekika kya kookolo kino, ayitibwa glucagonoma, kiri mu kiti ky’ebizimba by’obusimu obuyitibwa pancreatic neuroendocrine tumors , oba ebizimba by’obutoffaali bw’ebizinga . Ebiseera ebisinga, bino biba mu kitundu ky’omukira oba wakati w’olubuto.

Ddala ono kookolo?

Yee, ebiseera ebisinga, glucagonoma ye kookolo . Eky’ennaku kiri nti, ne bwe kizuulibwa, mu bitundu nga 50%, kwe kugamba, nga omu ku buli babiri, kookolo ono ayinza okuba nga yasaasaana (metastasized) mu bitundu by’omubiri ebirala naddala ekibumba .

Embeera eno ya bulijjo etya?

Glucagonoma mu butuufu mbeera ya bbula nnyo . Abapya abatakka wansi wa muntu omu ku buli bukadde be bazuulibwa buli mwaka. Businga kukwata bantu abali wakati w'emyaka 50 ne 70 .

Bubonero ki obulaga kino?

Glucagonomas zitera okukula mpola . Kale, okuggyako ng’omubiri gwo gukola glucagon emala okuleeta obuzibu, oyinza obutaba na bubonero bwonna.

Wabula glucagonoma bw’ekola glucagon mungi nnyo ate ng’omubiri tegusobola kugukwata, obulwadde bwa glucagonoma obwogeddwako emabegako bubaawo.Kibaawo. Olwo, ojja kulaba obubonero obw’olwatu. Bw’oba ​​olina obubonero buno, kikulu nnyo okulaba omusawo amangu ddala nga bwe kisoboka.

Okusiiyibwa kw’olususu (Necrolytic Migratory Erythema - NME) .

Kano ke kabonero akakulu era akasinga okumanyibwa mu bulwadde bwa glucagonoma syndrome. Abantu nga 90% abalina obulwadde buno bafuna ekizibu kino eky’olususu. Kiyitibwa obulwadde bwa necrolytic migratory erythema (NME) .

Teebereza olususu lwo naddala mu bitundu by’ekyama, enkwaso n’amagulu aga wansi, lutandika okufuuka ebimyufu, okusiiwa n’oluusi ebiruma. Bino oluvannyuma bifuuka ebizimba, ne bikutuka, ne bifuuka ebikuta. Ne bwe ziba nga ziwonye, ​​ekifo kya kitaka kiyinza okusigalawo. Kino kiyinza okutondebwa mu kifo ekimu, ne kiwona, ate ne kiddamu okulabika mu kifo ekirala. Kiba ng’ekizimba ekigenda okuva mu kifo ekimu okudda mu kirala.

Ebintu ebirala ebiri mu NME:

• Kino kiyinza okujja ne kigenda, era kisobola okutambula mu mubiri .
• Kiyinza okusiiwa ennyo n’okuluma mu kusooka.
• Ensigo eno efuuka emmyufu n’oluvannyuma n’efuuka ebizimba ne bikola ekikuta. Oluvannyuma lw’okuwona, ekifo kya kitaka kiyinza okusigalawo.
• Kino kiyinza okuvaako ebintu ng’amabwa mu lulimi (glossitis ), amabwa mu kamwa, emimwa egyakutuka, n’obulwadde bwa ‘angular cheilitis’ .
• Okuzimba kw’ebikowe ( blepharitis ), okugwa kw’enviiri, n’okufuna obuzibu mu misumaali nabyo biyinza okubaawo.

Obubonero bwa sukaali

Obulwadde buno buleeta ssukaali omungi mu musaayi ( hyperglycemia ), ekiyinza okuvaako ssukaali. Obubonero bwa sukaali mulimu:

• Okubeera omugonvu awatali nsonga.
• Ennyonta esukkiridde ennyo (Polydipsia) .
• Okufuka ennyo ( polyuria ), naddala ekiro.
• Enjala esukkiridde ( Polyphagia ).

Obubonero obulala obwa (glucagonoma syndrome) .

Waliwo obubonero obulala obuwerako:

• Ekiddukano ekitawona .
• Hemoglobin omutono mu musaayi (anemia ). Kino kiyinza okuvaako obukoowu n’okuziyira.
• Omusaayi guzimba naddala mu misuwa emiwanvu egy’amagulu ( Deep Vein Thrombosis (DVT) ).

Obubonero obukwata ku nkola y’obwongo n’obusimu

Oluusi, oyinza n’okulaba obubonero obukwata ku nkola y’obwongo n’obusimu, gamba nga:

• Ennaku
• Obulwadde bw’okubulwa amagezi
• Okutabulwatabulwa
• Hyperreflexia (okwanguya okuddamu kw’omubiri) .
• Entambula ewunyisa (ataxia ) .
• Obuzibu mu bwongo ( Psychosis) .) .
• Okutya n'okuteebereza okutali kwa magezi ( Paranoid Delusions ) .

Kiki ekivaako obulwadde bwa glucagonoma?

Ebiseera ebisinga abasawo tebamanyi kituufu kivaako obulwadde bwa glucagonoma. Wabula mu bitundu nga 10%, kookolo ono akwatagana n’embeera y’obuzaale eyitibwa Multiple Endocrine Neoplasia type 1 (MEN type 1) .

Wabula si buli muntu alina MEN type 1 nti afuna glucagonoma. Ekyo nakyo kitundu kitono nnyo ku buli kikumi.

Kino okitegeera otya?

Bw’oba ​​olina embeera y’olususu eya necrolytic migratory erythema (NME) eyayogeddwako emabegako, omusawo ayinza okuteebereza nti olina glucagonoma. Olwo bayinza okukola ebigezo nga:

• Okukebera ssukaali mu musaayi mu kisiibo: Singa ssukaali abeera mungi, osobola okuteeberezebwa nti alina glucagonoma era n’asobola okukakasibwa nti alina ssukaali akwatagana nabyo.
• Okukebera omusaayi gwa Glucagon mu kisiibo: Emiwendo gya glucagon giba mingi mu ngeri etaali ya bulijjo mu glucagonoma – ebiseera ebisinga gisukka picograms 500 buli mililita (pg/mL). Emiwendo gya glucagon egya bulijjo mu kisiibo giri wansi wa 150 pg/mL.
• Okukebera omusaayi mu Amino Acid: Glucagonoma etera okuleeta amino acids okubeera entono mu musaayi ( hypoaminoacidemia ).
• Complete Blood Count (CBC): Kino kikebera oba omusaayi gukendeera , kubanga omusaayi guyinza okubaawo ne glucagonoma.

Okukebera ebifaananyi nga kuno kuyinza okuyamba okukakasa oba ekizimba kiriwo:

• Okukebera CT
• MRI Scan
• Endoscopic Ultrasound ey’okukebera omubiri (Endoscopic Ultrasound).

Kijjanjabwa kitya?

Obujjanjabi bwa glucagonoma okusinga businziira ku oba kookolo akoma mu pancreas (localized) oba asaasaanidde mu bitundu by’omubiri ebirala (metastasized) .

Engeri y'okusooka okufuga obubonero

Omutendera ogusooka kwe kufuga obubonero n’ebizibu ebiva ku glucagon eyitiridde. Kino kikwatibwa bwe kiti:

• Eddagala erifuga glucagon ayitiridde: Empiso eziyitibwa Octreotide ne Lanreotide ziyamba okukendeeza ku bikolwa bya glucagon ayitiridde n’okuyimiriza okukola glucagon. Eddagala lino liyinza n’okukendeeza ku kukula kw’ebizimba. Era ziwa obuweerero okuva ku bubonero bwa NME, sukaali, ekiddukano, n’obuzibu mu nkola y’obusimu.
• Enzijanjaba ya sukaali: Oyinza okwetaaga eddagala lya sukaali ery’omu kamwa oba empiso za insulini okukuuma ssukaali mu musaayi ng’ali mu kigero ekituufu.
• Obuwagizi mu by’endya:Total Parenteral Nutrition (TPN) , amino acid ne zinc supplements zisobola okuweebwa okukendeeza ku bikolwa by’endya embi.
• Obujjanjabi bw’obulwadde bw’olususu bwa NME: Eddagala eritta obuwuka n’eddagala eritta obuwuka liyinza okulongoosa NME.
• Anticoagulant Therapy: Eddagala erikendeeza omusaayi nga heparin liyamba okuziyiza okuzimba emisuwa emiwanvu (DVT) .

Bwe kiba nga kikoma ku pancreas...

Singa kookolo aba mu lubuto lwokka, okulongoosa kye kisinga okujjanjaba . Singa omusawo alongoosa asobola okuggyawo ekizimba ekyo, obulwadde buno butera okuwona . Oluvannyuma lw’okuggyibwako glucagonoma, emiwendo gya glucagon gyo girina okudda mu mbeera eya bulijjo. Obubonero bwo nabwo bulina okugenda.

Bwe kiba nga kisaasaanidde mu bifo ebirala (metastasized)...

Buli lwe kiba kisoboka, abasawo bagamba nti ebizimba bimulongooseemu. Kino kiyinza okuzingiramu okuggya ebizimba mu lubuto, ennywanto eziriraanyewo n’ekibumba.

Naye singa omusawo alongoosa aba tasobola kuggyawo kizimba kyonna oba kyonna, ttiimu y’abasawo eyinza okukuwa amagezi ku bujjanjabi bumu oba obusingawo ku buno:

• Chemotherapy: Obujjanjabi buno bukola nga busaanyaawo obutoffaali bwa kookolo n’obuziyiza okukula.
• Radiofrequency Ablation: Kino kikozesa ebbugumu eriva mu mayengo ga leediyo okutta obutoffaali bwa kookolo.
• Cryosurgical Ablation: Kino kikozesa eddagala erinyogovu ennyo, gamba nga liquid nitrogen, okusaanyaawo obutoffaali bwa kookolo.
• Chemoembolisation: Obujjanjabi buno buziyiza omusaayi okutuuka ku kookolo.

Kiki ekitegeeza nti omuntu asobola okuwona embeera eno?

Endowooza y’omuntu alina obulwadde bwa glucagonoma esinziira ku bintu ebiwerako:

• Emyaka gyo n'obulamu bwo okutwaliza awamu .
• Enkula y'ekizimba kya kookolo .
• Oba kookolo asaasaana oba nedda .

Singa kookolo abeera mu lubuto, entunula etera okuba ennungi . Okulongoosa okuggyawo ekizimba kutera okuwonya, naye kino kibaawo ku balwadde ba glucagonoma nga 20% bokka.

Olw’okuba glucagonoma tatera nnyo, tewali data emala kwogera bbanga ki ddala ly’osobola okuwangaala oba kiki ekinaavaamu singa kookolo asaasaana. Ttiimu yo ey’abasawo ejja kusobola okukuwa ebisingawo okusinziira ku mbeera yo entongole.

Kino kisobola okuziyizibwa?

Olw’okuba bannassaayansi tebamanyi kivaako balwadde ba glucagonoma abasinga obungi, mu butuufu tewali ky’oyinza kukola kukiziyiza .

Wabula singa omu ku b’eŋŋanda zo eza ddaala erisooka (abazadde bo abazaala ne baganda bo) aba azuuliddwa n’obulwadde bwa MEN (Multiple Endocrine Neoplasia) , yogerako n’omusawo wo ku kukebera obuzaale. Bw’oba ​​naawe olina MEN, okukebera obuzaale kuyinza okuyamba okuzuula kookolo mu ntandikwa.

Okuzuulibwa nti olina kookolo kinyiiza nnyo. Bwe kiba kintu ekitali kya bulijjo nga glucagonoma, kibeera kizibu nnyo. Naye jjukira nti ttiimu yo ey’abasawo eriwo okuddamu ebibuuzo byo n’okukuwagira. Bw’oba ​​owulira ng’oli wekka mu birowoozo ne mu nneewulira ng’olina obulwadde bwa glucagonoma, buuza omusawo wo ku pulogulaamu n’obuweereza ebiyinza okukuyamba.

N’ekisembayo, ebintu by’olina okujjukira (Obubaka bw’okutwala awaka) .

Kale, newankubadde nga glucagonoma mbeera ya bbula nnyo, kikulu okugimanya. Naddala singa ofuna obubonero obufaananako ne ssukaali mu bwangu wamu n’okusiiyibwa ku lususu okw’ekyewuunyo (NME), nga bwe kyayogeddwa, laba omusawo awatali kulwa. Singa bumanyibwa nga bukyali, busobola okujjanjabibwa. Wadde nga kino tekitera kubaawo, waliwo obujjanjabi.

Tofaayo, toli wekka. Omusawo wo ne ttiimu y’abasawo bajja kukuyamba okuyita mu lugendo luno. Sigala ng’oli mugumu era ogoberere amagezi ge bakuwa.

` Glucagonoma, kookolo w’olubuto, glucagon, sukaali, obubonero bw’olususu, obusimu, kookolo atatera kulabika