Bw'oba lwanagana ne kookolo, oba bw'oba olina omwagalwa wo alina kookolo, osanga omanyidde ddala ebigambo nga "chemotherapy" ne "radiation therapy." Oboolyawo owulidde ku buzibu obuva mu bujjanjabi buno. Naye leero tugenda kwogera ku kiraasi empya ey’eddagala erigenderera obutoffaali bwa kookolo bwokka era nga likendeeza nnyo ku kwonooneka kw’obutoffaali obulamu. Zino ziyitibwa PARP Inhibitors .
Mu ngeri ennyangu, kino PARP Inhibitor kye ki?
Kino okusobola okukitegeera, tulina okusooka okutegeera enkola entono naye nga nkulu nnyo ebeerawo munda mu butoffaali bw’omubiri gwaffe. Munda mu buli katoffaali mu mubiri gwaffe mulimu ekintu ekiyitibwa DNA. Kilowoozeeko nga pulaani ennene ewandiise engeri buli kimu mu mubiri gwaffe gye kirina okukolamu. Oluusi, empapula za pulaani eno eya DNA zoonooneka katono.
Wano we wava puloteyina eyitibwa PARP . "PARP" kifupi kya Poly (ADP-ribose) polymerase . PARP eringa "makanika w'okuddaabiriza" munda mu butoffaali bwaffe. DNA bw’eyonooneka, puloteyina ya PARP eyingira n’agiddaabiriza. Kino kyetaagisa nnyo okusobola okuwangaala kw’obutoffaali obulamu.
Naye ekizibu kiri nti, obutoffaali bwa kookolo nabwo bukozesa enkola eno eya PARP mu bulungi bwabwo. DNA y’obutoffaali bwa kookolo bw’eyonooneka, era bakozesa PARP eno okugiddaabiriza. N’ekyavaamu, obutoffaali bwa kookolo tebufa, wabula bweyongera okukula n’okusaasaana mu mubiri gwonna.
Ng’eky’okugonjoola kino, abasawo bakozesa eddagala eriyitibwa PARP Inhibitor. "Ekiziyiza" kitegeeza "ekiziyiza." Eddagala lino kye likola kwe "kuziyiza" enkola ya PARP eyamba obutoffaali bwa kookolo. Awatali buyambi bwa PARP, akatoffaali ka kookolo kanafuwa mpolampola, nga tekasobola kuddaabiriza DNA eyonoonese, era okukkakkana nga kafa.
Kino kiringa okuggyako "enkola y'okuwangaala" y'obutoffaali bwa kookolo. Eno y'ensonga lwaki enkola eno ey'obujjanjabi era eyitibwa targeted therapy . Kwe kugamba, eddagala lino litunuulira butereevu obunafu mu butoffaali bwa kookolo.
Ebika ebikulu eby’ebiziyiza PARP ebikozesebwa mu nsi yonna
Waliwo ebiziyiza PARP ebiwerako mu kiseera kino ebikkirizibwa okujjanjaba kookolo. Singa omusawo akuwandiikira ekimu ku bino, kiyinza okuba ku lukalala luno.
| Erinnya ly’Eddagala erya Generic | Erinnya ly'Ekika |
|---|---|
| Olaparib | Lynparza® nga bwe kiri |
| Niraparib (Niraparib) nga bwe | Zejula® |
| Ekirungo kya Rucaparib | Rubraca® eyitibwa Rubraca® |
| Ekirungo kya Talazoparib | Talzenna® nga bwe kiri |
Eddagala lino likozesebwa ku bika ki ebya kookolo?
Ebiziyiza PARP bitera okukozesebwa ku kookolo asinga okukula oba asaasaanidde mu bitundu by’omubiri ebirala (metastatic). Waliwo ebika bya kookolo ebiwerako bye bisinga okukola obulungi.
- Kookolo w’amabeere
- Kookolo w’enkwaso
- Kookolo w’omumwa gwa nnabaana
- Kookolo w’enseke
- Kookolo w’olubuto asookerwako
- Kookolo w’olubuto
Enkolagana ey’enjawulo n’enkyukakyuka z’obuzaale bwa BRCA
Wano waliwo ekintu ky’olina okumanya ddala ku BRCA gene . BRCA ye gene endala enkulu eyamba okuddaabiriza DNA mu butoffaali bwaffe n’okuziyiza kookolo. Naye abantu abamu bayinza okuba n’enkyukakyuka mu ggiini eno eya BRCA. Kino kitegeeza nti emu ku nkola zaabwe enkulu ez’okuddaabiriza DNA tekola bulungi. Olw’ensonga eno, bali mu bulabe bwa maanyi okukwatibwa kookolo.
Lowooza ku mmotoka ng’erina enkola za buleeki bbiri. BRCA y’emu, ate PARP ye ndala. Mu katoffaali ka kookolo akalina enkyukakyuka mu buzaale bwa BRCA, enkola ya buleeki emu (BRCA) yamenyeka dda. Kale obutoffaali bwa kookolo obwo kumpi bwesigamye ddala ku nkola ya buleeki endala (PARP) okusobola okuwangaala.
Kati bwe tuwa eddagala lya PARP Inhibitor, tuggyako n’enkola eyo eya buleeki eyookubiri. Olwo akatoffaali ka kookolo tekalina ngeri gye kayinza kuddaabiriza DNA yaako, era kamala kufa. Eno y’ensonga lwaki PARP Inhibitors zikola nnyo ku kookolo abalina enkyukakyuka mu buzaale bwa BRCA.
Obujjanjabi mbufuna ntya era butwala bbanga ki?
Ekimu ku birungi mu bujjanjabi buno kwe kuba nti byonna bijja mu ngeri ya ddagala (capsules oba tablets). Kale eddagala lino olina okulimira omulundi gumu oba ebiri olunaku. Oluusi eddagala lino lyokka liyinza okumala. Oluusi kiyinza okwetaagisa okugimira wamu n’obujjanjabi obulala obwa kookolo.
Okugeza, oluvannyuma lw’obujjanjabi obwonoona DNA y’obutoffaali bwa kookolo, gamba ng’eddagala oba obujjanjabi obw’amasannyalaze, osobola okuwa eddagala eriziyiza PARP. Olwo, olw’okuba PARP teyamba butoffaali bwa kookolo obwo obwonooneddwa okweddaabiriza, obutoffaali obwo bukakasiddwa okufa.
Obudde bw’obujjanjabi
Kino kyawukana okusinziira ku muntu.
- Abantu abamu bawandiikibwa eddagala lino okumala ekiseera ekigere, gamba ng’emyaka ebiri oba esatu, oluvannyuma lw’obujjanjabi obw’eddagala eriweweeza ku bulwadde buno.
- Abantu abamu bakyagenda mu maaso n’okumira eddagala lino kasita likola ku mubiri gwabwe.
- Oluusi, singa ebizibu ebivaamu bisinga emigaso gy’eddagala, osobola okwogera n’omusawo wo n’oyimiriza obujjanjabi.
N’olwekyo kikulu nnyo okuteesa n’omusawo wo ku bbanga ly’osaanidde okumira eddagala lino n’otuuka ku ky’okusalawo.
Birungi ki n’ebibi ebiri mu bujjanjabi buno?
Ebiziyiza PARP tebisobola kuwonya kookolo ddala. Kyokka, zisobola okuyamba abalwadde abalina ebika bya kookolo ebimu okuwangaala . Eddagala lino lifuga okukula kwa kookolo. Abasawo kino bakiyita okwongeza "omuwendo gw'abantu abawangaala nga tebagenda mu maaso." Mu ngeri ennyangu, zongera ku budde kookolo bw’asigala ng’afugibwa bulungi nga teyeyongera kusajjuka. Mu mbeera ezimu, ziyinza okukola obulungi okusinga eddagala eriweweeza ku bulwadde.
Wabula ekiseera bwe kigenda kiyitawo, obutoffaali bwa kookolo obumu butandika okukola "okuziyiza" eddagala lino. Kino kitegeeza nti eddagala terikyakola. Kino kiyinza okutuuka ku balwadde wakati wa 40% ne 70%. Bannasayansi bagezaako okutegeera lwaki kino kibaawo era banoonyereza ku ngeri empya ez’okufuula eddagala lino okukola obulungi.
Era ka tubeere bamanyi ebizibu ebivaamu.
Okufaananako n’obujjanjabi bwonna obwa kookolo, eddagala eriziyiza PARP liyinza okuleeta ebizibu ebimu. Naye si buli muntu nti azifuna. Era bingi ku bino bisobola okufugibwa.
| Ebizibu ebitera okuvaamu | Ensonga lwaki ekyo oba ebisingawo |
|---|---|
| Obukoowu n’obukoowu | Ebiseera ebisinga kiyinza okuva ku kukendeera kw’omusaayi, nga kino kwe kukendeera kw’obutoffaali obumyufu mu musaayi. |
| Okuvaamu omusaayi (e.g., ebiwundu, okuvaamu omusaayi mu nnyindo) . | Kiyinza okuba nga kiva ku kukendeera kw’omuwendo gw’obutoffaali obukola omusaayi. |
| Okukwatibwa yinfekisoni enfunda eziwera | Omuwendo gw’obutoffaali obweru bwe gukendeera kiyinza okunafuya abaserikale b’omubiri. |
| Okuziyira n’okusiiyibwa | Eddagala eddala osobola okulimira okufuga bino. |
| Obulumi mu lubuto, okuzimba oba okuziyira | Kisobola okufugibwa ng’okyusakyusa mu mmere era bwe kiba kyetaagisa n’okozesa eddagala. |
| Enkyukakyuka mu buwoomi mu kamwa (dysgeusia) . | Emmere esobola okuwooma mu ngeri ey’enjawulo. |
| Okugejja, okuziyira, okulumwa omutwe | Zino nazo mbeera eziyinza okutuuka ku bantu abamu. |
Si bulijjo nnyo, ebimu ku biziyiza PARP biyinza okwongera ku bulabe bw’okufuna ekika kya kookolo w’omusaayi ayitibwa acute myeloid leukemia . Kyokka eno mbeera ya bbula nnyo.
Ddi lw’olina okutegeeza omusawo wo mu bwangu
Bw’oba omira eddagala eriziyiza PARP, kikulu okutegeeza omusawo wo singa ofuna ebizibu ebipya oba ebyeyongera okwonooneka . Ayinza okukyusa ddoozi oba okumuwa eddagala eddala okuyamba ku bintu ng’okuziyira.
Naddala singa ofuna obubonero buno wammanga:Buulira omusawo wo oba eddwaaliro erijjanjaba mu bwangu:
- Obubonero obulaga nti omuntu alina yinfekisoni: omusujja, okuwunya, n’okukankana.
- Obubonero bw’obulwadde bw’ekifuba: Okukaluubirirwa okussa, okuwunya, okunyiga ekifuba n’ebirala (Eno mbeera ya kuzimba mu mawuggwe).
- Obubonero bw’omusaayi okuzimba: okuzimba amagulu, okulumwa, okumyuuka oba okulumwa mu kifuba, okukaluubirirwa okussa.
Obubaka Obutwala Awaka
- PARP Inhibitors kika kya "targeted therapy" etunuulira enkola y'okuddaabiriza DNA y'obutoffaali bwa kookolo ne busaanyawo.
- Bino bikola nnyo naddala ku kookolo nga kookolo w’amabeere, enkwaso, n’enseke ezirina enkyukakyuka mu buzaale bwa BRCA.
- Obujjanjabi buno tebuweebwa mu mpiso, wabula nga tablets/capsules ezimira buli lunaku.
- Wadde nga kino tekiwonya ddala kookolo, kiyamba abalwadde okuwangaala nga kifuga okukula kwa kookolo.
- Okufaananako n’obujjanjabi bwa kookolo obulala, buno bulina ebizibu ebivaamu. Okukoowa, okuziyira, n’obutoffaali bw’omusaayi obutono bisobola okubaawo.
- Kikulu nnyo okukwatagana ennyo n’omusawo wo mu kiseera kyonna eky’obujjanjabi bwo era n’okuloopa ebizibu byonna ebiyinza okuvaamu amangu ddala.
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