Tukimanyi nti emibiri gyaffe gikolebwa obuwumbi n’obuwumbi bw’obutoffaali. Tutera okulowooza ku buli emu ku butoffaali buno ng’obulina amawulire ge gamu ag’obuzaale, okufaananako kkopi nnyingi eza pulaani y’emu. Naye oluusi kino kiyinza okuba eky’enjawulo katono. Teebereza nti obutoffaali obumu mu mubiri gwo bulina pulaani y’obuzaale y’emu, ate obutoffaali obumu bulina pulaani y’obuzaale eyawukana katono. Ekyo kye tuyita mosaicism mu busawo.
Mu ngeri ennyangu, Obufuzi bwa Musa kye ki?
Mu ngeri ennyangu, Mosaicism kwe kubeerawo kw’ebibinja by’obutoffaali bibiri oba okusingawo eby’enjawulo mu buzaale mu mubiri gw’omuntu omu. Kino kiringa art ya mosaic. Nga tile entonotono eza langi n’enkula ez’enjawulo bwe zikwatagana ne zikola ekifaananyi ekirabika obulungi, ekibaawo wano kwe kuba nti obutoffaali obulina obuzaale obw’enjawulo bwe bukwatagana ne bukola omubiri gumu.
Ekyokulabirako ekirungi ku kino y’enjawulo eriwo mu muwendo gwa chromosomes. Omuntu omulamu obulungi alina ensengekera z’obutonde (chromosomes) 46 mu buli katoffaali. Kyokka mu muntu alina mosaicism, obutoffaali obumu bulina chromosomes 46, ate ekibinja ekirala eky’obutoffaali kiyinza okuba n’omuwendo ogw’enjawulo, gamba nga chromosomes 47 oba 45. Enjawulo eno ey’obuzaale esobola okuleeta ebizibu ebimu eby’obulamu ng’azaalibwa, n’oluusi n’obuzibu ng’amaze ekiseera.
Endwadde ki eziyinza okukwatagana n’okukola mosaicism?
Enkola ya mosaic esobola okuleeta endwadde ez’enjawulo. Naye ebiva mu kino byawukana nnyo okusinziira ku muntu. Kisinziira ku bitundu 100 ku 100 eby’obutoffaali obutali bwa bulijjo mu mubiri n’ebitundu obutoffaali obwo mwe bubeera. Katutunuulire ezimu ku ndwadde enkulu ezikwatagana ne kino.
| Kakwakkulizo | Enkosa n’ebintu ebitera okubeerawo |
|---|---|
| Obulwadde bwa Mosaic Down syndrome | Eno ngeri ya bulwadde bwa Down syndrome. Kiyinza okuvaako obulema mu magezi, okunafuwa kw’ebinywa, n’okubeera ne ffeesi empanvu. Abaana abamu nabo bayinza okuba n’obulwadde bw’omutima, obuzibu mu kugaaya emmere, n’obuzibu mu thyroid. |
| Obulwadde bwa Pallister-Killan mosaic | Ne mu mbeera eno, obunafu bw’ebinywa, okulwawo mu magezi, enviiri okugonza, langi y’olususu etali ya bulijjo, n’obulema obulala obw’okuzaalibwa bulabibwa. |
| SOX2 obulwadde bw’okubulwa amaaso | Eno embeera etatera kubaawo nnyo eyinza okuleeta ebizibu eby’amaanyi ng’omwana okuzaalibwa nga talina maaso, okukonziba, obuzibu mu nkula y’obwongo, n’okulwawo okukula kw’omubiri. |
| Trisomy 18 (Ekifaananyi kya Mosaic) . | Eno mbeera ng’omwana akula mu lubuto alemeddwa. Omwana ayinza okuzaalibwa ng’omutwe mutono okusinga ogwa bulijjo, omutima alina obulemu, n’ebitundu by’omubiri ebirala. Ebyembi abalongo bangi abalina embeera eno tebawangaala kusukka mwaka gwabwe ogusooka. |
Okugatta ku ekyo, okukola mosaicism kuyinza okuba nga kukwatagana n’obutabeera bulungi mu chromosomal endala, gamba nga Turner syndrome, n’ebika bya kookolo ebimu naddala kookolo w’omusaayi.
Lwaki embeera eno ebaawo?
Kino mu butuufu ebiseera ebisinga kibaawo mu butanwa. Kino tekiva ku nsobi ya muntu yenna. Teebereza, eggi lya maama bwe limala okuzaala ensigo za taata, akatoffaali (zygote) akasooka okutondebwa katandika okwawukana. Mu ngeri eno, akatoffaali kamu bwe kaawukana mu bibiri, bibiri, bina, bina, munaana n’ebirala, embuto ekula.
Mu kiseera kino eky’okugabanya obutoffaali, buli katoffaali akapya kalina okufuna kkopi entuufu eya chromosomes z’obutoffaali obw’olubereberye. Naye si bulijjo nnyo, ensobi eyinza okubaawo mu nkola eno ey’okukoppa. Ensobi eno eyinza okuvaako akatoffaali akapya okuba n’omuwendo gwa chromosomes ogw’enjawulo. Obutoffaali obulema bwe bweyongera okwawukana, omubiri gukola omulembe gw’obutoffaali obulina ensengekera y’obuzaale etali ya bulijjo. Obutoffaali obw’olubereberye era obulamu nabwo bweyongera okwawukana, bwe kityo okukkakkana ng’omubiri gulina obutoffaali bubiri.
- High-level mosaicism: Singa ekikyamu kino kibaawo nga bukyali nnyo mu nkula y’embuto, ekitundu ekinene (50% oba okusingawo) eky’obutoffaali obutali bwa bulijjo busaasaana mu mubiri gwonna.
- Low-level mosaicism: Singa ekikyamu kibaawo ku mutendera ogw’oluvannyuma ogw’okukula, omuwendo gw’obutoffaali obukoseddwa guba mutono.
Waliwo ebika ebikulu eby’okukola mosaicism?
Yee, enzikiriza ya Musa esobola okugabanyizibwamu ebika ebikulu ebiwerako. Kino bw’okitegeera kiyinza okukuyamba okufuna okutegeera okulungi ku ngeri y’embeera eno.
| Okugabanya mu bika | Ennyinyonnyola ennyangu |
|---|---|
| Okusinziira ku kika ky’obutoffaali obukoseddwa | |
| Enkola ya Somatic Mosaicism | Wano, enkyukakyuka mu buzaale eri mu butoffaali bw’omubiri obwa bulijjo bwokka (obutoffaali bw’omubiri). Kwe kugamba, obutoffaali obuli mu bitundu by’omubiri ng’olususu, obwongo n’omutima. Ekikulu, embeera eno tekosa butoffaali bwa kuzaala (amagi n’ensigo), n’olwekyo tesikira bazadde okutuuka ku baana. |
| Enkola ya Mosaic ey’Olulimi Oluganda | Enkyukakyuka mu buzaale eri mu butoffaali bw’obuwuka bwokka, kwe kugamba, mu magi oba ensigo. N’olwekyo, abazadde ne bwe baba nga tebalina bubonero bwonna, abaana baabwe baba mu bulabe bw’okusikira embeera eno ey’obuzaale. |
| Okusinziira ku kusaasaana mu mubiri | |
| Enzikiriza ya Mosaic eya bulijjo | Wano, obutoffaali obutali bwa bulijjo bubaawo mu mubiri gw’omwana gwonna. |
| Obufuzi bwa Mosa obusibiddwa | Wano, obutoffaali obutali bwa bulijjo tebusangibwa mu mubiri gwonna, wabula bukoma ku kitundu oba ekitundu ekimu, gamba ng’obwongo, omutima oba ekibumba. Okugeza waliwo embeera eyitibwa Confined Placental Mosaicism, ekoma ku nnabaana. |
Abasawo bazuula batya embeera eno?
Okukebera obuzaale mu ngeri ey’enjawulo kwetaagibwa okuzuula obulwadde bwa mosaicism.
- Okuzuula obulwadde nga tonnazaala: Singa wabaawo okuteebereza nti omwana alina obulwadde bwa Mosaicism ng’ali lubuto, abasawo bayinza okumuwa amagezi okukeberebwa mu ngeri ey’enjawulo. Amniocentesis (okugezesa amazzi g’omu lubuto ageetoolodde omwana) neChorionic Villus Sampling (CVS) (okukebera akatundu akatono ak’ebitundu by’omubiri okuva mu nnabaana) kye kimu ku bigezo ng’ebyo.
- Okukebera oluvannyuma lw’okuzaala: Omwana bw’amala okuzaalibwa, embeera eno esobola okuzuulibwa ng’ayita mu kukebera omusaayi, okukebera olususu n’ebirala Oluusi, kiyinza okwetaagisa okukebera ebika by’ebitundu bibiri eby’enjawulo okukakasa embeera entuufu.
Naddala mu nkola nga in-vitro fertilization (IVF), kisoboka okukebera obulema mu buzaale nga bayita mu kukebera okuyitibwa Preimplantation Genetic Screening (PGS) nga embuto tennateekebwa mu nnabaana wa maama.
Waliwo obujjanjabi bw’okukozesa mosaicism?
Kino kizibu abantu bangi kye balina. Mu butuufu, mu kiseera kino tewali ngeri yonna gye tuyinza kuzzaawo oba kuwonya mbeera ya buzaale eyaliwo eyitibwa Mosaicism. Kwe kugamba, tekisoboka kuggyawo butoffaali obutali bwa bulijjo n’obuzzaamu obutoffaali obwa bulijjo.
Naye, ekisinga obukulu, waliwo engeri ez’enjawulo ez’okuddukanya n’okujjanjaba ebizibu by’ebyobulamu n’obubonero obuva ku Musa.
Enkola z’obujjanjabi zisinziira ku mbeera ekosa buli muntu. Ng’ekyokulabirako, omwana alina obulwadde bwa Mosaic Down syndrome ayinza okuganyulwa mu bujjanjabi bw’okwogera n’obujjanjabi bw’omubiri okusobola okumuyamba okukula n’okulongoosa obusobozi bwe. Singa wabaawo embeera y’omutima, obujjanjabi buweebwa okukola ku nsonga enkulu. Kino kitegeeza nti obujjanjabi tebugenderera ku Mosaicism, wabula ku biva mu mbeera. Kikulu okwogera n’omusawo wo ku nteekateeka y’obujjanjabi esinga obulungi gy’oli oba omwana wo.
Ebiseera eby’omu maaso binaabeera bitya ng’embeera eno ebaawo?
Kizibu okulagula prognosis y’omuntu alina mosaicism, kuba kisinziira ku bintu bingi. Ebikulu mulimu:
- Ebitundu ki ku buli kikumi eby’obutoffaali obutali bwa bulijjo? (Ebitundu ku kikumi eby’obutoffaali obutali bwa bulijjo) .
- Ebitundu/ebitundu ki ebikoseddwa?
- Obuzibu bw’embeera ekwatagana nayo.
Omuntu alina ebitundu ebitono ennyo eby’obutoffaali obutali bwa bulijjo (low-level mosaicism) ayinza okubeera obulamu obulungi ddala nga talina bubonero bwonna. Omuntu omulala ayinza okuba n’ebizibu ebitonotono. Singa ebitundu by’obutoffaali obutali bwa bulijjo biba bingi ate nga n’ebitundu ebikulu ng’obwongo n’omutima bikosebwa, ebizibu bisobola okweyongera.
N’olwekyo, mu kifo ky’okutya mu ngeri eteetaagisa ku nsonga eno, kikulu nnyo okulaba omukugu, okufuna okubudaabudibwa ku buzaale , n’okutegeera obulungi embeera y’omwana wo oba omwana wo.
Obubaka Obutwala Awaka
- Mosaicism kwe kubeerawo kw’ebibinja by’obutoffaali ebisukka mu kimu eby’enjawulo mu buzaale mu mubiri gw’omuntu omu.
- Kino si nsobi ya muntu yenna, wabula ensobi ya kimpowooze ebaawo mu kiseera ky’okugabanya obutoffaali mu biseera ebisooka eby’okukula kw’embuto.
- Ebiva mu kukola mosaic byawukana nnyo okusinziira ku muntu. Abamu bayinza obutakosebwa, ate abalala bayinza okufuna ebizibu eby’amaanyi mu bulamu.
- Wadde nga tewali ddagala liwonya mbeera eno, waliwo obujjanjabi obukola ennyo okuddukanya obubonero n’ebizibu by’obulamu ebivaamu.
- Bw’oba ggwe oba omuntu mu maka go alina okubuusabuusa oba ekibuuzo kyonna ku Mosaicism, ekisinga obulungi kwe kukikubaganyaako ebirowoozo mu lwatu n’omusawo wo .
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