Heng Helper T cell te hi engte nge ni? A awlsam zawngin...
Chuvangin, Helper T cells hi kan immune system-a cell chi hrang hrang ber a ni. Kan ram humhimtu sipai ang maiin kan taksa chhungah natna laka min humhimna tur system lian tak kan nei tih han ngaihtuah teh, chu chu immune system kan tih chu a ni . Heng T cells te hi chu system chhunga sipai bik an ni. Hetihlai hian Helper T cells te hi pawl pakhat, hna bik tak thawktu an ni. Heng cell-te hna ber chu natna hrik, chu chu natna thlentu hrik, kan taksaa a luh hunah hriatchhuah a , chutah chuan immune cell dangte nena inzawm a , chu natna do tura fuih (activate them) a ni Indona a lo chhuah huna commander ang bawkin. Heng Helper T cells te hi kan rilru chunglam thymus an tih gland te tak te ah an lo piang a, chu chu an lo thang lian tihna a ni. Hei hi heng cell-te hi training bik pe thin sikul ang a ni. Thymus-ah hian heng cell te hi an puitling a, an hnathawh tur dik taka thawk an zir thin. T cell hi chi hrang hrang a awm a. Helper T cells bakah hian chi dang chi hrang hrang a awm a:- Cytotoxic T cells : Hengte hi sipai zinga attack sipai ang maia hri kai cell te direct-a dotu leh tichhe theitu an ni.
- Regulatory T cells : An hna chu a tul huna immune system hnathawh control a ni a, a chang chuan a overactive loh nan tihtawp a ni bawk.
- NKT cells: Hengte hian a tlangpuiin immunity tichak turin a pui thin.
Engvangin nge heng Helper T cell te hi kan taksa tan an pawimawh em em? (Adaptive Immunity-in a chanvo)
Tunah chuan en teh, kan taksa hriselna (immune system) ah hian hmun hnih a awm a. Pakhat chu Innate Immunity , chu chu kan pian tirh atanga min pek thin defense system a ni a, a tlangpuiin eng hrik pawh laka hna a thawk thin. A dang chu Adaptive Immunity a ni . Hei hi a danglam bik hle mai. A chhan chu hei hi kan taksaa lut natna hrik bikte hre chiangtu leh a bik taka do dan zirtu a nih vang a ni. Hmelma pakhat a vawi hnihna i hmachhawn hunah chuan a vawi khatna aiin i inbuatsaih tha zawk ang mai a ni. Chutah chuan i kal ang.Adaptive immunity hero te hi heng helper T cells te hi an ni . Dik tak chuan adaptive immune response tam zawkah an inrawlh a ni. Anni hian cell chi hnih an tichak ber a, chungte chu: 1. B cells: Heng B cells te hi kan taksaa chemical bik antibodies an tih siam chhuaktu an ni. Heng antibodies te hi ralthuam bik ang mai an ni. Anni hian natna hrik tinte tana chiang tak antibodies an siam a, chu natna hrik chu tihchhiatnaah an pui bawk. 2. Cytotoxic T cells: A hmaa kan sawi tawh ang khan hengte hi infection direct-a dotu leh infected cells tichhetu an ni. A awlsam zawngin sawi ila, helper T cells te hi hruaitute ang mai an ni a, cell dangte hnenah, "Hey, harsatna a awm! Mi zawng zawngin hna an thawk tan!"Helper T cell chi hrang hrang a awm em?
Ni e, heng helper T cells te hian infection an hriat veleh subtype pahnih ah then lehin hna an thawk tan thin. Chungte chu:- TH1 helper cells: Heng cells te hian chemical message bik (command ti ila) an thawn chhuak a, chu chuan cell chi khat macrophage tih chu a tichak a ni. Macrophage te hi kan taksaa bawlhhlawh khawlkhawmtu ang an ni. Pawn lam atanga thil dang leh hrik te chu an "siam" a, taksa an tifai thin. TH1 cells hian a hmaa kan sawi tawh cytotoxic T cells te pawh a tichak bawk.
- TH2 helper cells: Heng cells te hian chemical message hrang hrang an tihchhuah avangin B cells te chu an tichak a. Chumi hnuah chuan B cells te chuan antibodies an siam tan ta a ni . Chu mai pawh ni lovin, heng TH2 cells te hian khuh, thawk hah, leh ril\am ang chi thil a thlen bawk a, chu chuan kan taksaah thil dang a paih chhuak \hin. Allergy thenkhat nena inzawm antibodies te pawh heng TH2 cells te puihnain an siam chhuak bawk.
Kan taksa invenna kalphung hian a buaithlâk êm a, chuti chung pawh chuan a fing êm êm êm êm tih han ngaihtuah teh! Heng zawng zawng hi natna laka min humhim nan a thleng vek a ni .
Engtin nge heng helper T cells te hian hna an thawh theih? (Activation) a ni.
Hei pawh hi thawnthu ngaihnawm tak a ni. Helper T cells te hian an chung lamah hmun bik an nei a , chu chu CD4 receptor an ti a ni . Hei hi kawngka chabi ang a ni. Kan taksaah hian molecule bik dang MHC class II molecules (Major Histocompatibility Complex II molecules) tih kan nei bawk.Heng MHC class II molecule te hi kan taksaah natna hrik emaw thil dang emaw a lut tih "sense" hmasa ber an ni. Tichuan, CD4 receptor leh MHC class II molecule te chu an inzawm khawm ta a ni. Chabi dah a, kawngkhar hawn ang mai a ni. Chutah chuan helper T cells te chu an activate ta a ni . Hêng ṭanpuitu T cell-te hi an activate hnu chuan chemical messenger cytokines an tihte chu an chhuah chhuak a ni. Heng cytokines te hi immune cell dangte hnena thuchah thawntu an ni a, "Tun atang hian kan insual tan a ngai a ni!"Engtin nge Helper T cells leh Cytotoxic T cells te hi an thawh dun?
Heng pahnih hi team pahnih thawhhona ang mai an ni. Helper T cells atanga cytokines chhuak te hian cytotoxic T cells te activate turin a pui thin . "Awle, tunah chuan i turn a ni tawh, i hna thawk rawh!" Chumi hnuah chuan cytotoxic T cells te hian anmahni chemical bik an tichhuak a, chu chuan natna hrik do turin a tichhuak a ni. Tin, hri kai cell te pawh an hre thei a, direct-in an that thei a, natna darh zel tur chu an titawp thei bawk. Teamwork hi a ropui zia hi han en teh!Kan taksaah hian khawiah nge heng helper T cells te hi an tam ber?
T cells hi kan ruh spongy part bone marrow an tih ah hian a lo piang tan thin a . Tichuan, an naupan lai, chu chu an lo puitlin laiin, thymus an tih gland-ah an kal a ni. Sawi tawh ang khan thymus hi heng T cells te tan hian "school" ang mai a ni. Chutah chuan heng cell te hi an puitlin a, an training tha hle. A pawimawh ber chu, thymus hian heng T cell te hi kan taksa chhunga cell engte nge kan ta tih leh pawn lam atanga lo chhuak natna hrik te hi chiang taka hriat turin a zirtir a ni Hei hi a pawimawh hle a, chuti lo chuan keimahni cell ngei pawh an rawn bei thei a ni. Training zawh veleh heng cell te hi thymus atang hian kan taksa pum puiah an inher chhuak thin. Kan lymphatic system pumpuiah hian T cell tam tak a awm a . A bik takin, helper T cells hi a tam thei ang berin:- Bone marrow a ni
- Intestines a awm
- Chuap
- Lymph nodes - Khawsik i neih chuan hengte hi a lo hring a, i kawr leh i kawr chhungah lump a siam thin.
- Spleen tih hi a ni
- Tonsils - I kawr chhunga tonsils awm hi i hre tawh mai thei.
Eng natnain nge Helper T cells te hi a nghawng?
Vanduaithlak takin heng helper T cell pawimawh tak takte hnathawh tichhe thei natna pawh a awm bawk. Chung zinga ṭhenkhat chu:- Autoimmune natna: 1.1.Hei hi kan taksa hriselna (immune system) hian kan cell hrisel tak takte a beih nasat em emna dinhmun a ni. Helpter T cells hnathawh dan inthlak danglamna hi a chhan a ni thei.
- Acute lymphocytic leukemia: Hei hi cancer chi khat a ni a, thisen leh ruhro atanga intan a ni.
- Adult Hodgkin lymphoma: Hei hi cancer chi khat a ni a, lymphatic system atanga intan a ni.
- HIV: Hei hi thisen var, a bik takin CD4 helper T cells te beitu virus a ni. Hei hian immune system a tichak lo thei a , AIDS tih natna a thlen thei bawk .
- Job syndrome: Hei hi immune system disorder awm lo tak a ni a, natna hrik kai fo thin a ni.
- Thymic aplasia: Hei hi nau piang laia thymus a lo thang tha lo a nih chuan a lo awm thin a ni. Thymus dik tak a awm loh avangin T-cell hmasawnna a tichhe thin.
Kan taksa hriselna hriselna atana thil awlsam tak tak kan tih theih
Kan immune system zawng zawng, kan helper T cells te pawh hi chak leh hrisel taka awm reng turin thil awlsam tlemte kan tih theih a awm. Chûngte zawm chuan natna laka min humhimna kawngah kawng thui tak a zawh ang.- Zu in tlem: A theih ang anga zu in loh tur, a nih loh leh a tlem lutuk chauh hmang thin ang che.
- Eat a balanced diet: Thei, thlai, whole grains, lean proteins, leh healthy fats te ei tur a ni.
- Exercise neih fo: Aerobic activity ang chi thil ti la, chu chuan chakna a siam a, chu chuan insiamrem theihna a tipung a, nitin thawk thûk takin thawk rawh.
- Mut tha: Zan tin darkar sarih atanga darkar riat tal mut thin ang che.
- Meizial zuk loh tur: Meizial i zuk chuan bansan rawh. I tan tawh a nih chuan tan ngai suh.
- Kut sil fo tur: Natna hrik laka inven nan sahbawn leh tui hmangin i kut silfai tha ang che.
Hriat reng tur pawimawh ber (Take-Home Message) .
Chuvangin, tunah chuan kan immune system-ah Helper T cells hi a pawimawh zia i hrethiam ta. Kan taksa venghimtu hruaitu fing tak tak ang an ni. Infection a lo thlen chuan heng Helper T cells te hian an hmuchhuak a, fighter cell dang (cytotoxic T cells leh B cells) te nen chuan chu infection dona kawngah hma an hruai thin.Kan taksa hian kan hre lo chung pawha min venghimtu tur system mak tak a nei hi thil mak a ni lo maw? Chuvangin, he immune system hlu tak hi a dinhmun tha taka vawn reng hi kan ngaihven tur a ni bawk. Chutianga tih theih dan tha ber chu hrisel taka nun hi a ni. Tichuan kan helper T cell te pawhin an hna an thawk tha thei tawh ang!Hemi chungchanga zawhna dang i neih chuan doctor zawt hreh suh. Hrisel takin awm rawh!
Immunity, T cells, helper T cells, hriselna, natna, hri kai, taksa invenna
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